What is the relationship between pain and the body? I claim that pain is best explained as a type of personal experience and the bodily response during pain is best explained in terms of a type of mechanical neurophysiologic operation. I apply the radical philosophy of identity theory from philosophy of mind to the relationship between the personal experience of pain and specific neurophysiologic mechanism and argue that the relationship between them is best explained as one of type identity. Specifically, (...) pain is a specific type of personal experience identical to a specific type of allostatic stress response comprised of interdependent nervous, endocrine and immune mechanical operations. (shrink)

Chronobiology, especially the study of circadian rhythms, provides a model scientific field in which philosophers can study how investigators from a variety of disciplines working at different levels of organization are each contributing to a multi-level account of the responsible mechanism. I focus on how the framework of mechanistic explanation integrates research designed to decompose the mechanism with efforts directed at recomposition that relies especially on computation models. I also examine how recently the integration has extended beyond basic research to (...) the processes through which the disruption of circadian rhythms contributes to disease, including various forms of cancer. Understanding these linkages has been facilitated by discoveries about how circadian mechanisms interact with mechanisms involved in other physiological processes, including the cell cycle and the immune system. (shrink)

This paper tracks the commitments of mechanistic explanations focusing on the relation between activities at different levels. It is pointed out that the mechanistic approach is inherently committed to identifying causal connections at higher levels with causal connections at lower levels. For the mechanistic approach to succeed a mechanism as a whole must do the very same thing what its parts organised in a particular way do. The mechanistic approach must also utilise bridge principles connecting different causal terms of different (...) theoretical vocabularies in order to make the identities of causal connections transparent. These general commitments get confronted with two claims made by certain proponents of the mechanistic approach: William Bechtel often argues that within the mechanistic framework it is possible to balance between reducing higher levels and maintaining their autonomy at the same time, whereas, in a recent paper, Craver and Bechtel argue that the mechanistic approach is able to make downward causation intelligible. The paper concludes that the mechanistic approach imbued with identity statements is no better candidate for anchoring higher levels to lower ones while maintaining their autonomy at the same time than standard reductive accounts are, and that what mechanistic explanations are able to do at best is showing that downward causation does not exist. (shrink)

This essay analyzes and develops recent views about explanation in biology. Philosophers of biology have parted with the received deductive-nomological model of scientific explanation primarily by attempting to capture actual biological theorizing and practice. This includes an endorsement of different kinds of explanation (e.g., mathematical and causal-mechanistic), a joint study of discovery and explanation, and an abandonment of models of theory reduction in favor of accounts of explanatory reduction. Of particular current interest are philosophical accounts of complex explanations that appeal (...) to different levels of organismal organization and use contributions from different biological disciplines. The essay lays out one model that views explanatory integration across different disciplines as being structured by scientific problems. I emphasize the philosophical need to take the explanatory aims pursued by different groups of scientists into account, as explanatory aims determine whether different explanations are competing or complementary and govern the dynamics of scientific practice, including interdisciplinary research. I distinguish different kinds of pluralism that philosophers have endorsed in the context of explanation in biology, and draw several implications for science education, especially the need to teach science as an interdisciplinary and dynamic practice guided by scientific problems and explanatory aims. (shrink)

In the context of mechanistic explanation, reductionistic research pursues a decomposition of complex systems into their component parts and operations. Using research on the mechanisms responsible for circadian rhythms, I consider both the gains that have been made by discovering genes and proteins that figure in these intracellular oscillators and also highlight the increasingly recognized need to understand higher-level integration, both between cells in the central oscillator and between the central and peripheral oscillators. This history illustrates a common need to (...) complement reductionistic inquiry with investigations at higher-levels. Unlike most other accounts of reduction, the mechanistic framework accommodates this complementary relationship between reductionistic and systems approaches. (shrink)

Arguments for the autonomy of psychology or other higher-level sciences have often taken the form of denying the possibility of reduction. The form of reduction most proponents and critics of the autonomy of psychology have in mind is theory reduction. Mechanistic explanations provide a different perspective. Mechanistic explanations are reductionist insofar as they appeal to lower-level entities—the component parts of a mechanism and their operations— to explain a phenomenon. However, unlike theory reductions, mechanistic explanations also recognize the fundamental role of (...) organization in enabling mechanisms to engage their environments as units (as well as the role of yet higher-level structures in constraining such engagement). Especially when organization is non-linear, it can enable mechanisms to generate phenomena that are quite surprising given the operations of the components taken in isolation. Such organization must be discovered—it cannot simply be derived from knowledge of lower-level parts and their operations. Moreover, the organized environments in which mechanisms operate must also be discovered. It is typically the higher-level disciplines that have the tools for discovering the organization within and between mechanisms. Although these inquiries are constrained by the knowledge of the parts and operations constituting the mechanism, they make their own autonomous contribution to understanding how a mechanism actually behaves. Thus, mechanistic explanations provide a strong sense of autonomy for higher levels of organization and the inquiries addressing them even while recognizing the distinctive contributions of reductionistic research investigating the operations of the lower level components. (shrink)

As much as assumptions about mechanisms and mechanistic explanation have deeply affected psychology, they have received disproportionately little analysis in philosophy. After a historical survey of the influences of mechanistic approaches to explanation of psychological phenomena, we specify the nature of mechanisms and mechanistic explanation. Contrary to some treatments of mechanistic explanation, we maintain that explanation is an epistemic activity that involves representing and reasoning about mechanisms. We discuss the manner in which mechanistic approaches serve to bridge levels rather than (...) reduce them, as well as the different ways in which mechanisms are discovered. Finally, we offer a more detailed example of an important psychological phenomenon for which mechanistic explanation has provided the main source of scientific understanding. (shrink)

Resumen En el marco de la filosofía de la mente, este artículo aborda el problema de la causación mental en el proyecto naturalista biológico de John Searle. A partir de la concepción de la mente como un fenómeno emergente de procesos cerebrales, evalúo las críticas que Jaegwon Kim realiza a la eficacia causal de la consciencia, centrándome en los argumentos de sobredeterminación y violación del principio de clausura físico causal. Luego analizo el debate de la causación mental a partir de (...) los descubrimientos de Benjamin Libet respecto a la existencia de actividad neuronal pre-consciente en la conducta motora voluntaria. Dicha actividad, llamada potencial de preparación, junto a la noción de causación trabajada en neurociencia, avala la eficacia causal de los estados mentales, pero en un sentido distinto al propuesto por Searle.Within the framework of philosophy of mind, this paper addresses the problem of mental causation in John Searle's biological naturalist project. Beginning with the conception of the mind as a phenomenon emerging from cerebral processes, I evaluate the criticisms that Jaegwon Kim makes to the causal efficacy of consciousness, focusing on the arguments of overdetermination and violation of the principle of physical causal closure. Then, I analyze the debate on mental causation from the findings of Benjamin Libet regarding the existence of pre-conscious neural activity in voluntary motor behavior. This activity, called readiness potential, and the notion of causation worked in neuroscience, support the causal efficacy of mental states, but in a different sense from that proposed by Searle. (shrink)

Functional decomposition is an important goal in the life sciences, and is central to mechanistic explanation and explanatory reduction. A growing literature in philosophy of science, however, has challenged decomposition-based notions of explanation. ‘Holists’ posit that complex systems exhibit context-sensitivity, dynamic interaction, and network dependence, and that these properties undermine decomposition. They then infer from the failure of decomposition to the failure of mechanistic explanation and reduction. I argue that complexity, so construed, is only incompatible with one notion of decomposition, (...) which I call ‘atomism’, and not with decomposition writ large. Atomism posits that function ascriptions must be made to parts with minimal reference to the surrounding system. Complexity does indeed falsify atomism, but I contend that there is a weaker, ‘contextualist’ notion of decomposition that is fully compatible with the properties that holists cite. Contextualism suggests that the function of parts can shift with external context, and that interactions with other parts might help determine their context-appropriate functions. This still admits of functional decomposition within a given context. I will give examples based on the notion of oscillatory multiplexing in systems neuroscience. If contextualism is feasible, then holist inferences are faulty—one cannot infer from the presence of complexity to the failure of decomposition, mechanism, and reductionism. (shrink)

SUMMARY Major theories of philosophical psychology and philosophy of mind are examined on the basis of the fundamental questions of ontology, metaphysics, epistemology, semantics and logic. The result is the choice between language of eliminative reductionism and dualism, neither of which answers properly the relation between mind and body. In the search for a non–dualistic and non–reductive language, Wittgenstein’s notion of language–games as the representative links between language and the world is considered together with Peirce’s semeiosis of cognition. The result (...) is a redefined notion of cognition as the goal–oriented ability to instantiate strategies from the rules of the language–games. Cognition is considered within the four-dimensional languagegames: rules/strategies, primitive/complete language-games, family-resemblances/forms of life, and non-temporal continuum as the language-games’ modality. Cognition is seen as a continuum process of non–individualized elements that unites perception, volition, emotion, will and thought against the commonly accepted understandings of cognition in exclusive terms of perception and thinking. The alternative to the mind/body problem is the continuity of cognition where rules and strategies, syntax and semantics, are considered inseparable within language–games. This continuity of cognition is explained in terms of virtual (univocal) identity, replacing the old philosophical paradigm of the mind/body problem. -/- SOMMARIO Le teorie maggiori della psicologia filosofica e filosofia della mente sono esaminate a partire dalle questioni fondamentali di ontologia, metafisica, epistemologia, semantica e logica. Il risultato è la scelta tra un linguaggio riduzionista eliminativo e un dualismo che però non confronta in modo adeguato la relazione tra mente e corpo. Nella ricerca per un linguaggio non-dualistico e non-riduttivo, viene considerata la nozione del gioco linguistico di Wittgenstein come un legame rappresentativo tra il linguaggio e il mondo insieme con la semiosi cognitiva di Peirce. Il risultato è la nozione ridefinita della cognizione come abilità goal-orientata di creare le strategie dalle regole dei giochi linguistici. La cognizione è considerata entro le quattro dimensioni dei giochi linguistici: regole/strategie, giochi linguistici primitivi/completi, somiglianze di famiglia/forme di vita, e la continuità atemporale come la modalità dei giochi linguistici. La cognizione diventa un processo continuo degli elementi non-individualizzati che tende ad unificare la percezione, volizione, emozione, la volontà e il pensiero contro un concetto generalmente accettato di vedere la cognizione nei termini esclusivamente di percezione e di pensiero. L’alternativa al problema della mente/corpo è la continuità della cognizione, dove le regole e le strategie, la sintassi e la semantica, sono considerate inseparabili nei giochi linguistici. Questa continuità della cognizione è spiegata nei termini dell’identità virtuale (univoca) sostituendo un paradigma filosofico previo del problema della mente/corpo. (shrink)

This paper employs a case study from the history of neuroscience—brain reward function—to scrutinize the inductive argument for the so-called ‘Heuristic Identity Theory’ (HIT). The case fails to support HIT, illustrating why other case studies previously thought to provide empirical support for HIT also fold under scrutiny. After distinguishing two different ways of understanding the types of identity claims presupposed by HIT and considering other conceptual problems, we conclude that HIT is not an alternative to the traditional identity theory so (...) much as a relabeling of previously discussed strategies for mechanistic discovery. (shrink)

This article examines to what extent a particular case of cross-disciplinary research in the 1930s was structured by mechanistic reasoning. For this purpose, it identifies the interfield theories that allowed biologists and chemists to use each other’s techniques and findings, and that provided the basis for the experiments performed to identify plant growth hormones and to learn more about their role in the mechanism of plant growth. In 1930, chemists and biologists in Utrecht and Pasadena began to cooperatively study plant (...) growth. I will argue that these researchers decided to join forces because they believed to rely on each other’s findings and methods to solve their research problems adequately. In the course of the cooperation, organic chemists arrived at isolating plant growth hormones by using a test method developed in plant physiology. This achievement, in turn, facilitated biologists’ investigation of the mechanism of plant growth. Researchers eventually believed to have the means to study the relation between a substance’s molecular structure and its physiological activity. The way they conceptualized the problem of identifying hormones and unraveling the mechanism of plant growth, as well as their actual research actions are compatible with the new mechanists’ account of mechanism research. The study illustrates that focusing on researchers’ mechanistic reasoning can contribute considerably to explaining the structure of cross-disciplinary research projects. (shrink)

In recent years, several authors have debated about the justifiability of so-called scientific imperialism. To date, however, widespread disagreements remain regarding both the identification and the normative evaluation of scientific imperialism. In this paper, I aim to remedy this situation by making some conceptual distinctions concerning scientific imperialism and by providing a detailed assessment of the most prominent objections to it. I shall argue that these objections provide a valuable basis for opposing some instances of scientific imperialism, but do not (...) yield cogent reasons to think that scientific imperialism in general is objectionable or unjustified. I then highlight three wide-ranging implications of this result for the ongoing philosophical debate about the justifiability of scientific imperialism. (shrink)

This paper offers a novel view of unity in neuroscience. I set out by discussing problems with the classical account of unity-by-reduction, due to Oppenheim and Putnam. That view relies on a strong notion of levels, which has substantial problems. A more recent alternative, the mechanistic “mosaic” view due to Craver, does not have such problems. But I argue that the mosaic ideal of unity is too minimal, and we should, if possible, aspire for more. Relying on a number of (...) recent works in theoretical neuroscience—network motifs, canonical neural computations and design-principles—I then present my alternative: a “flat” view of unity, i.e. one that is not based on levels. Instead, it treats unity as attained via the identification of recurrent explanatory patterns, under which a range of neuroscientific phenomena are subsumed. I develop this view by recourse to a causal conception of explanation, and distinguish it from Kitcher’s view of explanatory unification and related ideas. Such a view of unity is suitably ambitious, I suggest, and has empirical plausibility. It is fit to serve as an appropriate working hypothesis for 21st century neuroscience. (shrink)

Chronobiology, especially the study of circadian rhythms, provides a model scientific field in which philosophers can study how investigators from a variety of disciplines working at different levels of organization are each contributing to a multi-level account of the responsible mechanism. I focus on how the framework of mechanistic explanation integrates research designed to decompose the mechanism with efforts directed at recomposition that relies especially on computation models. I also examine how recently the integration has extended beyond basic research to (...) the processes through which the disruption of circadian rhythms contributes to disease, including various forms of cancer. Understanding these linkages has been facilitated by discoveries about how circadian mechanisms interact with mechanisms involved in other physiological processes, including the cell cycle and the immune system. (shrink)

Cancer is not one, but many diseases, and each is a product of a variety of causes acting at distinct temporal and spatial scales, or ‘‘levels’’ in the biological hierarchy. In part because of this diversity of cancer types and causes, there has been a diversity of models, hypotheses, and explanations of carcinogenesis. However, there is one model of carcinogenesis that seems to have survived the diversification of cancer types: the multi-stage model of carcinogenesis. This paper examines the history of (...) the multistage theory, and uses the theory as a case study in the limits and goals of unification as a theoretical virtue, comparing and contrasting it with ‘‘integrative’’ research. (shrink)

Biological sciences have strived to adopt the conceptual framework of physics and have become increasingly quantitatively oriented, aiming to refute the assertion that biology appears unquantifiable, unpredictable, and messy. But despite all effort, biology is characterized by a paucity of quantitative statements with universal applications. Nonetheless, many biological disciplines—most notably molecular biology—have experienced an ascendancy over the last 50 years. The underlying core concepts and ideas permeate and inform many neighboring disciplines. This surprising success is probably not so much attributable (...) to mathematical and statistical approaches in molecular biology, but rather to the preponderance of qualitative approaches, especially visualization. Visualizations can be afforded by quantitative research, but usually they rely on both, quantitative and qualitative research. I claim the following three features to be responsible for the unceasing zeal for using visualizations: visual representations facilitate reasoning, images can be cognitively processed in a “fast” manner, and abstractions of visual representations prompt conceptual advances. In summary, visualizations have largely contributed to the success of molecular biology by conveying its concepts to other disciplines, and at the same time, eclipsing mere quantitative approaches. However, visualizations also bear the risk of misinterpretation when traversing neighboring disciplines and even more so when pervading nonscientific domains. (shrink)

Keywords: climate change, integrated assessment, knowledge integration, transdisciplinary research, vulnerability, vulnerability assessment. This thesis explores how transdisciplinary knowledge integration can be facilitated in the context of integrated assessments and vulnerability assessments of climate change. Even though knowledge integration is fundamental in such transdisciplinary assessments, the actual process of integrating knowledge is rarely addressed explicitly and methodically. Here, knowledge integration is conceptualised into the subsequent phases of the elaboration of a shared language and the design of a methodology. Three devices for (...) facilitating knowledge integration are put forward: 1. semantic ascent or the shift from speaking in a language to speaking in a meta-language about the former, 2. formalisation or the translation of statements made in ordinary or technical language into a formal language, and 3. knowledge integration methods, which are methods that provide a meta-language for speaking about the knowledge to be integrated and organise the process of integration. Four cases of knowledge integration are presented. First, the general problem of methodology design is addressed and a graphical framework for representing methodologies is presented. Second, the problem of developing a shared language for speaking about vulnerability to climate change is addressed. A formal mathematical framework of vulnerability and related concepts is presented. Third, a special case of methodology design, the integration of computer models in the context of modular integrated assessment modelling is addressed. A modular approach developed in the PIAM project is presented. Fourth, the integration of computer models, this time in the context of a global assessment of coastal vulnerability to sea-level rise, is addressed. A knowledge integration method, which was developed and applied in the DINAS-COAST project, is presented. These cases show that semantic ascent is a useful device in those cases in which it is difficult to directly elaborate a shared language at the beginning of the assessment. Formalisation can contribute to the elaboration of a shared language in those cases in which concepts overlap non trivially in their meanings. More emphasis should be placed on the development and application of iterative knowledge integration methods as iteration is crucial in order to benefit from the mutual learning during the course of the assessment. (shrink)