Abstract
Gregory of Nyssa’s treatise 'De opificio hominis' was one of the only Greek anthropological texts translated into latin during the early Middle Ages, by Dionysius Exiguus between the late 5th and early 6th centuries and by John Scotus Eriugena in the 9th century. Nicholas of Cusa certainly became acquainted with this work indirectly through the extensive citations in Eriugena’s 'Periphyseon' and through their partial reproduction in the 'Clavis physicae' of Honorius Augustodunensis. Our paper will analyse these and other possible ways of reception –both direct and indirect– of Gregory's text by Cusanus, as well as the influence of certain philosophical themes of Nyssen’s anthropology in his thought, such as the conception of the 'imago Dei', of its ‘living’ character and its simplicity, the incomprehensibility of human intellect or mind (noûs) and theories regarding human free will and man as microcosm.