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  1. Resource Allocation, Treatment, Disclosure, and Mitochondrial Replacement Techniques: Some Comments on de Melo-Martin and Harris.César Palacios-gonzález - 2017 - Cambridge Quarterly of Healthcare Ethics 26 (2):278-287.
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  • Genethics and Human Reproduction: Religious Perspectives in the Academic Bioethics Literature.Aasim I. Padela & Mariel Kalkach Aparicio - 2019 - The New Bioethics 25 (2):153-171.
    The successes of the human genome project and genomics research programs portend great potential to improve upon health and enhance life. As scientific advancements continue, bioethicists and policy makers deliberate over the social and ethical implications of genetic and genomic technologies and information. The application of ggT/I to human reproduction raises conceptual and moral questions about being human and the links between offspring, parents, and society. Given ggT/I’s ability to significantly affect the biological constitution of humans and future human generations (...)
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  • Mitochondrial Donation and ‘the Right to Know’.Reuven Brandt - 2016 - Journal of Medical Ethics 42 (10):678-684.
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  • Genome Modifying Reproductive Procedures and Their Effects on Numerical Identity.Calum MacKellar - 2019 - The New Bioethics 25 (2):121-136.
    The advantages and risks of a number of new genome modifying procedures seeking to create healthy or enhanced individuals, such as Maternal Spindle Transfer, Pronuclear Transfer, Cytoplasmic Transfer and Genome Editing, are currently being assessed from an ethical perspective, by national and international policy organizations. One important aspect being examined concerns the effects of these procedures on different kinds of identity. In other words, whether or not a procedure only modifies the qualities or properties of an existing human being, meaning (...)
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  • Mitochondrial/Nuclear Transfer: A Literature Review of the Ethical, Legal and Social Issues.Raphaëlle Dupras-Leduc, Stanislav Birko & Vardit Ravitsky - 2018 - Canadian Journal of Bioethics / Revue canadienne de bioéthique 1 (2):1-17.
    Mitochondrial/nuclear transfer to avoid the transmission of serious mitochondrial disease raises complex and challenging ethical, legal and social issues. In February 2015, the United Kingdom became the first country in the world to legalize M/NT, making the heated debate surrounding this technology even more relevant. This critical interpretive review identified 95 relevant papers discussing the ELSI of M/NT, including original research articles, government-commissioned reports, editorials, letters to editors and research news. The review presents and synthesizes the arguments present in the (...)
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  • Lesbian Motherhood and Mitochondrial Replacement Techniques: Reproductive Freedom and Genetic Kinship.Giulia Cavaliere & César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):835-842.
    In this paper, we argue that lesbian couples who wish to have children who are genetically related to both of them should be allowed access to mitochondrial replacement techniques. First, we provide a brief explanation of mitochondrial diseases and MRTs. We then present the reasons why MRTs are not, by nature, therapeutic. The upshot of the view that MRTs are non-therapeutic techniques is that their therapeutic potential cannot be invoked for restricting their use only to those cases where a mitochondrial (...)
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  • Does Egg Donation for Mitochondrial Replacement Techniques Generate Parental Responsibilities?César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):817-822.
    Children created through mitochondrial replacement techniques are commonly presented as possessing 50% of their mother’s nuclear DNA, 50% of their father’s nuclear DNA and the mitochondrial DNA of an egg donor. This lab-engineered genetic composition has prompted two questions: Do children who are the product of an MRT procedure have three genetic parents? And, do MRT egg donors have parental responsibilities for the children created? In this paper, I address the second question and in doing so I also address the (...)
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  • Mitochondrial Replacement Techniques: Egg Donation, Genealogy and Eugenics.César Palacios-González - 2016 - Monash Bioethics Review 34 (1):37-51.
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  • Genome Editing and Assisted Reproduction: Curing Embryos, Society or Prospective Parents?Giulia Cavaliere - 2018 - Medicine, Health Care and Philosophy 21 (2):215-225.
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  • Resource Allocation, Treatment, Disclosure, and Mitochondrial Replacement Techniques.César Palacios-gonzález - 2017 - Cambridge Quarterly of Healthcare Ethics 26 (2):278-287.
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  • Are There Moral Differences Between Maternal Spindle Transfer and Pronuclear Transfer?César Palacios-González - 2017 - Medicine, Health Care and Philosophy 20 (4):503-511.
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  • Ethische Und Konzeptuelle Aspekte des Mitochondrien-Transfers Ethical and Conceptual Aspects of Mitochondrial Replacement Techniques.Giovanni Rubeis & Florian Steger - 2019 - Ethik in der Medizin 31 (2):143-158.
    ZusammenfassungDer weltweit erste Mitochondrien-Transfer, auch als Erzeugung eines „Drei-Eltern-Kindes“ bezeichnet, hat 2016 eine intensive Debatte ausgelöst. Hinsichtlich des Verfahrens, das bisher nur in Großbritannien zugelassen ist, werden auch verschiedene ethische Aspekte angesprochen. Dazu gehören die Risikoabwägung, die reproduktive Selbstbestimmung und die psychosoziale Entwicklung eines Kindes, das von drei Individuen abstammt. Dabei fällt auf, dass zentrale konzeptuelle Fragen hinsichtlich des Mitochondrien-Transfers nicht geklärt sind. Ist der Mitochondrien-Transfer eine genetische Intervention in die Keimbahn? Handelt es sich bei dem Verfahren um eine medizinisch (...)
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  • Should Mitochondrial Donation Be Anonymous?John B. Appleby - 2018 - Journal of Medicine and Philosophy 43 (2):261-280.
    Currently in the United Kingdom, anyone donating gametes has the status of an open-identity donor. This means that, at the age of 18, persons conceived with gametes donated since April 1, 2005 have a right to access certain pieces of identifying information about their donor. However, in early 2015, the UK Parliament approved new regulations that make mitochondrial donors anonymous. Both mitochondrial donation and gamete donation are similar in the basic sense that they involve the contribution of gamete materials to (...)
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  • What Is the Value of Three-Parent IVF?Tina Rulli - 2016 - Hastings Center Report 46 (4):38-47.
    In February 2016, the Institute of Medicine released a report, commissioned by the United States Food and Drug Administration, on the ethical and social-policy implications of so-called three-parent in vitro fertilization. The IOM endorses commencement of clinical trials on three-parent IVF, subject to some initial limitations. Also called mitochondrial replacement or transfer, three-parent IVF is an intervention comprising two distinct procedures in which the genetic materials of three people—the DNA of the father and mother and the mitochondrial DNA of an (...)
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