Avery’s et al. ’s 1944 paper provides the first direct evidence of DNA having gene-like properties and marks the beginning of a new phase in early molecular genetics (with a strong focus on chemistry and DNA). The study of its reception shows that on the whole, Avery’s results were immediately appreciated and motivated new research on transformation, the chemical nature of DNA’s biological specificity and bacteria genetics. It shows, too, that initial problems of transferring transformation to other systems and prominent (...) criticism of its results nurtured skepticism. Avery’s experiment was downplayed and neglected particularly by many of those scientists who worked in the new fields of biochemical and biophysical genetics, genetic phage, and TMV research. This was not due to the fact that the implications of the paper could not be connected to generally accepted knowledge. Contrary to a widespread belief, the assumed uniformity of DNA as opposed to proteins was not used as an argument against the validity of Avery’s et al.’s finding. The indifference rather reflected, among other things, the disciplinary gap between the chemically oriented microbiologists and the old and new geneticists who remained committed to genetic and physical methods (in particular x-ray studies) and clung to the assumption that proteins were the sole carriers of biological specificity. The responses to Avery’s et al.’s paper show how different research interests in the areas between microbiology, genetics, and biochemistry interacted with the prejudices, dogmas, individual farsightedness or short-sightedness, and scientific authority during a pivotal period of early molecular biology. (shrink)

This paper discusses the nature and the status of inference to the best explanation. We outline the foundational role given IBE by its defenders and the arguments of critics who deny it any place at all ; argue that, on the two main conceptions of explanation, IBE cannot be a foundational inference rule ; sketch an account of IBE that makes it contextual and dependent on substantive empirical assumptions, much as simplicity seems to be ; show how that account avoids (...) the critics ' complaints and leaves IBE an important role ; and sketch how our account can clarify debates over IBE in arguments for scientific realism. (shrink)

In this paper the problem of the relation between belief and acceptance is discussed in view of recent literature on the topic. Belief and acceptance are characterized in terms of a number of properties, which show both the similarities and the dissimilarities between these notions. In particular it is claimed - contrary to some recently expressed views - that acceptance need not be intentional action and that the differences between belief and acceptance do not boil down to the simple view (...) that acceptance, contrary to belief, is based on the agent's direct exercise of his will. Acceptance which is not based on intentional action is shown in the paper to be especially closely related to belief, especially to linguistic belief. Thus if a person is in a non-intentional-ly acquired and held state of acceptance that something p, he also believes that p. Another general difference is that acceptance is language-dependent while there can be non-linguistic belief. Collective beliefs and acceptances are also briefly discussed in the paper Among other things, it is noted that the notion of wide as contrasted with truth-oriented, narrow acceptance is central in the collective case. (shrink)

It is now twenty years since James Watson published his personal account of the discovery of the structure of DNA and triggered the growing scholarly study of the roots of molecular biology. Watson himself was not concerned with the study of nucleic acids before he became directly involved but at least three detailed histories of the early development of molecular biology have subsequently appeared, together with books, papers and reviews from others who took part, or their partisan representatives. Of these (...) three histories, only one does justice to Avery's work. His surviving DNA collaborator, MacLyn McCarty, believes that only Olby inThe Path to the Double Helixdeals adequately with Avery's contribution. (shrink)