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Genetic Interventions and the Ethics of Enhancement of Human Beings

In Bonnie Steinbock (ed.), The Oxford Handbook of Bioethics. Oxford University Press. pp. 516--535 (2007)

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  1. Ethical Concerns About Human Genetic Enhancement in the Malay Science Fiction Novels.Noor Munirah Isa & Muhammad Fakhruddin Hj Safian Shuri - 2018 - Science and Engineering Ethics 24 (1):109-127.
    Advancements in science and technology have not only brought hope to humankind to produce disease-free offspring, but also offer possibilities to genetically enhance the next generation’s traits and capacities. Human genetic enhancement, however, raises complex ethical questions, such as to what extent should it be allowed? It has been a great challenge for humankind to develop robust ethical guidelines for human genetic enhancement that address both public concerns and needs. We believe that research about public concerns is necessary prior to (...)
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  • Psychopathy: Morally Incapacitated Persons.Heidi Maibom - 2017 - In Thomas Schramme & Steven Edwards (eds.), Handbook of the Philosophy of Medicine. Springer. pp. 1109-1129.
    After describing the disorder of psychopathy, I examine the theories and the evidence concerning the psychopaths’ deficient moral capacities. I first examine whether or not psychopaths can pass tests of moral knowledge. Most of the evidence suggests that they can. If there is a lack of moral understanding, then it has to be due to an incapacity that affects not their declarative knowledge of moral norms, but their deeper understanding of them. I then examine two suggestions: it is their deficient (...)
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  • Experimental philosophy of medicine and the concepts of health and disease.Walter Veit - 2020 - Theoretical Medicine and Bioethics:1-18.
    If one had to identify the biggest change within the philosophical tradition in the twenty-first century, it would certainly be the rapid rise of experimental philosophy to address differences in intuitions about concepts. It is, therefore, surprising that the philosophy of medicine has so far not drawn on the tools of experimental philosophy in the context of a particular conceptual debate that has overshadowed all others in the field: the long-standing dispute between so-called naturalists and normativists about the concepts of (...)
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  • Experimental philosophy of medicine and the concepts of health and disease.Walter Veit - 2020 - Theoretical Medicine and Bioethics 42 (3):169-186.
    If one had to identify the biggest change within the philosophical tradition in the twenty-first century, it would certainly be the rapid rise of experimental philosophy to address differences in intuitions about concepts. It is, therefore, surprising that the philosophy of medicine has so far not drawn on the tools of experimental philosophy in the context of a particular conceptual debate that has overshadowed all others in the field: the long-standing dispute between so-called naturalists and normativists about the concepts of (...)
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  • Should Human Beings Have Sex? Sexual Dimorphism and Human Enhancement.Robert Sparrow - 2010 - American Journal of Bioethics 10 (7):3-12.
    Since the first sex reassignment operations were performed, individual sex has come to be, to some extent at least, a technological artifact. The existence of sperm sorting technology, and of prenatal determination of fetal sex via ultrasound along with the option of termination, means that we now have the power to choose the sex of our children. An influential contemporary line of thought about medical ethics suggests that we should use technology to serve the welfare of individuals and to remove (...)
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  • Queerin’ the PGD Clinic: Human Enhancement and the Future of Bodily Diversity.Robert Sparrow - 2013 - Journal of Medical Humanities 34 (2):177-196.
    Disability activists influenced by queer theory and advocates of “human enhancement” have each disputed the idea that what is “normal” is normatively significant, which currently plays a key role in the regulation of pre-implantation genetic diagnosis (PGD). Previously, I have argued that the only way to avoid the implication that parents have strong reasons to select children of one sex (most plausibly, female) over the other is to affirm the moral significance of sexually dimorphic human biological norms. After outlining the (...)
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  • Human enhancement and sexual dimorphism.Rob Sparrow - 2011 - Bioethics 26 (9):464-475.
    I argue that the existence of sexual dimorphism poses a profound challenge to those philosophers who wish to deny the moral significance of the idea of ‘normal human capacities’ in debates about the ethics of human enhancement. The biological sex of a child will make a much greater difference to their life prospects than many of the genetic variations that the philosophical and bioethical literature has previously been concerned with. It seems, then, that bioethicists should have something to say about (...)
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  • Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit.Robert Sparrow - 2021 - American Journal of Bioethics 22 (9):4-15.
    Ever since the publication of Derek Parfit’s Reasons and Persons, bioethicists have tended to distinguish between two different ways in which reproductive technologies may have implications for the...
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  • Gene Editing, Enhancing and Women’s Role.Frida Simonstein - 2019 - Science and Engineering Ethics 25 (4):1007-1016.
    A recent article on the front page of The Independent reported that the genetic ‘manipulation’ of IVF embryos is to start in Britain, using a new revolutionary gene-editing technique, called Crispr/Cas9. About three weeks later, on the front page of the same newspaper, it was reported that the National Health Service faces a one billion pound deficit only 3 months into the new year. The hidden connection between these reports is that gene editing could be used to solve issues related (...)
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  • ¿Igualdad para Los animales? Mejora cognitiva más allá de Los seres humanos.Olga Campos Serena - 2018 - Télos 21 (2):85-98.
    I will take a famous paragraph from J S. Mill as a starting point for defending the idea that moral philosophy has to take charge definitively of those who have been less fortunate in the natural lottery. This means that we must to take seriously the possibility of increasing the capacity for the well-being of nonhuman animals. The aim of the text is to show the relevance of the current ethical debate on enhancement also in the context of reflection on (...)
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  • Moderate eugenics and human enhancement.Michael J. Selgelid - 2014 - Medicine, Health Care and Philosophy 17 (1):3-12.
    Though the reputation of eugenics has been tarnished by history, eugenics per se is not necessarily a bad thing. Many advocate a liberal new eugenics—where individuals are free to choose whether or not to employ genetic technologies for reproductive purposes. Though genetic interventions aimed at the prevention of severe genetic disorders may be morally and socially acceptable, reproductive liberty in the context of enhancement may conflict with equality. Enhancement could also have adverse effects on utility. The enhancement debate requires a (...)
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  • Rational Freedom and Six Mistakes of a Bioconservative.Julian Savulescu - 2019 - American Journal of Bioethics 19 (7):1-5.
    Volume 19, Issue 7, July 2019, Page 1-5.
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  • Human Liberation: Removing Biological and Psychological Barriers to Freedom.Julian Savulescu - 2010 - Monash Bioethics Review 29 (1):1-18.
    In this article, the author argues that there are psychological and biological constraints on our moral behaviour, rational decision-making and capacities to love. For example, low oxytocin levels can constrain our willingness to cooperate with others, and our capacity to maintain long-term loving relationships. There is also evidence that increasing iodine intake can improve a person’s general intelligence, while drugs such as Modafinil can enhance cognitive performance. Savulescu argues that we have a moral obligation to remove those constraints, and that (...)
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  • Life-extending enhancements and the narrative approach to personal identity.Andrea Sauchelli - 2018 - Journal of Medical Ethics 44 (4):219-225.
    Various debates on the desirability and rationality of life-extending enhancements have been pursued under the presupposition that a generic psychological theory of personal identity is correct. I here discuss how the narrative approach to personal identity can contribute to these debates. In particular, I argue that two versions of the narrative approach offer good reasons to reject an argument against the rationality of life-extending enhancements.
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  • Defeaters to best interests reasoning in genetic enhancement.Sruthi Rothenfluch - 2017 - Philosophical Studies 174 (11):2845-2869.
    Pre-natal genetic enhancement affords us unprecedented capacity to shape our skills, talents, appearance and perhaps subsequently the quality of our lives in terms of overall happiness, success and wellbeing. Despite its powerful appeal, some have raised important and equally persuasive concerns against genetic enhancement. Sandel has argued that compassion and humility, themselves grounded in the unpredictability of talents and skills, would be lost. Habermas has argued that genetically altered individuals will see their lives as dictated by their parents’ design and (...)
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  • Liberalism and eugenics.Robert Sparrow - 2011 - Australasian Journal of Philosophy 89 (3):499 - 517.
    ‘Liberal eugenics’ has emerged as the most popular position amongst philosophers writing in the contemporary debate about the ethics of human enhancement. This position has been most clearly articulated by Nicholas Agar, who argues that the ‘new’ liberal eugenics can avoid the repugnant consequences associated with eugenics in the past. Agar suggests that parents should be free to make only those interventions into the genetics of their children that will benefit them no matter what way of life they grow up (...)
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  • Guest Editorial: How Moral is Moral Enhancement?Vojin Rakić & James Hughes - 2015 - Cambridge Quarterly of Healthcare Ethics 24 (1):3-6.
    Moral bioenhancement is a topic that will only increase in controversy as neuroscience advances.
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  • Sandel on enhancement: A response to Van Niekerk.Brian Penrose - 2016 - South African Journal of Philosophy 35 (2):145-163.
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  • Some Problems of the Transhumanist Conception of Love.Juraj Odorčák - 2020 - Pro-Fil 21 (1):51.
    Transhumanistická koncepcia lásky obecne predpokladá, že by sme mali romantickú lásku transformovať prostredníctvom súčasných možností vedy a techniky. Zástancovia transhumanistickej koncepcie lásky zvyčajne tvrdia, že správna technologická transformácia biologických základov lásky môže vyriešiť niektoré naše súčasné problémy s láskou. Proponenti transhumanistickej koncepcie lásky sa preto zvyčajne domnievajú, že korektná realizácia ich návrhu by taktiež viedla k vylepšeniu romantickej lásky. Hlavný zámer tejto štúdie spočíva v kritickej analýze niektorých filozofických a konceptuálnych nedostatkov, ktoré sú spojené s predstavou, že je vhodné aby (...)
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  • “Unfit for Life”: A Case Study of Protector-Protected Analogies in Recent Advocacy of Eugenics and Coercive Genetic Discrimination. [REVIEW]Mark Munsterhjelm - 2011 - Journal of Bioethical Inquiry 8 (2):177-189.
    This paper utilizes Iris Marion Young’s critical, post-9/11 reading of Thomas Hobbes, as a theorist of authoritarian government grounded in fear of threat (Young 2003). Applying Young’s reading of Hobbes to the high-profile ethicist Julian Savulescu’s advocacy of genetic enhancement reveals an underlying unjust discrimination in Savulescu’s use of patriarchal protector–protected analogies between family and state. First, the paper shows how Savulescu’s concept of procreative beneficence, in which parents use genetic selection to have children who will have the best lives (...)
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  • Can ‘eugenics’ be defended?Francesca Minerva, Diana S. Fleischman, Peter Singer, Nicholas Agar, Jonathan Anomaly & Walter Veit - 2021 - Monash Bioethics Review 39 (1):60-67.
    In recent years, bioethical discourse around the topic of ‘genetic enhancement’ has become increasingly politicized. We fear there is too much focus on the semantic question of whether we should call particular practices and emerging bio-technologies such as CRISPR ‘eugenics’, rather than the more important question of how we should view them from the perspective of ethics and policy. Here, we address the question of whether ‘eugenics’ can be defended and how proponents and critics of enhancement should engage with each (...)
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  • The Case for Perfection.W. Miller Brown - 2009 - Journal of the Philosophy of Sport 36 (2):127-139.
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  • Do-it-yourself brain stimulation: a regulatory model.Hannah Maslen, Tom Douglas, Roi Cohen Kadosh, Neil Levy & Julian Savulescu - 2015 - Journal of Medical Ethics 41 (5):413-414.
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  • The exercise pill: should we replace exercise with pharmaceutical means?Sigmund Loland - 2017 - Sport, Ethics and Philosophy 11 (1):63-74.
    New physiological and pharmacological research points to the possibility of a pill that produces the complete physiological effects of exercise. Is replacement of exercise with a pill a good idea? And if so, under what circumstances? To explore answers, I have examined three approaches to the understanding exercise. From a dualist point of view, exercise is explained mechanistically in terms of physiological cause and effect relationships. From this perspective, and in particular for reluctant exercisers, there seems to be no strong (...)
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  • A Well Balanced Life Based on 'The Joy of Effort': Olympic Hype or a Meaningful Ideal?Sigmund Loland - 2012 - Sport, Ethics and Philosophy 6 (2):155-165.
    A key goal in the Olympic value system of Olympism is the all-round cultivation of the individual. According to its so-called ?fundamental principles?, Olympism is a ?philosophy of life? with ideals of ?exalting and combining in a balanced whole the qualities of body, will, and mind? and creating ?a way of life based on the joy of effort?. These goals are to be reached by blending sport with culture and education. Olympism is often criticised for idealism and lack of impact (...)
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  • Biomedisinsk teknologi i idrett: Hvor går grensene?Sigmund Loland - 2010 - Etikk I Praksis - Nordic Journal of Applied Ethics 1 (1):87-100.
    I denne artikkelen drøfter jeg bruk av biomedisinsk teknologi i prestasjonsfremmende hensikt i konkurranseidrett. Mer presist utforsker jeg mulighetene for å skille mellom etisk akseptabel og etisk uakseptabel bruk. Jeg kritiserer WADAs normative grunnlag for å forby visse biomedisinske midler og metoder, og argumenterer for at eventuelle forbud må bygge på tydeligere verdisyn på idrett. Jeg undersøker to idealtypiske syn og deres teknologiske implikasjoner. Det smale synet er liberalt og avviser begrensninger i bruk av biomedisinske midler og metoder blant voksne (...)
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  • Is human enhancement intrinsically bad?Karolina Kudlek - 2021 - Medicine, Health Care and Philosophy 24 (2):269-279.
    A pertinent concern in the human enhancement debate is that human enhancement technologies (HET) are intrinsically bad and, hence, morally impermissible. This article evaluates the related claims about the intrinsic badness of HET by looking into philosophical theories of intrinsic value. It investigates how well-established conceptions of intrinsic value map onto typical bioconservative arguments about HET's intrinsic badness. Three predominant variants of these arguments are explored and found wanting: (i) HET are intrinsically bad owing to their unnaturalness; (ii) the pursuit (...)
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  • Contra: Soll das sogenannte „Gene Editing“ mittels CRISPR/Cas9-Technologie an menschlichen Embryonen erforscht werden?Kipke Roland, Rothhaar Markus & Hähnel Martin - 2017 - Ethik in der Medizin 29 (3):249-252.
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  • Kultürlichkeit statt Natürlichkeit: Ein vernachlässigtes Argument in der bioethischen Debatte um Enhancement und Anthropotechnik.Dietmar Hübner - 2015 - Jahrbuch für Wissenschaft Und Ethik 19 (1):25-58.
    Natürlichkeitsargumente haben allgemein in der Bioethik und speziell in der Debatte um Enhancement und Anthropotechnik keinen guten Ruf. Neben dem formalen Vorwurf, einen naturalistischen Fehlschluss zu begehen, werden sie mit dem inhaltli-chen Einwand konfrontiert, eine falsche Auffassung von menschlicher Natur zugrunde zu legen: Recht verstanden definiere sich diese menschliche Natur nicht durch eine biologische Substanz, die durch biotechnische Eingriffe korrumpiert werden könnte, sondern durch kulturelle Vollzüge, zu denen gerade auch der Einsatz biotechnischer Verfahren zähle und die daher durch biotechnische Manipulationen (...)
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  • Habermas and the Question of Bioethics.Hille Haker - 2019 - European Journal for Philosophy of Religion 11 (4):61-86.
    In The Future of Human Nature, Jürgen Habermas raises the question of whether the embryonic genetic diagnosis and genetic modification threatens the foundations of the species ethics that underlies current understandings of morality. While morality, in the normative sense, is based on moral interactions enabling communicative action, justification, and reciprocal respect, the reification involved in the new technologies may preclude individuals to uphold a sense of the undisposability of human life and the inviolability of human beings that is necessary for (...)
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  • The Concept of Harm and the Significance of Normality.Julian Savulescu Guy Kahane - 2012 - Journal of Applied Philosophy 29 (4):318-332.
    Many believe that severe intellectual impairment, blindness or dying young amount to serious harm and disadvantage. It is also increasingly denied that it matters, from a moral point of view, whether something is biologically normal to humans. We show that these two claims are in serious tension. It is hard explain how, if we do not ascribe some deep moral significance to human nature or biological normality, we could distinguish severe intellectual impairment or blindness from the vast list of seemingly (...)
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  • Back to Basics: Application of the Principles of Bioethics to Heritable Genome Interventions.Landon J. Getz & Graham Dellaire - 2020 - Science and Engineering Ethics 26 (5):2735-2748.
    Prior to their announcement of the birth of gene-edited twins in China, Dr. He Jiankui and colleagues published a set of draft ethical principles for discussing the legal, social, and ethical aspects of heritable genome interventions. Within this document, He and colleagues made it clear that their goal with these principles was to “clarify for the public the clinical future of early-in-life genetic surgeries” or heritable genome editing. In light of He’s widely criticized gene editing experiments it is of interest (...)
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  • Objectivity and human bioenhancement. The paradox of the natural.Francisco Güell, Luis Enrique Echarte & José Ignacio Murillo - 2019 - Scientia et Fides 7 (2):195-214.
    Para el transhumanismo, la humanidad es una etapa que, guiada por la evolución biológica, estuvo precedida por otras anteriores y a la que seguirán otras nuevas. Según el transhumanismo hemos de romper la inercia de causas ciegas que gobierna la evolución y, a través de la biotecnología, alcanzar lo que denominan una “vida mejor”. Los autores afines a esta corriente desarrollan sus propuestas negando la existencia de una naturaleza humana, pero sin abandonar la convicción de que resulta posible definir en (...)
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  • Enhancing justice?Tamara Garcia & Ronald Sandler - 2008 - NanoEthics 2 (3):277-287.
    This article focuses on the follow question: Are human enhancement technologies likely to be justice impairing or justice promoting? We argue that human enhancement technologies may not be inherently just or unjust, but when situated within obtaining social contexts they are likely to exacerbate rather than alleviate social injustices.
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  • La biología sintética y el imperativo de mejoramiento.Antonio Diéguez - 2016 - Isegoría 55:503.
    La biología sintética encierra un enorme potencial transformador de los organismos vivos, incluyendo en un futuro quizás no muy lejano la transformación del propio genoma humano. Son claras las conexiones que pueden establecerse entre este enorme potencial transformador y las pretensiones de los partidarios del biomejoramiento humano. La construcción de genomas completamente sintéticos puede cambiar de forma definitiva e irreversible aspectos fundamentales de la vida humana, quizás hasta el punto de dar lugar a un organismo que difiera de nuestra especie (...)
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  • Transcranial Direct Current Stimulation Use in Warfighting: Benefits, Risks, and Future Prospects.Steven E. Davis & Glen A. Smith - 2019 - Frontiers in Human Neuroscience 13.
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  • Genetic Enhancement and the Child’s Right to an Open Future.Davide Battisti - 2020 - Phenomenology and Mind 19 (19):212.
    In this paper, I analyze the ethical implications of genetic enhancement within the specific framework of the “child’s right to an open future” argument (CROF). Whilst there is a broad ethical consensus that genetic modifications for eradicating diseases or disabilities are in line with – or do not violate – CROF, there is huge disagreement about how to ethically understand genetic enhancement. Here, I analyze this disagreement and I provide a revised formulation of the argument in the specific field of (...)
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  • The case of transhumanism: The possibility of application of Nietzsche’s ethics and critique of morality today.Milos Agatonovic - 2018 - Filozofija I Društvo 29 (3):429-439.
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  • The ethics of doing human enhancement ethics.Jon Rueda - 2023 - Futures 153:103236.
    Human enhancement is one of the leading research topics in contemporary applied ethics. Interestingly, the widespread attention to the ethical aspects of future enhancement applications has generated misgivings. Are researchers who spend their time investigating the ethics of futuristic human enhancement scenarios acting in an ethically suboptimal manner? Are the methods they use to analyze future technological developments appropriate? Are institutions wasting resources by funding such research? In this article, I address the ethics of doing human enhancement ethics focusing on (...)
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  • Space travel does not constitute a condition of moral exceptionality. That which obtains in space obtains also on Earth!Maurizio Balistreri & Steven Umbrello - 2022 - Medicina E Morale 71 (3):311-321.
    There is a growing body of scholarship that is addressing the ethics, in particular, the bioethics of space travel and colonisation. Naturally, a variety of perspectives concerning the ethical issues and moral permissibility of different technological strategies for confronting the rigours of space travel and colonisation have emerged in the debate. Approaches ranging from genetically enhancing human astronauts to modifying the environments of planets to make them hospitable have been proposed as methods. This paper takes a look at a critique (...)
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  • From cognitive to moral enhancement: A possible reconciliation of religious outlooks and the biotechnological creation of a better human.Vojin Rakic - 2012 - Journal for the Study of Religions and Ideologies 11 (31):113-128.
    Religious outlooks on the use of new bio-technologies for the purpose of cognitive enhancement of humans are generally not favorably disposed to interventions in what is regarded as ordained by God or shaped by nature. I will present a number of perspectives that are derived from these outlooks and contrast them to the liberal standpoint. Subsequently, I will discuss two views that are compatible with religious outlooks, but that do not exclude cognitive enhancement altogether. They only pose significant moral limitations (...)
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  • (Christian) Bioethical Dilemmas in Using Synthetic Biology and Nanotechnologies.Antonio Sandu & Ana Caras - 2013 - Journal for the Study of Religions and Ideologies 12 (35):158-177.
    Ethical dilemmas raised by the use of nanotechnology in medical practice can be viewed from several perspectives: religious spiritualist perspective, the perspective of human dignity (nanotechnologies can be thought of as an affront to human dignity), the issue of controversial choice. The article aims to expose some bioethical dilemmas in using synthetic biology and nanotechnologies. Nowadays is often brought into discussion the fact it is possible to appear in the future new human species resulted not via natural selection and evolution, (...)
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  • The Ethics of Enhancement: Cognitive Inequalities and Sentient Animals.Olga Campos Serena - 2016 - Ramon Llull Journal of Applied Ethics 7 (7):71-91.
    What role should sentient animals play in the current debate on enhancement? The question covers several different philosophical fronts that demand urgent global ethical analysis. This touches issues that go from prohibition, permissivity or obligation that should characterize the new biotechnologies oriented to the enhancement of individuals, to the debate surrounding the moral rights of animals. Furthermore, the difficulty arises not only from the controversial moral categories involved, but also from the very extent of the objective proposed. However, this also (...)
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  • Stem Cell Research and Same Sex Reproduction.Thomas Douglas, Catherine Harding, Hannah Bourne & Julian Savulescu - 2012 - In Muireann Quigley, Sarah Chan & John Harris (eds.), Stem Cells: New Frontiers in Science and Ethics. World Scientific.
    Recent advances in stem cell research suggest that in the future it may be possible to create eggs and sperm from human stem cells through a process that we term in vitro gametogenesis (IVG). IVG would allow treatment of some currently untreatable forms of infertility. It may also allow same-sex couples to have genetically-related children. For example, cells taken from one man could potentially be used to create an egg, which could then be fertilised using naturally produced sperm from another (...)
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  • The moral psychology of Value Sensitive Design: the methodological issues of moral intuitions for responsible innovation.Steven Umbrello - 2018 - Journal of Responsible Innovation 5 (2):186-200.
    This paper argues that although moral intuitions are insufficient for making judgments on new technological innovations, they maintain great utility for informing responsible innovation. To do this, this paper employs the Value Sensitive Design (VSD) methodology as an illustrative example of how stakeholder values can be better distilled to inform responsible innovation. Further, it is argued that moral intuitions are necessary for determining stakeholder values required for the design of responsible technologies. This argument is supported by the claim that the (...)
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  • Los animales sensibles y la oportunidad de corregir las desigualdades cognitivas.Olga Campos Serena - 2017 - Daimon: Revista Internacional de Filosofía 70:97-114.
    Probablemente la mayor responsabilidad actual de la ética aplicada es hacerse cargo de las grandes dificultades teórico-prácticas generadas con el incipiente desarrollo de las nuevas tecnologías de biomejora. Dificultades más allá de las preferencias individuales, viéndose involucradas cuestiones en torno a nuestra comprensión de la justicia distributiva. La identificación de dos hechos importantes nos da la clave para orientar el debate. Por un lado, las situaciones de partida tan arbitrarias que proporciona la lotería natual con relación a las oportunidades de (...)
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