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  1. Interdisciplinarity in the Making: Models and Methods in Frontier Science.Nancy J. Nersessian - 2022 - Cambridge, MA: MIT.
    A cognitive ethnography of how bioengineering scientists create innovative modeling methods. In this first full-scale, long-term cognitive ethnography by a philosopher of science, Nancy J. Nersessian offers an account of how scientists at the interdisciplinary frontiers of bioengineering create novel problem-solving methods. Bioengineering scientists model complex dynamical biological systems using concepts, methods, materials, and other resources drawn primarily from engineering. They aim to understand these systems sufficiently to control or intervene in them. What Nersessian examines here is how cutting-edge bioengineering (...)
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  • Model Organisms as Scientific Representations.Lorenzo Sartori - forthcoming - British Journal for the Philosophy of Science.
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  • AI, Opacity, and Personal Autonomy.Bram Vaassen - 2022 - Philosophy and Technology 35 (4):1-20.
    Advancements in machine learning have fuelled the popularity of using AI decision algorithms in procedures such as bail hearings, medical diagnoses and recruitment. Academic articles, policy texts, and popularizing books alike warn that such algorithms tend to be opaque: they do not provide explanations for their outcomes. Building on a causal account of transparency and opacity as well as recent work on the value of causal explanation, I formulate a moral concern for opaque algorithms that is yet to receive a (...)
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  • Série Investigações Filosóficas: Textos Selecionados de Filosofia da Ciência II [Philosophical Investigation Series: Selected Texts on Philosophy of Science II].Luana Poliseli (ed.) - 2021 - Pelotas: Editora da Universidade Federal de Pelotas.
    A Série Investigação Filosófica, uma iniciativa do Núcleo de Ensino e Pesquisa em Filosofia do Departamento de Filosofia da UFPel e do Grupo de Pesquisa Investigação Filosófica do Departamento de Filosofia da UNIFAP, sob o selo editorial do NEPFil online e da Editora da Universidade Federal de Pelotas, com auxílio financeiro da John Templeton Foundation, tem por objetivo precípuo a publicação da tradução para a língua portuguesa de textos selecionados a partir de diversas plataformas internacionalmente reconhecidas, tal como a Stanford (...)
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  • Two Dimensions of Opacity and the Deep Learning Predicament.Florian J. Boge - 2021 - Minds and Machines 32 (1):43-75.
    Deep neural networks have become increasingly successful in applications from biology to cosmology to social science. Trained DNNs, moreover, correspond to models that ideally allow the prediction of new phenomena. Building in part on the literature on ‘eXplainable AI’, I here argue that these models are instrumental in a sense that makes them non-explanatory, and that their automated generation is opaque in a unique way. This combination implies the possibility of an unprecedented gap between discovery and explanation: When unsupervised models (...)
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  • Computer Simulations as Scientific Instruments.Ramón Alvarado - 2022 - Foundations of Science 27 (3):1183-1205.
    Computer simulations have conventionally been understood to be either extensions of formal methods such as mathematical models or as special cases of empirical practices such as experiments. Here, I argue that computer simulations are best understood as instruments. Understanding them as such can better elucidate their actual role as well as their potential epistemic standing in relation to science and other scientific methods, practices and devices.
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  • Capturing the representational and the experimental in the modelling of artificial societies.David Anzola - 2021 - European Journal for Philosophy of Science 11 (3):1-29.
    Even though the philosophy of simulation is intended as a comprehensive reflection about the practice of computer simulation in contemporary science, its output has been disproportionately shaped by research on equation-based simulation in the physical and climate sciences. Hence, the particularities of alternative practices of computer simulation in other scientific domains are not sufficiently accounted for in the current philosophy of simulation literature. This article centres on agent-based social simulation, a relatively established type of simulation in the social sciences, to (...)
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  • Degrees of Epistemic Opacity.Iñaki San Pedro - manuscript
    The paper analyses in some depth the distinction by Paul Humphreys between "epistemic opacity" —which I refer to as "weak epistemic opacity" here— and "essential epistemic opacity", and defends the idea that epistemic opacity in general can be made sense as coming in degrees. The idea of degrees of epistemic opacity is then exploited to show, in the context of computer simulations, the tight relation between the concept of epistemic opacity and actual scientific (modelling and simulation) practices. As a consequence, (...)
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  • A Formal Framework for Computer Simulations: Surveying the Historical Record and Finding Their Philosophical Roots.Juan M. Durán - 2019 - Philosophy and Technology 34 (1):105-127.
    A chronicled approach to the notion of computer simulations shows that there are two predominant interpretations in the specialized literature. According to the first interpretation, computer simulations are techniques for finding the set of solutions to a mathematical model. I call this first interpretation the problem-solving technique viewpoint. In its second interpretation, computer simulations are considered to describe patterns of behavior of a target system. I call this second interpretation the description of patterns of behavior viewpoint of computer simulations. This (...)
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  • A Formal Framework for Computer Simulations: Surveying the Historical Record and Finding Their Philosophical Roots.Juan M. Durán - 2019 - Philosophy and Technology 34 (1):105-127.
    A chronicled approach to the notion of computer simulations shows that there are two predominant interpretations in the specialized literature. According to the first interpretation, computer simulations are techniques for finding the set of solutions to a mathematical model. I call this first interpretation the problem-solving technique viewpoint. In its second interpretation, computer simulations are considered to describe patterns of behavior of a target system. I call this second interpretation the description of patterns of behavior viewpoint of computer simulations. This (...)
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  • Mesoscopic modeling as a cognitive strategy for handling complex biological systems.Miles MacLeod & Nancy J. Nersessian - 2019 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 78:101201.
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  • Why Simpler Computer Simulation Models Can Be Epistemically Better for Informing Decisions.Casey Helgeson, Vivek Srikrishnan, Klaus Keller & Nancy Tuana - 2021 - Philosophy of Science 88 (2):213-233.
    For computer simulation models to usefully inform climate risk management, uncertainties in model projections must be explored and characterized. Because doing so requires running the model many ti...
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  • Qualitative Models in Computational Simulative Sciences: Representation, Confirmation, Experimentation.Nicola Angius - 2019 - Minds and Machines 29 (3):397-416.
    The Epistemology Of Computer Simulation has developed as an epistemological and methodological analysis of simulative sciences using quantitative computational models to represent and predict empirical phenomena of interest. In this paper, Executable Cell Biology and Agent-Based Modelling are examined to show how one may take advantage of qualitative computational models to evaluate reachability properties of reactive systems. In contrast to the thesis, advanced by EOCS, that computational models are not adequate representations of the simulated empirical systems, it is shown how (...)
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  • The Epistemic Importance of Technology in Computer Simulation and Machine Learning.Michael Resch & Andreas Kaminski - 2019 - Minds and Machines 29 (1):1-9.
    Scientificity is essentially methodology. The use of information technology as methodological instruments in science has been increasing for decades, this raises the question: Does this transform science? This question is the subject of the Special Issue in Minds and Machines “The epistemological significance of methods in computer simulation and machine learning”. We show that there is a technological change in this area that has three methodological and epistemic consequences: methodological opacity, reproducibility issues, and altered forms of justification.
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  • Computer Modeling and Simulation: Increasing Reliability by Disentangling Verification and Validation.Vitaly Pronskikh - 2019 - Minds and Machines 29 (1):169-186.
    Verification and validation of computer codes and models used in simulations are two aspects of the scientific practice of high importance that recently have been discussed widely by philosophers of science. While verification is predominantly associated with the correctness of the way a model is represented by a computer code or algorithm, validation more often refers to the model’s relation to the real world and its intended use. Because complex simulations are generally opaque to a practitioner, the Duhem problem can (...)
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  • Simulations, Explanation, Understanding: An Analytical Overview.Cyrille Imbert - 2017 - Philosophia Scientiae 21:49-109.
    J’analyse dans cet article la valeur explicative que peuvent avoir les simulations numériques. On rencontre en effet souvent l’affirmation selon laquelle les simulations permettent de prédire, de reproduire ou d’imiter des phénomènes, mais guère de les expliquer. Les simulations rendraient aussi possible l’étude du comportement d’un système par la force brute du calcul mais n’apporteraient pas une compréhension réelle de ce système et de son comportement. Dans tous les cas, il semble que, à tort ou à raison, les simulations posent, (...)
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  • Epistemic Entitlements and the Practice of Computer Simulation.John Symons & Ramón Alvarado - 2019 - Minds and Machines 29 (1):37-60.
    What does it mean to trust the results of a computer simulation? This paper argues that trust in simulations should be grounded in empirical evidence, good engineering practice, and established theoretical principles. Without these constraints, computer simulation risks becoming little more than speculation. We argue against two prominent positions in the epistemology of computer simulation and defend a conservative view that emphasizes the difference between the norms governing scientific investigation and those governing ordinary epistemic practices.
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  • Mapping an expanding territory: computer simulations in evolutionary biology.Philippe Huneman - 2014 - History and Philosophy of the Life Sciences 36 (1):60-89.
    The pervasive use of computer simulations in the sciences brings novel epistemological issues discussed in the philosophy of science literature since about a decade. Evolutionary biology strongly relies on such simulations, and in relation to it there exists a research program (Artificial Life) that mainly studies simulations themselves. This paper addresses the specificity of computer simulations in evolutionary biology, in the context (described in Sect. 1) of a set of questions about their scope as explanations, the nature of validation processes (...)
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  • Are computer simulations experiments? And if not, how are they related to each other?Claus Beisbart - 2018 - European Journal for Philosophy of Science 8 (2):171-204.
    Computer simulations and experiments share many important features. One way of explaining the similarities is to say that computer simulations just are experiments. This claim is quite popular in the literature. The aim of this paper is to argue against the claim and to develop an alternative explanation of why computer simulations resemble experiments. To this purpose, experiment is characterized in terms of an intervention on a system and of the observation of the reaction. Thus, if computer simulations are experiments, (...)
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  • Mutant mice: Experimental organisms as materialised models in biomedicine.Lara Huber & Lara K. Keuck - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):385-391.
    Animal models have received particular attention as key examples of material models. In this paper, we argue that the specificities of establishing animal models—acknowledging their status as living beings and as epistemological tools—necessitate a more complex account of animal models as materialised models. This becomes particularly evident in animal-based models of diseases that only occur in humans: in these cases, the representational relation between animal model and human patient needs to be generated and validated. The first part of this paper (...)
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  • New Issues for New Methods: Ethical and Editorial Challenges for an Experimental Philosophy.Andrea Polonioli - forthcoming - Science and Engineering Ethics.
    This paper examines a constellation of ethical and editorial issues that have arisen since philosophers started to conduct, submit and publish empirical research. These issues encompass concerns over responsible authorship, fair treatment of human subjects, ethicality of experimental procedures, availability of data, unselective reporting and publishability of research findings. This study aims to assess whether the philosophical community has as yet successfully addressed such issues. To do so, the instructions for authors, submission process and published research papers of 29 main (...)
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  • When can a Computer Simulation act as Substitute for an Experiment? A Case-Study from Chemisty.Johannes Kästner & Eckhart Arnold - manuscript
    In this paper we investigate with a case study from chemistry under what conditions a simulation can serve as a surrogate for an experiment. The case-study concerns a simulation of H2-formation in outer space. We find that in this case the simulation can act as a surrogate for an experiment, because there exists comprehensive theoretical background knowledge in form of quantum mechanics about the range of phenomena to which the investigated process belongs and because any particular modelling assumptions as can (...)
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  • What is a Computer Simulation? A Review of a Passionate Debate.Nicole J. Saam - 2017 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 48 (2):293-309.
    Where should computer simulations be located on the ‘usual methodological map’ which distinguishes experiment from theory? Specifically, do simulations ultimately qualify as experiments or as thought experiments? Ever since Galison raised that question, a passionate debate has developed, pushing many issues to the forefront of discussions concerning the epistemology and methodology of computer simulation. This review article illuminates the positions in that debate, evaluates the discourse and gives an outlook on questions that have not yet been addressed.
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  • Big Data – The New Science of Complexity.Wolfgang Pietsch - unknown
    Data-intensive techniques, now widely referred to as 'big data', allow for novel ways to address complexity in science. I assess their impact on the scientific method. First, big-data science is distinguished from other scientific uses of information technologies, in particular from computer simulations. Then, I sketch the complex and contextual nature of the laws established by data-intensive methods and relate them to a specific concept of causality, thereby dispelling the popular myth that big data is only concerned with correlations. The (...)
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  • Computer simulations and experiments: The case of the Higgs boson.Michela Massimi & Wahid Bhimji - 2015 - Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics 51 (C):71-81.
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  • About the warrants of computer-based empirical knowledge.Anouk Barberousse & Marion Vorms - 2014 - Synthese 191 (15):3595-3620.
    Computer simulations are widely used in current scientific practice, as a tool to obtain information about various phenomena. Scientists accordingly rely on the outputs of computer simulations to make statements about the empirical world. In that sense, simulations seem to enable scientists to acquire empirical knowledge. The aim of this paper is to assess whether computer simulations actually allow for the production of empirical knowledge, and how. It provides an epistemological analysis of present-day empirical science, to which the traditional epistemological (...)
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  • Kuhn vs. Popper on criticism and dogmatism in science, part II: How to strike the balance.Darrell P. Rowbottom - 2013 - Studies in History and Philosophy of Science Part A 44 (2):161-168.
    This paper is a supplement to, and provides a proof of principle of, Kuhn vs. Popper on Criticism and Dogmatism in Science: A Resolution at the Group Level. It illustrates how calculations may be performed in order to determine how the balance between different functions in science—such as imaginative, critical, and dogmatic—should be struck, with respect to confirmation (or corroboration) functions and rules of scientific method.
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  • How can computer simulations produce new knowledge?Claus Beisbart - 2012 - European Journal for Philosophy of Science 2 (3):395-434.
    It is often claimed that scientists can obtain new knowledge about nature by running computer simulations. How is this possible? I answer this question by arguing that computer simulations are arguments. This view parallels Norton’s argument view about thought experiments. I show that computer simulations can be reconstructed as arguments that fully capture the epistemic power of the simulations. Assuming the extended mind hypothesis, I furthermore argue that running the computer simulation is to execute the reconstructing argument. I discuss some (...)
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  • Agent-based Models as Fictive Instantiations of Ecological Processes.Steven L. Peck - 2012 - Philosophy, Theory, and Practice in Biology 4 (20130604).
    Frigg and Reiss (2009) argue that philosophical problems in simulation bear enough resemblance to recognized issues in the philosophy of modeling that they only pose challenges analogous to those found in standard analytic models used to represent natural systems. They suggest that there are no new philosophical problems in computer simulation modeling beyond those found in traditional mathematical modeling. Winsberg (2009) has countered that there appear to be genuinely new epistemological problems in simulation modeling because the knowledge obtained from them (...)
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  • Tools or toys? On specific challenges for modeling and the epistemology of models and computer simulations in the social sciences.Eckhart Arnold - manuscript
    Mathematical models are a well established tool in most natural sciences. Although models have been neglected by the philosophy of science for a long time, their epistemological status as a link between theory and reality is now fairly well understood. However, regarding the epistemological status of mathematical models in the social sciences, there still exists a considerable unclarity. In my paper I argue that this results from specific challenges that mathematical models and especially computer simulations face in the social sciences. (...)
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  • Computer simulation and the philosophy of science.Eric Winsberg - 2009 - Philosophy Compass 4 (5):835-845.
    There are a variety of topics in the philosophy of science that need to be rethought, in varying degrees, after one pays careful attention to the ways in which computer simulations are used in the sciences. There are a number of conceptual issues internal to the practice of computer simulation that can benefit from the attention of philosophers. This essay surveys some of the recent literature on simulation from the perspective of the philosophy of science and argues that philosophers have (...)
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  • The philosophical novelty of computer simulation methods.Paul Humphreys - 2009 - Synthese 169 (3):615 - 626.
    Reasons are given to justify the claim that computer simulations and computational science constitute a distinctively new set of scientific methods and that these methods introduce new issues in the philosophy of science. These issues are both epistemological and methodological in kind.
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  • A Puzzle concerning Compositionality in Machines.Ryan M. Nefdt - 2020 - Minds and Machines 30 (1):47-75.
    This paper attempts to describe and address a specific puzzle related to compositionality in artificial networks such as Deep Neural Networks and machine learning in general. The puzzle identified here touches on a larger debate in Artificial Intelligence related to epistemic opacity but specifically focuses on computational applications of human level linguistic abilities or properties and a special difficulty with relation to these. Thus, the resulting issue is both general and unique. A partial solution is suggested.
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  • Computer Simulations Then and Now: an Introduction and Historical Reassessment.Arianna Borrelli & Janina Wellmann - 2019 - NTM Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin 27 (4):407-417.
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  • Verification and Validation of Simulations Against Holism.Julie Jebeile & Vincent Ardourel - 2019 - Minds and Machines 29 (1):149-168.
    It has been argued that the Duhem problem is renewed with computational models since model assumptions having a representational aim and computational assumptions cannot be tested in isolation. In particular, while the Verification and Validation methodology is supposed to prevent such holism, Winsberg argues that verification and validation cannot be separated in practice. Morrison replies that Winsberg overstates the entanglement between the steps. The paper aims at arbitrating these two positions, by stressing their respective validity in relation to domains of (...)
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  • Can we trust Big Data? Applying philosophy of science to software.John Symons & Ramón Alvarado - 2016 - Big Data and Society 3 (2).
    We address some of the epistemological challenges highlighted by the Critical Data Studies literature by reference to some of the key debates in the philosophy of science concerning computational modeling and simulation. We provide a brief overview of these debates focusing particularly on what Paul Humphreys calls epistemic opacity. We argue that debates in Critical Data Studies and philosophy of science have neglected the problem of error management and error detection. This is an especially important feature of the epistemology of (...)
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  • Grounds for Trust: Essential Epistemic Opacity and Computational Reliabilism.Juan M. Durán & Nico Formanek - 2018 - Minds and Machines 28 (4):645-666.
    Several philosophical issues in connection with computer simulations rely on the assumption that results of simulations are trustworthy. Examples of these include the debate on the experimental role of computer simulations :483–496, 2009; Morrison in Philos Stud 143:33–57, 2009), the nature of computer data Computer simulations and the changing face of scientific experimentation, Cambridge Scholars Publishing, Barcelona, 2013; Humphreys, in: Durán, Arnold Computer simulations and the changing face of scientific experimentation, Cambridge Scholars Publishing, Barcelona, 2013), and the explanatory power of (...)
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  • Hawking radiation and analogue experiments: A Bayesian analysis.Radin Dardashti, Stephan Hartmann, Karim P. Y. Thébault & Eric Winsberg - 2019 - Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics 67:1-11.
    We present a Bayesian analysis of the epistemology of analogue experiments with particular reference to Hawking radiation. Provided such experiments can be externally validated via universality arguments, we prove that they are confirmatory in Bayesian terms. We then provide a formal model for the scaling behaviour of the confirmation measure for multiple distinct realisations of the analogue system and isolate a generic saturation feature. Finally, we demonstrate that different potential analogue realisations could provide different levels of confirmation. Our results thus (...)
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  • Cultures of simulations vs. cultures of calculations? The development of simulation practices in meteorology and astrophysics.Mikaela Sundberg - 2010 - Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics 41 (3):273-281.
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  • The World in the Model: How Economists Work and Think, Mary S. Morgan. Cambridge University Press, 2012, xvii + 421 pages. [REVIEW]François Claveau - 2015 - Economics and Philosophy 31 (1):161-168.
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  • The Heuristic Defense of Scientific Models: An Incentive-Based Assessment.Armin W. Schulz - 2015 - Perspectives on Science 23 (4):424-442.
    It is undeniable that much scientific work is model-based. Despite this, the justification for this reliance on models is still controversial. A particular difficulty here is the fact that many scientific models are based on assumptions that do not describe the exact details of many or even any empirical situations very well. This raises the question of why it is that, despite their frequent lack of descriptive accuracy, employing models is scientifically useful.One..
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  • A practical philosophy of complex climate modelling.Gavin A. Schmidt & Steven Sherwood - 2015 - European Journal for Philosophy of Science 5 (2):149-169.
    We give an overview of the practice of developing and using complex climate models, as seen from experiences in a major climate modelling center and through participation in the Coupled Model Intercomparison Project. We discuss the construction and calibration of models; their evaluation, especially through use of out-of-sample tests; and their exploitation in multi-model ensembles to identify biases and make predictions. We stress that adequacy or utility of climate models is best assessed via their skill against more naïve predictions. The (...)
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  • Software Intensive Science.John Symons & Jack Horner - 2014 - Philosophy and Technology 27 (3):461-477.
    This paper argues that the difference between contemporary software intensive scientific practice and more traditional non-software intensive varieties results from the characteristically high conditionality of software. We explain why the path complexity of programs with high conditionality imposes limits on standard error correction techniques and why this matters. While it is possible, in general, to characterize the error distribution in inquiry that does not involve high conditionality, we cannot characterize the error distribution in inquiry that depends on software. Software intensive (...)
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  • Conceptual and Computational Mathematics†.Nicolas Fillion - 2019 - Philosophia Mathematica 27 (2):199-218.
    ABSTRACT This paper examines consequences of the computer revolution in mathematics. By comparing its repercussions with those of conceptual developments that unfolded in the nineteenth century, I argue that the key epistemological lesson to draw from the two transformative periods is that effective and successful mathematical practices in science result from integrating the computational and conceptual styles of mathematics, and not that one of the two styles of mathematical reasoning is superior. Finally, I show that the methodology deployed by applied (...)
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  • Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.Mary Jean Walker, Justin Bourke & Katrina Hutchison - 2019 - Theoretical Medicine and Bioethics 40 (2):103-121.
    Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...)
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  • How Computational Models Predict the Behavior of Complex Systems.John Symons & Fabio Boschetti - 2013 - Foundations of Science 18 (4):809-821.
    In this paper, we argue for the centrality of prediction in the use of computational models in science. We focus on the consequences of the irreversibility of computational models and on the conditional or ceteris paribus, nature of the kinds of their predictions. By irreversibility, we mean the fact that computational models can generally arrive at the same state via many possible sequences of previous states. Thus, while in the natural world, it is generally assumed that physical states have a (...)
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  • Science in the Age of Computer Simulation – By Eric Winsberg.Jesper Jerkert - 2012 - Theoria 78 (2):168-175.
    QC 20120521. Review of 'Science in the Age of Computer Simulation' by Eric Winsberg.
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  • Approximations, Idealizations and 'Experiments' at the Physics-Biology Interface.Darrell Patrick Rowbottom - 2008 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 42 (2):145-154.
    This paper, which is based on recent empirical research at the University of Leeds, the University of Edinburgh, and the University of Bristol, presents two difficulties which arise when condensed matter physicists interact with molecular biologists: (1) the former use models which appear to be too coarse-grained, approximate and/or idealized to serve a useful scientific purpose to the latter; and (2) the latter have a rather narrower view of what counts as an experiment, particularly when it comes to computer simulations, (...)
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  • What is a Simulation Model?Juan M. Durán - 2020 - Minds and Machines 30 (3):301-323.
    Many philosophical accounts of scientific models fail to distinguish between a simulation model and other forms of models. This failure is unfortunate because there are important differences pertaining to their methodology and epistemology that favor their philosophical understanding. The core claim presented here is that simulation models are rich and complex units of analysis in their own right, that they depart from known forms of scientific models in significant ways, and that a proper understanding of the type of model simulations (...)
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  • Large-Scale Brain Simulation and Disorders of Consciousness. Mapping Technical and Conceptual Issues.Michele Farisco, Jeanette H. Kotaleski & Kathinka Evers - 2018 - Frontiers in Psychology 9.
    Modelling and simulations have gained a leading position in contemporary attempts to describe, explain, and quantitatively predict the human brain's operations. Computer models are highly sophisticated tools developed to achieve an integrated knowledge of the brain with the aim of overcoming the actual fragmentation resulting from different neuroscientific approaches. In this paper we investigate plausibility of simulation technologies for emulation of consciousness and the potential clinical impact of large-scale brain simulation on the assessment and care of disorders of consciousness, e.g. (...)
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