Between 1940 and 1970 pioneers in the new field of cell biology discovered the operative parts of cells and their contributions to cell life. They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. Cell biology was a revolutionary science but in this book it also provides fuel for yet another revolution, one that focuses on (...) the very conception of science itself. Laws have traditionally been regarded as the primary vehicle of explanation, but in the emerging philosophy of science it is mechanisms that do the explanatory work. Bechtel emphasises how mechanisms were discovered, focusing especially on the way in which new instruments made these inquiries possible. He also describes how new journals and societies provided institutional structure to this new enterprise. (shrink)

The present paper surveys the three most prominent accounts in contemporary debates over how sound reduction should be executed. The classical Nagelian model of reduction derives the laws of the target-theory from the laws of the base theory plus some auxiliary premises (so-called bridge laws) connecting the entities of the target and the base theory. The functional model of reduction emphasizes the causal definitions of the target entities referring to their causal relations to base entities. The new-wave model of reduction (...) deduces not the original target theory but an analogous image of it, which remains inside the vocabulary of the base theory. One of the fundamental motivations of both the functional and the new-wave model is to show that bridge laws can be evaded. The present paper argues that bridge laws—in the original Nagelian sense—are inevitable, i.e. that none of these models can evade them. On the one hand, the functional model of reduction needs bridge laws, since its fundamental concept, functionalization, is an inter-theoretical process dealing with entities of two different theories. Theoretical entities of different theories (in a general heterogeneous case) do not have common causal relations, so the functionalization of an entity—without bridge laws—can only be executed in the framework of its own theory. On the other hand, the so-called images of the new-wave account cannot be constructed without the use of bridge laws. These connecting principles are needed to guide the process of deduction within the base theory; without them one would not be able to recognize if the deduced structure was an image of the target theory. (shrink)

In Physical Realization, Sydney Shoemaker considers the question of how physicalism can be true: how can all facts about the world, including mental ones, be constituted by facts about the distribution in the world of physical properties? Physicalism requires that the mental properties of a person are 'realized in' the physical properties of that person, and that all instantiations of properties in macroscopic objects are realized in microphysical states of affairs. Shoemaker offers an account of both these sorts of realization, (...) one which allows the realized properties to be causally efficacious. He also explores the implications of this account for a wide range of metaphysical issues, including the nature of persistence through time, the problem of material constitution, the possibility of emergent properties, and the nature of phenomenal consciousness. (shrink)

Philosophy and Neuroscience: A Ruthlessly Reductive Account is the first book-length treatment of philosophical issues and implications in current cellular and molecular neuroscience. John Bickle articulates a philosophical justification for investigating "lower level" neuroscientific research and describes a set of experimental details that have recently yielded the reduction of memory consolidation to the molecular mechanisms of long-term potentiation (LTP). These empirical details suggest answers to recent philosophical disputes over the nature and possibility of psycho-neural scientific reduction, including the multiple realization (...) challenge, mental causation, and relations across explanatory levels. Bickle concludes by examining recent work in cellular neuroscience pertaining to features of conscious experience, including the cellular basis of working memory, the effects of explicit selective attention on single-cell activity in visual cortex, and sensory experiences induced by cortical microstimulation. (shrink)

The 'completeness of physics' is the key premise in the causal argument for physicalism. Standard formulations of it fail to rule out emergent downwards causation. I argue that it must do this if it is tare in a valid causal argument for physicalism. Drawing on the notion of conferring causal power, I formulate a suitable principle, 'strong completeness'. I investigate the metaphysical implications of distinguishing this principle from emergent downwards causation, and I argue that categoricalist accounts of properties are better (...) equipped to sustain the distinction than dispositional essentialist accounts. Finally, I argue that the additional evidence needed for strong completeness renders the causal argument otiose for any properties amenable to scientific reduction. (shrink)

Carl Craver investigates what we are doing when we sue neuroscience to explain what's going on in the brain.

Most philosophical accounts of causation take causal relations to obtain between individuals and events in virtue of nomological relations between properties of these individuals and events. Such views fail to take into account the consequences of the fact that in general the properties of individuals and events will depend upon mechanisms that realize those properties. In this paper I attempt to rectify this failure, and in so doing to provide an account of the causal relevance of higher-level properties. I do (...) this by critiquing one prominent model of higher-level properties—Kim’s functional model of reduction—and contrasting it with a mechanistic approach to higher-level properties and causation. (shrink)

Our best philosophical and scientific pictures of the world organize material objects into a hierarchy or levels or layers- microparticles at the bottom, molecules, cells, and persons at higher layers. Are objects at higher layers identical to the sums of objects at lower layers that constitute them? (Note that this question is different from the question of whether composition- as opposed to constitution- is identity.).

In this paper I offer an analysis of causation based upon a theory of mechanisms-complex systems whose internal parts interact to produce a system's external behavior. I argue that all but the fundamental laws of physics can be explained by reference to mechanisms. Mechanisms provide an epistemologically unproblematic way to explain the necessity which is often taken to distinguish laws from other generalizations. This account of necessity leads to a theory of causation according to which events are causally related when (...) there is a mechanism that connects them. I present reasons why the lack of an account of fundamental physical causation does not undermine the mechanical account. (shrink)

Reductionism is a central issue in the philosophy of biology. One common objection to reduction is that molecular explanation requires reference to higher-level properties, which I refer to as the context objection. I respond to this objection by arguing that a well-articulated notion of a mechanism and what I term mechanism extension enables one to accommodate the context-dependence of biological processes within a reductive explanation. The existence of emergent features in the context could be raised as an objection to the (...) possibility of reduction via this strategy. I argue that this objection can be overcome by showing that there is no tenable argument for the existence of emergent properties that are not susceptible to a reductive explanation. (shrink)

We argue that intelligible appeals to interlevel causes (top-down and bottom-up) can be understood, without remainder, as appeals to mechanistically mediated effects. Mechanistically mediated effects are hybrids of causal and constitutive relations, where the causal relations are exclusively intralevel. The idea of causation would have to stretch to the breaking point to accommodate interlevel causes. The notion of a mechanistically mediated effect is preferable because it can do all of the required work without appealing to mysterious interlevel causes. When interlevel (...) causes can be translated into mechanistically mediated effects, the posited relationship is intelligible and should raise no special philosophical objections. When they cannot, they are suspect. (shrink)

As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot (...) explain cognition and complex behavior directly. These experimental practices involve intervening directly with molecular components of sub-cellular and gene expression pathways in neurons and then measuring specific behaviors. These behaviors are tracked using tests that are widely accepted by experimental psychologists to study the psychological phenomenon at issue (e.g., memory, attention, and perception). Here I illustrate these practices and their importance for explanation and reduction in current mainstream neuroscience by describing recent work on social recognition memory in mammals. (shrink)

The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.

You are asked to call out the letters on a chart during an eyeexamination: you see and then read out the letters ‘U’, ‘R’, and ‘X’. Commonsense says that your perceptual experiences causally control your calling out the letters. Or suppose you are playing a game of chess intent on winning: you plan your strategy and move your chess pieces accordingly. Again, commonsense says that your intentions and plans causally control your moving the chess pieces. These causal judgements are as (...) plain and evident as any can be. (shrink)

Several theories of emergence will be distinguished. In particular, these are synchronic, diachronic, and weak versions of emergence. While the weaker theories are compatible with property reductionism, synchronic emergentism and strong versions of diachronic emergentism are not. Synchronice mergentism is of particular interest for the discussion of downward causation. For such a theory, a system's property is taken to be emergent if it is irreducible, i.e., if it is not reductively explainable. Furthermore, we have to distinguish two different types of (...) irreducibility with quite different consequences: If, on the one hand, a system's property is irreducible because of the irreducibility of the system's parts' behavior on which the property supervenes, we seem to have a case of "downward causation". This kind of downward causation does not violate the principle of the causal closure of the physical domain. If, on the other hand, a systemic property is irreducible because it is not exhaustively analyzable in terms of its causal role, downward causation is not implied. Rather, it is dubitable how unanalyzable properties might play any causal role at all. Thus, epiphenomenalism seems to be implied. The failure to keep apart the two kinds of irreducibility has muddled recent debate about the emergence of properties considerably. (shrink)

1. A Historical Look at Unity 2. Field Guide to Modern Concepts of Reduction and Unity 3. Kitcher's Revisionist Account of Unification 4. Critics of Unity 5. Integration Instead of Unity 6. Reduction via Mechanisms 7. Case Studies in Reduction and Unification across the Disciplines.

Weak emergence has been offered as an explication of the ubiquitous notion of emergence used m complexity science After outlining the problem of emergence and comparing weak emergence with the two other weak objectivist approaches to emergence, the paper explains a version of weak emergence and illustrates at with cellular automata Then it explains the sort of downward causation and explanatory autonomy involved m weak emergence.

Let thin properties be properties shared by coincident entities, e.g., a person and her body, and thick properties ones that are not shared. Thick properties entail sortal properties, e.g., being a person, and the associated persistence conditions. On the first account of realization defined here, the realized property and its realizers will belong to the same individual. This restricts the physical realizers of mental properties, which are thick, to thick physical properties. We also need a sense in which mental properties (...) can be realized in thin physical properties shared by a person and her body. Defining this in turn requires defining a sense in which the instantiations of sortal properties and of thick properties are realized in micro‐structural states of affairs. A fourth notion of realization is needed to allow for the possibility of coincident entities that share a sortal property, e.g., coincident persons. (shrink)

A variety of scientific disciplines have set as their task explaining mental activities, recognizing that in some way these activities depend upon our brain. But, until recently, the opportunities to conduct experiments directly on our brains were limited. As a result, research efforts were split between disciplines such as cognitive psychology, linguistics, and artificial intelligence that investigated behavior, while disciplines such as neuroanatomy, neurophysiology, and genetics experimented on the brains of non-human animals. In recent decades these disciplines integrated, and with (...) the advent of techniques for imaging activity in human brains, the term cognitive neuroscience has been applied to the integrated investigations of mind and brain. This book is a philosophical examination of how these disciplines continue in the mission of explaining our mental capacities. (shrink)

Between 1940 and 1970 pioneers in the new field of cell biology discovered the operative parts of cells and their contributions to cell life. They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. Cell biology was a revolutionary science but in this book it also provides fuel for yet another revolution, one that focuses on (...) the very conception of science itself. Laws have traditionally been regarded as the primary vehicle of explanation, but in the emerging philosophy of science it is mechanisms that do the explanatory work. Bechtel emphasises how mechanisms were discovered, focusing especially on the way in which new instruments made these inquiries possible. He also describes how new journals and societies provided institutional structure to this new enterprise. (shrink)

The claim of the multiple realizability of mental states by brain states has been a major feature of the dominant philosophy of mind of the late 20th century. The claim is usually motivated by evidence that mental states are multiply realized, both within humans and between humans and other species. We challenge this contention by focusing on how neuroscientists differentiate brain areas. The fact that they rely centrally on psychological measures in mapping the brain and do so in a comparative (...) fashion undercuts the likelihood that, at least within organic life forms, we are likely to find cases of multiply realized psychological functions. (shrink)

Many areas of science develop by discovering mechanisms and role functions. Cummins' (1975) analysis of role functions-according to which an item's role function is a capacity of that item that appears in an analytic explanation of the capacity of some containing system-captures one important sense of "function" in the biological sciences and elsewhere. Here I synthesize Cummins' account with recent work on mechanisms and causal/mechanical explanation. The synthesis produces an analysis of specifically mechanistic role functions, one that uses the characteristic (...) active, spatial, temporal, and hierarchical organization of mechanisms to add precision and content to Cummins' original suggestion. This synthesis also shows why the discovery of role functions is a scientific achievement. Discovering a role function (i) contributes to the interlevel integration of multilevel mechanisms, and (ii) provides a unique, contextual variety of causal/mechanical explanation. (shrink)

Arguments for the autonomy of psychology or other higher-level sciences have often taken the form of denying the possibility of reduction. The form of reduction most proponents and critics of the autonomy of psychology have in mind is theory reduction. Mechanistic explanations provide a different perspective. Mechanistic explanations are reductionist insofar as they appeal to lower-level entities—the component parts of a mechanism and their operations— to explain a phenomenon. However, unlike theory reductions, mechanistic explanations also recognize the fundamental role of (...) organization in enabling mechanisms to engage their environments as units (as well as the role of yet higher-level structures in constraining such engagement). Especially when organization is non-linear, it can enable mechanisms to generate phenomena that are quite surprising given the operations of the components taken in isolation. Such organization must be discovered—it cannot simply be derived from knowledge of lower-level parts and their operations. Moreover, the organized environments in which mechanisms operate must also be discovered. It is typically the higher-level disciplines that have the tools for discovering the organization within and between mechanisms. Although these inquiries are constrained by the knowledge of the parts and operations constituting the mechanism, they make their own autonomous contribution to understanding how a mechanism actually behaves. Thus, mechanistic explanations provide a strong sense of autonomy for higher levels of organization and the inquiries addressing them even while recognizing the distinctive contributions of reductionistic research investigating the operations of the lower level components. (shrink)

Weak emergence has been offered as an explication of the ubiquitous notion of emergence used in complexity science (Bedau 1997). After outlining the problem of emergence and comparing weak emergence with the two other main objectivist approaches to emergence, this paper explains a version of weak emergence and illustrates it with cellular automata. Then it explains the sort of downward causation and explanatory autonomy involved in weak emergence.