Bateson's belated acceptance of the chromosome theory came in two main stages, and was permanent, although he retained to the end reservations about some implications and extensions of the theory. Coleman's attempt to explain Bateson's resistance in terms of his conservative mode of thought is critically examined, and rejected: the attributes Coleman assigns to Bateson are all either inappropriate, or irrelevant to chromosome theory, or both. Instead, the diverse factors which contributed to Bateson's resistance are enumerated and discussed. These include (...) deficiencies in the evidence then available to support the theory; embryological difficulties; Bateson's aversion to microscopy combined with the lack of a close colleague skilled in cytology; his iconoclastic temperament, and the fact that he found T. H. Morgan, the leader of the Drosophila school, an uncongenial personality. Taken together, these factors suffice to account for his resistance. Bateson's position is contrasted with that of the other most eminent opponent, W. Johannsen, whose organismic outlook was the main obstacle to acceptance. (shrink)

The argument from analogy is examined from the point of view of Carnap's confirmation theory. It is argued that if inductive arguments are to be applicable to the real world, they must contain elementary analogical inferences. Carnap's system as originally developed (theλ -system) is not strong enough to take account of analogical arguments, but it is shown that the new system, which he has announced but not published in detail (theη -system), is capable of satisfying the conditions of inductive analogy. (...) Finally it is shown that an elementary analysis of analogical inference yields postulates of the η -system with a minimum of arbitrary assumptions. (shrink)

William Bateson has long occupied a controversial role in the history of biology at the turn of the twentieth century. For the most part, Bateson has been situated as the British translator of Mendel or as the outspoken antagonist of W. F. R. Weldon and Karl Pearson's biometrics program. Less has been made of Bateson's transition from embryologist to advocate for discontinuous variation, and the precise role of British and American influences in that transition, in the years leading up to (...) the publication of his massive Materials for the Study of Variation. In this paper, I first attempt to trace Bateson's development in his early career before turning to search for the development of the moniker "anti-Darwinist" that has been attached to Bateson in well-known histories of the neo-Darwinian Synthesis. (shrink)

Early Victorian analogical arguments were used to order the natural and the social world by maintaining a coherent collective experience across cultural oppositions such as the ideal and material, the sacred and profane, theory and fact. Maxwell's use of analogical argument in ‘On Faraday's lines of force’ was a contribution to that broad nineteenth-century discussion which overlapped theology and natural philosophy. I argue here that Maxwell understood his theoretical work as both a technical and a socially meaningful practice and that (...) embedding his use of analogy in the social and intellectual context of Victorian Britain provides a means of telling a sociocultural history of Maxwell's development of a new cognitive tool: a way of thinking on paper analogous to thinking with objects in the laboratory. (shrink)

The recognition of Gregor Mendel's achievement in his study of hybridization was signalled by the ‘rediscovery’ papers of Hugo de Vries, Carl Correns and Erich Tschermak. The dates on which these papers were published are given in Table 1. The first of these—De Vries ‘Comptes renduspaper—was in French and made no mention of Mendel or his paper. The rest, led by De Vries’Berichtepaper, were in German and mentioned Mendel, giving the location of his paper. It has long been accepted that (...) the first account of Mendel's work in English was given by the Cambridge zoologist, William Bateson, to an audience of Fellows of the Royal Horticultural Society in London on 8 May, 1900. This is based on two sources: the paper ‘Problems of Heredity as a Subject for Horticultural Investigation’, published in the Society's journal later that year and stated as ‘Read 8 May, 1900’, and Beatrice Bateson's account of the event over a quarter of a century later. Of the paper which her husband gave on that occasion she wrote:He had already prepared this paper, but in the train on his way to town to deliver it, he read Mendel's actual paper on peas for the first time. As a lecturer he was always cautious, suggesting rather than affirming his own convictions. So ready was he however for the simple Mendelian law that he at once incorporated it into his lecture. (shrink)

Genetics was established on a strict particulate conception of heredity. Genetic linkage, the deviation from independent segregation of Mendelian factors, was conceived as a function of the material allocation of the factors to the chromosomes, rather than to the multiple effects (pleiotropy) of discrete factors. Although linkage maps were abstractions they provided strong support for the chromosomal theory of inheritance. Direct Cytogenetic evidence was scarce until X-ray induced major chromosomal rearrangements allowed direct correlation of genetic and cytological rearrangements. Only with (...) the discovery of the polytenic giant chromosomes in Drosophila larvae in the 1930s were the virtual maps backed up by physical maps of the genetic loci. Genetic linkage became a pivotal experimental tool for the examination of the integration of genetic functions in development and in evolution. Genetic mapping has remained a hallmark of genetic analysis. The location of genes in DNA is a modern extension of the notion of genetic linkage. (shrink)

The term ‘mechanism’ has been used in two quite different ways in the history of biology. Operative, or explanatory mechanism refers to the step-by-step description or explanation of how components in a system interact to yield a particular outcome . Philosophical Mechanism, on the other hand, refers to a broad view of organisms as material entities, functioning in ways similar to machines — that is, carrying out a variety of activities based on known chemical and physical processes. In the early (...) twentieth century philosophical Mechanism became the foundation of a ‘new biology’ that sought to establish the life sciences on the same solid and rigorous foundation as the physical sciences, including a strong emphasis on experimentation. In the context of the times this campaign was particularly aimed at combating the reintroduction of more holistic, non-mechanical approaches into the life sciences . In so doing, Mechanists failed to see some of the strong points of non-vitalistic holistic thinking. The two approaches are illustrated in the work of Jacques Loeb and Hans Spemann. (shrink)

In the early years of Mendelism, 1900-1910, William Bateson established a productive research group consisting of women and men studying biology at Cambridge. The empirical evidence they provided through investigating the patterns of hereditary in many different species helped confirm the validity of the Mendelian laws of heredity. What has not previously been well recognized is that owing to the lack of sufficient institutional support, the group primarily relied on domestic resources to carry out their work. Members of the group (...) formed a kind of extended family unit, centered on the Batesons' home in Grantchester and the grounds of Newnham College. This case illustrates the continuing role that domestic environments played in supporting scientific research in the early 20th century. (shrink)

Muriel Wheldale, a distinguished graduate of Newnham College, Cambridge, was a member of William Bateson's school of genetics at Cambridge University from 1903. Her investigation of flower color inheritance in snapdragons (Antirrhinum), a topic of particular interest to botanists, contributed to establishing Mendelism as a powerful new tool in studying heredity. Her understanding of the genetics of pigment formation led her to do cutting-edge work in biochemistry, culminating in the publication of her landmark work, The Anthocyanin Pigments of Plants (1916). (...) In 1915, she joined Frederick Gowland Hopkin's Department of Biochemistry as assistant and in 1926 became one of the first women to be appointed university lecturer. In 1919 she married the biochemist Huia Onslow, with whom she collaborated until his death in 1922. This paper examines Wheldale's work in genetics and especially focuses on the early linkage of Mendelian methdology with new techniques in biochemistry that eventually led to the founding of biochemical genetics. It highlights significant issues in the early history of women in genetics, including the critical role of mentors, funding opportunities, and career strategies. (shrink)

Research in Mendelian heredity was first given permanent institutional support in the U.K. at the John Innes Horticultural Institution. The path by which this was achieved is described. It is shown that Brooke-Hunt in the Board of Agriculture played a decisive part in redirecting the John Innes Bequest from a school for gardeners as intended by the testator to an institute given to research on plants of importance to the horticultural trade. The choice of William Bateson as the institute's first (...) director is traced to the influence of a lobby of academic biologists led by J. B. Farmer. The effects of Bateson's appointment on the shape taken by the new institute and on its subsequent history are described. (shrink)

T. H. Morgan, A. H. Sturtevant, H. J. Muller and C. B. Bridges published their comprehensive treatise "The Mechanism of Mendelian Heredity" in 1915. By 1920 Morgan 's "Chromosome Theory of Heredity" was generally accepted by geneticists in the United States, and by British geneticists by 1925. By 1930 it had been incorporated into most general biology, botany, and zoology textbooks as established knowledge. In this paper, I examine the reasons why it was accepted as part of a series of (...) comparative studies of theory-acceptance in the sciences. In this context it is of interest to look at the persuasiveness of confirmed novel predictions, a factor often regarded by philosophers of science as the most important way to justify a theory. Here it turns out to play a role in the decision of some geneticists to accept the theory, but is generally less important than the CTH's ability to explain Mendelian inheritance, sex-linked inheritance, non-disjunction, and the connection between linkage groups and the number of chromosome pairs; in other words, to establish a firm connection between genetics and cytology. It is remarkable that geneticists were willing to accept the CTH as applicable to all organisms at a time when it had been confirmed only for Drosophila. The construction of maps showing the location on the chromosomes of genes for specific characters was especially convincing for non-geneticists. (shrink)

Laudan's thesis that conceptual problem solving is at least as important as empirical problem solving in scientific research is given support by a study of the relation between the chromosome theory and the Mendelian research program. It will be shown that there existed a conceptual tension between the chromosome theory and the Mendelian program. This tension was to be resolved by changing the constraints of the Mendelian program. The relation between the chromosome theory and the Mendelian program is shown to (...) be a good illustration of the influence of science itself on the rational standards governing scientific development. (shrink)