In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology. In a post-Kuhnian move away from the hegemony of theory, he develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things. A central concern of the book is the basic question of how novelty is generated in the empirical sciences. In addressing this question, (...) the author brings French poststructuralist thinking—notably Jacques Derrida’s concepts of “différance” and “historiality”—to bear on the construction of epistemic things. Historiographical perspective shifts from the actors’ minds to their objects of manipulation. These epistemological and historical issues are illuminated in a detailed case study of a particular laboratory, that of the oncologist and biochemist Paul C. Zamecnik and his colleagues, located in a specific setting—the Collis P. Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital of Boston. The author traces how, between 1945 and 1965, this group developed an experimental system for synthesizing proteins in the test tube that put Zamecnik’s research team at the forefront of those who led biochemistry into the era of molecular biology. (shrink)

The algorithm, a building block of computer science, is defined from an intuitive and pragmatic point of view, through a methodological lens of philosophy rather than that of formal computation. The treatment extracts properties of abstraction, control, structure, finiteness, effective mechanism, and imperativity, and intentional aspects of goal and preconditions. The focus on the algorithm as a robust conceptual object obviates issues of correctness and minimality. Neither the articulation of an algorithm nor the dynamic process constitute the algorithm itself. Analysis (...) for implications in computer science and philosophy reveals unexpected results, new questions, and new perspectives on current questions, including the relationship between our informally construed algorithms and Turing machines. Exploration in terms of current computational and philosophical thinking invites further developments. (shrink)

Marking a major development in Foucault's thinking, this book derives from the lecture course which he gave at the College de France between January and April, 1978. Taking as his starting point the notion of "bio-power," introduced both in his 1976 course Society Must be Defended and in the first volume of his History of Sexuality, Foucault sets out to study the emergence of this new technology of power over population."--BOOK JACKET.

This book analyzes the different ways mathematics is applicable in the physical sciences, and presents a startling thesis--the success of mathematical physics ...

This article examines how the availability of Big Data, coupled with new data analytics, challenges established epistemologies across the sciences, social sciences and humanities, and assesses the extent to which they are engendering paradigm shifts across multiple disciplines. In particular, it critically explores new forms of empiricism that declare ‘the end of theory’, the creation of data-driven rather than knowledge-driven science, and the development of digital humanities and computational social sciences that propose radically different ways to make sense of culture, (...) history, economy and society. It is argued that: Big Data and new data analytics are disruptive innovations which are reconfiguring in many instances how research is conducted; and there is an urgent need for wider critical reflection within the academy on the epistemological implications of the unfolding data revolution, a task that has barely begun to be tackled despite the rapid changes in research practices presently taking place. After critically reviewing emerging epistemological positions, it is contended that a potentially fruitful approach would be the development of a situated, reflexive and contextually nuanced epistemology. (shrink)

Is Big Data science a whole new way of doing research? And what difference does data quantity make to knowledge production strategies and their outputs? I argue that the novelty of Big Data science does not lie in the sheer quantity of data involved, but rather in the prominence and status acquired by data as commodity and recognised output, both within and outside of the scientific community and the methods, infrastructures, technologies, skills and knowledge developed to handle data. These developments (...) generate the impression that data-intensive research is a new mode of doing science, with its own epistemology and norms. To assess this claim, one needs to consider the ways in which data are actually disseminated and used to generate knowledge. Accordingly, this article reviews the development of sophisticated ways to disseminate, integrate and re-use data acquired on model organisms over the last three decades of work in experimental biology. I focus on online databases as prominent infrastructures set up to organise and interpret such data and examine the wealth and diversity of expertise, resources and conceptual scaffolding that such databases draw upon. This illuminates some of the conditions under which Big Data needs to be curated to support processes of discovery across biological subfields, which in turn highlights the difficulties caused by the lack of adequate curation for the vast majority of data in the life sciences. In closing, I reflect on the difference that data quantity is making to contemporary biology, the methodological and epistemic challenges of identifying and analysing data given these developments, and the opportunities and worries associated with Big Data discourse and methods. (shrink)

There is no consensus yet on the definition of semantic information. This paper contributes to the current debate by criticising and revising the Standard Definition of semantic Information (SDI) as meaningful data, in favour of the Dretske‐Grice approach: meaningful and well‐formed data constitute semantic information only if they also qualify as contingently truthful. After a brief introduction, SDI is criticised for providing necessary but insufficient conditions for the definition of semantic information. SDI is incorrect because truth‐values do not supervene on (...) semantic information, and misinformation (that is, false semantic information) is not a type of semantic information, but pseudo‐information, that is not semantic information at all. This is shown by arguing that none of the reasons for interpreting misinformation as a type of semantic information is convincing, whilst there are compelling reasons to treat it as pseudo‐information. As a consequence, SDI is revised to include a necessary truth‐condition. The last section summarises the main results of the paper and indicates some interesting areas of application of the revised definition. (shrink)

This paper proposes an account of scientific data that makes sense of recent debates on data-driven and ‘big data’ research, while also building on the history of data production and use particularly within biology. In this view, ‘data’ is a relational category applied to research outputs that are taken, at specific moments of inquiry, to provide evidence for knowledge claims of interest to the researchers involved. They do not have truth-value in and of themselves, nor can they be seen as (...) straightforward representations of given phenomena. Rather, they are fungible objects defined by their portability and prospective usefulness as evidence. (shrink)

Taking scientific practice as its starting point, this book charts the complex territory of models used in science. It examines what scientific models are and what their function is. Reliance on models is pervasive in science, and scientists often need to construct models in order to explain or predict anything of interest at all. The diversity of kinds of models one finds in science – ranging from toy models and scale models to theoretical and mathematical models – has attracted attention (...) not only from scientists, but also from philosophers, sociologists, and historians of science. This has given rise to a wide variety of case studies that look at the different uses to which models have been put in specific scientific contexts. By exploring current debates on the use and building of models via cutting-edge examples drawn from physics and biology, the book provides broad insight into the methodology of modelling in the natural sciences. It pairs specific arguments with introductory material relating to the ontology and the function of models, and provides some historical context to the debates as well as a sketch of general positions in the philosophy of scientific models in the process. (shrink)

A theoretical physicist and feminist theorist, Karen Barad elaborates her theory of agential realism, a schema that is at once a new epistemology, ontology, and ethics.

In this book Bruno Latour brings together these different approaches to provide a lively and challenging analysis of science, demonstrating how social context..

Mathematics plays an inordinate role in the work of many of famous Western philosophers, from the time of Plato, through Husserl and Wittgenstein, and even to the present. Why? This paper points to the experience of learning or making mathematics, with an emphasis on proof. It distinguishes two sources of the perennial impact of mathematics on philosophy. They are classified as Ancient and Enlightenment. Plato is emblematic of the former, and Kant of the latter. The Ancient fascination arises from the (...) sense that mathematics explores something ‘out there’. This is illustrated by recent discussions by distinguished contemporary mathematicians. The Enlightenment strand often uses Kant's argot: ‘absolute necessity’, ‘apodictic certainty’ and ‘a priori’ judgement or knowledge. The experience of being compelled by proof, the sense that something must be true, that a result is certain, generates the philosophy. It also creates the illusion that mathematics is certain. Kant's leading question, ‘How is pure mathematics possible?’, is easily misunderstood because the modern distinction between pure and applied is an artefact of the 19th century. As Russell put it, the issue is to explain ‘the apparent power of anticipating facts about things of which we have no experience’. More generally the question is, how is it that pure mathematics is so rich in applications? Some six types of application are distinguished, each of which engenders its own philosophical problems which are descendants of the Enlightenment, and which differ from those descended from the Ancient strand. (shrink)