When the Human Genome Project (HGP) was launched, our genome was presented as our ‘blueprint’, a metaphor reflecting a genetic deterministic epistemology. Eventually, however, the HGP undermined rather than strengthened the understanding of genomes as blueprints and of genes as ultimate causal units. A symbolical turning point was the discovery that the human genome only contains 22,500 genes. Initially, this was seen as a narcissistic offence. Gradually, however, it strengthened the shift from traditional genetics and biotechnology (i.e., gene-oriented approaches) to (...) genomics, i.e. genome-oriented or systems approaches, emphasizing complexity. The 20th century can be regarded as the century of biotechnology and of the gene. Its history demonstrated that the will to know (notably: to know ourselves) has never been a disinterested affair: it is driven by a will to improve (notably: to improve ourselves). In this article it is claimed that, as genomics takes us beyond a genetic deterministic understanding of life, this must have consequences for societal research and debate as well. Policies for self-improvement will increasingly rely on the use of complex interpretation. Therefore, the emphasis must shift from issues such as genetic manipulation and human enhancement to issues involved in governance of novel forms of information. (shrink)

From 1900 onwards, scientists and novelists have explored the contours of a future society based on the use of “anthropotechnologies” (techniques applicable to human beings for the purpose of performance enhancement ranging from training and education to genome-based biotechnologies). Gradually but steadily, the technologies involved migrated from (science) fiction into scholarly publications, and from “utopia” (or “dystopia”) into science. Building on seminal ideas borrowed from Nietzsche, Peter Sloterdijk has outlined the challenges inherent in this development. Since time immemorial, and at (...) least since the days of Plato’s Academy, human beings have been interested in possibilities for (physical or mental) performance enhancement. We are constantly trying to improve ourselves, both collectively and individually, for better or for worse. At present, however, new genomics-based technologies are opening up new avenues for self-amelioration. Developments in research facilities using animal models may to a certain extent be seen as expeditions into our own future. Are we able to address the bioethical and biopolitical issues awaiting us? After analyzing and assessing Sloterdijk’s views, attention will shift to a concrete domain of application, namely sport genomics. For various reasons, top athletes are likely to play the role of genomics pioneers by using personalized genomics information to adjust diet, life-style, training schedules and doping intake to the strengths and weaknesses of their personalized genome information. Thus, sport genomics may be regarded as a test bed where the contours of genomics-based self-management are tried out. (shrink)

What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that (...) is life. (shrink)

In a sense, all technology is biotechnology: machines interacting with human organisms. Technology is designed to overcome the frailties and limitations of human beings in a state of nature -- to make us faster, stronger, longer-lived, smarter, happier. And all technology raises questions about its real contribution to human welfare: are our lives really better for the existence of the automobile, television, nuclear power? These questions are ethical and political, as well as medical; and they even reach to the philosophical (...) and spiritual. On the whole, we seem pretty well adapted to our technology, at least on the face of it -- but there have always been doubts about whether the human soul thrives best in the oppressively technological world we have created for ourselves. (I am continually struck by how much time I have to spend fixing the machines that supposedly improve my life.). (shrink)

Francis Fukuyama's controversial new book, Our Posthuman Future: Consequences of the Biotechnology Revolution, has elicited varied reactions, but like it or not, it seems likely to be influential. Here are three opinions. —Ed.

Dieses Buch ist ein Klassiker der philosophischen Anthropologie und Arnold Gehlens wichtigstes Buch. Es fasst Gehlens Modell vom Menschen als eines auf Handlung und kulturelle Kompensation angewiesenen und sich damit eigentatig von der ihn bedrohenden Umwelt entlastenden "Mangelwesens" gultig zusammen. Auch wurde in "Der Mensch" 1950 erstmals Gehlens Institutionenlehre skizziert, die er aus der Revision seiner ursprunglichen Theorie "oberster Fuhrungssysteme" entwickelte. Gehlens Hauptwerk war "ohne Zweifel der fortgeschrittenste Versuch, die Philosophische Anthropologie an die Erkenntnisse empirischer Disziplinen zu binden". Diese Ausgabe (...) bringt die textkritische Edition der Kritischen Gesamtausgabe mit dem Text der 4. Auflage von 1950, der die letzte tiefgreifende Umarbeitung darstellt, die Gehlen an dem erstmals 1940 erschienenen Text vornahm. (shrink)

Two groups of researchers released the formal report of data for the human genome last Monday -- on the birthday of Charles Darwin, who jump-started our biological understanding of life's nature and evolution when he published ''The Origin of Species'' in 1859. On Tuesday, and for only the second time in 35 years of teaching, I dropped my intended schedule -- to discuss the importance of this work with my undergraduate course on the history of life. (The only other case, (...) in a distant age of the late 60's, fell a half-hour after radical students had seized University Hall and physically ejected the deans; this time at least, I told my students, the reason for the change lay squarely within the subject matter of the course!). (shrink)

Sigmund Freud – ein bekannter osterreichischer Psychiater, Psychoanalytiker und Neurologe. Er ist der Begrunder der Psychoanalyse, die einen wesentlichen Einfluss auf die Psychologie, Medizin, Soziologie, Anthropologie, Literatur und Kunst des 20. Jahrhunderts ausubte. „Die Traumdeutung“ ist die erste bedeutende Monographie des Psychoanalytikers. In diesem Traktat erlautert Freud erstmals einen solchen Schlusselbegriff der Psychoanalyse, wie es das Unbewusste ist.

"I know of no religious writer more pertinent to our time."—T. S. Eliot, Introduction to Pensees Intended to prove that religion is not contrary to reason, Pascal's Pensees rank among the liveliest and most eloquent defenses of Christianity. Motivated by the seventeenth-century view of the supremacy of human reason, Pascal (1623–1662) had intended to write an ambitious apologia for Christianity in which he argued the inability of reason to address metaphysical problems. His untimely death prevented the work's completion, but the (...) fragments published posthumously in 1670 as Pensees remain a vital part of religious and philosophical literature. W. F. Trotter translation. Introduction by T. S. Eliot. (shrink)