Cancer is typically spoken of as a “complex” disease. But, in what sense are cancers “complex”? Is there one sense, or several? What implications does this complexity have – both for how we study, and how we intervene upon cancers? The aim of this paper is first, to clarify the variety of senses in which cancer is spoken of as "complex" in the scientific literature, and second, to discover what explanatory and predictive roles such features play.

An adequate understanding of the ubiquitous practice of mechanistic explanation requires an account of what Craver termed “constitutive relevance.” Entities or activities are constitutively relevant to a phenomenon when they are parts of the mechanism responsible for that phenomenon. Craver’s mutual manipulability account extended Woodward’s account of manipulationist counterfactuals to analyze how interlevel experiments establish constitutive relevance. Critics of MM argue that applying Woodward’s account to this philosophical problem conflates causation and constitution, thus rendering the account incoherent. These criticisms, we (...) argue, arise from failing to distinguish the semantic, epistemic, and metaphysical aspects of the problem of constitutive relevance. In distinguishing these aspects of the problem and responding to these critics accordingly, we amend MM into a refined epistemic criterion, the “matched interlevel experiments” account. Further, we explain how this epistemological thesis is grounded in the plausible metaphysical thesis that constitutive relevance is causal betweenness. (shrink)

Can Contemporary Science Inspire Philosophical and Theological Reflection on Causality? The cooperation between natural science, philosophy, and theology in an analysis of the causal structure and co-dependency of entities in the universe seems to be both legitimate and expected. It turns out, however, that in practice it oftentimes raises some tensions, questions and difficulties, leading to the development of alternative and in a sense competitive models of causality and of God’s action in the world. What is more, the attitude of (...) natural sciences since modernity, concentrated on gaining knowledge about natural phenomena to predict and control them, without trying to determine the nature of their ultimate causes, Humean criticism and rejection of the concept of causality as such, and concentration of analytic philosophers on the description of what accompanies phenomena classified as causal, leaving aside the question of the metaphysical status of causes and effects – they all seem to make impossible an interaction and mutual reference of contemporary science, philosophy, and theology in their reflection on the topic of causation. The main goal of this article is to defend the thesis about the possible and actual influence of scientific analysis of cause and effect relationships on the philosophical and theological reflection on causation, not only in the Middle Ages and Modernity, but also in contemporary thought. The presentation of the latest positions in the debate on divine action in the natural world will be followed by an argument in favor of the relevance of the model developed by philosophers and theologians representing the Thomistic school. (shrink)

I argue for a soft compatibilist theory of free will, i.e., such that free will is compatible with both determinism and indeterminism, directly opposite hard incompatibilism, which holds free will incompatible both with determinism and indeterminism. My intuitions in this book are primarily based on an analysis of meditation, but my arguments are highly syncretic, deriving from many fields, including behaviorism, psychology, conditioning and deconditioning theory, philosophy of language, philosophy of mind, simulation theory, etc. I offer a causal/functional analysis of (...) meta-mental control, or 'metacausality', cashed out in counterfactual terms, to solve what I call the easy problem of free will. (shrink)

This paper tracks the commitments of mechanistic explanations focusing on the relation between activities at different levels. It is pointed out that the mechanistic approach is inherently committed to identifying causal connections at higher levels with causal connections at lower levels. For the mechanistic approach to succeed a mechanism as a whole must do the very same thing what its parts organised in a particular way do. The mechanistic approach must also utilise bridge principles connecting different causal terms of different (...) theoretical vocabularies in order to make the identities of causal connections transparent. These general commitments get confronted with two claims made by certain proponents of the mechanistic approach: William Bechtel often argues that within the mechanistic framework it is possible to balance between reducing higher levels and maintaining their autonomy at the same time, whereas, in a recent paper, Craver and Bechtel argue that the mechanistic approach is able to make downward causation intelligible. The paper concludes that the mechanistic approach imbued with identity statements is no better candidate for anchoring higher levels to lower ones while maintaining their autonomy at the same time than standard reductive accounts are, and that what mechanistic explanations are able to do at best is showing that downward causation does not exist. (shrink)

We argue that intelligible appeals to interlevel causes (top-down and bottom-up) can be understood, without remainder, as appeals to mechanistically mediated effects. Mechanistically mediated effects are hybrids of causal and constitutive relations, where the causal relations are exclusively intralevel. The idea of causation would have to stretch to the breaking point to accommodate interlevel causes. The notion of a mechanistically mediated effect is preferable because it can do all of the required work without appealing to mysterious interlevel causes. When interlevel (...) causes can be translated into mechanistically mediated effects, the posited relationship is intelligible and should raise no special philosophical objections. When they cannot, they are suspect. (shrink)

This volume announces a new era in the philosophy of God. Many of its contributions work to create stronger links between the philosophy of God, on the one hand, and mathematics or metamathematics, on the other hand. It is about not only the possibilities of applying mathematics or metamathematics to questions about God, but also the reverse question: Does the philosophy of God have anything to offer mathematics or metamathematics? The remaining contributions tackle stereotypes in the philosophy of religion. The (...) volume includes 35 contributions. It is divided into nine parts: 1. Who Created the Concept of God; 2. Omniscience, Omnipotence, Timelessness and Spacelessness of God; 3. God and Perfect Goodness, Perfect Beauty, Perfect Freedom; 4. God, Fundamentality and Creation of All Else; 5. Simplicity and Ineffability of God; 6. God, Necessity and Abstract Objects; 7. God, Infinity, and Pascal's Wager; 8. God and (Meta-)Mathematics; and 9. God and Mind. (shrink)

The purpose of this paper is to lay bare the major problems underlying the concept of downward causation as discussed within the perspective of the present interest for phenomena that are characterized by self-organization. In our discussion of the literature, we have focussed on two questions: (1) What sorts of things are said to be, respectively, causing and caused within the context of downward causation? And (2) What is the meaning of ‘causing’ in downward causation? We have concluded that the (...) concept of ‘downward causation’ is muddled with regard to the meaning of causation and fuzzy with regard to the nature of the causes and the effects. Moreover, we have concluded that ‘causation’ in respect of ‘downward causation’ is usually understood in terms of explanation and determination rather than in terms of causation in the sense of ‘bringing about’. Thus, the term ‘downward causation’ is badly chosen. (shrink)

The paper attempts to explicate and justify the position I call `Agency Incompatibilism'- that is to say, the view that agency itself is incompatible with determinism. The most important part of this task is the characterisation of the conception of agency on which the position depends; for unless this is understood, the rationale for the position is likely to be missed. The paper accordingly proceeds by setting out the orthodox philosophical position concerning what it takes for agency to exist, before (...) going on to explain why and how that orthodoxy should be challenged. The relations between my own views and those of others writing on the issues of free will and moral responsibility, in three crucial and inter-connected areas are then explored. These are (1) the question how animals should figure in the philosophy of action; (2) the question what the lesson is of `Frankfurt-style' examples; and (3) the distinction between so-called `leeway' incompatibilism and `source' incompatibilism. The paper moves on to consider and respond to various objections to Agency Incompatibilism, including the claim that to embrace the conception of agency that makes incompatibilism plausible is to beg the question against the compatibilist, and also the worry that determinism is an empirical thesis which ought not to be straightforwardly falsifiable by such a priori reasoning as Agency Incompatibilism appears to involve. I also try to rebut the worry that Agency Incompatibilism is committed to the existence of an unintelligible and/or naturalistically impossible variety of irreducible agent causation. (shrink)

The expression ‘nonreductive materialism’ refers to a variety of positions whose roots lie in attempts to solve the mind-body problem. Proponents of nonreductive materialism hold that the mental is ontologically part of the material world; yet, mental properties are causally efficacious without being reducible to physical properties.s After setting out a minimal schema for nonreductive materialism (NRM) as an ontological position, I’ll canvass some classical arguments in favor of (NRM).1 Then, I’ll discuss the major challenge facing any construal of (NRM): (...) the problem of mental causation, pressed by Jaegwon Kim. Finally, I’ll offer a new solution to the problem of mental causation. (shrink)

In what sense are the activities and properties of components in a mechanism explanatorily relevant to the behavior of a mechanism as a whole? I articulate this problem, the problem of constitutive relevance, and I show that it must be solved if we are to understand mechanisms and mechanistic explanation. I argue against some putative solutions to the problem of constitutive relevance, and I sketch a positive account according to which relevance is analyzed in terms ofrelationships of mutual manipulability between (...) the behavior of a mechanism as a whole and the properties and activities of its components. My account is a causal-mechanical account in the sense that it is a particular expression of the idea that constitutive explanation is a matter of showing how an explanandum phenomenon is situated within the causal structure of the world. It is thus offered as a rival to epistemic (argument-centered) and psychological accounts of interlevel explanation. (shrink)

The purpose of this paper is to lay bare the major problems underlying the concept of downward causation as discussed within the perspective of the present interest for phenomena that are characterized by self-organization. In our Discussion of the literature, we have focussed on two questions: (1) What sorts of things are said to be, respectively, causing and caused within the context of downward causation? And (2) What is the meaning of 'causing' in downward causation? We have concluded that the (...) concept of 'downward causation' is muddled with regard to the meaning of causation and fuzzy with regard to the nature of the causes and the effects. Moreover, we have concluded that 'causation' in respect of 'downward causation' is usually understood in terms of explanation and determination rather than in terms of causation in the sense of 'bringing about'. Thus, the term 'downward causation' is badly chosen. (shrink)

. An attempt is made to identify a concept of ‘downward causation’ that will fit the claims of some recent writers and apply to interesting cases in biology and cognitive theory, but not to trivial cases. After noting some difficulties in achieving this task, it is proposed that in interesting cases commonly used to illustrate ‘downward causation’, (a) regularities hold between multiply realizable properties and (b) the explanation of the parallel regularity at the level of the realizing properties is non-trivial. (...) It is argued that the relation between a realizable property and the property that realizes its effect in a particular case is not usefully regarded as a species of causation and that use of the concept of downward causation deflects our attention from our central explanatory tasks. (shrink)

From the perspective of nonlinear science, it is argued that one may accept physicalism and reject substance dualism without being forced into reductionism. This permits a property dualism under which biological and mental phenomena may emerge from intricate positive feedback networks, involving many levels of both the biological and cognitive hierarchies.

Downward causation exercised by emergent properties of wholes upon their lower-level constituents’ properties has been accused of conceptual and metaphysical incoherence. Only upward causation is usually peacefully accepted. The aim of this paper is to criticize and refuse the traditional hierarchical-vertical way of conceiving both types of causation, although preserving their deepest ontological significance, as well as the widespread acceptance of the traditional atomistic-combinatorial view of the entities and the relations that constitute the so-called ‘emergence base’. Assuming those two perspectives (...) with no reserves, we are condemned to confine our debate to the question of whether reified wholes can have the power to downwardly change or influence their lower-level parts, a question which seems profoundly misleading to me. I therefore propose an alternative relational ontological view, assuming a straightforward horizontal and intra-level way of representing those putative cases of cross-level causation. I finally confront two recent replies to Kim’s well-known objections to DC—Craver and Bechtel and Kistler :595–609, 2009)—, emphasizing their global positive approaches, as well as the reasons why their accounts still seem insufficient to me. I conclude arguing that both Kim’s principle of the causal closure of the physical domain and its allegation of an overdetermination in cases of DC can be surpassed by the new relational ontological perspective presented here. (shrink)

Dans cet article, nous nous proposons de mettre en évidence deux stratégies émergentistes possibles qui constituent une médiation intéressante entre les extrêmes classiques que sont le physicalisme réductionniste et le dualisme des substances. En distinguant trois niveaux de tension possibles entre monisme et dualisme — le niveau des substances, le niveau des propriétés causales et celui des prédicats — nous sommes amené à formuler deux positions philosophiques associées à deux concepts d’émergence distincts : l’émergence représentationnelle et l’émergence causale. Ces deux (...) concepts s’avèrent fidèles aux intuitions des premiers émergentistes véhiculées au travers de l’étymologie même du concept d’émergence, et permettent une interprétation non triviale de la maxime classique : « Le tout est plus que la somme des parties. »I emphasize in this paper two possible emergentist strategies that constitute interesting middle grounds between classical views that are reductive physicalism and substance dualism. By distinguishing three levels of tension between monism and dualism — the levels of substance, causal properties and predicates — one is allowed to formulate two philosophical views that may be associated with two distinct concepts of emergence : representational emergence and causal emergence. Both concepts are faithful to the intuitions of early emergentists that are conveyed in the very etymology of the concept of emergence, and they allow a non-trivial reading of the classical maxim : “the whole is more than the sum of the parts”. (shrink)

In this paper, I try to argue that the recognition that non-human animals are relevant to the free will problem delivers interesting new ways of thinking about the central metaphysical issues at the heart of that problem. Some such dividends, I suggest, are the following: that the problem of free will can be considered to be just a more specific version of a general question concerning how agency is to be fitted into the natural world; that action can be usefully (...) regarded as an especially interesting form of downward causation; and that the metaphysical possibility of downward causation, and hence, indirectly, also of free will, can be illuminated in valuable ways by thinking about the hierarchical structure of, and systems of functioning within, biological organisms. (shrink)

The emergentist position that R. Keith Sawyer has formulated, nonreductive individualism, contains three propositions. First, that social characteristics must always be realized in individuals; second, that it is nevertheless possible to understand social properties as irreducible; and third, that therefore it is possible to demonstrate how social properties are able to exercise independent causal influences on individuals and their properties. It is demonstrated that Sawyer is not able to meet an objection that Kim has formulated against the analogous position in (...) the philosophy of mind. In his defense of the claim of irreducibility Sawyer refers to Fodor’s argument about multiple realizability, but this line of argument cannot preserve the claim for downward causation because Fodor’s claim for irreducibility rests on assumptions that are not compatible with a systematic formulation of downward causation. The article proposes a reading of Fodor’s argument that is consistent with individualism but not with nonreductive individualism. (shrink)

In Part I, the author argued for nonreductive individualism (NRI), an account of the individual-collective relation that is ontologically individualist yet rejects methodological individualism. However, because NRI is ontologically individualist, social entities and properties would seem to be only analytic constructs, and if so, they would seem to be epiphenomenal, since only real things can have causal power. In general, a nonreductionist account is a relatively weak defense of sociological explanation if it cannot provide an account of how social properties (...) can participate in causal relations. In this article, the author extends NRI to address this weakness and provides an account of social causation that he refers to as supervenient causation. Key Words: individualism • collectivism • social realism • social causation. (shrink)

Cancer—and scientific research on cancer—raises a variety of compelling philosophical questions. This entry will focus on four topics, which philosophers of science have begun to explore and debate. First, scientific classifications of cancer have as yet failed to yield a unified taxonomy. There is a diversity of classificatory schemes for cancer, and while some are hierarchical, others appear to be “cross-cutting,” or non-nested. This literature thus raises a variety of questions about the nature of the disease and disease classification. Second, (...) philosophers of science have historically taken the aim of science to be arriving at true theories. However, scientists studying cancer come from a variety of disciplines, with different scientific as well as practical aims. Perhaps it is not surprising, then, that historians and philosophers of science do not seem to agree on how best to characterize the aim and structure of cancer research; it is far from clear whether the appropriate characterization of the aim is arriving at true theories, or even whether the proper units of analysis are “theories”, or instead, “models”, “explanatory frameworks”, “research programs”, “paradigms”, or perhaps, “experimental traditions”. With the rise of “big data” science—such as the Cancer Genome Atlas Project (or TCGA)—and “systems” approaches to the study of disease, both philosophers and historians of science are rethinking how best to describe and explain these distinctive kinds of scientific inquiry. -/- Third, cancer is in part a byproduct of our developmental and life history, as well as our evolutionary history. Cancer progression can be compared to a reversion of development, or, to the evolution of multicellularity. Thus, cancer raises intriguing questions about how we conceive of “functions”, “development”, and the role of our evolutionary history and particularly, selective trade-offs, in vulnerability to disease. -/- Last but not least, cancer research provides a case study for consideration of the roles of values at the science-policy interface. Epidemiological and toxicological research on cancer’s causes informs toxics law and regulatory policy, which raises a variety of questions about the nature of evidence and inductive risk in such contexts. (shrink)

Part–whole causation is the thesis that some causes are part of their effects. PWC has been objected to because of its incompatibility with the criterion that causes not be spatially included within their effects and the criterion that causes and effects are ontologically distinct in some sense. This paper serves to undermine the sufficiency of these ways of objecting to PWC by showing that for each criterion either cause-effect relationships need not satisfy it or part–whole relationships can. A case-study of (...) the collapse of Bridge 9340 is employed to facilitate the discussion. (shrink)

This paper argues that scale-dependence of physical and biological processes offers resistance to reductionism and has implications that support a specific kind of downward causation. I demonstrate how insights from multiscale modeling can provide a concrete mathematical interpretation of downward causation as boundary conditions for models used to represent processes at lower scales. The autonomy and role of macroscale parameters and higher-level constraints are illustrated through examples of multiscale modeling in physics, developmental biology, and systems biology. Drawing on these examples, (...) I defend the explanatory importance of constraining relations for understanding the behavior of biological systems. (shrink)

Part–whole causation (PWC) is the thesis that some causes are part of their effects. PWC has been objected to because of its incompatibility with the criterion that causes not be spatially included within their effects and the criterion that causes and effects are ontologically distinct in some sense. This paper serves to undermine the sufficiency of these ways of objecting to PWC by showing that for each criterion either cause-effect relationships need not satisfy it or part–whole relationships can. A case-study (...) of the collapse of Bridge 9340 is employed to facilitate the discussion. (shrink)

In this paper we criticize the “Ashbyan interpretation” (Froese & Stewart, 2010) of autopoietic theory by showing that Ashby’s framework and the autopoietic one are based on distinct, often incompatible, assumptions and that they aim at addressing different issues. We also suggest that in order to better understand autopoiesis and its implications, a different and wider set of theoretical contributions, developed previously or at the time autopoiesis was formulated, needs to be taken into consideration: among the others, the works of (...) Rosen, Weiss and Piaget. By analyzing the concepts of organization and closure, the idea of components, and the role of materiality in the theory proposed by Maturana and Varela, we advocate the view that autopoiesis necessarily entails self-production and intrinsic instability and can be realized only in domains characterized by the same transformative and processual properties exhibited by the molecular domain. From this theoretical standpoint it can be demonstrated that autopoietic theory neither commits to a sharp dualism between organization and structure nor to a reflexive view of downward causation, thus avoiding the respective strong criticisms. (shrink)