This article sheds new light on the Theogenius and the Profugiorum ab erumna libri III, two Italian dialogues in which Leon Battista Alberti was influenced by Seneca’s On the Tranquillity of the Mind and Petrarch’s De remediis utriusque fortunae, but developed an innovative reflection on the care of the self as medicine of the mind. The novelty hinged not on his pessimistic diagnosis of the human condition, which linked the disquiet caused by the inconstancy of fortune with the natural instability (...) of the mind, but rather on his ironic conception of therapy, which challenged the Stoic belief in the possibility of finding a definitive cure for hardship. To what extent and in what sense Alberti’s therapy exhibits an ironic stance is clarified by the analysis of two Intercenales, the Latin work which aimed to relieve the mind’s maladies through laughter. While Erumna made the case that the way of life championed by the Stoics as well as the choice of living the life of another man cannot alleviate human misery, Patientia mocked the efficacy of Stoic remedies such as patience and time. People can only hope to come to terms with the mind’s maladies and should bear their burdens cheerfully rather than despair of them: this is one of the most intriguing aspects of Alberti’s medicine of the mind. (shrink)