In debates about the nature of scientific explanation, one theme repeatedly arises: that explanation is about providing understanding. However, the concept of understanding has only recently been explored in any depth, and this paper attempts to introduce a useful concept of understanding to that literature and explore it. Understanding is a higher level cognition, the recognition of connections between various pieces of knowledge. This conception can be brought to bear on the conceptual issues that have thus far been unclear in (...) the literature. Though this notion of understanding is broad, explaining various concepts of explanation, it is robust enough to underwrite an objective and useful notion of explanation. (shrink)

Pluralism with respect to the structure of explanations of facts is not uncommon. Wesley Salmon, for instance, distinguished two types of explanation: causal explanations (which provide insight in the causes of the fact we want to explain) and unification explanations (which fit the explanandum into a unified world view). The pluralism which Salmon and others have defended is compatible with several positions about the exact relation between these two types of explanations. We distinguish four such positions, and argue in favour (...) of one of them. We also compare our results with the views of some authors who have recently written on this subject. (shrink)

In this paper I show that a novel ontic reading of explanation, intending to capture the de re essential features of individuals, can support the qualitative view of individual essences. It is argued further that the putative harmful consequences of the Leibniz Principle and its converse for the qualitative view can be avoided, provided that individual essences are not construed in the style of the naïve bundle theory with set-theoretical identity- conditions. Adopting either the more sophisticated two-tier BT or, alternatively, (...) the neo-Aristotelian position of taking essences as natures in the Aristotelian sense, can help to evade these main charges against the qualitative view. The functional parallels with the alternative haecceitistic view of individuation and individual essence will also be considered. (shrink)

I consider the problem of extending Reichenbach's principle of the common cause to more than two events, vis-a-vis an example posed by Bernstein. It is argued that the only reasonable extension of Reichenbach's principle stands in conflict with a recent proposal due to Horwich. I also discuss prospects of the principle of the common cause in the light of these and other difficulties known in the literature and argue that a more viable version of the principle is the one provided (...) by Penrose and Percival (1962). (shrink)

Proponents of the dispositional theory of properties typically claim that their view is not one that offers a realist, governing conception of laws. My first aim is to show that, contrary to this claim, if one commits to dispositionalism then one does not automatically give up on a robust, realist theory of laws. This is because dispositionalism can readily be developed within a Platonic framework of universals. Second, I argue that there are good reasons for realist dispositionalists to favour a (...) Platonic view. This is because the alternative Aristotelian version of dispositionalism, on which universals are immanent entities, is unstable for various reasons. My final aim is to address a common criticism facing Platonic theories of laws, which is the problem of how external entities can play an explanatory role where the world’s law-like patterns of behaviour are concerned. I argue that the Platonists’ response to the one over many problem can help to shed light on this matter, and a possible solution is sketched, one which makes use of the notions of essence, constitution and ontological dependence. (shrink)

My aim is to question an assumption that is often made in the philosophical literature on dispositions. This is the assumption that, generally, the stimulation (or ‘triggering’) of a disposition temporally precedes the manifesting of that disposition. I will begin by examining precisely what the trigging of a disposition may be thought to consist in, and will identify two plausible views. I will then argue that on either of these views about triggering, a case can be made against the view (...) that the triggering of a disposition always occurs before the manifesting of that disposition. More precisely, if the first view about triggering is accepted, and certain plausible assumptions about dispositions are put into place, a metaphysical argument can be formulated for the claim that the stimulation of a disposition never occurs before that disposition manifests. If the second view about triggering is accepted, the question concerning simultaneity becomes an empirical one. There are, however, examples of dispositional interaction which, on the second view about triggering, clearly seem to involve simultaneity.1. (shrink)

I provide a brief history of pragmatics as it relates to explanation, highlighting the great neglect of pragmatics and pragmatic considerations in regard to explanation during the mid-twentieth century. In order to understand pragmatic considerations regarding explanation, I utilize the work of Bas C. van Fraassen, Peter Achinstein, and Jan Faye. These thinkers provide crucial tools for understanding pragmatics, especially with regard to concepts such as context and exigence. The work of these thinkers provides the platform from which I compose (...) a definition of pragmatic considerations. (shrink)

John Dewey provided a robust and thorough conception of scientific explanation within his philosophical writing. I provide an exegesis of Dewey's concept of scientific explanation and argue that this concept is important to contemporary philosophy of science for at least two reasons. First, Dewey's conception of scientific explanation avoids the reification of science as an entity separated from practical experience. Second, Dewey supplants the realist-antirealist debate within the philosophical literature concerning explanation, thus moving us beyond the current stalemate within philosophy (...) of science. (shrink)

Optimality models are widely used in different parts of biology. Two important questions that have been asked about such models are: are they explanatory and, if so, what type of explanations do they offer? My concern in this paper is with the approach of Rice (2012, 2015) and Irvine (2015), who claim that these models provide non-causal explanations. I argue that there are serious problems with this approach and with the accounts of explanation it is intended to justify. The idea (...) behind this undertaking is to draw attention to an important issue associated with the recent pluralist stance on explanation: the rampant proliferation of theories of explanation. This proliferation supports a pluralist perspective on explanation, and pluralism encourages such a proliferation. But, if we are not careful about how we arrive at and how we justify new accounts of explanation — i.e., if we do not try to avoid the sort of problems discussed in this paper — we may end up trivializing the concept of explanation. (shrink)

Can mathematics contribute to our understanding of physical phenomena? One way to try to answer this question is by getting involved in the recent philosophical dispute about the existence of mathematical explanations of physical phenomena. If there is such a thing, given the relation between explanation and understanding, we can say that there is an affirmative answer to our question. But what if we do not agree that mathematics can play an explanatory role in science? Can we still consider that (...) the above question can have an affirmative answer? My main aim here is to give an account that takes mathematics, in some of the cases discussed in the literature, as contributing to our understanding of physical phenomena despite not being explanatory. (shrink)

What exactly do we need in order to enjoy the cognitive benefit that is supposed to be provided by an explanation? Some philosophers :15–37, 2012, Episteme 10:1–17, 2013, Eur J Philos Sci 5:377–385, 2015, Understanding, explanation, and scientific knowledge, Cambridge University Press, Cambridge, 2017) would say that all that we need is to know the explanation. Others :1–26, 2012; Strevens in Stud Hist Philos Sci Part A 44:510–515, 2013) would say that achieving understanding with the help of an explanation requires (...) more than that, that it requires a grasping or an understanding of the explanation. My aim in this paper is to come up with a new answer to this problem by exploring the shortcomings of the received view of understanding. In my view, besides having testimonial knowledge of an explanation, obtaining explanatory understanding requires full cognitive access to the explanation. (shrink)

Philosophers agree that scientific explanations aim to produce understanding, and that good ones succeed in this aim. But few seriously consider what understanding is, or what the cues are when we have it. If it is a psychological state or process, describing its specific nature is the job of psychological theorizing. This article examines the role of understanding in scientific explanation. It warns that the seductive, phenomenological sense of understanding is often, but mistakenly, viewed as a cue of genuine understanding. (...) The article closes with a discussion of several new paths of research that tie the psychology of scientific explanation to cognate notions of learning, testimony, and understanding. (shrink)

Characterization of a form of explanation involving grounding on the model of mechanistic causal explanation.

In this paper, I critique two conceptions of mechanisms, namely those put forth by Stuart Glennan (Erkenntnis 44:49–71, 1996; Philosophy of Science 69:S342–S353, 2002) and Machamer et al. (Philosophy of Science 67:1–25, 2000). Glennan’s conception, I argue, cannot account for mechanisms involving negative causation because of its interactionist posture. MDC’s view encounters the same problem due to its reificatory conception of activities—this conception, I argue, entails an onerous commitment to ontological dualism. In the place of Glennan and MDC, I propose (...) a “modified conception” of mechanisms, which (a) obviates the problem of negative causation by reinterpreting MDC’s activities according to a “descriptivist” account, and (b) avoids MDC’s problem by postulating a monistic ontology of entities. Thus, by solving these problems, my modified conception offers a cogent, more adequate alternative to Glennan’s and MDC’s conceptions of mechanisms. (shrink)

It is widely thought that there is an important argument to be made that starts with premises taken from the science of physics and ends with the conclusion of physicalism. The standard view is that this argument takes the form of a causal argument for physicalism. Roughly, physics tells us that the physical realm is causally complete, and so minds (among other entities) must be physical if they are to interact with the world as we think they do. In what (...) follows, I raise problems for this view. After an initial review of the causal argument, I begin my case by showing that the totality of physical truths do not deductively entail the causal completeness of the physical realm, using a double-prevention scenario and causation by omission to show that nonphysical causes of physical effects would not need to violate physical conservation laws. I then move on to raise problems for an inductive argument for causal completeness by drawing on the neo-Russellian view that there is no causation in fundamental physics, and so causation must itself be a realized or derived entity. I conclude by suggesting that the underlying problem is that the causal argument has fallen out of touch with the sophisticated understanding that philosophers have developed of the role of causation within physics. (shrink)

The article begins by describing two longstanding problems associated with direct inference. One problem concerns the role of uninformative frequency statements in inferring probabilities by direct inference. A second problem concerns the role of frequency statements with gerrymandered reference classes. I show that past approaches to the problem associated with uninformative frequency statements yield the wrong conclusions in some cases. I propose a modification of Kyburg’s approach to the problem that yields the right conclusions. Past theories of direct inference have (...) postponed treatment of the problem associated with gerrymandered reference classes by appealing to an unexplicated notion of projectability . I address the lacuna in past theories by introducing criteria for being a relevant statistic . The prescription that only relevant statistics play a role in direct inference corresponds to the sort of projectability constraints envisioned by past theories. (shrink)

This paper explores a middle way between realism and eliminativism about grounding. Grounding-talk is intelligible and useful, but it fails to pick out grounding relations that exist or obtain in reality. Instead, grounding-talk allows us to convey facts about what metaphysically explains what, and about the worldly dependence relations that give rise to those explanations.

Mechanistic explanation is at present the received view of scientific explanation. One of its central features is the idea that mechanistic explanations are both “downward looking” and “upward looking”: they explain by offering information about the internal constitution of the mechanism as well as the larger environment in which the mechanism is situated. That is, they offer both constitutive and contextual explanatory information. Adequate mechanistic explanations, on this view, accommodate the full range of explanatory factors both “above” and “below” the (...) target phenomenon. The aim of this paper is to demonstrate that mechanistic explanation cannot furnish both constitutive and contextual information simultaneously, because these are different types of explanation with distinctly different aims. Claims that they can, I argue, depend on several intertwined confusions concerning the nature of explanation. Particularly, such claims tend to conflate mechanistic and functional explanation, which I argue ought to be understood as distinct. Conflating them threatens to oversell the explanatory power of mechanisms and obscures the means by which they explain. I offer two broad reasons in favor of distinguishing mechanistic and functional explanation: the first concerns the direction of explanation of each, and the second concerns the type of questions to which these explanations offer answers. I suggest an alternative picture on which mechanistic explanation is understood as fundamentally constitutive, and according to which an adequate understanding of a phenomenon typically requires supplementing the mechanistic explanation with a functional explanation. (shrink)

Recently, some mechanists have embraced reductionism and some reductionists have endorsed mechanism. However, the two camps disagree sharply about the extent to which mechanistic explanation is a reductionistic enterprise. Reductionists maintain that cellular and molecular mechanisms can explain mental phenomena without necessary appeal to higher-level mechanisms. Mechanists deny this claim. I argue that this dispute turns on whether reduction is a transitive relation. I show that it is. Therefore, mechanistic explanations at the cellular and molecular level explain mental phenomena. I (...) make my case in part by noting that mechanisms at higher levels are composed of mechanisms at lower levels. Compositional relations are transitive. In addition, they are explanatory. I conclude that there are explanatory linkages from cellular and molecular mechanisms to mental phenomena within a hierarchy of nested mechanisms. (shrink)

In 1983, Dr. J. Robin Warren and Dr. Barry Marshall reported finding a new kind of bacteria in the stomachs of people with gastritis. Warren and Marshall were soon led to the hypothesis that peptic ulcers are generally caused, not by excess acidity or stress, but by a bacterial infection. Initially, this hypothesis was viewed as preposterous, and it is still somewhat controversial. In 1994, however, a U. S. National Institutes of Health Consensus Development Panel concluded that infection appears to (...) play an important contributory role in the pathogenesis of peptic ulcers, and recommended that antibiotics be used in their treatment. Peptic ulcers are common, affecting up to 10% of the population, and evidence has mounted that many ulcers can be cured by eradicating the bacteria responsible for them. (shrink)

The principle that causes always render their effects more likely is fundamental to the enterprise of reducing facts of causation to facts about (objective) chances. This reductionist enterprise faces famous difficulties in accommodating common-sense intuitions about causal processes, if it insists on cashing out causal processes in terms of streams of events in which every event that belongs to the stream is a cause of the adjoining event downstream of it. I shall propose modifications to this way of cashing out (...) causal processes, still well within the reductionist faith. These modifications will allow the reductionist to handle processes successfully, on the assumption that the reductionist proposal is itself otherwise satisfactory. I shall then argue that the reductionist enterprise lies squarely behind the Theory of Relativity, and so has all the confirmatory weight of Relativity behind it. However this is not all good news for reductionists. For throughout I shall simply assume that the reductionist proposal, to the effect that causes are just chance-raisers, is correct. And I shall sidestep problems with that proposal as such. And so I shall show that, if in the end we find the reductionist proposal unsatisfactory, it cannot be on grounds of its treatment of causal processes as such. Thus, while I shall argue that causal processes pose no extra trouble for reductionists, I shall be making a case that all the action between reductionists and their opponents should be focused upon the proposal to reduce the two-term causal relation itself to relations amongst probabilities. (shrink)

A biochemical pathway is a sequence of chemical reactions in a biological organism. Such pathways specify mechanisms that explain how cells carry out their major functions by means of molecules and reactions that produce regular changes. Many diseases can be explained by defects in pathways, and new treatments often involve finding drugs that correct those defects. This paper presents explanation schemas and treatment strategies that characterize how thinking about pathways contributes to biomedical discovery. It discusses the significance of pathways for (...) understanding the nature of diseases, explanations, and theories. (shrink)

I shall endeavor to show that every physical theory since Newton explains without drawing attention to causes–that, in other words, physical theories as physical theories aspire to explain under an ideal quite distinct from that of causal explanation. If I am right, then even if sometimes the explanations achieved by a physical theory are not in violation of the standard of causal explanation, this is purely an accident. For physical theories, as I will show, do not, as such, aim at (...) accommodating the goals or aspirations of causal explanation. This will serve as the founding insight for a new theory of explanation, which will itself serve as the cornerstone of a new theory of scientific method. (shrink)

This target article presents a new computational theory of explanatory coherence that applies to the acceptance and rejection of scientific hypotheses as well as to reasoning in everyday life, The theory consists of seven principles that establish relations of local coherence between a hypothesis and other propositions. A hypothesis coheres with propositions that it explains, or that explain it, or that participate with it in explaining other propositions, or that offer analogous explanations. Propositions are incoherent with each other if they (...) are contradictory, Propositions that describe the results of observation have a degree of acceptability on their own. An explanatory hypothesis is acccpted if it coheres better overall than its competitors. The power of the seven principles is shown by their implementation in a connectionist program called ECHO, which treats hypothesis evaluation as a constraint satisfaction problem. Inputs about the explanatory relations are used to create a network of units representing propositions, while coherende and incoherence relations are encoded by excitatory and inbihitory links. ECHO provides an algorithm for smoothly integrating theory evaluation based on considerations of explanatory breadth, simplicity, and analogy. It has been applied to such important scientific cases as Lovoisier's argument for oxygen against the phlogiston theory and Darwin's argument for evolution against creationism, and also to cases of legal reasoning. The theory of explanatory coherence has implications for artificial intelligence, psychology, and philosophy. (shrink)

Why do people get sick? I argue that a disease explanation is best thought of as causal network instantiation, where a causal network describes the interrelations among multiple factors, and instantiation consists of observational or hypothetical assignment of factors to the patient whose disease is being explained. This paper first discusses inference from correlation to causation, integrating recent psychological discussions of causal reasoning with epidemiological approaches to understanding disease causation, particularly concerning ulcers and lung cancer. It then shows how causal (...) mechanisms represented by causal networks can contribute to reasoning involving correlation and causation. The understanding of causation and causal mechanisms provides the basis for a presentation of the causal network instantiation model of medical explanation. (shrink)

Social sciences face a well-known problem, which is an instance of a general problem faced as well by psychological and biological sciences: the problem of establishing their legitimate existence alongside physics. This, as will become clear, is a problem in metaphysics. I will show how a new account of structural explanations, put forward by Frank Jackson and Philip Pettit, which is designed to solve this metaphysical problem with social sciences in mind, fails to treat the problem in any importantly new (...) way. Then I will propose a more modest approach, and show how it does not deserve the criticism directed at a prototype by Jackson and Pettit. (shrink)

The article first addresses the importance of cognitive modeling, in terms of its value to cognitive science (as well as other social and behavioral sciences). In particular, it emphasizes the use of cognitive architectures in this undertaking. Based on this approach, the article addresses, in detail, the idea of a multi-level approach that ranges from social to neural levels. In physical sciences, a rigorous set of theories is a hierarchy of descriptions/explanations, in which causal relationships among entities at a high (...) level can be reduced to causal relationships among simpler entities at a more detailed level. We argue that a similar hierarchy makes possible an equally productive approach toward cognitive modeling. The levels of models that we conceive in relation to cognition include, at the highest level, sociological/anthropological models of collective human behavior, behavioral models of individual performance, cognitive models involving detailed mechanisms, representations, and processes, as well as biological/physiological models of neural circuits, brain regions, and other detailed biological processes. (shrink)

In the physical sciences a rigorous theory is a hierarchy of descriptions in which causal relationships between many general types of entity at a phenomenological level can be derived from causal relationships between smaller numbers of simpler entities at more detailed levels. The hierarchy of descriptions resembles the modular hierarchy created in electronic systems in order to be able to modify a complex functionality without excessive side effects. Such a hierarchy would make it possible to establish a rigorous scientific theory (...) of consciousness. The causal relationships implicit in definitions of access consciousness and phe- nomenal consciousness are made explicit, and the corresponding causal relationships at the more detailed levels of perception, memory, and skill learning described. Extension of these causal relationships to physiological and neural levels is discussed. The general capability of a range of current consciousness models to support a modular hierarchy which could generate these causal relationships is reviewed, and the specific capabilities of two models with good general capabilities are compared in some detail. Ó 2003 Elsevier Inc. All rights reserved. (shrink)

When we say “I know why he was late”, we know not only the fact that he was late, but also an explanation of this fact. We propose a logical framework of “knowing why” inspired by the existing formal studies on why-questions, scientific explanation, and justification logic. We introduce the Kyi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{\mathcal {K}}{}\textit{y}}_i$$\end{document} operator into the language of epistemic logic to express “agent i knows why φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} (...) \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}” and propose a Kripke-style semantics of such expressions in terms of knowing an explanation of φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}. We obtain two sound and complete axiomatizations w.r.t. two different model classes depending on different assumptions about introspection. Finally we connect our logic with justification logic technically by providing an alternative semantics and an in-depth comparison on various design choices. (shrink)

This paper argues that there is no single universal conception of scientific explanation that is consistently employed throughout the whole domain of Higgs physics—ranging from the successful experimental search for a standard model Higgs particle and the hitherto unsuccessful searches for any particles beyond the standard model, to phenomenological model builders in the Higgs sector and theoretical physicists interested in how the core principles of quantum field theory apply to spontaneous symmetry breaking and the Higgs mechanism. Yet the coexistence of (...) deductive-statistical, unificationist, model-based, and statistical-relevance explanations does not amount to a fragmentation of the discipline, but allows elementary particle physicists to simultaneously pursue a plurality of research strategies and keep the field together by joint convictions about the SM and shared explanatory ideals. These convictions include that the SM both represents a successful explanation of the available particle data and contains aspects in need of further explanation. Especially in the domain of BSM physics, explanatory ideals typically appear as stories motivating the different models and linking them to the whole of the discipline. (shrink)

Hans Reichenbach’s posthumous book The Direction of Time ends somewhere between Socratic aporia and historical irony. Prompted by Feynman’s diagrammatic formulation of quantum electrodynamics, Reichenbach eventually abandoned the delicate balancing between the macroscopic foundation of the direction of time and microscopic descriptions of time order undertaken throughout the previous chapters in favor of an exclusively macroscopic theory that he had vehemently rejected in the 1920s. I analyze Reichenbach’s reasoning against the backdrop of the history of Feynman diagrams and the current (...) practice of particle physics. Building upon the debates about processes and conserved quantities between Wesley Salmon and Phil Dowe in the 1990s, and the exchange between Reichenbach and the gestalt theorist Kurt Lewin during the 1920s about topology and genidentity, I investigate whether the aporia about local time order could be avoided by following a strategy that Reichenbach adopted elsewhere in the book and develop a notion of functional genidentity that captures the practice of present-day elementary particle physics and the fact that Feynman diagrams have to be understood in the context of a complex mathematical description of scattering processes. (shrink)

On Two Types of Realism in Quantum Theory. Current realist approaches to the foundations of quantum theory emphasize the dichotomy between (Copenhagen) positivism and ‘beable’-realism. Recently it was even attempted to turn this picture into two (equally possible) histories in order to legitimate Bohmian Mechanics as a viable alternative. This paper argues that this dichotomy is philosophically inadequate and historically questionable by embedding it into the philosophical discussion on positivism and realism that has taken place since the 1920s. Logical Empiricists (...) back then advocated empirical realism and contrasted it to absolutistic metaphysical realism. From this viewpoint David Bohm's ‘beable’-realism combines elements of Mach's sensualism with a pre-Kantian metaphysics. As Wesley Salmon's position shows, empirical realism can become quite pronounced without relapsing into Bohmian philosophy. Instead it arrives close to the GRWP-interpretation. Hence, when Bernard d'Espagnat binds both together as ‘ontological interpretations’, he blurs the borderline between empirical and metaphysical realism that his Veiled Reality has set out to draw, quite in concordance with Logical Empiricism. (shrink)

Consensus conferences are social techniques which involve bringing together a group of scientific experts, and sometimes also non-experts, in order to increase the public role in science and related policy, to amalgamate diverse and often contradictory evidence for a hypothesis of interest, and to achieve scientific consensus or at least the appearance of consensus among scientists. For consensus conferences that set out to amalgamate evidence, I propose three desiderata: Inclusivity, Constraint, and Evidential Complexity. Two examples suggest that consensus conferences can (...) readily satisfy Inclusivity and Evidential Complexity, but consensus conferences do not as easily satisfy Constraint. I end by discussing the relation between social inclusivity and the three desiderata. (shrink)

Several authors have claimed that mechanisms play a vital role in distinguishing between causation and mere correlation in the social sciences. Such claims are sometimes interpreted to mean that without mechanisms, causal inference in social science is impossible. The author agrees with critics of this proposition but explains how the account of how mechanisms aid causal inference can be interpreted in a way that does not depend on it. Nevertheless, he shows that this more charitable version of the account is (...) still unsuccessful as it stands. Consequently, he advances a proposal for shoring up the account, which is founded on the possibility of acquiring knowledge of social mechanisms by linking together norms or practices found in a society. Key Words: causality • social mechanisms • interpretation • anthropology. (shrink)

Robustness is a common platitude: hypotheses are better supported with evidence generated by multiple techniques that rely on different background assumptions. Robustness has been put to numerous epistemic tasks, including the demarcation of artifacts from real entities, countering the “experimenter’s regress,” and resolving evidential discordance. Despite the frequency of appeals to robustness, the notion itself has received scant critique. Arguments based on robustness can give incorrect conclusions. More worrying is that although robustness may be valuable in ideal evidential circumstances (i.e., (...) when evidence is concordant), often when a variety of evidence is available from multiple techniques, the evidence is discordant. †To contact the author, please write to: Jacob Stegenga, Department of Philosophy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093; e‐mail: [email protected]. (shrink)

Robustness arguments hold that hypotheses are more likely to be true when they are confirmed by diverse kinds of evidence. Robustness arguments require the confirming evidence to be independent. We identify two kinds of independence appealed to in robustness arguments: ontic independence —when the multiple lines of evidence depend on different materials, assumptions, or theories—and probabilistic independence. Many assume that OI is sufficient for a robustness argument to be warranted. However, we argue that, as typically construed, OI is not a (...) sufficient independence condition for warranting robustness arguments. We show that OI evidence can collectively confirm a hypothesis to a lower degree than individual lines of evidence, contrary to the standard assumption undergirding usual robustness arguments. We employ Bayesian networks to represent the ideal empirical scenario for a robustness argument and a variety of ways in which empirical scenarios can fall short of this ideal. (shrink)

During the past two decades, philosophers of biology have increasingly turned their attention to mechanisms of biological phenomena. Through analyses of mechanistic proposals advanced by biologists, the goal of these philosophers is to understand what a mechanism is and how mechanisms explain. These analyses have generally focused on mechanistic proposals for phenomenon that occur at the cellular or sub-cellular level, such as synapse firing, protein synthesis, or metabolic pathway operation. Little is said about the mechanisms of the macromolecular reactions that (...) underpin these phenomena. These reactions comprise a diverse family of reaction types, and include protein folding, macromolecular complex formation, receptor-ligand interactions, and enzyme catalysis. In this paper, I develop an account of mechanism that focuses exclusively on macromolecular reactions. I begin by reviewing how mechanism is understood in enzymology, and how mechanistic concepts of enzymology apply to macromolecular reactions in general. We will see that the mechanism of a macromolecular reaction is most accurately described as a progression of reaction intermediates, where the evolution of intermediates, from one to the next, is characterized by an energetic coupling between chemistry and protein dynamics. I then make the case that this description necessitates a grounding in a process ontology. To describe the mechanism by which a macromolecular reaction occurs is to describe a process. (shrink)

This article examines methodological individualism in terms of the theory that invariance under intervention is the signal feature of generalizations that serve as a basis for causal explanation. This theory supports the holist contention that macro-level generalizations can explain, but it also suggests a defense of methodological individualism on the grounds that greater range of invariance under intervention entails deeper explanation. Although this individualist position is not threatened by multiple-realizability, an argument for it based on rational choice theory is called (...) into question by experimental results concerning preference reversals. Key Words: methodological individualism • mechanisms • explanation • invariance • preference reversal. (shrink)

In this paper two accounts of Reichenbachian common cause systems are compared. Examples are provided which show that Hofer-Szabó and Rédei account and Hofer-Szabó et al. account is compatible, with but not equivalent, to Mazzola’s. Moreover, the difference of the two accounts with respect to their explanatory adequacy is discussed, in the light of Salmon’s statistical-relevance approach to statistical explanation.

In this paper, we attempt to explicate Salmon’s idea of a causal process, as defined in terms of the mark method, in the context of C*-dynamical systems. We prove two propositions, one establishing mark manifestation infinitely many times along a given interval of the process, and, a second one, which establishes continuous manifestation of mark with the exception of a countable number of isolated points. Furthermore, we discuss how these results can be implemented in the context of the Haag–Araki theories (...) of relativistic quantum fields on Minkowski spacetime. (shrink)

The paper argues that actions should be thought of as processes and not events. A number of reasons are offered for thinking that the things that it is most plausible to suppose we are trying to cotton on to with the generic talk of ‘actions’ in which philosophy indulges cannot be events. A framework for thinking about the event-process distinction which can help us understand how we ought to think about the ontology of processes we need instead is then developed, (...) building on some excellent work already done by philosophers working at the intersection of philosophy and linguistics. (shrink)

Sherri Roush ([2005]) and I ([2001], [2006]) have each argued independently that the most significant challenge to scientific realism arises from our inability to consider the full range of serious alternatives to a given hypothesis we seek to test, but we diverge significantly concerning the range of cases in which this problem becomes acute. Here I argue against Roush's further suggestion that the atomic hypothesis represents a case in which scientific ingenuity has enabled us to overcome the problem, showing how (...) her general strategy is undermined by evidence I have already offered in support of what I have called the 'problem of unconceived alternatives'. I then go on to show why her strategy will not generally (if ever) allow us to formulate and test exhaustive spaces of hypotheses in cases of fundamental scientific theorizing. (shrink)