I present an account of classical genetics to challenge theory-biased approaches in the philosophy of science. Philosophers typically assume that scientific knowledge is ultimately structured by explanatory reasoning and that research programs in well-established sciences are organized around efforts to fill out a central theory and extend its explanatory range. In the case of classical genetics, philosophers assume that the knowledge was structured by T. H. Morgan’s theory of transmission and that research throughout the later 1920s, 30s, and 40s was (...) organized around efforts to further validate, develop, and extend this theory. I show that classical genetics was structured by an integration of explanatory reasoning and investigative strategies . The investigative strategies, which have been overlooked in historical and philosophical accounts, were as important as the so-called laws of Mendelian genetics. By the later 1920s, geneticists of the Morgan school were no longer organizing research around the goal of explaining inheritance patterns; rather, they were using genetics to investigate a range of biological phenomena that extended well beyond the explanatory domain of transmission theories. Theory-biased approaches in history and philosophy of science fail to reveal the overall structure of scientific knowledge and obscure the way it functions.Author Keywords: Investigation; Genetic approach; Structure of knowledge; Classical genetics. (shrink)

This paper investigates what molecular biology has done for our understanding of the gene. I base a new account of the gene concept of classical genetics on the classical dogma that gene differences cause phenotypic differences. Although contemporary biologists often think of genes in terms of this concept, molecular biology provides a second way to understand genes. I clarify this second way by articulating a molecular gene concept. This concept unifies our understanding of the molecular basis of a wide variety (...) of phenomena, including the phenomena that classical genetics explains in terms of gene differences causing phenotypic differences. (shrink)

In this paper I provide a novel argument against the claim that classical genetics is being reduced to molecular genetics. Specifically, I demonstrate that reductionists must subscribe to the unargued and problematic thesis that molecular genetics is 'independent' of classical genetics. I also argue that several standard antireductionist positions can be faulted for unnecessarily conceding the Independence Thesis to the reductionists. In place of a 'tale of two sciences', I offer a 'heroic' stance that denies classical genetics is being reduced, (...) yet sees classical and molecular genetics as fundamentally unified. (shrink)

What is a natural kind? As we shall see, the concept of a natural kind has a long history. Many of the interesting doctrines can be detected in Aristotle, were revived by Locke and Leibniz, and have again become fashionable in recent years. Equally there has been agreement about certain paradigm examples: the kinds oak, stickleback and gold are natural kinds, and the kinds table, nation and banknote are not. Sadly agreement does not extend much further. It is impossible to (...) discover a single consistent doctrine in the literature, and different discussions focus on different doctrines without writers or readers being aware of the fact. In this paper I shall attempt to find a defensible distinction between natural and non-natural kinds. (shrink)

Stuart Glennan, and the team of Peter Machamer, Lindley Darden, and Carl Craver have recently provided two accounts of the concept of a mechanism. The main difference between these two versions rests on how the behavior of the parts of the mechanism is conceptualized. Glennan considers mechanisms to be an interaction of parts, where the interaction between parts can be characterized by direct, invariant, change-relating generalizations. Machamer, Darden, and Craver criticize traditional conceptualizations of mechanisms which are based solely on parts (...) interacting and introduce a new conceptactivity. This essay is an attempt at carving out a relationship between these two philosophical interpretations of a mechanism. I will claim that, rather than being in conflict, Glennan's concept of interaction and Machamer, Darden, and Craver's notion of activity actually complement one another, each emphasizing a missing element of the other. (shrink)

Philosophers and historians of biology have argued that genes are conceptualized differently in different fields of biology and that these differences influence both the conduct of research and the interpretation of research by audiences outside the field in which the research was conducted. In this paper we report the results of a questionnaire study of how genes are conceptualized by biological scientists at the University of Sydney, Australia. The results provide tentative support for some hypotheses about conceptual differences between different (...) fields of biological research. (shrink)

In this paper I develop three conceptions of the relationship between evolutionary and developmental biology. I further argue that: (a) the choice between them largely turns on as yet unresolved empirical considerations; (b) none of these conceptions demand a fundamental conceptual reevaluation of evolutionary biology; and (c) while developmental systems theorists have constructed an important and innovative alternative to the standard view of the genotype/phenotype relations, in considering the general issue of the relationship between evolutionary and developmental biology, we can (...) remain neutral on this debate. (shrink)

This chapter aims to resolve some of Nathan Salmon's puzzlement by clarifying the relationship between theses and questions about reference and theses and questions about necessity and possibility. It argues that while Saul Kripke defends metaphysical theses about the descriptive semantics of names, the way the reference relation is determined, and the capacities and dispositions of human beings and physical objects, his most important philosophical accomplishment is in the way he posed and clarified the questions, and not in the particular (...) answers that he gave to them. In response to the question about the capacities and potentialities of the things that peoples commonly refer to with names, Kripke defends the thesis that it makes sense to talk about the logical potential of an individual thing independently of how it is referred to, and that this potential is greater in certain ways, and less great in others, than some philosophers have supposed. (shrink)

I argue for accepting a pluralist approach to species, while rejecting the realism about species espoused by P. Kitcher and a number of other philosophers of biology. I develop an alternative view of species concepts as divisions of organisms into groups for study which are relative to the systematic explanatory interests of biologists at a particular time. I also show how this conception resolves a number of difficult puzzles which plague the application of particular species concepts.

The Nature of Selection is a straightforward, self-contained introduction to philosophical and biological problems in evolutionary theory. It presents a powerful analysis of the evolutionary concepts of natural selection, fitness, and adaptation and clarifies controversial issues concerning altruism, group selection, and the idea that organisms are survival machines built for the good of the genes that inhabit them. "Sober's is the answering philosophical voice, the voice of a first-rate philosopher and a knowledgeable student of contemporary evolutionary theory. His book merits (...) broad attention among both communities. It should also inspire others to continue the conversation."-Philip Kitcher, Nature "Elliott Sober has made extraordinarily important contributions to our understanding of biological problems in evolutionary biology and causality. The Nature of Selection is a major contribution to understanding epistemological problems in evolutionary theory. I predict that it will have a long lasting place in the literature."-Richard C. Lewontin. (shrink)

In this essay I defend meaning holism against certain criticisms that Jerry Fodor has presented against it. In "Psychosemantics" he argued that meaning holism is incompatible with the development of scientific psychology given the ways in which scientific psychology adverts to intentional content. In his recent book "Holism" (co-authored with Ernest Lepore) he indicates that he still upholds this argument. I argue that Fodor's argument fails, and argue in favor of the compatibility of meaning holism with scientific psychology. I also (...) argue positively in favor of meaning holism, arguing in part that, contrary to Fodor's claims, psychofunctionalism provides a strong basis for defending meaning holism. As part of this argument, I contend, contrary to Fodor, that narrow content, as derived from psychofunctionalism, should be construed as semantic. (shrink)

This paper examines the "causal theory of reference", according to which science aims at the discovery of "essences" which are the objects of reference of natural kind terms (among others). This theory has been advanced as an alternative to traditional views of "meaning", on which a number of philosophical accounts of science have relied, and which have been criticized earlier by the present author. However, this newer theory of reference is shown to be equally subject to fatal internal difficulties, and (...) to be incompatible with actual science as well. Indeed, it rests on assumptions which it shares with the purportedly opposing theory of meaning. Behind those common assumptions is the supposition that the nature of science can be illuminated by an examination of alleged necessities of language which are independent of the results and methods of scientific inquiry. An alternative view of science is proposed, according to which the goals and language of science develop as integral parts of the process of demarcating science from non-science, a process in which the notion of a "reason" gradually assumes a decisive role. On this view, the comparability, competition, and development of scientific ideas are understood without reliance on either common "meanings" or common "references" as fundamental tools of analysis. (shrink)

The alleged problem of "incommensurability" is examined, and attempts to explain scientific change in terms of concepts of meaning and reference are analyzed and rejected. A way of understanding scientific change through a properly developed concept of "reasons" is presented, and the issues of reasons, meaning, and reference are placed in the context of this broader interpretation of scientific change.

1. It seems plausible to say that a language is a system of expressions the use of which is subject to certain rules. It would seem, thus, that learning to use a language is learning to obey the rules for the use of its expressions. However, taken as it stands, this thesis is subject to an obvious and devastating refutation. After formulating this refutation, I shall turn to the constructive task of attempting to restate the thesis in a way which (...) avoids it. In doing so, I shall draw certain distinctions the theoretical elaboration of which will, I believe, yield new insight into the psychology of language and of what might be called “norm conforming behavior” generally. The present paper contains an initial attempt along these lines. (shrink)

Formal implication is usually represented by symbolization such as ‘ φx ⊃ Ψx,’ which may be read, “for all values of ‘x’, φx implies Ψx.” If the values of the variable ‘x’, in ‘φx’ and ‘Ψx’ be ‘x1’ ‘x2’ ‘x3’, etc., then … ‘φx’ formally implies ‘Ψx’ if and only if, whatever values of ‘x’, ‘xn’, be chosen, ‘φxn’ materially implies ‘Ψxn’ …However, this still leaves it doubtful which of two possible interpretations of expressions having the form ‘ φx ⊃ (...) Ψx’ is to be taken as correct. … It means one thing to say, “Every existent having the property φ … has also the property Ψ,” and it means quite a different thing to say, “Every thinkable thing which should have the property φ must also have the property Ψ.” The second of these holds only when having the properly φ logically entails having the property Ψ; when ‘Ψx’ is deductible from ‘φx’. … The first of them, however, holds not only in such cases … but also in every case where among existent things, one property is universally accompanied by another. (shrink)

The book, written in a clear, engaging style, contains four chapters.

I have not attempted to provide here an analysis of the methodology of molecular biology or molecular genetics which would demonstrate at what specific points a more reductionist aim would make sense as a research strategy. This, I believe, would require a much deeper analysis of scientific growth than philosophy of science has been able to provide thus far. What I have tried to show is that a straightforward reductionist strategy cannot be said to be follwed in important cases of (...) theory development in molecular biology, and that in at least one important case, the Jacob-Monod operon theory, the methodology followed was more biological than chemical. It should be noted in closing, however, that since biological systems are thought by molecular biologists to be nothing but chemical systems, in the long run detailed investigations of such systems will be in full accord with the dictates suggested by the general reduction model. (shrink)

It seems that the above account of explanation-strategy in the area of temperature adaptation underscores many of the points made earlier. First, it discloses the fruitful interaction of classical, evolutionary, and molecular approaches. Secondly, it indicates that biological characterizations are not rival accounts to chemical ones. Thirdly, it stresses the importance of the DNA sequence order in chemical explanations of biological organisms.One feature which this area does not seem to reveal, which genetics does, is the development of a biological (that (...) is, non-chemical) theory which would explain temperature adaptation in nonchemical terms. What this shows is that one should not always expect systematization at the biological level, in the sense of being able to refer many phenomena to a small number of basic principles. The future development of laws and theories in biological terms in this area is, of course, not precluded by the fact that none have yet been discovered. The case does indicate that physical and chemical language and theories are extremely useful in biological investigations, and the physicochemical approach may well be the best approach in this area. In any event, ultimate reduction of the biological to the chemical seems to be a foregone non-controversial conclusion here as elsewhere. (shrink)

In the above pages I have sketched a history of the genesis and comparative evaluation of the repressor model of genetic regulation of enzyme induction. I have not attempted in this article to carry out an analysis of the more scientifically interesting fully developed Jacob-Monod operon theory of genetic regulations but such an analysis of the operon theory would not, I believe, involve any additional logical or epistemological features than have been discussed above. I have argued that the above account (...) of the development of a theory of enzyme induction involved inferential moves and well-characterized desiderata, of both empirical and non-empirical character, in the genesis and evaluation of new hypotheses and theories. I have also contended that the reasoning displayed in the genesis of a theory is in a large measure identical to that utilized in evaluating a theory. Both of these conclusions are at variance with the views of philosophers such as H. Reichenbach, Sir Karl Popper, and C.G. Hempel who have argued that the genesis of new hypotheses is primarily an irrational affair and that only the context of justification is susceptible of rational reconstruction. In the alternative view presented here, scientific discovery and scientific justification represent the application in contexts, which are primarily telically distinguishable, of a fundamentally unitary logic of scientific inquiry. (shrink)

Four current accounts of theory reduction are presented, first informally and then formally: (1) an account of direct theory reduction that is based on the contributions of Nagel, Woodger, and Quine, (2) an indirect reduction paradigm due to Kemeny and Oppenheim, (3) an "isomorphic model" schema traceable to Suppes, and (4) a theory of reduction that is based on the work of Popper, Feyerabend, and Kuhn. Reference is made, in an attempt to choose between these schemas, to the explanation of (...) physical optics by Maxwell's electromagnetic theory, and to the revisions of genetics necessitated by partial biochemical reductions of genetics. A more general reduction schema is proposed which: (1) yields as special cases the four reduction paradigms considered above, (2) seems to be in better accord with both the canons of logic and actual scientific practice, and (3) clarifies the problems of meaning variance and ontological reduction. (shrink)

A classification of models of reduction into three categories — theory reductionism, explanatory reductionism, and constitutive reductionism — is presented. It is shown that this classification helps clarify the relations between various explications of reduction that have been offered in the past, especially if a distinction is maintained between the various epistemological and ontological issues that arise. A relatively new model of explanatory reduction, one that emphasizes that reduction is the explanation of a whole in terms of its parts is (...) also presented in detail. Finally, the classification is used to clarify the debate over reductionism in molecular biology. It is argued there that while no model from the category of theory reduction might be applicable in that case, models of explanatory reduction might yet capture the structure of the relevant explanations. (shrink)

Maynard Smith notes that he provides a natural history and not a philosophical analysis of the use of concepts of information in contemporary biology. Just a natural history, however rich, would do little to resolve the ongoing controversy about the role of these concepts in biology. None of the disputants deny that the biological use of these concepts is pervasive. The dispute is about whether these concepts—and the framework in which they are embedded—continue to be of explanatory value in contemporary (...) biology. Fortunately, Maynard Smith does much more than provide a natural history: his contribution is also a sustained attempt to justify many of the uses of information in biology. (shrink)

This paper argues that the consensus physicalist antireductionism in the philosophy of biology cannot accommodate the research strategy or indeed the recent findings of molecular developmental biology. After describing Wolperts programmatic claims on its behalf, and recent work by Gehring and others to identify the molecular determinants of development, the paper attempts to identify the relationship between evolutionary and developmental biology by reconciling two apparently conflicting accounts of bio-function – Wrights and Nagels (as elaborated by Cummins). Finally, the paper seeks (...) a way of defending the two central theses of physicalist antireductionism in the light of the research program of molecular developmental biology, by sharply reducing their metaphysical force. (shrink)

Evolutionary developmental biology (evo-devo) offers both an account of developmental processes and also new integrative frameworks for analyzing interactions between development and evolution. Biologists and philosophers are keen on evo-devo in part because it appears to offer a comfort zone between, on the one hand, what some take to be the relative inability of mainstream evolutionary biology to integrate a developmental perspective; and, on the other hand, what some take to be more intractable syntheses of development and evolution. In this (...) article, I outline core concerns of evo-devo, distinguish theoretical and practical variants, and counter Sterelny's recent argument that evo-devo's attention to development, while important, offers no significant challenge to evolutionary theory as we know it. (shrink)