Results for 'dosing'

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  1. Dose optimisation and scarce resource allocation: two sides of the same coin.Garth Strohbehn, Govind Persad, William F. Parker & Srinivas Murthy - 2022 - BMJ Open 12 (10):e063436.
    Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these (...)
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  2. Relieving pain using dose-extending placebos.Luana Colloca, Paul Enck & David DeGrazia - 2016 - PAIN 157:1590-1598.
    Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be intentionally exploited to extend analgesic therapeutic effects. Is it possible to extend the effects of drug treatments by interspersing placebos? We reviewed a database of placebo studies, searching for studies that indicate that placebos given after repeated administration of active treatments acquire medication-like (...)
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  3. A minimal dose of self-reflective humor in Wild Wise Weird: The Kingfisher story collection.Manh-Tung Ho - manuscript
    In this essay, I review one of my beloved fictional titles, Wild Wise Weird: The Kingfisher Story collection. The minimal sense of humor and satire in storytelling of Wild Wise Weird are sure to bring readers smiles, better yet, moments of quiet reflection, a much under-appreciated remedy in the world driven almost insane with the abundance of information co-created with AI technologies. I hope to deliver justice to the book.
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  4. Evaluation of the Image Quality of Ultra-Low-Dose Paranasal Sinus Computed Tomography Scans.Melih Akşamoğlu & Mehmet Sait Menzilcioğlu - 2023 - European Journal of Therapeutics 29 (2):143-148.
    Objective: We aimed to investigate the image quality of paranasal sinus computed tomography (CT) scans obtained with the “Advanced intelligent Clear-IQ Engine” (AICE) software and ultra-low dose parameters in patients with prediagnosed rhinitis, sinusitis or nasal septum deviation. -/- Methods: The first 50 patients (31 men and 19 women, aged 18-70 years) who agreed to participate in our prospectively planned study were included in the study. Imaging of the patients was performed with a 160-slice multidetector CT device Canon Aquilion Prime (...)
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  5. Medical Nihilism by Jacob Stegenga: What is the right dose? [REVIEW]Jonathan Fuller - 2020 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 81.
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  6. Effect of Oxygen Consumption of Thylakoid Membranes (Chloroplasts) From Spinach after Inhibition Using JNN.Hisham Ziad Belbeisi, Youssef Samir Al-Awadi, Muhammad Munir Abbas & Samy S. Abu-Naser - 2020 - International Journal of Academic Health and Medical Research (IJAHMR) 4 (11):1-7.
    Abstract: In this research, an Artificial Neural Network (ANN) model was developed and tested to predict effect of oxygen consumption of thylakoid membranes (chloroplasts) from spinach after inhibition. A number of factors were identified that may affect of oxygen consumption of thylakoid membranes from spinach. Factors such as curve, herbicide, dose, among others, as input variables for the ANN model. A model based on multi-layer concept topology was developed and trained using the data from some inhibition of photosynthesis in farms. (...)
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  7. Pandemic ethics: the case for risky research.Richard Yetter Chappell & Peter Singer - 2020 - Research Ethics 16 (3-4):1-8.
    There is too much that we do not know about COVID-19. The longer we take to find it out, the more lives will be lost. In this paper, we will defend a principle of risk parity: if it is permissible to expose some members of society (e.g. health workers or the economically vulnerable) to a certain level of ex ante risk in order to minimize overall harm from the virus, then it is permissible to expose fully informed volunteers to a (...)
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  8. Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution.Raphaël Millière - 2017 - Frontiers in Human Neuroscience 11:1-22.
    There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the dissolution of the sense of self and the loss of boundaries between self and world. This article discusses the relevance of this phenomenon, known as “drug-induced ego dissolution (DIED)”, for cognitive neuroscience, psychology and philosophy of mind. Data from self-report questionnaires suggest that three neuropharmacological classes of drugs can induce ego dissolution: classical psychedelics, dissociative anesthetics and agonists of the kappa opioid (...)
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  9. COVID-19 vaccine boosters for all adults: An optimal U.s. approach?Ameet Sarpatwari, Ankur Pandya, Emily P. Hyle & Govind Persad - 2022 - Annals of Internal Medicine 175 (2):280-282.
    By 20 October 2021, the U.S. Food and Drug Administration (FDA) had amended its Emergency Use Authorizations for immunocompetent adults who previously received the Pfizer-BioNTech, Moderna, or Johnson & Johnson COVID-19 vaccines. For the 2-dose Pfizer-BioNTech and Moderna vaccines, the FDA permitted a single booster dose for adults aged 65 years or older and adults aged 18 to 64 years at high-risk for severe COVID-19 or at high risk for occupational or institutional COVID-19 exposure. For the single-dose Johnson & Johnson (...)
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  10. Countable Additivity, Idealization, and Conceptual Realism.Yang Liu - 2020 - Economics and Philosophy 36 (1):127-147.
    This paper addresses the issue of finite versus countable additivity in Bayesian probability and decision theory -- in particular, Savage's theory of subjective expected utility and personal probability. I show that Savage's reason for not requiring countable additivity in his theory is inconclusive. The assessment leads to an analysis of various highly idealised assumptions commonly adopted in Bayesian theory, where I argue that a healthy dose of, what I call, conceptual realism is often helpful in understanding the interpretational value of (...)
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  11. Don’t Worry, This Will Only Hurt a Bit: The Role of Expectation and Attention in Pain Intensity.Nada Gligorov - 2017 - The Monist 100 (4):501-513.
    To cause pain, it is not enough to deliver a dose of noxious stimulation. Pain requires the interaction of sensory processing, emotion, and cognition. In this paper, I focus on the role of cognition in the felt intensity of pain. I provide evidence for the cognitive modulation of pain. In particular, I show that attention and expectation can influence the experience of pain intensity. I also consider the mechanisms that underlie the cognitive effects on pain. I show that all the (...)
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  12. Life, the Universe, and Connectedness.Kyle York - 2024 - Journal of Value Inquiry:1-19.
    The cosmic perspective (or view sub specie aeternitatis) is associated with concerns about the meaning of life, our significance in the universe, and the universe’s indifference. I suggest that there is another important and common, albeit tacit, concern related to the cosmic view. Adopting the cosmic view can justifiably bring about a sense of disconnection from one’s life. Moreover, many of the explicit concerns we have regarding the cosmic view are issues that have a rational bearing upon this sense of (...)
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  13. Éthique et santé publique.Samia A. Hurst - 2012 - Les ateliers de l'éthique/The Ethics Forum 7 (3):59-67.
    Quelles sont les principales problématiques en émergence dans l’éthique de la santé publique ces 10 prochaines années? Se hasarder à prédire l’avenir nécessite toujours une certaine dose d’autodérision, mais les fondements des enjeux sur une échéance aussi proche sont en grande partie déjà présents. Ils peuvent être décrits à différents niveaux d’observation. Le premier de ces niveaux est technique : la santé publique recouvre toute une série d’interventions, dont la mise en œuvre rencontre des obstacles qui, pour certains, ont une (...)
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  14. Might stimulant drugs support moral agency in ADHD children?Steven Edward Hyman - 2013 - Journal of Medical Ethics 39 (6):369-370.
    Stimulants have been shown to be safe and effective for reduction of the symptoms of attention deficit hyperactivity disorder. Despite much debate, however, there has been little empirical evidence as to whether stimulants affect authenticity and moral agency in children. Singh presents evidence that stimulants do not undercut children's' sense of self and increase their experience of agency. These findings are consistent with laboratory evidence that stimulant drugs in therapeutic doses improve cognitive control over thought and behavior.
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  15. Postdigital Prospects for Blockchain-Disrupted Higher Education: Beyond the Theater, Memes and Marketing Hype.Shane J. Ralston - 2020 - Postdigital Science and Education 2 (1):280-288.
    With DLT’s success in driving the development of cryptocurrency (such as Bitcoin), the technology bridged to a myriad of knowledge-based applications, most notably in the areas of commerce, industry and government . In the language of technology sector insiders, these areas were ‘disrupted’ by Blockchain. Some higher education analysts, technology industry insiders and futurists have claimed that Blockchain technology will inevitably disrupt higher education in a similarly dramatic fashion. The aim of this commentary is to introduce a healthy dose of (...)
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  16.  96
    A comparative study of intravenous midazolam marketed in Libya.Amal K. Belaid - 2024 - Mediterranean Journal of Pharmacy and Pharmaceutical Sciences 4 (4):9-14.
    Midazolam, a benzodiazepine medication, is used for sedation during diagnostic and therapeutic medical procedures. Insufficient doses of sedatives, including midazolam, can result in patient anxiety and awareness during the procedure. Several brands of midazolam are available in the Libyan market. This study aims to identify and estimate the medication content of intravenous midazolam in various marketed products using different analytical methods. Product identity was confirmed using Infrared methods (IR) and retention times of High-Performance Liquid Chromatographic methods (HPLC). Quantification was performed (...)
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  17.  68
    Ascorbic acid has an anxiolytic-like effect in the presence of flumazenil in rats.Suhera M. Aburawi - 2024 - Mediterranean Journal of Pharmacy and Pharmaceutical Sciences 4 (3):57-64.
    Ascorbic acid (vitamin C) is a water-soluble vitamin; it is present in the highest concentration in the brain. Ascorbic acid in high doses acts as a potential treatment for various neuropathological and psychiatric conditions. Flumazenil is a benzodiazepine antagonist; it competitively inhibits the activity of benzodiazepine and non-benzodiazepine substances that interact with benzodiazepine receptors site on the GABA/benzodiazepine receptor complex. This study aims to investigate the effect of flumazenil on the anxiolytic action of ascorbic acid using an elevated plus maze (...)
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  18. Duas traduções e um argumento - o 'sonho' do livre arbítrio segundo Espinosa.Lia Levy - 2012 - In Ana Carolina Fonseca, Eduardo Pohlmann & Gabriel Goldmeier (eds.), Ética, política e esclarecimento público: ensaios em homenagem a Nelson Boeira. Bestiário. pp. 257-278.
    Um argumento esquecido em um verdadeiro arsenal de guerra que Espinosa se dedicou a reunir contra o que considerava um dos maiores, senão o maior, empecilho para que os homens alcançassem a verdadeira felicidade, a saber, o falso conceito que possuem da liberdade humana quando a tomam por uma liberdade de arbítrio, contrária a toda e qualquer necessidade. Argumento forjado, certamente, com boa dose de ironia e ânimo polemista contra um objetor que se diz defensor do cartesianismo, e, portanto, em (...)
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  19. Accumulation of potentially toxic elements in fourfinger threadfin (Eleutheronema tetradactylum) and black pomfret (Parastromateus niger) from Selangor, Malaysia.Chuck Chuan Ng - 2024 - Environmental Monitoring and Assessment 196 (382).
    The accumulation of potentially toxic elements (PTEs) has raised public awareness due to harmful contamination to both human and marine creatures. This study was designed to determine the concentration of copper (Cu), zinc (Zn), cadmium (Cd), and nickel (Ni) in the intestine, kidney, muscle, gill, and liver tissues of local commercial edible fish, fourfinger threadfin (Eleutheronema tetradactylum), and black pomfret (Parastromateus niger) collected from Morib (M) and Kuala Selangor (KS). Among the studied PTEs, Cu and Zn were essential elements to (...)
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  20. Once more Into the numbers.Richard Brook - manuscript
    Abstract Tom Dougherty observes that challenges to counting the numbers often cite John Taurek’s 1977 article, “Should the Numbers Count.” Dougherty, though sympathetic to Taurek’s (and others) critique of consequentialism’s aggregating good across individuals, defends a non-consequentialist principle for addition he calls “the Ends Principle. Take the case (he labels “Drug”) when an agent, possessing a dose of a lifesaving drug, can save one person with the entire dose, or two people, each of whom only need half the dose. Dougherty (...)
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  21. An Argument in Defense of Voluntary Euthanasia.Hossein Atrak - 2019 - Philosophical Investigations 13 (28):221-234.
    One of the most challenging issues in medical ethics is a permission or prohibition of euthanasia. Is a patient with an incurable disease who has lots of pain permitted to kill oneself or ask others to do that? The main reason advanced by the opponents is the absolute prohibition of murder. Accordingly, the meaning of murder plays a key role in determining the moral judgment of euthanasia. The aim of this paper is to confirm the role of intention in moral (...)
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  22. On the Presence of Educated Religious Beliefs in the Public Sphere.Gheorghe-Ilie Farte - 2015 - Argumentum. Journal of the Seminar of Discursive Logic, Argumentation Theory and Rhetoric 13 (2):146-178.
    Discursive liberal democracy might not be the best of all possible forms of government, yet in Europe it is largely accepted as such. The attractors of liberal democracy (majority rule, political equality, reasonable self-determination and an ideological framework built in a tentative manner) as well as an adequate dose of secularization (according to the doctrine of religious restraint) provide both secularist and educated religious people with the most convenient ideological framework. Unfortunately, many promoters of ideological secularization take too strong a (...)
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  23. Fair allocation of scarce therapies for COVID-19.Govind Persad, Monica E. Peek & Seema K. Shah - 2021 - Clinical Infectious Diseases 18:ciab1039.
    The U.S. FDA has issued emergency use authorizations for monoclonal antibodies for non-hospitalized patients with mild or moderate COVID-19 disease and for individuals exposed to COVID-19 as post-exposure prophylaxis. One EUA for an oral antiviral drug, molnupiravir, has also been recommended by FDA’s Antimicrobial Drugs Advisory Committee, and others appear likely in the near future. Due to increased demand because of the Delta variant, the federal government resumed control over the supply and asked states to ration doses. As future variants (...)
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  24. Antiquarianism as genealogy: Arnaldo Momigliano's method.Rebecca Gould - 2014 - History and Theory 53 (2):212-233.
    This essay uses Arnaldo Momigliano's genealogy of antiquarianism and historiography to propose a new method for engaging the past. Momigliano traced antiquarianism from its advent in ancient Greece and later growth in Rome to its early modern efflorescence, its usurpation by history, and its transformation into anthropology and sociology in late modernity. Antiquarianism performed for Momigliano the work of excavating past archives while infusing historiographical inquiry with a much-needed dose of contingency. This essay aims to advance our understanding of the (...)
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  25. Pharmacological Evaluation of the Libyan Folk Herb Retama Raetam Seeds in Mice.Aisha N. A. Alwasia, Nora M. J. Altawirghi & Fathi M. Sherif - 2018 - International Journal of Academic Health and Medical Research (IJAHMR) 2 (11):1-6.
    Abstract: Retama raetam (RR) is a traditional medicinal plant belongs to fabaceae family which grows in North Africa and East Mediterranean region. Locally, RR is used in several diseases including diabetes mellitus and hypertension. Thus, this study aims to investigate certain behavioral and central effects of methanolic extract of RR seeds in experimental animals (male Albino adult mice of 20 – 35 gm). Three exploratory behavioral models are used in this study, open field, elevated plus maze and light-dark box models, (...)
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  26. Philosophical post-anthropology for the Chthulucene: Levinasian and feminist new materialist perspectives in more-than-human crisis times.Amarantha Groen & Evelien Geerts - 2020 - Internationales Jahrbuch für Philosophische Anthropologie 10 (1):195-214.
    Finishing this essay exactly one year after the official arrival of the SARS-COV-2 virus in Belgium and the Netherlands—where the cartographers of this essay are currently located—it is safe to say that the COVID-19 pandemic has immensely impacted our day-to-day lives. The pandemic has not only forced us to question various taken-for-granted existential certainties and luxuries provided by a capitalist system out to destroy the earth but has also re-spotlighted post-Enlightenment critiques of the human subject. If these pandemic times are (...)
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  27. LSD and ketamine in schizoaffective paranoid psychosis involving childhood and war trauma—a retrospective case study.Mika Turkia - manuscript
    Currently, documentation on the effects of psychedelics on psychosis appears scarce. In the present case, a higher-dose LSD experience during acute paranoid psychosis before the initiation of antipsychotics induced feelings of love, which resolved the majority of the symptoms of the paranoid psychosis in one session, leading the person to reconnect with his family and seek treatment in a psychiatric hospital. The session did not resolve schizoaffective disorder, however. More than a decade later, while using the antipsychotic aripiprazole, concurrent self-administration (...)
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  28. Issues at the intersection of ethics, evolution and neuroscience.Timothy Lane - 2010 - EurAmerica 40 (3):519-527.
    It is becoming increasingly difficult for those who engage in ethical analysis to ignore evolution and neuroscience. The kind of creature that we are and that we have evolved to be matters when determining how we ought to live. There is still a need to aim for a reflective equilibrium that includes reflection over not straightforwardly empirical issues. It would, for example, be inaccurate to say that "good" just means "highly evolved." But it does turn out to be the case (...)
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  29. Self-treatment of psychosis and complex post-traumatic stress disorder with LSD and DMT—A retrospective case study.Mika Turkia - 2022 - Psychiatry Research Case Reports 1 (2):100029.
    This article describes a case of a teenager with early complex trauma due to chronic domestic violence. Cannabis use triggered auditory hallucinations, after which the teenager was diagnosed with an acute schizophrenia-like psychotic disorder. Antipsychotic medication did not fully resolve symptoms. Eventually the teenager chose to self-medicate with LSD in order to resolve a suicidal condition. The teenager carried out six unsupervised LSD sessions, followed by an extended period of almost daily use of inhaled low-dose DMT. Psychotic symptoms were mostly (...)
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  30. Language and identity policies in the glocal age: New processes, effects and principles of organization.Albert Bastardas-Boada - 2012 - Barcelona, Spain: Generalitat de Catalunya.
    Contact between culturally distinct human groups in the contemporary ‘glocal’ -global and local- world is much greater than at any point in history. The challenge we face is the identification of the most convenient ways to organise the coexistence of different human language groups in order that we might promote their solidarity as members of the same culturally developed biological species. Processes of economic and political integration currently in motion are seeing increasing numbers of people seeking to become polyglots. Thus, (...)
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  31. Deve a Interpretação Musical Ser Eticamente Condicionada?António Lopes - manuscript
    The paper addresses the issue of ethical obligations in the performance of musical works in the Western classical tradition, arguing that there are indeed such obligations, although they are not categorical. -/- PT: Na tradição clássica ocidental, as obras de arte musicais, teatrais e, até certo ponto, as coreografias, são criadas por artistas-autores, mas necessitam de ser executadas por intérpretes (instrumentistas, cantores e maestros, actores e encenadores, bailarinos, etc.). Estes são assim chamados porque existe sempre uma dose de descricionariedade, não (...)
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  32. An integral investigation into the phenomenology and neurophysiology of Christian Trinity meditation.Stephen D. Edwards & David J. Edwards - 2012 - HTS Theological Studies 68 (1).
    This integral investigation explored phenomenological and neurophysiologic, individual and collective dimensions of Christian Trinitarian meditation experiences in a volunteer, convenience sample of 10 practicing Christians, 6 men and 4 women, with a mean age of 48 years and an age range from 21 to 85 years. Participants meditated for a minimum period of 15 minutes, during which neurophysiologic data in the form of electroencephalographic (EEG), electromyographic (EMG), blood volume pulse (BVP) and respiratory activity were recorded. A phenomenological analysis indicated that (...)
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  33. John McGowan, Pragmatist Politics[REVIEW]Shane Ralston - 2013 - Philosophy in Review 33 (5):388-390.
    John McGowan is a prolific humanities scholar whose writings engage topical issues in political philosophy, literary criticism and rhetorical studies. In Pragmatist Politics, American liberal democracy and its contentious philosophical commitments are his chosen subject-matter for a second time. What distinguishes this recent treatment from the one previous—aptly titled American Liberalism (University of North Carolina Press 2007)—is its more thorough grounding in the homegrown American philosophy known as pragmatism. In the introduction, McGowan announces the primary aim of his project: ‘Pragmatism, (...)
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  34. Answers to five questions.Joshua Knobe - 2009 - In Jesús H. Aguilar & Andrei A. Buckareff (eds.), Philosophy of Action: 5 Questions. Automatic Press/VIP.
    Back when I was a college freshman, I started working as a research assistant to a young graduate student named Bertram Malle. I hadn’t actually known very much about Malle’s work when I first signed up for the position, but as luck would have it, he was a brilliant researcher with an innovative new approach. Malle was interested in understanding people’s ordinary intuitions about intentional action – the way in which people’s ascriptions of belief, desire, awareness and so forth ultimately (...)
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  35.  85
    Sorghum bicolor-based supplement reduces oxidative stress and pro-inflammatory cytokines to mitigate rotenone-induced Parkinsonian-like motor dysfunctions in rats.Solomon Umukoro - 2024 - Mediterranean Journal of Pharmacy and Pharmaceutical Sciences 4 (3):15-26.
    Parkinson’s disease is a common movement disorder associated primarily with oxidative stress-mediated degeneration of dopaminergic neurons. Earlier studies showed that Sorghum bicolor-based supplement (SbS) exhibited antioxidant and neuroprotective activities and might likely rescue the death of dopaminergic neurons in Parkinson’s disease. This study examined the effect of SbS on rotenone-induced Parkinsonian-like motor deficits in rats and the involvement of oxidative stress and pro-inflammatory cytokines. Rats were divided into six groups and treated orally with sunflower oil (vehicle-control), rotenone (2.5 mg/kg) alone (...)
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  36. An unexpected opening to teach the impact of interactions between healthcare personnel.Alison Reiheld - 2006 - American Journal of Bioethics 6 (4):29 – 30.
    Goold and Stern (2006) offer a much needed dose of insight into the weakness of medical education from the perspective of resident and nonresident physicians. One of their findings pertains not to...
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  37.  72
    Metformin dosage and renal protection in type 2 diabetes mellitus: Impact on estimated glomerular filtration rate.Hamza M. Alasbily - 2024 - Mediterranean Journal of Pharmacy and Pharmaceutical Sciences 4 (3):7-14.
    Metformin is considered the first-line treatment as a monotherapy for patients with type 2 diabetes mellitus. Emerging evidence suggests that metformin may have a renoprotective role; therefore, understanding the impact of metformin dose and therapy duration on renal function may significantly improve renal outcomes in type 2 diabetes patients. This study aims to investigate the renoprotective effects of metformin by analyzing its dose-dependent impacts on the estimated glomerular filtration rate in patients with type 2 diabetes mellitus. A retrospective cross-sectional study (...)
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  38. Nutrição e Suplementação Mineral de Bovinos de Corte.Emanuel Isaque Cordeiro da Silva - manuscript
    INTRODUÇÃO -/- A produção bovina no Brasil é fundamentalmente em condições de pastoreio, isto é, à pasto. Dado que as pastagens e as forragens não suprem as exigências minerais dos bovinos, principalmente na seca, a suplementação mineral desses animais torna-se uma prática essencial e obrigatória para obtenção de êxito na produção de carne e leite. Negligenciar os requerimentos minerais dos bovinos pode levar ao aparecimento de alterações metabólicas diretamente relacionadas com o desempenho produtivo do rebanho, além de complicações mínimas ou (...)
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  39. Ideation and Appropriation: Wittgenstein on Intellectual Property.Julian Friedland - 2001 - Law and Critique 12 (2):185-199.
    This paper provides a critique of the contemporary notion of intellectual property based on the consequences of Wittgenstein's “private language argument”. The reticence commonly felt toward recent applications of patent law, e.g., sports moves, is held to expose erroneous metaphysical assumptions inherent in the spirit of current IP legislation. It is argued that the modern conception of intellectual property as a kind of natural right, stems from the mistaken internalist or Augustinian picture of language that Wittgenstein attempted to diffuse. This (...)
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  40. Julius Nyerere's Philosophy of Education: Implication for Nigeria's Educational System Reforms.Diana-Abasi Ibanga - 2016 - Africology: The Journal of Pan African Studies 9 (3):109-125.
    Nyerere’s philosophy of education is one of the most influential and widely studied theories of education. Policy-makers have continued to draw from it for policy re-engineering. In this paper, the Nigerian educational system is examined in the light of the philosophy. This approach is predicated on the informed belief that there are social and historical commonalities between Nigeria and the target-society of Nyerere’s philosophy. To this end, it argues that the philosophy holds some important lessons for Nigeria’s education. For this (...)
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  41.  45
    What Comes After 'Critique'?Poul F. Kjaer - 2024 - Transformative Private Law Blog.
    'Critique' seems to have run out of steam, increasingly being reduced to a ritualized performative act. 'Of course, I am critical' one says and goes on with everyday practice. This is most visible in the gradual fading out of the Frankfurt School of Critical Theory. Surprisingly few read Habermas today. The US-American critical legal studies movement, essentially a lightweight version of Frankfurt School insights adjusted to the US-American context and to law and combined with a dose of French poststructuralism, has (...)
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  42. Comportamento Sexual dos Animais Domésticos.Emanuel Isaque Cordeiro Da Silva -
    COMPORTAMENTO SEXUAL DOS ANIMAIS OBJETIVO O estudante explicará a conduta sexual de fêmeas e machos de diferentes espécies domésticas para detectar a fase de receptividade sexual, com a finalidade de programar de maneira adequada a monta ou a inseminação artificial. A observação da conduta sexual dos animais é indispensável para o sucesso da estação reprodutiva em uma determinada propriedade. Logo, o estudante obterá o alicerce necessário sobre os pontos teóricos e práticos a serem observados para a seleção dos animais aptos (...)
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  43. COVID-19 Pandemic: Evidences from Clinical Studies.Ravi Shankar Singh, Abhishek Kumar Singh, Kamla Kant Shukla & Amit Kumar Tripathi - 2020 - Journal of Community and Public Health Nursing 6 (4):251.
    The public health crisis is started with emergence of new coronavirus on 11 February 2020 which triggered as coronavirus disease-2019 (COVID-19) pandemics. The causative agent in COVID-19 is made up of positively wrapped single-stranded RNA viruses ~ 30 kb in size. The epidemiology, clinical features, pathophysiology, and mode of transmission have been documented well in many studies, with additional clinical trials are running for several antiviral agents. The spreading potential of COVID-19 is faster than its two previous families, the severe (...)
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  44. Transferência de Embriões nos Animais e a Indústria de Embriões no Brasil.Emanuel Isaque Cordeiro da Silva -
    REPRODUÇÃO ANIMAL: TRANSFERÊNCIA DE EMBRIÕES EM ANIMAIS, E A INDÚSTRIA DE EMBRIÕES NO BRASIL -/- ANIMAL BREEDING: EMBRYO TRANSFER IN ANIMALS, AND THE EMBRYO INDUSTRY IN BRAZIL Apoio: Emanuel Isaque Cordeiro da Silva Departamento de Zootecnia da UFRPE E-mail: emanuel.isaque@ufrpe.br WhatsApp: (82)98143-8399 -/- 1. INTRODUÇÃO A técnica da inseminação artificial tornou possível aumentar o impacto na descendência de touros geneticamente superiores em termos de produção láctea das filhas. Com a transferência de embriões é possível aumentar o impacto da fêmea sobre (...)
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  45. The History of Methylprednisolone, Ascorbic Acid, Thiamine, and Heparin Protocol and I-MASK+ Ivermectin Protocol for COVID-19.Mika Turkia - 2020 - Cureus 12 (12):e12403.
    An alliance of established experts on critical care, Front Line COVID-19 Critical Care Alliance (FLCCC), has published two protocols for treatment of COVID-19. The first one, methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+), is intended for hospital and intensive care unit treatment of pulmonary phases of the disease. It is based on affordable, commonly available components: anti-inflammatory corticosteroids (methylprednisolone, "M"), high-dose vitamin C infusion (ascorbic acid, "A"), vitamin B1 (thiamine, "T"), anticoagulant heparin ("H"), antiparasitic agent ivermectin, and supplemental components ("+") (...)
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  46. Anestro em Vacas Leiteiras: Fisiologia e Manejo.Emanuel Isaque Cordeiro da Silva - manuscript
    INTRODUÇÃO O anestro pós-parto é o período após o parto no qual a fêmea não apresenta ciclos estrais (atividade cíclica). Na vaca leiteira, o parto é seguido de um período de inatividade ovariana de duração variável, que é principalmente afetada pelo estado nutricional, produção leiteira, ganho ou perda de condição corporal antes e depois do parto, e por condições patológicas como hipoplasia dos ovários, cistos ovarianos, mumificação uterina, piometra entre outras, além, também, de condições ambientais como instalações que podem causar (...)
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  47. Ayahuasca in the treatment of bipolar disorder with psychotic features—A retrospective case study.Mika Turkia - manuscript
    Ayahuasca is a plant-based brew of indigenous Amazonian origin. It has psychedelic, anti-inflammatory, neuroprotective, cytotoxic, and anti-parasitic effects, which are primarily due to monoamine oxidase inhibitors (MAOIs) and N,N-dimethyltryptamine (DMT). This article describes the case of a woman in her late thirties with complex trauma due to severe, years-long sexual abuse in early childhood, resulting in a decades-long chronic condition involving suicidality. She was diagnosed with bipolar disorder and borderline personality disorder, but refused to accept either of them. She presented (...)
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  48. Ketamine in severe, highly treatment-resistant depression—a retrospective case study and a perspective.Mika Turkia - manuscript
    Ketamine is a well-known and widely available general anesthetic from the 1960s that, in sub-anesthetic doses, has been adopted in a limited manner for the treatment of acute suicidality and treatment-resistant depression. Its short onset time and short duration of action make it feasible for use at outpatient clinics. In the US, it has a long history of off-label use and was officially approved for depression treatment in 2019. In Finland, it has been administered to selected hospitalized patients in the (...)
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  49. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos.Emanuel Isaque Cordeiro da Silva - manuscript
    APRESENTAÇÃO O material Nutrição sobre a Reprodução e Fertilidade dos Bovinos é fruto de diversas pesquisas realizadas com o rebanho leiteiro do Instituto Agronômico de Pernambuco (IPA) de São Bento do Una em parceria com curso técnico em agropecuária do Instituto Federal de Pernambuco Campus Belo Jardim que visa demonstrar os fatores nutricionais como agentes diretos de alterações no sistema fisiológico do aparelho reprodutivo dos bovinos bem como na fertilidade destes animais. O trabalho estruturado de forma sistemática e mais didática (...)
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  50. Diferenciação e Determinação Sexual dos Animais.Emanuel Isaque Cordeiro da Silva -
    DIFERENCIAÇÃO SEXUAL -/- Emanuel Isaque Cordeiro da Silva Instituto Agronômico de Pernambuco Embrapa Semiárido -/- • _____OBJETIVO -/- Os estudantes de Veterinária e de Zootecnia estão ligados à disciplina Reprodução Animal, um pelos mecanismos fisiológicos para evitar e tratar as possíveis patologias do trato reprodutivo dos animais domésticos, e outro para o entendimento dos processos fisiológicos visando o manejo reprodutivo e a procriação para a formação de um plantel geneticamente melhorado. Sendo assim, a finalidade do presente trabalho é apresentar os (...)
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