The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a way that they realize metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realize and on the continuous management of the exchange of matter and energy with their environment. One (...) of the virtues of the organismic approach focused on organization is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes. Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviors are constrained and controlled by the system they realize. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organization, we argue that these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system. In this paper, we provide a new theoretical framework to understand multicellularity, capable to overcome these issues. Our thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organization of the intercellular space. In our view, the capability to be organized in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialized functions such as immunity. We argue that the extracellular matrix plays a crucial active role in this respect, as an evolutionary ancient and specific (non-cellular) control subsystem that contributes as a key actor to the functional specification of the multicellular space and to modulate cell fate and behavior. We also analyze how multicellular systems exert control upon internal movement and communication. Finally, we show how the organization of space is involved in some of the failures of multicellular organization, such as aging and cancer. (shrink)

In this paper, I develop a philosophical clarification of the statement "faith in the resurrection of Christ saves men from sin", using some of the main arguments and hypotheses of my recent book, ’The Ways of Salvation (Les Voies du salut’, Paris 2010). I begin with some remarks on the theme of salvation in contemporary language and philosophy. I then sketch a conceptual analysis of the concept of salvation, first in its general sense, then in its specifically Christian one. Finally, (...) I offer a hypothesis on the ’modus operandi’ of salvation, or at least of one aspect of salvation as understood by Christianity. (shrink)

From antiquity, Galenic physicians extensively discussed the active powers of simple and compound drugs. In their views, simple drugs, that is, single ingredients, acted according to their material qualities and the properties of their substance. As for compound drugs, their efficacy resulted from the mutual interaction of their ingredients and their modes of preparation. In the late Renaissance, Galenic physicians and naturalists, such as Leonhart Fuchs and Pietro Andrea Mattioli, attempted to explain these pharmacological properties or “faculties” at the intersection (...) of medicine, botany, and natural philosophy. This chapter examines the case of the Italian physician and botanist Andrea Cesalpino. His pharmacological treatise De medicamentorum facultatibus [On the Faculties of Drugs, 1593] was particularly significant for its reception of ancient and medieval texts on drug properties, materia medica, and the role of the senses in the knowledge of bodies. (shrink)

Résumé Charles Wolfe vient de publier Lire le matérialisme (ENS Éditions, 2020), où il esquisse une histoire des différentes formes de matérialisme, y compris le matérialisme vitaliste et les versions du XXe et du XXIe siècle. Pierre-François Moreau, auteur de la préface de l’ouvrage, entame ici une discussion sur les problèmes et les ressources d’une telle histoire.

This chapter examines the use of vegetal analogy in late Renaissance physiology through the case of the German physician Daniel Sennert. It is centered on Sennert’s explanation of generation, in particular the transmission of life through the vegetative soul within the seed, as developed in his early works on medicine and alchemy, the _Institutionum medicinae libri V_ and _De chymicorum…liber_. This chapter first summarizes Sennert’s account of generation and the seed’s “formative force” according to Aristotle and Galen, as well as (...) his appraisal of the medical debates on the origin of the seed’s soul and form. Then, the next part explores Sennert’s own interpretation of the origin of forms, for which plant physiology served as a common denominator of his medical, alchemical and theological inclinations. Finally, this chapter considers how Sennert attempted to harmonize his reasoning with the Paracelsian account of generation, seed and life. (shrink)

In late Renaissance medicine, the example of digestion was frequently invoked to prove the elemental composition of the human body. Food was considered as being decomposed in its first elements by the stomach, and digested into a thick juice, which was assimilated by the liver and the body parts. Such a process points to the structure of the human body into four elements that are transformed into different types of humors during several stages of “concoction”. This chapter examines the Galenic (...) interpretation of digestion expounded by the French physician Jean Fernel (1497–1558) in his Physiologia (1567). In this treatise, Fernel states the body composition into elemental portions, while stressing the role of the “innate heat” as the physiological counterpart of the body’s essence or “substantial form”. He applies this view in his account of digestion, where he states that the conversion of food follows the rule of “mixture”. This chapter aims to explore how Fernel applies his interpretation of elements and innate heat to the process of digestion, as well as his sources in Galen’s De facultatibus naturalibus, Avicenna’s Canon and Aristotle’s Meteorologica. It first examines the role of the natural soul and its “nourishing” faculties in nutrition as a physiological function. It then considers the role of elements, humors and innate heat during the “concoction” of food in the stomach, liver and veins. (shrink)

Essay review of William R. Newman: Newton the alchemist: science, enigma, and the quest for nature’s “secret fire.” Princeton: Princeton University Press, 2019, 560 pp, $39.95.