Recent successes of systems biology clarified that biological functionality is multilevel. We point out that this fact makes it necessary to revise popular views about macromolecular functions and distinguish between local, physico-chemical and global, biological functions. Our analysis shows that physico-chemical functions are merely tools of biological functionality. This result sheds new light on the origin of cellular life, indicating that in evolutionary history, assignment of biological functions to cellular ingredients plays a crucial role. In this wider picture, even if (...) aggregation of chance mutations of replicator molecules and spontaneously self-assembled proteins led to the formation of a system identical with a living cell in all physical respects but devoid of biological functions, it would remain an inanimate physical system, a pseudo-cell or a zombie-cell but not a viable cell. In the origin of life scenarios, a fundamental circularity arises, since if cells are the minimal units of life, it is apparent that assignments of cellular functions require the presence of cells and vice versa. Resolution of this dilemma requires distinguishing between physico-chemical and biological symbols as well as between physico-chemical and biological information. Our analysis of the concepts of symbol, rule and code suggests that they all rely implicitly on biological laws or principles. We show that the problem is how to establish physico-chemically arbitrary rules assigning biological functions without the presence of living organisms. We propose a solution to that problem with the help of a generalized action principle and biological harnessing of quantum uncertainties. By our proposal, biology is an autonomous science having its own fundamental principle. The biological principle ought not to be regarded as an emergent phenomenon. It can guide chemical evolution towards the biological one, progressively assigning greater complexity and functionality to macromolecules and systems of macromolecules at all levels of organization. This solution explains some perplexing facts and posits a new context for thinking about the problems of the origin of life and mind. (shrink)

The case of John Snow has long been important to epidemiologists and public health officials. However, despite the fact that there have been many discussions about the various aspects of Snow’s case, there has been virtually no discussion about what guided Snow’s reasoning in his coming to believe his various conclusions about cholera. Here, I want to take up this question in some detail and show that there are a number of specific principles of reasoning that played a crucial role (...) for Snow. Moreover, these principles were episte- mologically important to Snow, a fact about which Snow is explicit in many places. An analysis of Snow’s case suggests that, because of the epistemic role such principles of reasoning can play, health care practitioners ought to understand their practices to be theoretically informed in these ways, and not just data driven. (shrink)

Although biological autonomy is widely discussed, its description in scientific terms remains elusive. I present here a series of recent evidences on the existence of genuine biological autonomy. Nevertheless, nowadays it seems that the only acceptable ground to account for any natural phenomena, including biological autonomy, is physics. But if this were the case, then arguably there would be no way to account for genuine biological autonomy. The way out of such a situation is to build up an exact theoretical (...) biology, and one of the first steps is to clarify the basic concepts of biology, among them biological aim, function and autonomy. We found a physical mechanism to realize biological autonomy, namely, biologically initiated vacuum processes. In the newly emerging picture, biological autonomy shows up as a new, fundamental and inevitable element in our scientific world picture. It offers new perspectives for solving problems regarding the origin and nature of life, connecting ancient Greek philosophy with modern science. Namely, our proposal sheds light in what sense can the God as conceived by Xenophanes can move the material objects of the Universe by its thoughts without toil. (shrink)

Philosophy can shed light on mathematical modeling and the juxtaposition of modeling and empirical data. This paper explores three philosophical traditions of the structure of scientific theory—Syntactic, Semantic, and Pragmatic—to show that each illuminates mathematical modeling. The Pragmatic View identifies four critical functions of mathematical modeling: (1) unification of both models and data, (2) model fitting to data, (3) mechanism identification accounting for observation, and (4) prediction of future observations. Such facets are explored using a recent exchange between two groups (...) of mathematical modelers in plant biology. Scientific debate can arise from different modeling philosophies. (shrink)

The concept of hierarchical organization is commonplace in science. Subatomic particles compose atoms, which compose molecules; cells compose tissues, which compose organs, which compose organisms; etc. Hierarchical organization is particularly prominent in ecology, a field of research explicitly arranged around levels of ecological organization. The concept of levels of organization is also central to a variety of debates in philosophy of science. Yet many difficulties plague the concept of discrete hierarchical levels. In this paper, we show how these difficulties undermine (...) various implications ascribed to hierarchical organization, and we suggest the concept of scale as a promising alternative to levels. Investigating causal processes at different scales offers a way to retain a notion of quasi-levels that avoids the difficulties inherent in the classic concept of hierarchical levels of organization. Throughout, our focus is on ecology, but the results generalize to other invocations of hierarchy in science and philosophy of science. (shrink)

I offer an account of how the quantum theory we have helps us explain so much. The account depends on a pragmatist interpretation of the theory: this takes a quantum state to serve as a source of sound advice to physically situated agents on the content and appropriate degree of belief about matters concerning which they are currently inevitably ignorant. The general account of how to use quantum states and probabilities to explain otherwise puzzling regularities is then illustrated by showing (...) how we can explain single-particle interference phenomena, the stability of matter, and interference of Bose–Einstein condensates. Finally, I note some open problems and relate this account to alternative approaches to explanation that emphasize the importance of causation, of unification, and of structure. 1 Introduction2 Two Requirements on Explanations in Physics3 What We Can use Quantum Theory to Explain4 The Function of Quantum States and Born Probabilities5 How These Functions Contribute to the Explanatory Task6 Example One: Single-Particle Interference7 Example Two: Explanation of the Stability of Matter8 Example Three: Bose Condensation9 Conclusion. (shrink)

Peter Ludlow presents the first book on the philosophy of generative linguistics, including both Chomsky's government and binding theory and his minimalist ...

Pluralism with respect to the structure of explanations of facts is not uncommon. Wesley Salmon, for instance, distinguished two types of explanation: causal explanations (which provide insight in the causes of the fact we want to explain) and unification explanations (which fit the explanandum into a unified world view). The pluralism which Salmon and others have defended is compatible with several positions about the exact relation between these two types of explanations. We distinguish four such positions, and argue in favour (...) of one of them. We also compare our results with the views of some authors who have recently written on this subject. (shrink)

Abstract: This essay critically examines whether there are ethical dimensions to the way that expertise, knowledge claims, and expressions of skepticism intersect on technical matters that influence public policy, especially during times of crisis. It compares two different perspectives on the matter: a philosophical outlook rooted in discourse and virtue ethics and a sociological outlook rooted in the so-called third-wave approach to science studies. The comparison occurs through metaphilosophical analysis and applied claims that clarify how the disciplinary orientations appear to (...) lead to different judgments about matters related to Robert Paarlberg's condemnation of activists who advise African politicians to ban genetically modified food. (shrink)

Putnam (1975) infers from the success of a scientific theory to its approximate truth and the reference of its key term. Laudan (1981) objects that some past theories were successful, and yet their key terms did not refer, so they were not even approximately true. Kitcher (1993) replies that the past theories are approximately true because their working posits are true, although their idle posits are false. In contrast, I argue that successful theories which cohere with each other are approximately (...) true, and that their key terms refer. My position is immune to Laudan’s counterexamples to Putnam’s inference and yields a solution to a problem with Kitcher’s position. (shrink)

The purpose of this paper is to draw attention to a pattern of development, the significance of which has not been generally recognized. This pattern is characterized by an initial occurrence of what I shall call an overdetermined problem - i.e. a problem with no solution compatible with accepted belief and practice - followed by a resolution of the problem which relies on and exploits a change in what was previously taken as given.

We show how an epistemology informed by cognitive science promises to shed light on an ancient problem in the philosophy of mathematics: the problem of exactness. The problem of exactness arises because geometrical knowledge is thought to concern perfect geometrical forms, whereas the embodiment of such forms in the natural world may be imperfect. There thus arises an apparent mismatch between mathematical concepts and physical reality. We propose that the problem can be solved by emphasizing the ways in which the (...) brain can transform and organize its perceptual intake. It is not necessary for a geometrical form to be perfectly instantiated in order for perception of such a form to be the basis of a geometrical concept. (shrink)

Schaffner’s model of theory reduction has played an important role in philosophy of science and philosophy of biology. Here, the model is found to be problematic because of an internal tension. Indeed, standard antireductionist external criticisms concerning reduction functions and laws in biology do not provide a full picture of the limits of Schaffner’s model. However, despite the internal tension, his model usefully highlights the importance of regulative ideals associated with the search for derivational, and embedding, deductive relations among mathematical (...) structures in theoretical biology. A reconstructed Schaffnerian model could therefore shed light on mathematical theory development in the biological sciences and on the epistemology of mathematical practices more generally. *Received November 2006; revised March 2009. †To contact the author, please write to: Philosophy Department, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064; e‐mail: [email protected]. (shrink)

Pluralism is a sound strategy in classifying disciplines of biology. The relevance of a particular classification depends on various methodological issues, on the way in which the scientist's problems are specified, and on factual matters.

Claude Bernard, the father of scientific physiology, believed that if medicine was to become truly scientiifc, it would have to be based on rigorous and controlled animal experiments. Bernard instituted a paradigm which has shaped physiological practice for most of the twentieth century. ln this paper we examine how Bernards commitment to hypothetico-deductivism and determinism led to (a) his rejection of the theory of evolution; (b) his minima/ization of the role of clinical medicine and epidemiological studies; and (c) his conclusion (...) that experiments on nonhuman animals were, "entirely conclusive for the toxicology and hygiene of man". We examine some negative consequences of Bernardianism for twentieth century medicine, and argue that physio/ogy's continued adherence to Bernardianism has caused it to diverge from the other biological sciences which have become increasingly infused with evolutionary theory. (shrink)

The use of unrealistic assumptions in Economics is usually defended not only for pragmatic reasons, but also because of the intrinsic difficulties in determining the degree of realism of assumptions. Additionally, the criterion used for evaluating economic models is associated with their ability to provide accurate predictions. This mode of thought involves –at least implicitly– a commitment to the existence of unvarying invariant factors or regularities. Contrary to this, the present paper presents a critique to the use of invariant knowledge (...) in economics. One reason for this analysis lies in the fact that economic phenomena are not compatible with the logic of invariance, but with the logic of "possibility trees" or "open-ended results". The other reason is that the use of invariant knowledge may entail both external validity problems and negative exposures to a "black swan". Alternatively, an approach where models are understood as possible scenarios is proposed. It is argued that the realism of assumptions is crucial here, since it helps to ascertain the degree of resemblance between the different models and the target system. (shrink)

it is likely that there are many different social processes occurring in different parts of science and at different times, and that these processes will impact upon the nature, quality and quantity of the knowledge that is produced in a multitude of ways and to different extents. It seems clear to me that sometimes the social processes act to increase the reliability of knowledge (such as when there is a tradition of independently reproducing experiments) but sometimes does the opposite (when (...) a closed clique act to perpetuate itself by reducing opportunity for criticism). Simulation can perform a valuable role here by providing and refining possible linkages between the kinds of social processes and its results in terms of knowledge. Earlier simulations of this sort include Gilbert et al. in [10]. The simulation described herein aims to progress this work with a more structural and descriptive approach, that relates what is done by individuals and journals and what collectively results in terms of the overall process. (shrink)

This article has three aims. The first is to give a partial explication of the concept of unification. My explication will be partial because I confine myself to unification of particular events, because I do not consider events of a quantitative nature, and discuss only deductive cases. The second aim is to analyze how unification can be reached. My third aim is to show that unification is an intellectual benefit. Instead of being an intellectual benefit unification could be an intellectual (...) harm, i.e., a state of mind we should try to avoid by all means. By calling unification an intellectual benefit, we claim that this form of understanding has an intrinsic value for us. I argue that unification really has this alleged intrinsic value. (shrink)

There is a rather striking video currently used in police training. A firearms officer is caught on video shooting an armed suspect. The officer then gives his account of what happened, and there is no suggestion that he is tying to fabricate evidence. He says that he shot the suspect once; his partner says that he fired two shots. On the video we see four shots being deliberately fired. Memory, it seems, is an unreliable witness in situations of stress.

an observation to formulate a theory, it is no surprise that the resulting theory accurately captures that observation. However, when the theory makes a novel prediction—when it predicts an observation that was not used in its formulation—this seems to provide more substantial confirmation of the theory. This paper presents a new approach to the vexed problem of understanding the epistemic difference between prediction and accommodation. In fact, there are several problems that need to be disentangled; in all of them, the (...) key is the concept of overfitting. We float the hypothesis that accommodation is a defective methodology only when the methods used to accommodate the data fail to guard against the risk of overfitting. We connect our analysis with the proposals that other philosophers have made. We also discuss its bearing on the conflict between instrumentalism and scientific realism. Introduction Predictivisms—a taxonomy Observations Formulating the problem What might Annie be doing wrong? Solutions Observations explained Mayo on severe tests The miracle argument and scientific realism Concluding comments. (shrink)

In Part I, we presented and motivated a new formulation of Humean Supervenience about Laws of Nature (HS). Here in Part II, we present an epistemological argument in defense of HS, thus formulated. Our contention is that one can combine a modest realism about laws of nature with a proper recognition of the importance of empirical testability in the epistemology of science only if one accepts HS.

Though many agree that we need to account for the role that social factors play in inquiry, developing a viable social epistemology has proved to be difficult. According to Longino, it is the processes that make inquiry possible that are aptly described as "social," for they require a number of people to sustain them. These processes, she claims, not only facilitate inquiry, but also ensure that the results of inquiry are more than mere subjective opinions, and thus deserve to be (...) called "knowledge." In this paper, I (a) explain Longino's epistemology, and (b) defend it against charges that have recently been raised by Kitcher, Schmitt, and Solomon. Longino rightly recognizes that not all social factors have the same (adverse) affect on inquiry. She also recommends that we distinguish knowledge from mere opinion by reference to a social standard. (shrink)

My thesis is that biology is most plausibly regarded as a universal, as distinct from a provincial, science. First, I develop the general notion of a provincial science, formulate three criteria for applying the concept, and present brief examples illustrating their use. Second, I argue that a consideration of population genetics as a characteristic example of a basic biological theory strengthens the prior presumption that biology is not a provincial science. Finally, I examine two arguments to the effect that biology (...) is a provincial science. The first concerns biology's exclusively terrestrial evidence base, the second the logical character of its laws. I introduce considerations that weaken the persuasiveness of the first argument and then show that the second one rests upon a false premise and so should be rejected. (shrink)

The official model of explanation proposed by the logical empiricists, the covering law model, is subject to familiar objections. The goal of the present paper is to explore an unofficial view of explanation which logical empiricists have sometimes suggested, the view of explanation as unification. I try to show that this view can be developed so as to provide insight into major episodes in the history of science, and that it can overcome some of the most serious difficulties besetting the (...) covering law model. (shrink)

The purpose of this paper is to introduce an approach to clinical practice aiming to resolve the dilemma of choosing between a mechanistic and a phenomenological model. The approach is an extension of Polanyi's epistemology. Michael Polanyi, devised an epistemology of science which overcomes the problem of detachment, inherent in the mechanistic approach, and resolves the problem of subjectivity troubling phenomenologists. His epistemology is known as Personal Knowledge. An extension of this epistemology, a Neo-Polanyian proposal, is offered as a more (...) successful model for clinical practice than previous suggestions addressing the dilemma. (shrink)

On the assumption that theistic religious commitment takes place in the face of evidential ambiguity, the question arises under what conditions it is permissible to make a doxastic venture beyond one’s evidence in favour of a religious proposition. In this paper I explore the implications for orthodox theistic commitment of adopting, in answer to that question, a modest, moral coherentist, fideism. This extended Jamesian fideism crucially requires positive ethical evaluation of both the motivation and content of religious doxastic ventures. I (...) suggest that, even though the existence of horrendous evil does not resolve evidential ambiguity in favour of atheism, there are reasonable value commitments that would preclude those who hold them from satisfying extended Jamesian fideist conditions for committing themselves to classical theism. I then begin a discussion of a possible revisionary theistic alternative (in the Christian tradition) which – one might hope – may meet those conditions. An earlier, shorter, version of this paper was delivered as a keynote address at the APA Pacific 2007 Mini-Conference on Models of God. (shrink)

One of our more fundamental beliefs is that causal chains are continuous in time: we believe that every influence from the past upon the future runs through the present. I argue that this tenet, given certain data, can force conceptual changes upon us. I attempt to formulate a heuristic for discovery, based as explicitly as possible upon this tenet, and illustrate it by means of several examples, one of which is Mendel's discovery of genes.

There is an underappreciated respect in which the widespread availability of generative artificial intelligence (AI) models poses a threat to human connection. My central contention is that human creativity is especially capable of helping us connect to others in a valuable way, but the widespread availability of generative AI models reduces our incentives to engage in various sorts of creative work in the arts and sciences. I argue that creative endeavors must be motivated by curiosity, and so they must disclose (...) the creative agent’s inquisitive self. It is through self-disclosure, including the disclosure of the inquisitive self, that we put ourselves in a position to be seen by and connect with others through our creative pursuits. Because relying on AI for certain generative tasks is less self-disclosive than the creative work such technologies supplant, this reliance threatens to weaken our connections to one another. (shrink)

The resurgence in antiracist activism and education brought with it the need to better understand what racism is and how it operates in the production of racial injustice. Prevailing theories understand racism as fundamentally structural, essentially cognitive, and requiring political philosophical investigation over moral philosophical investigation. Such theories are useful within limits, but ultimately offer an inaccurate or incomplete view of racism. In what follows, I offer a virtue-based account of racism that begins its genesis story with individuals, yet acknowledges (...) and attends to the reality and severity of institutional and structural racism; is essentially both cognitive and non-cognitive; and, prioritizes moral philosophical investigation. Throughout, I apply my theory of racism to various spheres of human experience and history to demonstrate its ability to accurately and comprehensively capture the relevant entities and phenomena implicated in racism. In improving our understanding of racism, I aim to generate more targeted and comprehensive reform that effectively mitigates racism and promotes human and societal flourishing. (shrink)

Observational and experimental discoveries of new factual entities such as objects, systems, or processes, are major contributors to some advances in the life sciences. Yet, whereas discovery of theories was extensively deliberated by philosophers of science, very little philosophical attention was paid to the discovery of factual entities. This paper examines historical and philosophical aspects of the experimental discovery by Carl Woese of archaea, prokaryotes that comprise one of the three principal domains of the phylogenetic tree. Borrowing Kuhn’s terminology, this (...) discovery of a major biological entity was made during a ‘normal science’ project of building molecular taxonomy for prokaryotes. Unexpectedly, however, an observed anomaly instigated the discovery of archaea. Substantiation of the existence of the new archaeal entity and consequent reconstruction of the phylogenetic tree prompted replacement of a long-held model of a prokarya and eukarya bipartite tree of life by a new model of a tripartite tree comprising of bacteria, archaea, and eukarya. This paper explores the history and philosophical implications of the progression of Woese’s project from normal science to anomaly-instigated model-changing discovery. It is also shown that the consequential discoveries of RNA splicing and of ribozymes were similarly prompted by unexpected irregularities during normal science activities. It is thus submitted that some discoveries of factual biological entities are triggered by unforeseen observational or experimental anomalies. (shrink)

Explores the science and creative process behind Poe’s cosmological treatise. Silver Winner for Philosophy, 2017 Foreword INDIES Book of the Year Awards In 1848, almost a year and a half before Edgar Allan Poe died at the age of forty, his book Eureka was published. In it, he weaved together his scientific speculations about the universe with his own literary theory, theology, and philosophy of science. Although Poe himself considered it to be his magnum opus, Eureka has mostly been overlooked (...) or underappreciated, sometimes even to the point of being thought an elaborate hoax. Remarkably, however, in Eureka Poe anticipated at least nine major theories and developments in twentieth-century science, including the Big Bang theory, multiverse theory, and the solution to Olbers’ paradox. In this book—the first devoted specifically to Poe’s science side—David N. Stamos, a philosopher of science, combines scientific background with analysis of Poe’s life and work to highlight the creative and scientific achievements of this text. He examines Poe’s literary theory, theology, and intellectual development, and then compares Poe’s understanding of science with that of scientists and philosophers from his own time to the present. Next, Stamos pieces together and clarifies Poe’s theory of scientific imagination, which he then attempts to update and defend by providing numerous case studies of eureka moments in modern science and by seeking insights from comparative biography and psychology, cognitive science, neuroscience, and evolution. David N. Stamos teaches philosophy at York University in Toronto. He is the author of several books, including Darwin and the Nature of Species, also published by SUNY Press. (shrink)

According to a popular account, rationality is a kind of coherence of an agent’s mental states and, more specifically, a matter of fulfilling norms of coherence. For example, in order to be rational, an agent is required to intend to do what they judge they ought to and can do. This norm has been called ‘Enkrasia’. Another norm requires that, ceteris paribus, an agent retain their intention over time. This has been called ‘Persistence of Intention’. This paper argues that thus (...) understood norms of rationality may at times conflict. More specifically, Enkrasia and Persistence of Intention may place demands on the agent that are impossible to fulfil. In these cases, the framework of requirements does not provide us with norms that make us rational. A rival account, according to which rationality is a kind of responsiveness to one’s available reasons, can overcome the problem. (shrink)

This paper seeks to answer the question: Can contemporary forms of artificial intelligence be creative? To answer this question, I consider three conditions that are commonly taken to be necessary for creativity. These are novelty, value, and agency. I argue that while contemporary AI models may have a claim to novelty and value, they cannot satisfy the kind of agency condition required for creativity. From this discussion, a new condition for creativity emerges. Creativity requires curiosity, a motivation to pursue epistemic (...) goods. I argue that contemporary AI models do not satisfy this new condition. Because they lack both agency and curiosity, it is a mistake to attribute the same sort of creativity to AI that we prize in humans. Finally, I consider the question of whether these AI models stand to make human creativity in the arts and sciences obsolete, despite not being creative themselves. I argue, optimistically, that this is unlikely. (shrink)

This article proposes a new account of the relation between the sciences and common sense. A debate between Alfred North Whitehead and Arthur S. Eddington highlighted both the tendency of the natural sciences to repudiate commonsense conceptions of the world and the greater closeness of the human sciences to common sense. While analytic writers have mostly regarded these features as self-evident, I offer an explanation of them by appealing to Wilhelm Dilthey and the phenomenological tradition. Dilthey suggested that, whereas the (...) natural sciences could individuate their phenomena purely from empirical data, human sciences were compelled to refer to commonsense understanding in order to individuate mental phenomena. I apply this insight to episodes from the history of science, and use it to contrast the work of Alfred Schutz and Carl G. Hempel in philosophy of social and natural science. In the final section, I argue that Dilthey’s framework also offers resources to challenge present-day reductionism about mental phenomena. (shrink)

A commonplace thesis of the “new philosophy of science” is the view that the testing of a given theory is not a simple comparison of the theory with nature but also requires the comparison of the theory with competing theories. More specifically the version of the intertheoretic competition thesis that shall be examined is as follows:(ITC) In addition to comparing a theory with nature, a necessary condition for the rejection of a theory is the acceptance of an alternative theory.It is (...) Thomas Kuhn’s The Structure of Scientific Revolutions that is responsible for the widespread popularity of (ITC).1,2…a scientific theory is declared invalid only if an alternative candidate is available to take its place. No process yet disclosed by the historical study of scientific development at all resembles the methodological stereotype of falsification by direct comparison with nature. …the act of judgment that leads scientists to reject a previously accepted theory is always based upon more than a comparison of that theory with the world. (shrink)

What is the function of color vision? In this paper, I focus on perceptual phenomena studied in psychophysics and argue that the best explanation for these phenomena is that the color visual system is a perceptual enhancement system. I first introduce two rival conceptions of the function of color vision: that color vision aims to detect or track the fine-grained colors of distal objects and scenes (Seeing Color) and that it aims to help organisms discriminate, detect, track and/or recognize ecologically (...) important objects, properties, and relations more directly (Seeing with Color). I then discuss two kinds of systematic perceptual phenomena investigated by psychophysicists: approximate color constancy and color induction. I argue from the premise that Seeing with Color better accommodates and explains these phenomena to the conclusion that it is the conception that an empirically-guided philosopher of color ought to adopt. (shrink)

Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they bind to complementary protein-coding nucleic acid, and their liberated amino acids are (...) incorporated into growing protein chains. Independently from and concomitantly with Crick’s hypothesis, Mahlon Hoagland and Paul Zamecnik conducted experiments with no guiding theory that culminated in discoveries of the actual adaptors, transfer RNA (tRNA) molecules, and their amino acids charging enzymes. This paper traces the parallel histories of Crick’s adaptor hypothesis and of the experimental discovery of tRNA and compares their relative impacts on the scientific community. Remarkably, despite the brilliance of Crick’s confirmed prognostication, it had marginal impact on practicing scientists. Conversely, Hoagland and Zamecnik’s experimental discoveries and their evidence-based model of protein synthesis had immediate and enduring impact. I discuss possible explanations for the different impacts of the theoretical prediction and experimental identifications of the same entities. (shrink)

Dwayne Moore raises the physical indeterminism luck objection to libertarian theories of free will, which claims that because agents lack control over the indeterministic physical processes that cause choices, agents lack control over those choices. Moore considers the libertarian strategy of identifying these processes with agential states, such as efforts of will, in order to secure agential control over the outcome of these processes. According to Moore, this strategy faces an insurmountable obstacle in the form of a quausation problem. He (...) argues that naturalistically minded libertarians like Kane are committed to the idea that agential states cause what they do only in virtue of their physical properties. This implies that the agential properties are causally irrelevant to the outcome of these indeterministic processes in which case they cannot help to secure agential control over the outcome. I argue that if Kane is a nonreductive physicalist, he has a way of dealing with the quausation problem. (shrink)

Physicalism is standardly construed as a form of monism, on which all concrete phenomena fall under one fundamental type. It is natural to think that monism, and therefore physicalism, is committed to a supervenience claim. Monism is true only if all phenomena supervene on a certain fundamental type of phenomena. Physicalism, as a form of monism, specifies that these fundamental phenomena are physical. But some argue that physicalism might be true even if the world is disorderly, i.e., not ordered by (...) supervenience relations in the way commonly supposed (Montero in J Philos 110:92–110, 2013; Leuenberger in Inquiry 57:151–174, 2014; Montero and Brown in Topoi 37(3):523–532, 2018; Zhong in Philos Stud 178(5):1529–1544, 2021). Unless these authors intend to challenge the claim that physicalism is a type of monism—a claim so central to the dialectic in philosophy of mind that rejecting it risks changing the subject—they are committed to challenging a supervenience requirement for monism. We argue that monism entails that there are substantial supervenience relations among concrete phenomena: relations that would not obtain in a disorderly world. Our argument thus has implications for debates about physicalism and supervenience, and sheds light on an under-discussed issue: what is implied by classifying a theory in the philosophy of mind as a form of monism? We also argue that physicalism’s commitment to monism creates problems for _via negativa_ physicalism, on which the physical is characterized negatively. (shrink)

Recent years have seen increasing interest in interventionist analyses of metaphysical explanation. One area where interventionism traditionally shines, is in providing an account of explanatory depth; the sense in which explanation comes in degrees. However, the literature on metaphysical explanation has left the notion of depth almost entirely unexplored. In this paper I shall attempt to rectify this oversight by motivating an interventionist analysis of metaphysical explanatory depth (MED), in terms of the range of interventions under which a metaphysically explanatory (...) generalization remains invariant. After elucidating the notion through a toy-example, I demonstrate the important work which MED can perform in characterizing debate within contemporary metaphysics. Focusing upon rival approaches to explaining the identity and distinctness of concrete objects, I argue that the progress achieved in this debate can be characterized in terms of increasing explanatory depth. Having made an initial case for the utility of MED, I then turn this analysis to the metaphysics of explanation itself. By adopting an interventionist framework with respect to MED, I will show that we can assess the depth of competing theories of explanation. This application has two interesting results: first, it suggests that an interventionist analysis of explanation provides deeper explanations of the connection between explanans and explanandum than rival accounts; and second, it suggests that explanations provided by interventionism become deeper still, if one accepts that this methodology ranges over metaphysical, as well as causal, instances. (shrink)

This is a paper about the methodology of normative ethics. I claim that much work in normative ethics can be interpreted as modelling, the form of inquiry familiar from science, involving idealised representations. I begin with the anti-theory debate in ethics, and note that the debate utilises the vocabulary of scientific theories without recognising the role models play in science. I characterise modelling, and show that work with these characteristics is common in ethics. This establishes the plausibility of my interpretation. (...) Taking methodological inspiration from modelling in science gives us new tools for managing idealisations, and a new perspective on pluralism. I demonstrate why this interpretation is a fruitful way of interpreting ethics, by looking at three case studies. First, I return to the anti-theory debate and argue that modelling opens up a new middle ground. Second, I argue that a modelling lens offers a new way of understanding impossibility theorems in population ethics, and their bearing on ethics as a whole. Finally, I show how viewing our work as modelling can be deployed in debates within ethics, using the debate over prioritarianism as an example. I close with further methodological suggestions for those who choose to see themselves as modellers. I discuss the role of counterexamples, our responses to moral disagreement, and the training of new ethicists. (shrink)

The inaugural title in the new, Open Access series BSPS Open, The Material Theory of Induction will initiate a new tradition in the analysis of inductive inference. The fundamental burden of a theory of inductive inference is to determine which are the good inductive inferences or relations of inductive support and why it is that they are so. The traditional approach is modeled on that taken in accounts of deductive inference. It seeks universally applicable schemas or rules or a single (...) formal device, such as the probability calculus. After millennia of halting efforts, none of these approaches has been unequivocally successful and debates between approaches persist. The Material Theory of Induction identifies the source of these enduring problems in the assumption taken at the outset: that inductive inference can be accommodated by a single formal account with universal applicability. Instead, it argues that that there is no single, universally applicable formal account. Rather, each domain has an inductive logic native to it. Which that is, and its extent, is determined by the facts prevailing in that domain. Paying close attention to how inductive inference is conducted in science and copiously illustrated with real-world examples, The Material Theory of Induction will initiate a new tradition in the analysis of inductive inference. (shrink)

According to conceptual reductive accounts, if properties of one domain can be conceptually reduced to properties of another domain, then the former properties are ontologically reduced to the latter properties. I will argue that conceptual reductive accounts face problems: either they do not recognise that many higher-level properties are correlated with multiple physical properties, or they do not clarify how we can discover new truthmakers of sentences about a higher-level property. Still, there is another way to motivate ontological reduction, the (...) truthmaker reductive explanations (TRE). TRE can be given by using resources from John Heil’s truthmaker theory and the a priori entailment view or the a posteriori entailment view. I will argue that we can give these truthmaker reductive explanations if there are various less-than-perfectly similar physical properties that can be the truthmakers of sentences about higher-level properties and the physical similarity between them can explain why an irreducible higher-level property is not needed. (shrink)

[[THIS IS THE COMPLETE SECOND ISSUE OF MΕTASCIENCE]] -/- This second issue of the journal Mεtascience continues the char acterization of this new branch of knowledge that is metasci ence. If it is new, it is not in a radical sense since Mario Bunge practiced it in an exemplary way, since logical positivists were accused of practicing only a mere metascience, since scientists have always practiced it implicitly, and since some philosophers no longer practice philosophy but rather metascience, but without (...) characterizing it or theorizing it, that is, without realizing that they have abandoned one general discourse for another. The novelty therefore lies in this aware ness that a general discourse without philosophy is possible: a scien tific general discourse. The twelve contributions gathered in this volume illustrate the metascientific approach to knowledge of the world as well as to knowledge of knowledge of the world, that is, science. And like Bunge’s project, they are neither part of the analytical movement nor the continental movement in philosophy. We will read here studies about the Bungean system, some applications of Bungean thought, some metascientific contributions, and some reflections around meta science. Among metascientific disciplines, ontology occupies a prominent place in this issue of Mεtascience. Metascience differs from philoso phy in its rejection of the fundamental philosophical distinction be tween appearance and reality. Metascientific ontology therefore does not postulate the existence of any metaphysical reality. But metasci entific ontology, no more than philosophical ontology, is a factual sci ence. The first, because it studies scientific constructs and not concrete objects, the second, because it is interested in transcendent or meta physical objects. (shrink)

The main idea of this thesis is multi-descriptional physicalism. According to it, only physical entities are elements of our ontology, and there are different ways to describe them. Higher-level vocabularies (e.g., mental, neurological, biological) truly describe reality. Sentences about higher-level entities are made true by physical entities. Every chapter will develop multi-descriptional physicalism or defend it from objections. In chapter 1, I will propose a new conceptual reductive account that conceptually reduces higher-level entities to physical entities. This conceptual reductive account (...) combines resources from Heil’s truthmaker theory and either a priori physicalism or a posteriori physicalism. In chapter 2, I apply this conceptual reductive account to various debates. Physicalism, the multiple-realisability argument, the prototype theory of concepts, and truthmaker explanations will be discussed. In chapter 3, I will argue that a major aim of metaphysics should be to discover which entities are fundamental and explain why they suffice for the existence of derivative entities. In chapter 4, I will propose a new way to explain why sentences apparently about composite objects are true even though there are no composite objects. It combines resources from Cameron’s truthmaker theory and van Inwagen’s paraphrase strategy. In chapter 5, I will argue that the intuition that the mind and the body are very different does not show that the mind is distinct from the body. This intuition can be explained away by mentioning our dispositions to give non-physical explanations when we are ignorant of physical facts. In chapter 6, I will examine two arguments for the existence of a metaphysically independent level, and I will argue that only a modified version of one of them succeeds. I will argue that methodological principles support the view that there is a metaphysically independent level. (shrink)

General ontology is a prominent theoretical foundation for information technology analysis, design, and development. Ontology is a branch of philosophy which studies what exists in reality. A widely used ontology in information systems, especially for conceptual modeling, is the BWW (Bunge–Wand–Weber), which is based on ideas of the philosopher and physicist Mario Bunge, as synthesized by Wand and Weber. The ontology was founded on an early subset of Bunge’s philosophy; however, many of Bunge’s ideas have evolved since then. An important (...) question, therefore, is: do the more recent ideas expressed by Bunge call for a new ontology? In this paper, we conduct an analysis of Bunge’s earlier and more recent works to address this question. We present a new ontology based on Bunge’s later and broader works, which we refer to as Bunge’s Systemist Ontology (BSO). We then compare BSO to the constructs of BWW. The comparison reveals both considerable overlap between BSO and BWW, as well as substantial differences. From this comparison and the initial exposition of BSO, we provide suggestions for further ontology studies and identify research questions that could provide a fruitful agenda for future scholarship in conceptual modeling and other areas of information technology. (shrink)

Qiyās, or “correlational inference” (often glossed as “analogy”), comprises a primary set of methodological tools recognized by a majority of premodern Sunnī jurists. Its elements, valid modes, and proper applications were the focus of continual argument and refinement. A particular area of debate was the methodology of determining or justifying the ʿilla: the legal cause (or occasioning factor, or ratio legis) giving rise to a ruling in God’s Law. This was most often discussed (and disputed) under the rubric of “the (...) modes of causal justification” (masālik al-taʿlīl). Among these modes was the much debated test of dawarān (concomitance of presumed cause and effect). In brief, proponents of dawarān employed it to justify claims that a property (waṣf) occasioned the ruling (ḥukm) in an authoritative source-case (aṣl). In concert with other considerations, the demonstrated co-presence (ṭard) and co-absence (ʿaks) of property and ruling—that is, their concomitance “in existence” (wujūdan) and “in nonexistence” (ʿadaman)— was taken as an indication that the property was the ruling’s ʿilla. Delving further into dawarān and causation (ʿilliyya), the current study interprets “in existence” and “in nonexistence” not as a kind of metaphor for true and false (within the framework of a classical truth-functional formal semantics), but as an accurate terminology vis-à-vis the meaning of causality statements, fully compatible with dominant Islamicate views on causal agency. In brief, a deeper logical and linguistic analysis of the different existential modes of dawarān strongly suggests that we should distinguish property (or phenomenon) and ruling (or effect) as types (concepts or propositions linguistically expressed by a sentence) as opposed to tokens (instantiations of the type; the real, ontological events that verify the proposition). Our reading of dawarān as shaped by a finer-grained structure not only allows us to identify the efficient occasioning process as a function which takes some particular token of the ʿilla (arguably, the property or properties which provide the ruling’s material cause) and renders a token of the general ruling type, but it allows us to elucidate the role of taʿlīl (causal justification) in shaping an epistemological theory of argument to the best explanation: a sophisticated, premodern manifestation of abductive reasoning. (shrink)

Different why-questions emerge under different contexts and require different information in order to be addressed. Hence a relevance relation can hardly be invariant across contexts. However, what is indeed common under any possible context is that all explananda require scientific information in order to be explained. So no scientific information is in principle explanatorily irrelevant, it only becomes so under certain contexts. In view of this, scientific thought experiments can offer explanations, should we analyze their representational strategies. Their representations involve (...) empirical as well as hypothetical statements. I call this the “representational mingling” which bears scientific information that can explain events. Buchanan’s thought experiment from constitutional economics is examined to show how mingled representations explain. (shrink)