The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different (...) research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge. (shrink)

The objectivity of Bayesian induction relies on the ability of evidence to produce a convergence to agreement among agents who initially disagree about the plausibilities of hypotheses. I will describe three sorts of Bayesian convergence. The first reduces the objectivity of inductions about simple "occurrent events" to the objectivity of posterior probabilities for theoretical hypotheses. The second reveals that evidence will generally induce converge to agreement among agents on the posterior probabilities of theories only if the convergence is 0 or (...) 1. The third establishes conditions under which evidence will very probably compel posterior probabilities of theories to converge to 0 or 1. (shrink)