This article explains Blumenberg's reluctance to make humankind the saviour of nature, and the implied scepticism towards environmental politics.

The article gives a short characterization of Russell's solution to Hume's problem: empirical postulates.

I want to show that truth is an important concept, and that it can be explained. However, we must deal with what are called ‘deflationist’ concepts of truth first. Deflationism is the view that there is nothing more to be said about truth once a semantic theory for the truth-predicate (such as Tarski's) has been provided.

The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should play in the future of the discipline and to comprehend the gaps that exist because of its absence. The development of pharmacometric informatics has important implications for expediting decision making and for improving the reliability of decisions made in model-based development. We argue that well-defined informatics for pharmacometrics can lead to much needed improvements in the efficiency, (...) effectiveness, and reliability of the pharmacometrics process. The purpose of this paper is to provide a description of the pervasive yet often poorly appreciated role of informatics in improving the process of data assembly, a critical task in the delivery of pharmacometric analysis results. First, we provide a brief description of the pharmacometric analysis process. Second, we describe the business processes required to create analysis-ready data sets for the pharmacometrician. Third, we describe selected informatic elements required to support the pharmacometrics and data assembly processes. Finally, we offer specific suggestions for performing a systematic analysis of existing challenges as an approach to defi ning the next generation of pharmacometric informatics. (shrink)