The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should play in the future of the discipline and to comprehend the gaps that exist because of its absence. The development of pharmacometric informatics has important implications for expediting decision making and for improving the reliability of decisions made in model-based development. We argue that well-defined informatics for pharmacometrics can lead to much needed improvements in the efficiency, (...) effectiveness, and reliability of the pharmacometrics process. The purpose of this paper is to provide a description of the pervasive yet often poorly appreciated role of informatics in improving the process of data assembly, a critical task in the delivery of pharmacometric analysis results. First, we provide a brief description of the pharmacometric analysis process. Second, we describe the business processes required to create analysis-ready data sets for the pharmacometrician. Third, we describe selected informatic elements required to support the pharmacometrics and data assembly processes. Finally, we offer specific suggestions for performing a systematic analysis of existing challenges as an approach to defi ning the next generation of pharmacometric informatics. (shrink)

This article explains Blumenberg's reluctance to make humankind the saviour of nature, and the implied scepticism towards environmental politics.

Discussion of the challenge that acquaintance with the nature of experience poses to physicalism.

The Swiss psychologist Jean Piaget contends that children below the age of 12 see no necessity for the logical law of non-contradiction. I argue this view is problematic. First of all, Piaget's dialogues with children which are considered supportive of this position are not clearly so. Secondly, Piaget underestimates the necessary nature of following the logical law of non-contradiction in everyday discourse. The mere possibility of saying something significant and informative at all presupposes that the law of non-contradiction is enforced.

Characterization of a form of explanation involving grounding on the model of mechanistic causal explanation.

Grounding-theoretic account of the notion of transparency relevant to the explanatory gap between the mental and physical.

Discussion of partial grounds that aren't parts of full grounds; definition of full grounding in terms of partial grounding.

"Heidegger on Being a Sexed or Gendered Human Being" is my contribution to a Symposium dedicated to the topic "Heidegger's idea of the human being." Editor Scott Campbell requested that participants (myself, Kevin Aho, Jesús Adrián Escudero, Tricia Glazebrook, Róisín Lally, and Iain Thomson) write a 1000 word statement addressing this question. Participants read each others contributions and submitted a 500 word response. This is my original statement.

Discussion of a metaphysical sense of 'inheritance' and cognate notions relevant to fundamentality.

This article argues that postwar Seventeen magazine, a publication deeply invested in enforcing heteronormativity and conventional models of girlhood and womanhood, was in fact a more complex and multivocal serial text whose editors actively sought out, cultivated, and published girls’ creative and intellectual work. Seventeen's teen-authored “Curl Up and Read” book review columns, published from 1958 through 1969, are examples of girls’ creative intellectual labor, introducing Seventeen's readers to fiction and nonfiction which ranged beyond the emerging “young-adult” literature of the (...) period. Written by young people – including thirteen-year-old Eve Kosofsky (later Sedgwick) – who perceived Seventeen to be an important publication venue for critical work, the “Curl Up and Read” columns are literary products in their own right, not simply juvenilia. Seventeen provided these young authors the opportunity to publish their work in a forum which offered girl readers and writers opportunities for intellectual development and community. (shrink)

Amendment of the Witmer, Butchard, and Trogdon (2005) account of intrinsic properties with the aim of neutrality between competing theories of what is fundamental.

Using Ursula K. Le Guin’s The Left Hand of Darkness as an inspirational backdrop, a novel whose story unfolds on a genderless planet that nevertheless relies on reproductive sex for the sake of generativity, this paper tackles the sex/gender debate, its entanglements with procreation, and its consequences for transgender pregnancies. More specifically, I analyze three issues that pose barriers to thinking about a more inclusive reproductive ethics: state-sanctioned sterilization, non-reproductive futurism, and access to assisted reproductive technology.

Argument that priority monism is best understood as being a contingent thesis.

Le climat politique actuel en France abonde de débats à propos de l’identité nationale et du voile; en fait, le voile est devenu un symbole séparant l’idée d’une nation française et d’une nation islamique. Cependant, peu d’attention est portée sur la façon dont la perception de la différence de la femme est essentielle à la formation du citoyen français. Au lieu de se demander simplement “que veut dire être Français?” une seconde interrogation devrait suivre sur la façon dont se construit (...) la femme voilée dans la société française. En faisant appel à la philosophie de Hegel, les réflexions philosophiques employées pour ce projet cherchent à poser de nouvelles questions pouvant éclairer le débat sur l’identité nationale: la femme voilée est-elle l’Antigone des temps modernes? Quel est l’enjeu de dévoiler la femme voilée? D’où vient ce désir de la dévoiler? (shrink)

In her Dinny Gordon series (1958–1965), junior novelist Anne Emery’s heroine manifests intellectual desire, a passionate engagement in the life of the mind along with the desire to connect with like-minded others. Within a genre which focused on socialization and dating, in Dinny, Emery normalizes a studious, inner-directed, yet feminine heroine, passionate about ancient history rather than football captains. Emery’s endorsement of the pleasure Dinny takes in intellectual work, and the friends and boyfriends Dinny collects, challenge stereotypes of intellectual girls (...) as dateless isolates while suggesting an alternative model of girlhood operating within apparent conformism to postwar “good girl” standards. (shrink)

I want to show that truth is an important concept, and that it can be explained. However, we must deal with what are called ‘deflationist’ concepts of truth first. Deflationism is the view that there is nothing more to be said about truth once a semantic theory for the truth-predicate (such as Tarski's) has been provided.

Argument that full grounds modally entail what they ground.

My modest aim in this piece is to frame and illuminate some of the issues surrounding normative motivation, rather than take a firm position on any of them. I begin by clarifying the key terms in my title of this essay, and unpacking some of the assumptions that underpin its question. I then distinguish four kinds of answers one might give. In this short essay I will not be able to properly develop and evaluate an argument for the view that (...) normative motivations are psychologically primitive, but I will have some comments about what such an argument might look like, and what it would have to show. (shrink)

On Oct. 24, 2019, French philosopher Sylviane Agacinski was scheduled to speak at the Université de Bordeaux-Montaigne on « l’être humain à l’époque de sa reproductibilité technique » [the human being in the era of its technological reproducibility]. Amidst “violent threats” and their purported inability to assure the safety of Agacinski, the organizers cancelled the event. Agacinski and other French intellectuals lament what they perceive to be part of a “drifting liberticide”, a form of censorship that forbids the exchange of (...) ideas and forecloses open space for debate. The story goes that Agacinski, notable for her staunch opposition to surrogacy and extending assisted reproductive technologies (ARTs) to non- heterosexual couples, as well as her anthropological claim that the fabric of our social order relies on the heteronormative structure of sexual difference, has been silenced. In a communiqué to the university, student organizations such as Riposte Trans and Mauvais Genre-s pleaded “no platform”, indicating that Agacinski’s reactionary homophobic and transphobic positions run contrary to the university’s mission of safeguarding against discrimination. What to do when an incitement to (epistemic) violence masks itself as free speech? Bring Sara Ahmed’s hammer to France. (shrink)

Defense of a psychological account of what it is for an artwork to be complete.

This is a short reminder that Bertrand Russell suggested a number of a priori postulates which are to serve as foundation for an empiricist philsophy.

Rather than set out an overarching view or take a stand on the debunking of morality tout court, in what follows I’ll explore a divide and conquer strategy. First, I will briefly sketch a debunking argument that, instead of targeting all of morality or human moral nature, has a more narrow focus—namely, the intuitive moral authority of disgust. The argument concludes that as vivid and compelling as they can be while one is in their grip, feelings of disgust should be (...) granted no power to justify moral judgments. Importantly, the argument is grounded in empirical advances concerning the character of the emotion itself. Next, I will step back and consider the argument’s general form. I then point to arguments that others have made that seem to share this form and selective focus, and comment on what such arguments do and do not presuppose. Finally, I locate the selective strategy with respect to other approaches moral debunking. (shrink)

Health care providers (HCPs) are routinely placed into morally challenging situations that have the potential to cause moral distress. This is especially true for HCPs working in the military, whether they are on deployment outside their typical contexts of practice such as in disaster relief (e.g., Haiti and the Ebola missions in West Africa), or in more typically military settings such as peace keeping or armed conflicts (e.g., Afghanistan, Syria). Moral distress refers to “painful feelings and/or psychological disequilibrium” (Nilsson, Sjöberg, (...) Kallenberg, & Larsson, 2011, p. 50) that occur when an individual is aware of a morally appropriate action in a moral dilemma but obstruction prevents them from carrying it out, or when in a situation where they must choose between upholding equally treasured but conflicting moral values. Similarly, moral distress can occur when faced with a ‘tragic choice’ where all available courses of action require something of moral significance to be given up, such as surgical triage in a mass casualty event (Hunt, Sinding, & Schwartz, 2012). In the literature, moral distress has been connected to negative psychological effects and even stress related mental health issues including compassion fatigue, burnout, and post-traumatic stress disorder (Owen & Wanzer, 2014; Gustafsson, Eriksson, Strandberg, & Norberg, 2010; Litz, et al., 2009). (shrink)

Discussion of atomistic and monistic theses about abstract reality.

ABSTRACT This article takes Judith Butler’s epistemological problem of “framing” alongside Dana S. Belu’s notion of “reproductive enframing” to analyze whose bodies lie outside the borders of who is considered the appropriate reproductive citizen. Are all bodies subject to reproductive enframing under a totalizing technological ideology that Martin Heidegger refers to as Gestell? Or, does Belu’s notion of “partial enframing” allow a space to queer, or upset, our current understanding of such ideology? By queering the way that we currently view (...) assisted reproductive technology, can we widen the frame or cross its borders? In this article, I am primarily concerned with the necessity to queer French reproductive policy, though the questions I raise can be extended to any critiques of ART. (shrink)

What kind of rhetoric frames French reproductive policy debate? Who does such policies exclude? Through an examination of the “American import” of gender studies, along with an analysis of France’s Catholic heritage and secular politics, I argue that an unwavering belief in sexual difference as the foundation of French society defines the productive reproductive citizen. Sylviane Agacinski is perhaps the most vocal public philosopher who has framed the terms of reproductive policy debate in France, building an oppositional platform to reproductive (...) technology around anthropological assertions of sexual difference. This paper engages with Agacinski to examine rhetorical claims of sexual difference and how such claims delayed passage of France’s revised bioethics legislation that extends access of assisted reproductive technology (ART) to “all women.” Though the “PMA pour toutes” [ART for all women] legislation was eventually passed, such rhetoric motivated the explicit exclusion of all trans person from its extension, thus hardly permitting ART to all women. (shrink)

Investigation of a puzzle concerning complete yet authorless artworks.

Comments and replies from the 2021 Eastern APA book symposium on Jill North's Physics, Structure, and Reality.

This paper uses the figure of the nomad from the work of Rosi Braidoti to critically examine rhetoric about vaccine and masking mandates, and the science of covid more broadly. I draw out the tensions and ambivalence felt as we navigate this on-going crisis in ways epitomized by the phrase “I have a healthy mistrust of authority, and I am still vaccinated.” Though ambivalent, the nomadic subject finds an affirmative ethics, navigating the “right” response to incite positive change and expose (...) our current states of subjectivity. Recognizing the ambivalence of this state may be useful for feminists who critique medicine for its historical sexist and racist “objectivism,” while also supporting medical science and trust in the case of vaccine mandates. (shrink)

Clinical ethics consultants (CECs) are not moral authorities. Standardization of CECs’ professional role does not confer upon them moral authority. Certification of particular CECs does not confer upon them moral authority (nor does it reflect such authority). Or, so we will argue. This article offers a distinctly Orthodox Christian response to those who claim that CECs—or any other academically trained bioethicist—retain moral authority (i.e., an authority to know and recommend the right course of action). This article proceeds in three parts. (...) First, we discuss recent movements toward the certification of CECs in the United States, focusing primarily on proposals and programs put forth by the American Society for Humanities and Bioethics (ASBH). Second, we outline two secular reasons to be concerned about the relevant trends toward certification. For one thing, certification is currently being advanced via political dominance, rather than gaining authority by reliance on rigorous philosophical argument or reason. For another, the trends operate on the assumption that there exists a secular, content-full, canonical, morality. There is no such morality. Next, we argue that Orthodox Christians should resist the current trends toward certification of CECs. Specifically, we unpack ways in which the ASBH’s certification program (and those like it) conflict with Orthodox claims about moral authority and the moral life more generally. We conclude that Orthodox Christians should resist the current certification trends. (shrink)

Discussion of grounding-theoretic accounts of truthmaking in terms of the theoretical role of “catching cheaters”.

Cet article parle de la nécessité de repenser la notion de la différence sexuelle après le mal appropriation de celle-ci par « la manif pour tous ». Chaque tentative de former une ontologie fondée sur cette différence risque une favorisation de l’hétéronormativité et de l’essentialisme. En me servant de la philosophie d’Elizabeth Grosz sur Darwin, j’essaie de reformuler la différence sexuelle en des termes positifs et de voir celle-ci comme une notion qui facilite (plutôt que limite) la diversité. Le texte (...) est divisé en deux parties : 1. L’instrumentalisation de la différence sexuelle pour promouvoir l’hétéronormativité, et 2. Repenser une ontologie fondée sur la différence sexuelle. (shrink)

This paper argues that, although Margaret Cavendish’s main philosophical contributions are not in philosophy of religion, she makes a case for a defense of God, in spite of the worst sorts of harms being present in the world. Her arguments about those harms actually presage those of contemporary feminist ethicists, which positions Cavendish’s scholarship in a unique position: it makes a positive theodical contribution, by relying on evils that contemporary atheists think are the best evidence against the existence of God. (...) To demonstrate that Cavendish’s work should be considered as early modern feminist theodicy, this paper will briefly introduce the contemporary feminist worry about theodicy as a project, show that Cavendish shares the contemporary feminist view about situated evil, and argue that her theodicy aims for agreement about how to eradicate great moral evils while preserving free will—and so, carves out a space for future female philosophers of religion who aim to be agents of healing in the face of such evil. (shrink)

A large chorus of voices has grown around the claim that theistic belief is epistemically suspect since, as some cognitive scientists have hypothesized, such beliefs are a byproduct of cognitive mechanisms which evolved for rather different adaptive purposes. This paper begins with an overview of the pertinent cognitive science followed by a short discussion of some relevant epistemic concepts. Working from within a largely Williamsonian framework, we then present two different ways in which this research can be formulated into an (...) argument against theistic belief. We argue that neither version works. (shrink)

Grounding-theoretic reformulation of Fodor's theory of content that addresses recalcitrant Quinean concerns.

General discussion of grounding, including its formal features, relations to other notions, and applications.

Response to Skiles (2009) on Trogdon (2009) on intrinsic properties and fundamentality.

Charlotte Witt covers a remarkable amount of ground in this concise and elegantly written book. Coming in at under 150 pages, she artfully weaves together Aristotle’s theory of functions with contemporary work on cultural transmission and apprenticeship, ideas about self-creation with theories of aspiration and transformative experience, and reflections on the relationships among social norms and games with thoughts about social roles and the nature of hierarchy. At the heart of it is an elaboration and defense of a thoroughly externalist (...) account of social normativity. Witt takes skilled experts, especially artisans like chefs and carpenters, as paradigm cases for theorizing about social normativity. She uses them to argue that the ultimate source of many normative obligations is found not in the acquiescence, attitudes, or any other features internal to those on whom those obligations fall. Rather, the demands are rooted in the world itself, and flow from specific circumstances, especially from the constraints those circumstances impose on different actors in virtue of the tasks they need to perform. The result is a view that depicts social normativity not just as external to individuals but also unavoidably role specific; what is right for a chef is not necessarily right for a carpenter, and what makes for a good nurse might make for a poor drill sergeant. Witt’s presentation of this package of ideas is both careful and austere, and it makes for a wonderfully thought provoking read. Social Goodness: On the Ontology of Social Norms will reward the careful attention of anyone interested in social ontology, especially the metaphysical foundations of normativity, the nature of social norms, and the relationship between social roles and the self. (shrink)

Disproof of heaven? -- Brain and gods -- The rational stance -- Reason and belief in God -- Against naturalism -- Atheism, inference, and IQ -- Atheism, autism, and intellectual humility -- Googling God -- Inference, intuition, and rationality.

There is strong disagreement about whether indicative conditionals have truth values. In this paper, I present a new argument for the conclusion that indicative conditionals have truth values based on the claim that some true statements entail indicative conditionals. I then address four arguments that conclude that indicative conditionals lack truth values, showing them to be inadequate. Finally, I present further benefits to having a worldly view of conditionals, which supports the assignment of truth values to indicative conditionals. I conclude (...) that certain types of account of indicative conditionals, which have been ignored in the literature partly on the basis of assigning truth values to indicative conditionals, deserve consideration. (shrink)

ABSTRACT‘Exaltation views’ of humility are grounded on a kenotic view of humility, such that divine blessing comes proportionate to the extent to which an agent humbles herself. This article rejects exaltation views of humility which define humility kenotically, justify their arguments from a divine hiddenness perspective, and which conclude that divine concurrence with evil is justified as long as all humble believers eventually are exalted and blessed. Rather, I will contend that exaltation views misunderstand the meaning of both ‘humility’ and (...) ‘exaltation,’ even from their own Christian standpoint. I ultimately offer an alternate response to the problem of evil based on an existentially grounded conception of ‘humility’, which provides for a transmuted turn away from individual kenotic acts and toward community to transform those who suffer from atrocities. (shrink)

The intuitions at the core of environmental ethics and of other neglected value realms put pressure on traditional anthropocentric ethics based on monistic value theories. Such pressure is so severe that it has led many to give up on the idea of monistic value theories altogether. I argue that value monism is still preferable to value pluralism and that, indeed, these new challenges are opportunities to vastly improve impoverished traditional theories. I suggest an alternative monistic theory, Richness Theory, and show (...) how it provides an opportunity to capture the needs of both environmental ethics and of our traditional ethics. (shrink)

Response to Gover (2015) on Trogdon and Livingston (2015) on artwork completion.