Results for 'Catharine Diehl'

76 found
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  1. A Language for Ontological Nihilism.Catharine Diehl - 2018 - Ergo: An Open Access Journal of Philosophy 5:971-996.
    According to ontological nihilism there are, fundamentally, no individuals. Both natural languages and standard predicate logic, however, appear to be committed to a picture of the world as containing individual objects. This leads to what I call the \emph{expressibility challenge} for ontological nihilism: what language can the ontological nihilist use to express her account of how matters fundamentally stand? One promising suggestion is for the nihilist to use a form of \emph{predicate functorese}, a language developed by Quine. This proposal faces (...)
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  2. The Norms of Realism and the Case of Non-Traditional Casting.Catharine Abell - 2022 - Ergo 9.
    This paper concerns the conditions under which realism is an artistic merit in perceptual narratives, and its consequences for the practice of non-traditional casting. Perceptual narratives are narrative representations that perceptually represent at least some of their contents, and include works of film, television, theatre and opera. On certain construals of the conditions under which realism is an artistic merit in such works, non-traditional casting, however morally merited, is often artistically flawed. I defend an alternative view of the conditions under (...)
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  3. The Epistemic Value of Photographs.Catharine Abell - 2010 - In Catharine Abell & Katerina Bantinaki (eds.), Philosophical Perspectives on Depiction. Oxford University Press.
    There is a variety of epistemic roles to which photographs are better suited than non-photographic pictures. Photographs provide more compelling evidence of the existence of the scenes they depict than non-photographic pictures. They are also better sources of information about features of those scenes that are easily overlooked. This chapter examines several different attempts to explain the distinctive epistemic value of photographs, and argues that none is adequate. It then proposes an alternative explanation of their epistemic value. The chapter argues (...)
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  4. Art: What it Is and Why it Matters.Catharine Abell - 2011 - Philosophy and Phenomenological Research 85 (3):671-691.
    In this paper, I provide a descriptive definition of art that is able to accommodate the existence of bad art, while illuminating the value of good art. This, I argue, is something that existing definitions of art fail to do. I approach this task by providing an account according to which what makes something an artwork is the institutional process by which it is made. I argue that Searle’s account of institutions and institutional facts shows that the existence of all (...)
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  5. Comics and Genre.Catharine Abell - 2012 - In Aaron Meskin & Roy T. Cook (eds.), The Art of Comics: A Philosophical Approach. Blackwell. pp. 68--84.
    An adequate account of the nature of genre and of the criteria for genre membership is essential to understanding the nature of the various categories into which comics can be classified. Because they fail adequately to distinguish genre categories from other ways of categorizing works, including categorizations according to medium or according to style, previous accounts of genre fail to illuminate the nature of comics categories. I argue that genres are sets of conventions that have developed as means of addressing (...)
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  6. II—Genre, Interpretation and Evaluation.Catharine Abell - 2015 - Proceedings of the Aristotelian Society 115 (1pt1):25-40.
    The genre to which an artwork belongs affects how it is to be interpreted and evaluated. An account of genre and of the criteria for genre membership should explain these interpretative and evaluative effects. Contrary to conceptions of genres as categories distinguished by the features of the works that belong to them, I argue that these effects are to be explained by conceiving of genres as categories distinguished by certain of the purposes that the works belonging to them are intended (...)
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  7. Against Depictive Conventionalism.Catharine Abell - 2005 - American Philosophical Quarterly 42 (3):185 - 197.
    In this paper, I discuss the influential view that depiction, like language, depends on arbitrary conventions. I argue that this view, however it is elaborated, is false. Any adequate account of depiction must be consistent with the distinctive features of depiction. One such feature is depictive generativity. I argue that, to be consistent with depictive generativity, conventionalism must hold that depiction depends on conventions for the depiction of basic properties of a picture’s object. I then argue that two considerations jointly (...)
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  8. Pictorial implicature.Catharine Abell - 2005 - Journal of Aesthetics and Art Criticism 63 (1):55–66.
    It is generally recognised that an adequate resemblance-based account of depiction must specify some standard of correctness which explains how a picture’s content differs from the content we would attribute to it purely on the basis of resemblance. For example, an adequate standard should explain why stick figure drawings do not depict emaciated beings with gargantuan heads. Most attempts to specify a standard of correctness appeal to the intentions of the picture’s maker. However, I argue that the most detailed such (...)
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  9. The Epistemology of Attention.Catharine Saint-Croix - forthcoming - In Kurt Sylvan, Ernest Sosa, Jonathan Dancy & Matthias Steup (eds.), The Blackwell Companion to Epistemology, 3rd edition. Wiley Blackwell.
    Root, branch, and blossom, attention is intertwined with epistemology. It is essential to our capacity to learn and decisive of the evidence we obtain, it influences the intellectual connections we forge and those we remember, and it is the cognitive tool whereby we enact decisions about inquiry. Moreover, because it is both an epistemic practice and a site of agency, attention is a natural locus for questions about epistemic morality. This article surveys the emerging epistemology of attention, reviewing the existing (...)
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  10. On outlining the shape of depiction.Catharine Abell - 2005 - Ratio 18 (1):27–38.
    In this paper, I discuss the account of depiction proposed by Robert Hopkins in his book Picture, Image and Experience. I first briefly summarise Hopkins’s account, according to which we experience depictions as resembling their objects in respect of outline shape. I then ask whether Hopkins’s account can perform the explanatory tasks required of an adequate account of depiction. I argue that there are at least two reasons for which Hopkins’s account of depiction is inadequate. Firstly, the notion of outline (...)
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  11. (What) Is Feminist Logic? (What) Do We Want It to Be?Catharine Saint-Croix & Roy T. Cook - 2024 - History and Philosophy of Logic 45 (1):20-45.
    ‘Feminist logic’ may sound like an impossible, incoherent, or irrelevant project, but it is none of these. We begin by delineating three categories into which projects in feminist logic might fall: philosophical logic, philosophy of logic, and pedagogy. We then defuse two distinct objections to the very idea of feminist logic: the irrelevance argument and the independence argument. Having done so, we turn to a particular kind of project in feminist philosophy of logic: Valerie Plumwood's feminist argument for a relevance (...)
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  12. Rumination and Wronging: The Role of Attention in Epistemic Morality.Catharine Saint-Croix - 2022 - Episteme 19 (4):491-514.
    The idea that our epistemic practices can be wrongful has been the core observation driving the growing literature on epistemic injustice, doxastic wronging, and moral encroachment. But, one element of our epistemic practice has been starkly absent from this discussion of epistemic morality: attention. The goal of this article is to show that attention is a worthwhile focus for epistemology, especially for the field of epistemic morality. After presenting a new dilemma for proponents of doxastic wronging, I show how focusing (...)
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  13. VO: Vaccine Ontology.Yongqun He, Lindsay Cowell, Alexander D. Diehl, H. L. Mobley, Bjoern Peters, Alan Ruttenberg, Richard H. Scheuermann, Ryan R. Brinkman, Melanie Courtot, Chris Mungall, Barry Smith & Others - 2009 - In Barry Smith (ed.), ICBO 2009: Proceedings of the First International Conference on Biomedical Ontology. Buffalo: NCOR.
    Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...)
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  14. Privilege and Position: Formal Tools for Standpoint Epistemology.Catharine Saint-Croix - 2020 - Res Philosophica 97 (4):489-524.
    How does being a woman affect one’s epistemic life? What about being Black? Or queer? Standpoint theorists argue that such social positions can give rise to otherwise unavailable epistemic privilege. “Epistemic privilege” is a murky concept, however. Critics of standpoint theory argue that the view is offered without a clear explanation of how standpoints confer their benefits, what those benefits are, or why social positions are particularly apt to produce them. For this reason, many regard standpoint theory as being out (...)
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  15. Epistemic Virtue Signaling and the Double Bind of Testimonial Injustice.Catharine Saint-Croix - forthcoming - Philosophers' Imprint.
    Virtue signaling—using public moral discourse to enhance one’s moral reputation—is a familiar concept. But, what about profile pictures framed by “Vaccines work!”? Or memes posted to anti-vaccine groups echoing the group’s view that “Only sheep believe Big Pharma!”? These actions don’t express moral views—both claims are empirical (if imprecise). Nevertheless, they serve a similar purpose: to influence the judgments of their audience. But, where rainbow profiles guide their audience to view the agent as morally good, these acts guide their audience (...)
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  16. Chisholm's Paradox and Conditional Oughts.Catharine Saint Croix & Richmond Thomason - 2014 - Lecture Notes in Computer Science 8554:192-207.
    Since it was presented in 1963, Chisholm’s paradox has attracted constant attention in the deontic logic literature, but without the emergence of any definitive solution. We claim this is due to its having no single solution. The paradox actually presents many challenges to the formalization of deontic statements, including (1) context sensitivity of unconditional oughts, (2) formalizing conditional oughts, and (3) distinguishing generic from nongeneric oughts. Using the practical interpretation of ‘ought’ as a guideline, we propose a linguistically motivated logical (...)
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  17. Review of Gregory Currie , Narratives and Narrators: A Philosophy of Stories. [REVIEW]Catharine Abell - 2011 - Philosophy in Review 31 (5):324-326.
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  18. Human Suffering as a Challenge for the Meaning of Life.Ulrich Diehl - 2009 - Existenz. An International Journal in Philosophy, Religion, Politics, and the Arts.
    When people suffer they always suffer as a whole human being. The emotional, cognitive and spiritual suffering of human beings cannot be completely separated from all other kinds of suffering, such as from harmful natural, ecological, political, economic and social conditions. In reality they interact with each other and influence each other. Human beings do not only suffer from somatic illnesses, physical pain, and the lack of decent opportunities to satisfy their basic vital, social and emotional needs. They also suffer (...)
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  19. Review of Zenon Pylyshyn's Seeing and Visualizing: It's Not What You Think. [REVIEW]Catharine Abell - 2005 - PSYCHE: An Interdisciplinary Journal of Research On Consciousness 11.
    This book has three principle aims: to show that neither vision nor mental imagery involves the creation or inspection of picture-like mental representations; to defend the claim that our visual processes are, in significant part, cognitively impenetrable; and to develop a theory of “visual indexes”. In what follows, I assess Pylyshyn’s success in realising each of these aims in turn. I focus primarily on his arguments against “picture theories” of vision and mental imagery, to which approximately half the book is (...)
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  20. Review of Anthony Everett, The Nonexistent. [REVIEW]Catharine Abell - 2016 - British Journal of Aesthetics 56 (2):209-212.
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  21. Jaspers’ Existenzerhellung der Freiheit.Ulrich Diehl - 2013 - In Thomas Fuchs, Stefano Micali & Boris Wandruszka (eds.), Karl Jaspers - Phänomenologie und Psychopathologie. Karl Alber.
    In seiner ‘Existenzerhellung der Freiheit’ reflektiert Jaspers, das Problemfeld der Freiheit in einem Kontrast zu den Begriffen, Phänomenen und Bedingungen der Unfreiheit und der Grenzen der Freiheit. Dem Problemfeld der Freiheit kann man im Denken und Handeln nur dann gerecht werden, wenn man nicht nur zwischen den verschiedenen Begriffen und Phänomenen der Freiheit unterscheidet, sondern auch zwischen den verschiedenen Begriffen und Phänomenen von Grenzen der Freiheit, wie z.B. durch die allgemeine Naturgesetzlichkeit und die menschliche Natur, durch besondere Bedingungen in Natur, (...)
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  22. Was ist das eigentlich, das Fromme? Zu Platons Dialog Eutyphron.Ulrich Diehl - 2006 - In Gregor Fitzi (ed.), Platon im Diskurs. Universitätsverlag Winter.
    This essay is a close reading analysis of Plato's Eutyphron coming to the conclusion that Plato's Socrates is still a model for an open minded, but critical attitude towards the ethical and metaphysical claims of religions.
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  23. Grenzsituationen als existenzielle Herausforderung.Ulrich Diehl - 2015 - E-Journal Für Philosophie der Psychologie 21 (October):1-15.
    In seiner "Psychologie der Weltanschauungen" hat Karl Jaspers erstmals die seelischen Quellen und geistigen Typen der Weltanschauungen und der Philosophie aus psychologischer Sicht dargestellt. Ziel und Aufgabe seiner Untersuchung war es, zu verstehen, welche irreduziblen Grundkräfte die Seele bewegen, um das menschliche Leben auch noch in den Grenzsituationen bewältigen zu können. Dazu unterscheidet Jaspers zwischen Einstellungen, Weltbildern und Geistestypen als Elementen der jeweiligen Weltanschauung. Um das Leben des menschlichen Geistes zu verstehen, muss man nach Jaspers zwischen aktuellen Wertungen, abstrahierten Werten, (...)
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  24. Was heißt "Philosophie als strenge Wissenschaft"?Ulrich Diehl - 2005 - In G. von Sivers & U. Diehl (eds.), Wege Zur Politischen Philosophie. Königshausen & Neumann. pp. 199.
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  25. Neid als Mangel an gelingendem Selbstsein.Ulrich Diehl - 2010 - In B. Harress (ed.), Neid. Darstellung un Deutung in den Wissenschaften und Künsten. LIST.
    Neidische Gedanken, neidische Gefühle, neidische Menschen sind im alltäglichen Leben gegenwärtig. Kaum vergeht ein Tag, an dem man nicht mit dem Phänomen des Neides konfrontiert wäre. Bei sich selbst mag man ihn schon gar nicht, denn der Neid ist ein schmerzliches und unschönes Gefühl. Obwohl der Neid ein alltägliches Phänomen ist, bleibt er im Alltag ein weitgehend tabuisiertes Thema: Über den Neid spricht man entweder gar nicht oder nur selten. Falls man doch über den Neid spricht, dann zumeist über den (...)
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  26. Karl Jaspers und die Vernunft.Ulrich Diehl - 2011 - In Hamid Reza Yousefi, Werner Schüßler, Reinhard Schulz & Ulrich Diehl (eds.), Karl Jaspers - Grundbegriffe seines Denkens. Lau Verlag.
    Der Begriff der Vernunft gehört zu den Begriffen, die für Jaspers‘ philosophisches Denken und schriftliche verfaßte Philosophie eine besonders wichtige Rolle spielen. Gleichwohl kann es im Folgenden nicht um Jaspers‘ ganze Philosophie gehen, sondern nur um seinen Begriff der Vernunft. Sein Begriff der Vernunft ist jedoch für die wesentlichen Grundzüge seiner Philosophie konstitutiv und charakteristisch. Im ersten Teil werde ich kurz auf die Entwicklung der Schriften eingehen, in denen Jaspers hauptsächlich sein Verständnis von Vernunft dargelegt hat. Im zweiten Teil werde (...)
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  27. Misologie und Misanthropie in Platons Phaidon.Ulrich Diehl - 2013 - In H.-J. Gerigk / H. Koopmann (ed.), Hass. Darstellung und Deutung in den Wissenschaften und Künsten. Mattes Verlag.
    Das Thema der Misologie und Misanthropie lässt sich wie so viele anderen philosophischen Themen der europäischen Geistesgeschichte bis zu einem platonischen Dialog zurückverfolgen. In diesem Fall handelt es sich um Platons berühmten Dialog Phaidon. Nun handelt dieser Dialog bekanntlich von der Frage nach der Unsterblichkeit der menschlichen Seele. Dennoch verweist Sokrates an einer bestimmten Stelle des Dialoges auf die für den Menschen drohenden Gefahren der Misologie und der Misanthropie hin, dem Hass auf die Vernunft und den Hass auf den Menschen, (...)
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  28. Zur Frage nach dem Leiblichen bei Karl Jaspers.Ulrich Diehl - 2014 - Jahrbuch der Karl-Jaspers-Gesellschaft, Austria 27.
    Obwohl Jaspers in seiner Philosophie Methoden und Motive der Phänomenologie Husserls und der Hermeneutik Diltheys aufgenommen hatte, hat er sich nicht besonders für die Leibphilosophie interessiert. Das bedeutet jedoch nicht, dass der menschliche Leib in seinem Denken gar nicht vorkommt. Aber es handelt sich bei ihm jedoch nicht um ein Schlüsselthema, sondern um ein randständiges Phänomen. Der menschliche Leib ist bei Jaspers die vitale Basis der überlieferten Trias von Leib, Seele und Geist. Damit steht Jaspers in der klassischen Traditionslinie des (...)
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  29. Mißdeutung der Kritik? Eberhards Vorbehalte gegen Kants kritische Philosophie.Ulrich Diehl - 2012 - In Hans J. Kertscher & Ernst Stöckmann (eds.), Ein Antipode Kants? Johann August Eberhard ... de Gruyter.
    Johann August Eberhard gründet 1788 die Zeitschrift "Philosophisches Magazin", um die sog. Leibniz-Wolffsche Schulphilosophie gegen die zunehmend erfolgreichen Angriffe der kantischen Philosophie zu verteidigen. Zu diesem Zweck publizierte er insgesamt sieben Artikel, um seiner Leserschaft zu zeigen, dass die ältere Philosophie Leibnizens bereits eine gründliche Vernunftkritik enthalte, die der neueren Vernunftkritik Kants nicht nur ebenbürtig, sondern sogar überlegen sei. Als Anhänger der leibnizianischen Vernunftkritik war Eberhard vor allem deswegen von ihrer Überlegenheit überzeugt, weil man mit ihr noch eine dogmatische Metaphysik (...)
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  30. Jaspers on Drives, Wants and Volitions.Ulrich Diehl - 2012 - Jahrbuch der Österreichischen Karl-Jaspers-Gesellschaft 25:101-125.
    In § 6 of his General Psychopathology (1st edition 1913) Jaspers distinguished between drives, wants and volitions as three different and irreducible kinds of motivational phenomena which are involved in human decision making and which may lead to successful actions. He has characterized the qualitative differences between volitions in comparison with basic vital drives and emotional wants such as being (a.) intentional, (b.) content-specific and (b.) directed towards concrete objects and actions as goals. Furthermore, Jaspers has presented and discussed three (...)
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  31. Gesundheit – hohes oder höchstes Gut? Über den Wert und Stellenwert der Gesundheit.Ulrich Diehl - 2005 - In Hermes Andreas Kick (ed.), Gesundheitswesen zwischen Wirtschaftlichkeit und Menschlichkeit. LIST. pp. 10--113.
    Was kann ein Philosoph dazu beitragen, dass wir uns nicht nur ein adäquates Bild vom tatsächlichen Gesundheitswesen machen, sondern auch verstehen, wie in der Gesundheitspolitik ökonomische Rationalität dem übergeordneten Ziel der Realisierung humaner Verhältnisse dienen könnte? Wenn er kein weltfremder Utopist ist, dann wird er zunächst einmal anerkennen, dass die ökonomische Rationalität und die rechtsstaatliche Regulierung des Gesundheitswesens selbst schon notwendige Bedingungen für die Realisierung von Humanität sind. Denn humane Verhältnisse im Gesundheitswesen sind unter den Realbedingungen von mehr oder weniger (...)
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  32. On the Art of Intercultural Dialogue. Some Forms, Conditions and Structures.Ulrich Diehl - 2005 - In P. N. Liechtenstein & Ch M. Gueye (eds.), Peace and Intercultural Dialogue. Universitätsverlag Winter.
    This essay begins with the claim that intercultural dialogue is an art rather than a science or technique and it attempts to point out what it takes to learn the art of intercultural dialogue. In PART ONE some basic forms of intercultural dialogue are presented which correlate to some basic forms of human life, such as family, politics, economy, science, art and religion. Also a few common traits about how intercultural dialogue is practised today are specified. PART TWO is pointing (...)
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  33. Ist Jaspers ein Kantianer?Ulrich Diehl - 2008 - In K. Eming & Th Fuchs (eds.), Karl Jaspers – Philosophie und Psychopathologie. Universitätsverlag Winter.
    Die Frage, ob Karl Jaspers ein Kantianer ist, wird nicht nur kompetente Jasperskenner überraschen, sondern auch die meisten Philosophiehistoriker, die mit der Geschichte der Philosophie der Neuzeit und Moderne vertraut sind. Denn einerseits werden nicht nur die meisten Jasperskenner, sondern auch die meisten Philosophiehistoriker überhaupt, diese Frage zunächst einmal mit einem gewissen Recht verneinen. Denn der überlieferten Lehrmeinung zufolge, war Jaspers kein Kantianer, sondern ein Existenzphilosoph. Andererseits werden vermutlich die meisten Jasperskenner und Philosophiehistoriker zugestehen, dass Kant für Jaspers zumindest einer (...)
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  34. Neidüberwindung als Problem der philosophischen Lebenskunst.Ulrich Diehl - 2010 - In B. Harress (ed.), Neid. Darstellung und Deutung in den Wissenschaften und Künsten. LIST.
    Der Neid wirft als Thema der philosophischen und psychologischen Reflexion eine ganze Reihe von Fragen auf, die theoretischer Natur sind. Dazu gehören die Frage nach der Analyse des alltagspsychologischen Neidbegriffes, die damit verbundene Frage nach der Abgrenzung des psychologischen Phänomens des Neides im Verhältnis zu verwandten Emotionen, wie z.B. Eifersucht, Habgier, Ehrgeiz, Wetteifer, Geiz, etc., die Frage nach dem Wesen des Neides als einem reflexartigen und unkontrollierbaren Affekt, als einer dauerhaften und unbewussten Stimmung, als einem momentanen, intentionalen und bewussten Gefühl, (...)
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  35. Über die Würde der Kinder als Patienten.Ulrich Diehl - 2003 - In C. Wiesemann, A. Dörries, G. Wolfslast & A. Simon (eds.), Das Kind als Patient. Campus.
    In der Medizin gehören Kinder neben Ausländern, Behinderten und psychiatrisch Erkrankten zu den besonders vulnerablen Patientengruppen. Im Folgenden soll die Frage nach der Würde der Kinder in medizinethischer Hinsicht behandelt werden. Dazu werden drei Thesen erläutert und begründet: (1.) das Prinzip der Menschenwürde kann nicht ganz außer Acht gelassen werden, wenn Kinder als Patienten in medizinethischer Hinsicht thematisiert werden; (2.) das Prinzip der Menschenwürde wird in der Medizinethik nicht schon vollständig durch die medizinethischen Prinzipien der Patientenautonomie und der Fürsorge für (...)
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  36. Klinische Phänomenologie und therapeutische Situation.Ulrich Diehl & Hermes Andreas Kick - 1998 - Fundamenta Psychiatrica 12:53-57.
    Phänomenologie intendiert allgemein eine Beschreibung und intersubjektiv nachvollziehbare Analyse der in einer konkreten Situation sich erschließenden Phänomene des menschlichen Bewußtseins. Klinische Phänomenologie hat darüber hinaus die therapeutische Situation zu berücksichtigen. Im Folgenden wird die These vertreten, daß die psychische Verfassung eines Menschen niemals allein aufgrund einer rein phänomenologischen Analyse auf alle praktisch und therapeutisch relevanten Konsequenzen hin ergründet werden kann. Das kann insbesondere dann nicht der Fall sein, wenn sich solche Konsequenzen aus einem außerhalb der konkreten Situation gewonnenen, empirisch verallgemeinerbaren (...)
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  37. An improved ontological representation of dendritic cells as a paradigm for all cell types.Anna Maria Masci, Cecilia N. Arighi, Alexander D. Diehl, Anne E. Liebermann, Chris Mungall, Richard H. Scheuermann, Barry Smith & Lindsay Cowell - 2009 - BMC Bioinformatics 10 (1):70.
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  38. Protein-centric connection of biomedical knowledge: Protein Ontology research and annotation tools.Cecilia N. Arighi, Darren A. Natale, Judith A. Blake, Carol J. Bult, Michael Caudy, Alexander D. Diehl, Harold J. Drabkin, Peter D'Eustachio, Alexei Evsikov, Hongzhan Huang, Barry Smith & Others - 2011 - In Proceedings of the 2nd International Conference on Biomedical Ontology. Buffalo, NY: NCOR. pp. 285-287.
    The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.
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  39. The ImmPort Antibody Ontology.William Duncan, Travis Allen, Jonathan Bona, Olivia Helfer, Barry Smith, Alan Ruttenberg & Alexander D. Diehl - 2016 - Proceedings of the International Conference on Biological Ontology 1747.
    Monoclonal antibodies are essential biomedical research and clinical reagents that are produced by companies and research laboratories. The NIAID ImmPort (Immunology Database and Analysis Portal) resource provides a long-term, sustainable data warehouse for immunological data generated by NIAID, DAIT and DMID funded investigators for data archiving and re-use. A variety of immunological data is generated using techniques that rely upon monoclonal antibody reagents, including flow cytometry, immunofluorescence, and ELISA. In order to facilitate querying, integration, and reuse of data, standardized terminology (...)
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  40. An improved ontological representation of dendritic cells as a paradigm for all cell types.Masci Anna Maria, N. Arighi Cecilia, D. Diehl Alexander, E. Lieberman Anne, Mungall Chris, H. Scheuermann Richard, Barry Smith & G. Cowell Lindsay - 2009 - BMC Bioinformatics 10 (1):70.
    The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...)
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  41. Ontologies for the study of neurological disease.Alexander P. Cox, Mark Jensen, William Duncan, Bianca Weinstock-Guttman, Kinga Szigeti, Alan Ruttenberg, Barry Smith & Alexander D. Diehl - 2012 - In Alexander P. Cox, Mark Jensen, William Duncan, Bianca Weinstock-Guttman, Kinga Szigeti, Alan Ruttenberg, Barry Smith & Alexander D. Diehl (eds.), Towards an Ontology of Mental Functioning (ICBO Workshop), Third International Conference on Biomedical Ontology. Graz:
    We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...)
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  42. OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies.Rebecca C. Jackson, Nicolas Matentzoglu, James A. Overton, Randi Vita, James P. Balhoff, Pier Luigi Buttigieg, Seth Carbon, Melanie Courtot, Alexander D. Diehl, Damion Dooley, William Duncan, Nomi L. Harris, Melissa A. Haendel, Suzanna E. Lewis, Darren A. Natale, David Osumi-Sutherland, Alan Ruttenberg, Lynn M. Schriml, Barry Smith, Christian J. Stoeckert, Nicole A. Vasilevsky, Ramona L. Walls, Jie Zheng, Christopher J. Mungall & Bjoern Peters - 2021 - BioaRxiv.
    Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...)
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  43. Representing disease courses: An application of the Neurological Disease Ontology to Multiple Sclerosis Typology.Mark Jensen, Alexander P. Cox, Barry Smith & Alexander Diehl - 2013 - In Jensen Mark, Cox Alexander P., Diehl Alexander & Smith Barry (eds.), Proceedings of the Fourth International Conference on Biomedical Ontology (ICBO), CEUR 1060.
    The Neurological Disease Ontology (ND) is being developed to provide a comprehensive framework for the representation of neurological diseases (Diehl et al., 2013). ND utilizes the model established by the Ontology for General Medical Science (OGMS) for the representation of entities in medicine and disease (Scheuermann et al., 2009). The goal of ND is to include information for each disease concerning its molecular, genetic, and environmental origins, the processes involved in its etiology and realization, as well as its clinical (...)
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  44. Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  45. The Neurological Disease Ontology.Mark Jensen, Alexander P. Cox, Naveed Chaudhry, Marcus Ng, Donat Sule, William Duncan, Patrick Ray, Bianca Weinstock-Guttman, Barry Smith, Alan Ruttenberg, Kinga Szigeti & Alexander D. Diehl - 2013 - Journal of Biomedical Semantics 4 (42):42.
    We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...)
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  46. Protein Ontology: A controlled structured network of protein entities.A. Natale Darren, N. Arighi Cecilia, A. Blake Judith, J. Bult Carol, R. Christie Karen, Cowart Julie, D’Eustachio Peter, D. Diehl Alexander, J. Drabkin Harold, Helfer Olivia, Barry Smith & Others - 2013 - Nucleic Acids Research 42 (1):D415-21..
    The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...)
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  47. Protein Ontology: Enhancing and scaling up the representation of protein entities.Darren A. Natale, Cecilia N. Arighi, Judith A. Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R. Christie, Julie Cowart, Peter D'Eustachio, Alexander D. Diehl, Harold J. Drabkin, William D. Duncan, Hongzhan Huang, Jia Ren, Karen Ross & Alan Ruttenberg - 2017 - Nucleic Acids Research 45 (D1):D339-D346.
    The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...)
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  48. The structuralist approach to underdetermination.Chanwoo Lee - 2022 - Synthese 200 (2):1-25.
    This paper provides an exposition of the structuralist approach to underdetermination, which aims to resolve the underdetermination of theories by identifying their common theoretical structure. Applications of the structuralist approach can be found in many areas of philosophy. I present a schema of the structuralist approach, which conceptually unifies such applications in different subject matters. It is argued that two classic arguments in the literature, Paul Benacerraf’s argument on natural numbers and W. V. O. Quine’s argument for the indeterminacy of (...)
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  49. Catharine Trotter Cockburn.Ruth Boeker - 2023 - Cambridge: Cambridge University Press.
    This Element offers the first detailed study of Catharine Trotter Cockburn's philosophy and covers her contributions to philosophical debates in epistemology, metaphysics, moral philosophy, and philosophy of religion. It examines not only Cockburn's view that sensation and reflection are the sources of knowledge, but also how she draws attention to the limitations of human understanding and how she approaches metaphysical debates through this lens. In the area of moral philosophy, this Element argues that it is helpful to take seriously (...)
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  50. Catharine Trotter Cockburn on the virtue of atheists.Jacqueline Broad - 2021 - Intellectual History Review 31 (1):111-128.
    In her Remarks Upon Some Writers (1743), Catharine Trotter Cockburn takes a seemingly radical stance by asserting that it is possible for atheists to be virtuous. In this paper, I examine whether or not Cockburn’s views concerning atheism commit her to a naturalistic ethics and a so-called radical enlightenment position on the independence of morality and religion. First, I examine her response to William Warburton’s critique of Pierre Bayle’s arguments concerning the possibility of a society of virtuous atheists. I (...)
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