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  1. Reliability in Machine Learning.Thomas Grote, Konstantin Genin & Emily Sullivan - forthcoming - Philosophy Compass.
    Issues of reliability are claiming center-stage in the epistemology of machine learning. This paper unifies different branches in the literature and points to promising research directions, whilst also providing an accessible introduction to key concepts in statistics and machine learning---as far as they are concerned with reliability.
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  • Theory Roulette: Choosing that Climate Change is not a Tragedy of the Commons.Jakob Ortmann & Walter Veit - 2023 - Environmental Values 32 (1):65-89.
    Climate change mitigation has become a paradigm case both for externalities in general and for the game-theoretic model of the Tragedy of the Commons (ToC) in particular. This situation is worrying, as we have reasons to suspect that some models in the social sciences are apt to be performative to the extent that they can become self-fulfilling prophecies. Framing climate change mitigation as a hardly solvable coordination problem may force us into a worse situation, by changing real-world behaviour to fit (...)
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  • Medical Epistemology Meets Economics: How (Not) to GRADE Universal Basic Income Research.Adrian K. Yee & Kenji Hayakawa - 2023 - Journal of Economic Methodology 30 (3):245-264.
    There have recently been novel applications of medical systematic review guidelines to economic policy interventions which contain controversial methodological assumptions that require further scrutiny. A landmark 2017 Cochrane review of unconditional cash transfer (UCT) studies, based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE), exemplifies both the possibilities and limitations of applying medical systematic review guidelines to UCT and universal basic income (UBI) studies. Recognizing the need to upgrade GRADE to incorporate the differences between medical and policy interventions, (...)
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  • Epistemic and Non-epistemic Values in Earthquake Engineering.Luca Zanetti, Daniele Chiffi & Lorenza Petrini - 2023 - Science and Engineering Ethics 29 (3):1-16.
    The importance of epistemic values in science is universally recognized, whereas the role of non-epistemic values is sometimes considered disputable. It has often been argued that non-epistemic values are more relevant in applied sciences, where the goals are often practical and not merely scientific. In this paper, we present a case study concerning earthquake engineering. So far, the philosophical literature has considered various branches of engineering, but very rarely earthquake engineering. We claim that the assessment of seismic hazard models is (...)
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  • Explaining Human Diversity: the Need to Balance Fit and Complexity.Armin W. Schulz - 2021 - Review of Philosophy and Psychology 14 (2):1-19.
    While the existence of human cognitive and behavioral diversity is now widely recognized, it is not yet well established how to explain this diversity. In particular, it is still unclear how to determine whether any given instance of human cognitive and behavioral diversity is due to a common psychology that is merely “triggered” differently in different bio-cultural environments, or whether it is due to deeply and fundamentally different psychologies. This paper suggests that, to answer this question, we need to employ (...)
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  • Explaining Human Diversity: the Need to Balance Fit and Complexity.Armin W. Schulz - 2021 - Review of Philosophy and Psychology 14 (2):457-475.
    While the existence of human cognitive and behavioral diversity is now widely recognized, it is not yet well established how to explain this diversity. In particular, it is still unclear how to determine whether any given instance of human cognitive and behavioral diversity is due to a common psychology that is merely “triggered” differently in different bio-cultural environments, or whether it is due to deeply and fundamentally different psychologies. This paper suggests that, to answer this question, we need to employ (...)
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  • Two Exploratory Uses for General Circulation Models in Climate Science.Joseph Wilson - 2021 - Perspectives on Science 29 (4):493-509.
    . In this paper I present two ways in which climate modelers use general circulation models for exploratory purposes. The complexity of Earth’s climate system makes it difficult to predict precisely how lower-order climate dynamics will interact over time to drive higher-order dynamics. The same issues arise for complex models built to simulate climate behavior like the Community Earth Systems Model. I argue that as a result of system complexity, climate modelers use general circulation models to perform model dynamic exploration (...)
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  • Paleoclimate analogues and the threshold problem.Joseph Wilson - 2023 - Synthese 202 (1):1-30.
    Climate models calibrated exclusively with observations from the 19th through 21st centuries are unsuitable for assessing many important hypotheses about the future. Many systems in the modern climate are expected to cross dynamic thresholds in the near future, requiring more than the instrumental record for adequate calibration. In this paper I argue that paleoclimate analogues from earth’s past can mitigate this threshold problem, even if the modern climate exhibits features that make it historically unique. While this requires that paleoclimatologists be (...)
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  • Scaling procedures in climate science: Using temporal scaling to identify a paleoclimate analogue.Aja Watkins - 2023 - Studies in History and Philosophy of Science Part A 102 (C):31-44.
    Using past episodes of climate change as a source of evidence to inform our projections about contemporary climate change requires establishing the extent to which episodes in the deep past are analogous to the current crisis. However, many scientists claim that contemporary rates of climate change (e.g., rates of carbon emissions or temperature change) are unprecedented, including compared to episodes in the deep past. If so, this would limit the utility of paleoclimate analogues. In this paper, I show how a (...)
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  • Multi-model approaches to phylogenetics: Implications for idealization.Aja Watkins - 2021 - Studies in History and Philosophy of Science Part A 90 (C):285-297.
    Phylogenetic models traditionally represent the history of life as having a strictly-branching tree structure. However, it is becoming increasingly clear that the history of life is often not strictly-branching; lateral gene transfer, endosymbiosis, and hybridization, for example, can all produce lateral branching events. There is thus motivation to allow phylogenetic models to have a reticulate structure. One proposal involves the reconciliation of genealogical discordance. Briefly, this method uses patterns of disagreement – discordance – between trees of different genes to add (...)
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  • Describing model relations: The case of the capital asset pricing model (CAPM) family in financial economics.Melissa Vergara-Fernández, Conrad Heilmann & Marta Szymanowska - 2023 - Studies in History and Philosophy of Science Part A 97 (C):91-100.
    The description of how individual models in families of models are related to each other is crucial for the general philosophical understanding of model-based scientific practice. We focus on the Capital Asset Pricing Models (CAPM) family, a cornerstone in financial economics, to provide a descriptive analysis of model relations within a family. We introduce the concepts of theoretical and empirical complementarity to characterise model relations. Our complementarity analysis of model relations has two types of payoff. Specifically regarding the CAPM, our (...)
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  • Contextualist model evaluation: models in financial economics and index funds.Melissa Vergara-Fernández, Conrad Heilmann & Marta Szymanowska - 2023 - European Journal for Philosophy of Science 13 (1):1-23.
    Philosophers of science typically focus on the epistemic performance of scientific models when evaluating them. Analysing the effects that models may have on the world has typically been the purview of sociologists of science. We argue that the reactive (or “performative”) effects of models should also figure in model evaluations by philosophers of science. We provide a detailed analysis of how models in financial economics created the impetus for the growing importance of the phenomenon of “passive investing” in financial markets. (...)
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  • Chomsky in the playground: Idealization in generative linguistics.Giulia Terzian - 2021 - Studies in History and Philosophy of Science Part A 87 (C):1-12.
    For a long time, the accepted explanatory model of language acquisition was the so-called Principles and Parameters framework (P&P). P&P seemingly provides an elegant answer to the central puzzle of generative linguistics: How do children acquire their native language given the limited time and input resources available to them? Yet P&P tells a story that is evolutionarily implausible, and for this reason it has since been abandoned. I argue that this is an unwarranted move, and that it could and should (...)
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  • Inductive Risk, Understanding, and Opaque Machine Learning Models.Emily Sullivan - 2022 - Philosophy of Science 89 (5):1065-1074.
    Under what conditions does machine learning (ML) model opacity inhibit the possibility of explaining and understanding phenomena? In this article, I argue that nonepistemic values give shape to the ML opacity problem even if we keep researcher interests fixed. Treating ML models as an instance of doing model-based science to explain and understand phenomena reveals that there is (i) an external opacity problem, where the presence of inductive risk imposes higher standards on externally validating models, and (ii) an internal opacity (...)
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  • Well-Being Contextualism and Capabilities.Sebastian Östlund - 2024 - Journal of Happiness Studies 25:1-18.
    Typically, philosophers analysing well-being’s nature maintain three claims. First, that well-being has essential properties. Second, that the concept of well-being circumscribes those properties. Third, that well-being theories should capture them exhaustively and exclusively. This predominant position is called well-being monism. In opposition, contextualists argue that no overarching concept of well-being referring to a universally applicable well-being standard exists. Such a standard would describe what is good, bad, and neutral, for us without qualification. Instead, well-being research is putatively about several central (...)
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  • Making coherent senses of success in scientific modeling.Beckett Sterner & Christopher DiTeresi - 2021 - European Journal for Philosophy of Science 11 (1):1-20.
    Making sense of why something succeeded or failed is central to scientific practice: it provides an interpretation of what happened, i.e. an hypothesized explanation for the results, that informs scientists’ deliberations over their next steps. In philosophy, the realism debate has dominated the project of making sense of scientists’ success and failure claims, restricting its focus to whether truth or reliability best explain science’s most secure successes. Our aim, in contrast, will be to expand and advance the practice-oriented project sketched (...)
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  • Novel & worthy: creativity as a thick epistemic concept.Julia Sánchez-Dorado - 2020 - European Journal for Philosophy of Science 10 (3):1-23.
    The standard view in current philosophy of creativity says that being creative has two requirements: being novel and being valuable. The standard view on creativity has recently become an object of critical scrutiny. Hills and Bird have specifically proposed to remove the value requirement from the definition, as it is not clear that creative objects are necessarily valuable or creative people necessarily praiseworthy. In this paper, I argue against Hills and Bird, since eliminating the element of value from the explanation (...)
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  • Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response.Davide Serpico & Mariusz Maziarz - 2023 - European Journal for Philosophy of Science 13 (4):1-28.
    Heterogeneous treatment effects represent a major issue for medicine as they undermine reliable inference and clinical decision-making. To overcome the issue, the current vision of precision and personalized medicine acknowledges the need to control individual variability in response to treatment. In this paper, we argue that gene-treatment-environment interactions (G × T × E) undermine inferences about individual treatment effects from the results of both genomics-based methodologies—such as genome-wide association studies (GWAS) and genome-wide interaction studies (GWIS)—and randomized controlled trials (RCTs). Then, (...)
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  • Expert judgment in climate science: How it is used and how it can be justified.Mason Majszak & Julie Jebeile - 2023 - Studies in the History and Philosophy of Science 100 (C):32-38.
    Like any science marked by high uncertainty, climate science is characterized by a widespread use of expert judgment. In this paper, we first show that, in climate science, expert judgment is used to overcome uncertainty, thus playing a crucial role in the domain and even at times supplanting models. One is left to wonder to what extent it is legitimate to assign expert judgment such a status as an epistemic superiority in the climate context, especially as the production of expert (...)
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  • Non-epistemic values and scientific assessment: an adequacy-for-purpose view.Greg Lusk & Kevin C. Elliott - 2022 - European Journal for Philosophy of Science 12 (2):1-22.
    The literature on values in science struggles with questions about how to describe and manage the role of values in scientific research. We argue that progress can be made by shifting this literature’s current emphasis. Rather than arguing about how non-epistemic values can or should figure into scientific assessment, we suggest analyzing how scientific assessment can accommodate non-epistemic values. For scientific assessment to do so, it arguably needs to incorporate goals that have been traditionally characterized as non-epistemic. Building on this (...)
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  • Evaluating community science.Karen Kovaka - 2021 - Studies in History and Philosophy of Science Part A 88 (C):102-109.
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  • Understanding climate phenomena with data-driven models.Benedikt Knüsel & Christoph Baumberger - 2020 - Studies in History and Philosophy of Science Part A 84 (C):46-56.
    In climate science, climate models are one of the main tools for understanding phenomena. Here, we develop a framework to assess the fitness of a climate model for providing understanding. The framework is based on three dimensions: representational accuracy, representational depth, and graspability. We show that this framework does justice to the intuition that classical process-based climate models give understanding of phenomena. While simple climate models are characterized by a larger graspability, state-of-the-art models have a higher representational accuracy and representational (...)
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  • When Experiments Need Models.Donal Khosrowi - 2021 - Philosophy of the Social Sciences 51 (4):400-424.
    This paper argues that an important type of experiment-target inference, extrapolating causal effects, requires models to be successful. Focusing on extrapolation in Evidence-Based Policy, it is ar...
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  • Managing Performative Models.Donal Khosrowi - 2023 - Philosophy of the Social Sciences 53 (5):371-395.
    Scientific models can be performative: they can causally affect the phenomena they are intended to represent. The existing literature offers two responses. The appraisal view emphasizes that performativity can sometimes be a good-making model attribute, e.g., when predictions steer the public’s behavior in desirable ways. The mitigation view seeks to endogenize agents’ behavioral response to model-issued forecasts to get rid of performativity instead. This paper argues that neither approach is fully compelling: the appraisal view encounters severe concerns about moral values (...)
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  • Confirming (climate) change: a dynamical account of model evaluation.Suzanne Kawamleh - 2022 - Synthese 200 (2):1-26.
    Philosophers of science have offered various accounts of climate model evaluation which have largely centered on model-fit assessment. However, despite the wide-spread prevalence of process-based evaluation in climate science practice, this sort of model evaluation has been undertheorized by philosophers of science. In this paper, I aim to expand this narrow philosophical view of climate model evaluation by providing a philosophical account of process evaluation that is rooted in a close examination of scientific practice. I propose dynamical adequacy as a (...)
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  • Models and Numbers: Representing the World or Imposing Order?Matthias Kaiser, Tatjana Buklijas & Peter Gluckman - 2022 - Perspectives on Science 30 (4):525-548.
    We argue for a foundational epistemic claim and a hypothesis about the production and uses of mathematical epidemiological models, exploring the consequences for our political and socio-economic lives. First, in order to make the best use of scientific models, we need to understand why models are not truly representational of our world, but are already pitched towards various uses. Second, we need to understand the implicit power relations in numbers and models in public policy, and, thus, the implications for good (...)
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  • Understanding climate change with statistical downscaling and machine learning.Julie Jebeile, Vincent Lam & Tim Räz - 2020 - Synthese (1-2):1-21.
    Machine learning methods have recently created high expectations in the climate modelling context in view of addressing climate change, but they are often considered as non-physics-based ‘black boxes’ that may not provide any understanding. However, in many ways, understanding seems indispensable to appropriately evaluate climate models and to build confidence in climate projections. Relying on two case studies, we compare how machine learning and standard statistical techniques affect our ability to understand the climate system. For that purpose, we put five (...)
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  • ΛCDM and MOND: A debate about models or theory?Melissa Jacquart - 2021 - Studies in History and Philosophy of Science Part A 89 (C):226-234.
    The debate between ΛCDM and MOND is often cast in terms of competing gravitational theories. However, recent philosophical discussion suggests that the ΛCDM–MOND debate demonstrates the challenges of multiscale modeling in the context of cosmological scales. I extend this discussion and explore what happens when the debate is thought to be about modeling rather than about theory, offering a model-focused interpretation of the ΛCDM–MOND debate. This analysis shows how a model-focused interpretation of the debate provides a better understanding of challenges (...)
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  • Reckoning with Continuum Idealizations: Some Lessons from Soil Hydrology.Travis Holmes - 2022 - Philosophy of Science 89 (2):319-336.
    In scientific modeling, continuum idealizations bridge scales but at the cost of fundamentally misrepresenting the microstructure of the system. This engenders a mystery. If continuum idealizations are dispensable in principle, this de-problematizes their representational inaccuracy, since continuum properties reduce to lower-scale properties, but the mystery of how this reduction could be carried out endures. Alternatively, if continuum idealizations are indispensable in principle, this is consistent with their explanatory and predictive success but renders their representational inaccuracy mysterious. I argue for a (...)
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  • The usefulness of well-being temporalism.Gil Hersch - 2022 - Journal of Economic Methodology 30 (4):322-336.
    It is an open question whether well-being ought to primarily be understood as a temporal concept or whether it only makes sense to talk about a person’s well-being over their whole lifetime. In this article, I argue that how this principled philosophical disagreement is settled does not have substantive practical implications for well-being science and well-being policy. Trying to measure lifetime well-being directly is extremely challenging as well as unhelpful for guiding well-being public policy, while temporal well-being is both an (...)
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  • The epistemic value of independent lies: false analogies and equivocations.Margherita Harris - 2021 - Synthese 199 (5-6):14577-14597.
    Here I critically assess an argument put forward by Kuorikoski et al. (Br J Philos Sci, 61(3):541–567, 2010) for the epistemic import of model-based robustness analysis. I show that this argument is not sound since the sort of probabilistic independence on which it relies is unfeasible. By revising the notion of probabilistic independence imposed on the models’ results, I introduce a prima-facie more plausible argument. However, despite this prima-facie plausibility, I show that even this new argument is unsound in most (...)
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  • Allure of Simplicity.Thomas Grote - 2023 - Philosophy of Medicine 4 (1).
    This paper develops an account of the opacity problem in medical machine learning (ML). Guided by pragmatist assumptions, I argue that opacity in ML models is problematic insofar as it potentially undermines the achievement of two key purposes: ensuring generalizability and optimizing clinician–machine decision-making. Three opacity amelioration strategies are examined, with explainable artificial intelligence (XAI) as the predominant approach, challenged by two revisionary strategies in the form of reliabilism and the interpretability by design. Comparing the three strategies, I argue that (...)
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  • Sloppy Models, Renormalization Group Realism, and the Success of Science.David Freeborn - forthcoming - Erkenntnis:1-29.
    The “sloppy models” program originated in systems biology, but has seen applications across a range of fields. Sloppy models are dependent on a large number of parameters, but highly insensitive to the vast majority of parameter combinations. Sloppy models proponents claim that the program may explain the success of science. I argue that the sloppy models program can at best provide a very partial explanation. Drawing a parallel with renormalization group realism, I argue that it would only give us grounds (...)
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  • Pandemics and flexible lockdowns: In praise of agent-based modeling.Igor Douven - 2023 - European Journal for Philosophy of Science 13 (3):1-27.
    Philosophers have recently questioned the methodological status of agent-based modeling. Meanwhile, this methodology has been central to various studies of the COVID-19 pandemic. Few agent-based COVID-19 models are accessible to philosophers for inspection or experimentation. We make available a package for modeling the COVID-19 pandemic and similar pandemics and give an impression of what can be achieved with it. In particular, it is shown that by coupling an agent-based model to a standard optimizer we are able to identify strategies for (...)
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  • Addressing the Reproducibility Crisis: A Response to Hudson.Heather Douglas & Kevin C. Elliott - 2022 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 53 (2):201-209.
    In this response to Robert Hudson’s article, “Should We Strive to Make Science Bias-Free? A Philosophical Assessment of the Reproducibility Crisis,” we identify three ways in which he misrepresents our work: he conflates value-ladenness with bias; he describes our view as one in which values are the same as evidential factors; and he creates a false dichotomy between two ways that values could be considered in science for policy. We share Hudson’s concerns about promoting scientific reproducibility and reducing bias in (...)
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  • Sins of Inquiry: How to Criticize Scientific Pursuits.Marina DiMarco & Kareem Khalifa - 2022 - Studies in History and Philosophy of Science Part A 92 (C):86-96.
    Criticism is a staple of the scientific enterprise and of the social epistemology of science. Philosophical discussions of criticism have traditionally focused on its roles in relation to objectivity, confirmation, and theory choice. However, attention to criticism and to criticizability should also inform our thinking about scientific pursuits: the allocation of resources with the aim of developing scientific tools and ideas. In this paper, we offer an account of scientific pursuitworthiness which takes criticizability as its starting point. We call this (...)
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  • Climate Models and the Irrelevance of Chaos.Corey Dethier - 2021 - Philosophy of Science 88 (5):997-1007.
    Philosophy of science has witnessed substantial recent debate over the existence of a structural analogue of chaos, which is alleged to spell trouble for certain uses of climate models. The debate over the analogy can and should be separated from its alleged epistemic implications: chaos-like behavior is neither necessary nor sufficient for small dynamical misrepresentations to generate erroneous results. The kind of sensitivity that matters in epistemology is one that induces unsafe beliefs, and the existence of a structural analogue to (...)
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  • Calibrating statistical tools: Improving the measure of Humanity's influence on the climate.Corey Dethier - 2022 - Studies in History and Philosophy of Science Part A 94 (C):158-166.
    Over the last twenty-five years, climate scientists working on the attribution of climate change to humans have developed increasingly sophisticated statistical models in a process that can be understood as a kind of calibration: the gradual changes to the statistical models employed in attribution studies served as iterative revisions to a measurement(-like) procedure motivated primarily by the aim of neutralizing particularly troublesome sources of error or uncertainty. This practice is in keeping with recent work on the evaluation of models more (...)
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  • Taming the tyranny of scales: models and scale in the geosciences.Alisa Bokulich - 2021 - Synthese 199 (5-6):14167-14199.
    While the predominant focus of the philosophical literature on scientific modeling has been on single-scale models, most systems in nature exhibit complex multiscale behavior, requiring new modeling methods. This challenge of modeling phenomena across a vast range of spatial and temporal scales has been called the tyranny of scales problem. Drawing on research in the geosciences, I synthesize and analyze a number of strategies for taming this tyranny in the context of conceptual, physical, and mathematical modeling. This includes several strategies (...)
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  • Data models, representation and adequacy-for-purpose.Alisa Bokulich & Wendy Parker - 2021 - European Journal for Philosophy of Science 11 (1):1-26.
    We critically engage two traditional views of scientific data and outline a novel philosophical view that we call the pragmatic-representational view of data. On the PR view, data are representations that are the product of a process of inquiry, and they should be evaluated in terms of their adequacy or fitness for particular purposes. Some important implications of the PR view for data assessment, related to misrepresentation, context-sensitivity, and complementary use, are highlighted. The PR view provides insight into the common (...)
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  • A New Heuristic for Climate Adaptation.Kate Nicole Hoffman & Karen Kovaka - 2023 - Philosophy of Science:1-11.
    An influential heuristic for thinking about climate adaptation asserts that “natural” adaptation strategies are the best ones. This heuristic has been roundly criticized but is difficult to dislodge in the absence of an alternative. We introduce a new heuristic that assesses adaptation strategies by looking at their maturity, power, and commitment. Maturity is the extent to which we understand an adaptation strategy’s effects. Power is the size of the effect an adaptation strategy will have. Commitment is the degree to which (...)
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  • How to Interpret Covid-19 Predictions: Reassessing the IHME’s Model.S. Andrew Schroeder - 2021 - Philosophy of Medicine 1 (2).
    The IHME Covid-19 prediction model has been one of the most influential Covid models in the United States. Early on, it received heavy criticism for understating the extent of the epidemic. I argue that this criticism was based on a misunderstanding of the model. The model was best interpreted not as attempting to forecast the actual course of the epidemic. Rather, it was attempting to make a conditional projection: telling us how the epidemic would unfold, given certain assumptions. This misunderstanding (...)
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  • How Values Shape the Machine Learning Opacity Problem.Emily Sullivan - 2022 - In Insa Lawler, Kareem Khalifa & Elay Shech (eds.), Scientific Understanding and Representation. Routledge. pp. 306-322.
    One of the main worries with machine learning model opacity is that we cannot know enough about how the model works to fully understand the decisions they make. But how much is model opacity really a problem? This chapter argues that the problem of machine learning model opacity is entangled with non-epistemic values. The chapter considers three different stages of the machine learning modeling process that corresponds to understanding phenomena: (i) model acceptance and linking the model to the phenomenon, (ii) (...)
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  • Scientific representation.Roman Frigg & James Nguyen - 2016 - Stanford Encyclopedia of Philosophy.
    Science provides us with representations of atoms, elementary particles, polymers, populations, genetic trees, economies, rational decisions, aeroplanes, earthquakes, forest fires, irrigation systems, and the world’s climate. It's through these representations that we learn about the world. This entry explores various different accounts of scientific representation, with a particular focus on how scientific models represent their target systems. As philosophers of science are increasingly acknowledging the importance, if not the primacy, of scientific models as representational units of science, it's important to (...)
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  • Framing the Epistemic Schism of Statistical Mechanics.Javier Anta - 2021 - Proceedings of the X Conference of the Spanish Society of Logic, Methodology and Philosophy of Science.
    In this talk I present the main results from Anta (2021), namely, that the theoretical division between Boltzmannian and Gibbsian statistical mechanics should be understood as a separation in the epistemic capabilities of this physical discipline. In particular, while from the Boltzmannian framework one can generate powerful explanations of thermal processes by appealing to their microdynamics, from the Gibbsian framework one can predict observable values in a computationally effective way. Finally, I argue that this statistical mechanical schism contradicts the Hempelian (...)
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  • Principled Mechanistic Explanations in Biology: A Case Study of Alzheimer's Disease.Sepehr Ehsani - manuscript
    Following an analysis of the state of investigations and clinical outcomes in the Alzheimer's research field, I argue that the widely-accepted 'amyloid cascade' mechanistic explanation of Alzheimer's disease appears to be fundamentally incomplete. In this context, I propose that a framework termed 'principled mechanism' (PM) can help with remedying this problem. First, using a series of five 'tests', PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria, and hints at various ways of making (...)
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