The presence of both myocardial hypertrophy and coronary-to-cameral fistula has been reported previously. However, the exact mechanisms are not clear. Herein, we reported a patient with mid-cavitary hypertrophic cardiomyopathy and concomitant connections between coronary arteries and left ventricular cavity.

According to Einstein, a universal time does not exist. But what if time is different than what we think of it? Cosmic Microvawe Background Radiation was accepted as a reference for a universal clock and a new time concept has been constructed. According to this new concept, time was tackled as two-dimensional having both a wavelength and a frequency. What our clocks measure is actually a derivation of the frequency of time. A relativistic time dilation actually corresponds to an increase (...) in the wavelength of time. At the point where time wavelength and time frequency is equal, where light is positioned, quantum-world and macro- world are seperated. Gravity was redefined with respect to time and the new two dimensional time fabric of the universe was speculated to be the source of dark energy causing the universe to expand. According to this new point of view quantum realm and macro-world can be better understood. This new time concept provide a basis for our understanding of quantum gravity and provide the long-sought answers to well known problems of it. A prediction of the presented theory is that the universe will expand at various rates at different regions due to the fact that particular surroundings will create different gravities and cause a different gravity- time wavelength effect yielding various time delays for calculating this rate of expansion. (shrink)

Philosophers, psychologists, economists and other social scientists continue to debate the nature of human well-being. We argue that this debate centers around five main conceptualizations of well-being: hedonic well-being, life satisfaction, desire fulfillment, eudaimonia, and non-eudaimonic objective-list well-being. Each type of well-being is conceptually different, but are they empirically distinguishable? To address this question, we first developed and validated a measure of desire fulfillment, as no measure existed, and then examined associations between this new measure and several other well-being measures. (...) In addition, we explored associations among all five types of well-being. We found high correlations among all measures of well-being, but generally correlations did not approach unity, even when correcting for unreliability. Furthermore, correlations between well-being and related constructs (e.g., demographics, personality) depended on the type of well-being measured. We conclude that empirical findings based on one type of well-being measure may not generalize to all types of well-being. (shrink)

Quine’s “Epistemology Naturalized” is the locus classicus of naturalism in epistemology. Many traditional epistemologists criticized the naturalization of epistemology specifically targeting this article. The critics argue that Quine abolishes the normativity of epistemology. For he proposes epistemology as a chapter of psychology. Laudan, like Quine, believes that epistemology should be naturalized. However, he criticizes Quine’s project of naturalization for similar reasons as Quine’s critics. Instead, he proposes a new project that he calls “normative naturalism”. In this work, I will first (...) argue against the critics of Quine and then argue that both Quine’s and Laudan’s naturalized epistemologies are hypothetically normative. -/- Quine’ın “Epistemology Naturalized” başlıklı makalesi epistemolojide doğallaştırma düşüncesinin klasik yapıtıdır. Pek çok geleneksel bilgi kuramcısı özellikle bu makaleyi hedef alarak epistemolojinin doğallaştırılmasını eleştirmiştir. Eleştirilerin odağında Quine’ın, psikolojinin bir alt bölümü haline getirerek, epistemolojinin normatifliğini ortadan kaldırdığı savı yer almaktadır. Laudan epistemolojide doğallaştırmanın gerekli olduğunu savunmasına karşın Quine’a yöneltilen bu eleştiriye katılmakta ve “normatif doğalcılık” adını verdiği yeni bir epistemolojik yaklaşım önermektedir. Bu çalışmada Quine’a yöneltilen eleştirinin yersiz ve Quine’ın doğallaştırılmış epistemolojisinin Laudan’ın normatif doğalcılığı gibi hipotetik normatif olduğunu tartışacağım. (shrink)

Science is, if not the most, at least one of the most important human activities which has an undeniable impact on our lives. However, it is a matter of debate that science and its various applications have many negative effects besides their numerous positive contributions. As the negative effects of the science and its applications have become more visible, the science-value relation has regained popularity in the philosophy of science. Precautionary principle is one of the central concepts of the late (...) science-value debates. We first scrutinize the science-value relation, especially whether the science is value-free or value-laden activity, from the perspective of history and philosophy of science, and argue that sciences involve both epistemic and non-epistemic values. Then we introduce the precautionary principle and discuss the possible causes and outcomes of having it as a methodological component of scientific research. Finally, we argue that, if the science-value relation can be reestablished on ethical grounds, as the precautionary principle demands, the negative effects of science and its applications on human health and environment might be minimized and science could contribute more to human happiness. -/- Bilim yaşamımızı biçimlendiren en önemli insan etkinliklerinden birisi, belki de en önemlisidir. Ancak bilimlerin ve onun çeşitli uygulamalarının insan yaşamına olumlu katkılarının yanında insan ve çevre sağlığı üzerinde pek çok olumsuz etkilerinin de olduğu tartışılmaktadır. Bilim ve uygulamalarının insan sağlığı ve çevre üzerindeki olumsuz etkilerinin her geçen gün daha çok görünür hâle gelmesi, bilim-değer ilişkisini yeniden önemli bir tartışma başlığı hâline getirmiştir. İhtiyat ilkesi bilim-değer ilişkisi üzerine yapılan tartışmaların odağında yer alan kavramlardan biridir. Biz çalışmamızda önce bilim-değer ilişkisini, bilimin değerden bağımsız bir etkinlik olup olmadığını bilim tarihi ve felsefesi perspektifinden ele alıyor ve bilimlerin hem epistemik hem de epistemik olmayan değerler içerdiğini savunuyoruz. Daha sonra ihtiyat ilkesini ele alıyor ve onun bilimsel araştırmaların yöntembilimsel bir bileşeni hâline getirilmesinin olası nedenleri ve sonuçları üzerinde duruyoruz. Son olarak, bilim-değer ilişkisinin, ihtiyat ilkesi örneğinde olduğu gibi etik temelli kurulması durumunda bilim ve uygulamalarının insan sağlığı ve çevre üzerindeki olumsuz etkilerinin azaltılabileceğini ve bilimin insan mutluluğuna daha çok katkı sağlayabileceğini tartışıyoruz. (shrink)

Normativity of naturalized epistemology is one of the most extensively and hotly debated topics in contemporary epistemology. In order to reveal the relationship between normativity and naturalized epistemology, we firstly conduct an analysis of “Epistemology Naturalized,” the article on which the naturalized epistemology was founded. Then we compare the views which argue that normativity goes by the board with those which defend that normativity is conserved if epistemology is naturalized. Finally, based especially on Quine’s own views, we argue that naturalized (...) epistemology is hypothetically normative. -/- Doğallaştırılmış epistemolojinin normatifliği çağdaş epistemolojide çok tartışılan konulardan birisidir. Biz bu çalışmada önce doğallaştırılmış epistemoloji yaklaşımının normatiflikle ilişkisini ortaya çıkarmak amacıyla doğallaştırılmış epistemolojinin temelinin atıldığı “Epistemology Naturalized” makalesinin bir çözümlemesini yapıyoruz. Daha sonra doğallaştırma ile epistemolojinin normatifliğinin ortadan kalktığını ya da tam tersine korunduğunu savunan kimi bilgi kuramcılarının argümanlarını karşılaştırıyor ve Quine’ın yapıtlarında yer alan görüşleri esas alarak doğallaştırılmış epistemolojinin koşullu ya da hipotetik olarak normatif olduğunu savunuyoruz. (shrink)

In this work, I scrutinize Leopold’s land ethic and Callicott’s interpretation of it both from normative and meta-ethical perspectives by making textual and conceptual analyses. Leopold suggests that an ethic which makes us responsible for the protection of whole nature is evolutionarily possible and ecologically necessary. Callicott tried to buttress Leopold’s land ethic by developing a nonanthropocentric axiology and some meta-principles. Moreover, in his view, Leopold’s views are not only compatible with nonanthropocentric axiology but also imply it. I show that (...) Leopold did not build the land ethic on nonanthropocentrism and he did not enforce attribution of intrinsic value to nature and its constituents. I argue that weak anthropocentrism is quite compatible with Leopold’s views, and it provides a way to maintain normative power of land ethic without being ecofascistic. Furthermore, I discuss that Leopold might not have objected attribution of intrinsic value to nonhuman beings although he primarily referred to instrumental values of nature. Moreover, I argue that Leopold preferred a middle position between the concepts of preservation and conservation. As a man of practical wisdom Leopold has always tried to find middle and practicable ways between opposing extremes to harmonize human realm with nonhuman one and to grow the embryo of the conservationist movement. Finally, I argue that Leopold’s land ethic is a human ethic which requires human moral agents to accept responsibility for protecting whole nature in order to attain good life. (shrink)

Objective: Vascular disorders severely impair the psycho-social status of individuals. Various laser and light systems, which have advantages and disadvantages, including the pro-yellow laser are used for the therapy of these disorders. Aim: The goal of the present study was to investigate the effectiveness and feasibility of the 577 nm pro-yellow laser for a broad range of indications including erythematelangiectatic rosacea, facial erythema, post-acne erythema, facial telangiectasis, hemangioma, genital angiokeratoma, and port wine stain nevus. Methods: A total of 98 patients (...) (25 male, 73 female) older than 15 years who were treated with the pro-yellow laser for vascular disorders at the cosmetology unit between 2017 and 2019 were retrospectively included in the study. Results: The mean rate of recovery was 100% in genital angiokeratoma, 94.4% in spider angioma, 83.3% in facial telangiectasis, 74.8% in erythematotelangiectatic rosacea, 72% in facial erythema + facial telangiectasis, and 68.3% in facial erythema. Over 60% of improvement was observed in most patients with vascular disorders. There was no significant link between the Fitzpatrick skin type and treatment success. Treatment success was significantly low in cases with nasal involvement. Conclusion: The current study concluded that pro-yellow laser is an efficient and safe laser modality that may yield satisfactory outcomes regardless of the different skin types. (shrink)

Coronary artery vasospasm (CAVS) is a clinical entity that can cause angina, but also unstable angina pectoris, acute myocardial infarction, fatal arrhythmias, and sudden death. Although it is a condition that is usually controlled with medical treatment, more aggressive treatments may rarely be required. In this case, the patient with a known diagnosis of CAVS had multiple arrests despite optimal medical treatment. We observed that fatal arrhythmias persisted in the Implantable Cardioverter Defibrillator (ICD) records, even though we implanted a stent (...) and gave the patient maximal medical treatment. We performed sympathectomy as a last resort and we did not detect any recurrence in the 6-month follow-up of the patient. ICD implantation and sympathectomy should always be considered in resistant CAVS cases. (shrink)