Through an examination of the actual research strategies and assumptions underlying the Human Genome Project (HGP), it is argued that the epistemic basis of the initial model organism programs is not best understood as reasoning via causal analog models (CAMs). In order to answer a series of questions about what is being modeled and what claims about the models are warranted, a descriptive epistemological method is employed that uses historical techniques to develop detailed accounts which, in turn, help to reveal (...) forms of reasoning that are explicit, or more often implicit, in the practice of a particular field of scientific study. It is suggested that a more valid characterization of the reasoning structure at work here is a form of case-based reasoning. This conceptualization of the role of model organisms can guide our understanding and assessment of these research programs, their knowledge claims and progress, and their limitations, as well as how we educate the public about this type of biomedical research. (shrink)

Through an examination of the actual research strategies and assumptions underlying the Human Genome Project, it is argued that the epistemic basis of the initial model organism programs is not best understood as reasoning via causal analog models. In order to answer a series of questions about what is being modeled and what claims about the models are warranted, a descriptive epistemological method is employed that uses historical techniques to develop detailed accounts which, in turn, help to reveal forms of (...) reasoning that are explicit, or more often implicit, in the practice of a particular field of scientific study. It is suggested that a more valid characterization of the reasoning structure at work here is a form of case-based reasoning. This conceptualization of the role of model organisms can guide our understanding and assessment of these research programs, their knowledge claims and progress, and their limitations, as well as how we educate the public about this type of biomedical research. (shrink)

The biological sciences have become increasingly reliant on so-called 'model organisms'. I argue that in this domain, the concept of a descriptive model is essential for understanding scientific practice. Using a case study, I show how such a model was formulated in a preexplanatory context for subsequent use as a prototype from which explanations ultimately may be generated both within the immediate domain of the original model and in additional, related domains. To develop this concept of a descriptive model, I (...) focus on use of the nematode worm Caenorhabditis elegans and the wiring diagrams that were developed as models of its neural structure. In addition, implications of the concept of a descriptive model, particularly its relevance for the data-phenomena distinction as well as its relation to long-standing debates on realism, are briefly examined. (shrink)

Knowledge in a Social World offers a philosophy for the information age. Alvin Goldman explores new frontiers by creating a thoroughgoing social epistemology, moving beyond the traditional focus on solitary knowers. Against the tides of postmodernism and social constructionism Goldman defends the integrity of truth and shows how to promote it by well-designed forms of social interaction. From science to education, from law to democracy, he shows why and how public institutions should seek knowledge-enhancing practices. The result is a bold, (...) timely, and systematic treatment of the philosophical foundations of an information society. (shrink)

Helen Longino seeks to break the current deadlock in the ongoing wars between philosophers of science and sociologists of science--academic battles founded on disagreement about the role of social forces in constructing scientific knowledge. While many philosophers of science downplay social forces, claiming that scientific knowledge is best considered as a product of cognitive processes, sociologists tend to argue that numerous noncognitive factors influence what scientists learn, how they package it, and how readily it is accepted. Underlying this disagreement, however, (...) is a common assumption that social forces are a source of bias and irrationality. Longino challenges this assumption, arguing that social interaction actually assists us in securing firm, rationally based knowledge. This important insight allows her to develop a durable and novel account of scientific knowledge that integrates the social and cognitive. Longino begins with a detailed discussion of a wide range of contemporary thinkers who write on scientific knowledge, clarifying the philosophical points at issue. She then critically analyzes the dichotomous understanding of the rational and the social that characterizes both sides of the science studies stalemate and the social account that she sees as necessary for an epistemology of science that includes the full spectrum of cognitive processes. Throughout, her account is responsive both to the normative uses of the term knowledge and to the social conditions in which scientific knowledge is produced. Building on ideas first advanced in her influential book Science as Social Knowledge, Longino brings her account into dialogue with current work in social epistemology and science studies and shows how her critical social approach can help solve a variety of stubborn problems. While the book focuses on epistemological concerns related to the sociality of inquiry, Longino also takes up its implications for scientific pluralism. The social approach, she concludes, best allows us to retain a meaningful concept of knowledge in the face of theoretical plurality and uncertainty. (shrink)

A scientific community cannot practice its trade without some set of received beliefs. These beliefs form the foundation of the "educational initiation that prepares and licenses the student for professional practice". The nature of the "rigorous and rigid" preparation helps ensure that the received beliefs are firmly fixed in the student's mind. Scientists take great pains to defend the assumption that scientists know what the world is like...To this end, "normal science" will often suppress novelties which undermine its foundations. Research (...) is therefore not about discovering the unknown, but rather "a strenuous and devoted attempt to force nature into the conceptual boxes supplied by professional education". (shrink)

Thomas S. Kuhn's classic book is now available with a new index.

Inviting a reappraisal of the status of scientific knowledge, Andrew Pickering suggests that scientists are not mere passive observers and reporters of nature.

This paper argues that the appraisal of theory is in important respects closer in structure to value-judgement than it is to the rule-governed inference that the classical tradition in philosophy of science took for granted.

In this essay, which was his presidential address to the Philosophy of Science Association, Ernan McMullin argued that the watershed between “classic” philosophy of science and the “new” philosophy of science can best be understood by analyzing the change in our perception of the role played by values in science. He begins with some general remarks about the nature of value, goes on to explore some of the historical sources for the claim that judgement in science is value‐laden, and concludes (...) by reflecting on the implications of this claim for traditional views of the objectivity of scientific knowledge‐claims. (shrink)

Metaphysical presuppositions are important for guiding scientific practices and research. The success of twentieth-century biology, for instance, is largely attributable to presupposing that complex biological processes are reducible to elementary components. However, some biologists have challenged the sufficiency of reductionism for investigating complex biological phenomena and have proposed alternative presuppositions like organicism. In this article, contemporary cancer research is used as a case study to explore the importance of metaphysical presuppositions for guiding research. The predominant paradigm directing cancer research is (...) the somatic mutation theory, in which mutated genes are presumed to be ultimately responsible for explaining carcinogenesis. This reductionistic approach to cancer has been criticised recently, and an organistic approach has been proposed. The article concludes with a discussion of the reciprocal interaction of metaphysical presuppositions and scientific practices for investigating cancer's complex nature. (shrink)

A notion of experimental series is developed, in which experiments or experimental sets are connected through experimental suggestions arising from previous experimental outcomes. To that end, the justification of Howard Temin’s DNA provirus hypothesis is examined. The hypothesis originated with evidence from two exploratory experimental sets on an oncogenic virus and was substantiated by including evidence from three additional experimental sets. Collectively these sets comprise an experimental series and the accumulative evidence from the series was adequate to justify the hypothesis (...) by persuading the virology community of its veracity. The notion of crucial experiment is also discussed in terms of experimental series. (shrink)

A notion of experimental series is developed, in which experiments or experimental sets are connected through experimental suggestions arising from previous experimental outcomes. To that end, the justification of Howard Temin's DNA provirus hypothesis is examined. The hypothesis originated with evidence from two exploratory experimental sets on an oncogenic virus and was substantiated by including evidence from three additional experimental sets. Collectively these sets comprise an experimental series and the accumulative evidence from the series was adequate to justify the hypothesis (...) by persuading the virology community of its veracity. The notion of crucial experiment is also discussed in terms of experimental series. (shrink)

"--Richard Grandy, Rice University "This is the first compelling diagnosis of what has gone awry in the raging 'science wars.

Knowledge of many facts does not amount to understanding unless one also has a sense of how the facts fit together. This aspect of coherence among scientific observations and theories is usually overlooked in summaries of scientific method, since the emphasis is on justification and verification rather than on understanding. I argue that the inter-theoretic coherence, as the hallmark of understanding, is an essential and informative component of any accurate description of science.

Protagonists in the so-called Science Wars differ most markedly in their views about the role of values in science and what makes science valuable. Scientists and philosophers of science have traditionally considered the principal aims of science to be explanation and application. Only cognitive values should influence what is taken to be explanatory. Social and political values affect the priority assigned to various scientific problems and the ways in which scientific results are applied. Ethical considerations may be brought to bear (...) on the treatment of human and animal subjects, and the manner in which scientific results are communicated. Recent critiques of science allege that the content of scientific explanations reflects the dominant ideology and interests of scientists and their patrons. Instead of calling for more value neutrality, some now urge that science take as a principal aim the emancipation of oppressed subcultures. Not only should progressive political values be allowed to set the problems attempted, they also should be used to constrain the types of answers which are pursued. Since scientific knowledge is constructed by us, we should take responsibility for its content. This paper argues that the project of Emancipationist science is impractical and self-defeating. There is good reason to believe that there would be unresolvable political disputes concerning which kinds of scientific theories are truly emancipiatory. Furthermore, just as placebos cease to work when recognized as such, so would a science known to be constrained by political considerations lose its special epistemic authority. (shrink)

During the last three decades, reflections on the growth of scientific knowledge have inspired historians, sociologists, and some philosophers to contend that scientific objectivity is a myth. In this book, Kitcher attempts to resurrect the notions of objectivity and progress in science by identifying both the limitations of idealized treatments of growth of knowledge and the overreactions to philosophical idealizations. Recognizing that science is done not by logically omniscient subjects working in isolation, but by people with a variety of personal (...) and social interests, who cooperate and compete with one another, he argues that, nonetheless, we may conceive the growth of science as a process in which both our vision of nature and our ways of learning more about nature improve. Offering a detailed picture of the advancement of science, he sets a new agenda for the philosophy of science and for other "science studies" disciplines. (shrink)

Striving to boldly redirect the philosophy of science, this book by renowned philosopher Philip Kitcher examines the heated debate surrounding the role of science in shaping our lives. Kitcher explores the sharp divide between those who believe that the pursuit of scientific knowledge is always valuable and necessary--the purists--and those who believe that it invariably serves the interests of people in positions of power. In a daring turn, he rejects both perspectives, working out a more realistic image of the sciences--one (...) that allows for the possibility of scientific truth, but nonetheless permits social consensus to determine which avenues to investigate. He then proposes a democratic and deliberative framework for responsible scientists to follow. Controversial, powerful, yet engaging, this volume will appeal to a wide range of readers. Kitcher's nuanced analysis and authorititative conclusion will interest countless scientists as well as all readers of science--scholars and laypersons alike. (shrink)

Developmental systems theory (DST) expands the unit of replication from genes to whole systems of developmental resources, which DST interprets in terms of cycling developmental processes. Expansion seems required by DST's argument against privileging genes in evolutionary and developmental explanations of organic traits. DST and the expanded replicator brook no distinction between biological and cultural evolution. However, by endorsing a single expanded unit of inheritance and leaving the classical molecular notion of gene intact, DST achieves only a nominal reunification of (...) heredity and development. I argue that an alternative conceptualization of inheritance denies the classical opposition of genetics and development while avoiding the singularity inherent in the replicator concept. It also yields a new unit--the reproducer--which genuinely integrates genetic and developmental perspectives. The reproducer concept articulates the non-separability of "genetic" and "developmental" roles in units of heredity, development, and evolution. DST reformulated in terms of reproducers rather than replicators preserves an empirically interesting distinction between cultural and biological evolution. (shrink)

Required reading at more than 100 colleges and universities throughout North America.

Social constructionists maintain that we invent the properties of the world rather than discover them. Is reality constructed by our own activity? Do we collectively invent the world rather than discover it? André Kukla presents a comprehensive discussion of the philosophical issues that arise out of this debate, analysing the various strengths and weaknesses of a range of constructivist arguments and arguing that current philosophical objections to constructivism are inconclusive. However, Kukla offers and develops new objections to constructivism, distinguishing between (...) the social causes of scientific beliefs and the view that all ascertainable facts are constructed. (shrink)

The central theme running throughout this outstanding new survey is the nature of the philosophical debate created by modern science's foundation in experimental and mathematical method. More recently, recognition that reasoning in science is probabilistic generated intense debate about whether and how it should be constrained so as to ensure the practical certainty of the conclusions drawn. These debates brought to light issues of a philosophical nature which form the core of many scientific controversies today. _Scientific Method: A Historical and (...) Philosophical Introduction_ presents these debates through clear and comparative discussion of key figures in the history of science. Key chapters critically discuss * Galileo's demonstrative method, Bacon's inductive method, and Newton's rules of reasoning * the rise of probabilistic `Bayesian' methods in the eighteenth century * the method of hypotheses through the work of Herschel, Mill and Whewell * the conventionalist views of Poincaré and Duhem * the inductivism of Peirce, Russell and Keynes * Popper's falsification compared with Reichenbach's enumerative induction * Carnap's scientific method as Bayesian reasoning The debates are brought up to date in the final chapters by considering the ways in which ideas about method in the physical and biological sciences have affected thinking about method in the social sciences. This debate is analyzed through the ideas of key theorists such as Kuhn, Lakatos, and Feyerabend. (shrink)

2014 Reprint of 1940 Edition. Full facsimile of the original edition, not reproduced with Optical Recognition Software. One of Collingwood's finest works, "Essay on Metaphysics" considers the nature of philosophy, and puts forward Collingwood's original and influential theories of causation, presuppositions, and the logic of question and answer. From the mid-thirties onwards Collingwood's work increasingly engaged in a dialogue with the newly emerging school of analytic philosophy. In this work he attacked the neo-empiricist assumptions prevalent in early analytic philosophy and (...) advocated a logical/epistemological transformation of metaphysics from a study of being or ontology to a study of the absolute presuppositions or heuristic principles which govern different forms of enquiry. Collingwood thus occupies a distinctive position in the history of British philosophy in the first half of the 20th century. He rejects equally the neo-empiricist assumptions that prevailed in early analytic philosophy and the kind of metaphysics that the analytical school sought to overthrow. (shrink)

Papers presented at a conference held at the University of Notre Dame in April 1986.

The anthropological approach is the central focus of this study. Laboratories are looked upon with the innocent eye of the traveller in exotic lands, and the societies found in these places are observed with the objective yet compassionate eye of the visitor from a quite other cultural milieu. There are many surprises that await us if we enter a laboratory in this frame of mind... This study is a realistic enterprise, an attempt to truly represent the social order of life (...) in laboratories and institutes of research, just as they are. By bringing the philosophical issues to the surface as matters not of prejudgement but as matters of concern, Karin Knorr-Cetina has developed the first really positive challenge to the philosophy of science since the days of paradigms and internal definitions of meanings. (shrink)

This fascinating study in the sociology of science explores the way scientists conduct, and draw conclusions from, their experiments. The book is organized around three case studies: replication of the TEA-laser, detecting gravitational rotation, and some experiments in the paranormal. "In his superb book, Collins shows why the quest for certainty is disappointed. He shows that standards of replication are, of course, social, and that there is consequently no outside standard, no Archimedean point beyond society from which we can lever (...) the intellects of our fellows. "- -Donald M. McCloskey, Journal of Economic Psychology "Collins is one of the genuine innovators of the sociology of scientific knowledge.... Changing Order is a rich and entertaining book. "- - Isis "The book gives a vivid sense of the contingent nature of research and is generally a good read. "- -Augustine Brannigan, Nature "This provocative book is a review of [Collins's] work, and an attempt to explain how scientists fit experimental results into pictures of the world.... A promising start for new explorations of our image of science, too often presented as infallibly authoritative. "- -Jon Turney, New Scientist. (shrink)

Social constructivists maintain that we invent the properties of the world rather than discover them. Is reality constructed by our own activity? Or, more provocatively, are scientific facts--is everything --constructed? Social Constructivism and the Philosophy of Science is a clear assessment of this critical and increasingly important debate. Andre Kukla presents a comprehensive discussion of the philosophical issues involved and analyzes the strengths and weaknesses of a range of constructivist arguments, illustrating the divide between the sociology and the philosophy of (...) science through examples as varied as laboratory science, time, and criminality. He argues that current philosophical objections to constructivism are drastically inconclusive, while offering and developing new objections. Throughout, Kukla distinguishes between the social causes of scientific beliefs and the view that all ascertainable facts are constructed. (shrink)

Early practitioners of the social studies of science turned their attention away from questions of institutionalisation, which had tended to emphasize macrolevel explanations, and attended instead to microstudies of laboratory practice. The author is interested in re-investigating certain aspects of institution formation, notably the formation of scientific, medical, and engineering disciplines. He emphasises the manner in which science as cultural practice is imbricated with other forms of social, political, and even aesthetic practices. The author considers the following topics: the organic (...) physics of 1847; the innovative research program of Carl Ludwig as a model for institutionalising science-based medicine, optics, painting, and ideology in Germany, 1845-95; the Haber-Bosch synthesis of ammonia; and the introduction of nuclear magnetic resonance instrumentation into the practice of organic chemistry. (shrink)

At a time when scientific knowledge is systematically whisked out of the domain of education and converted into private capital, the essays in this volume are ...

This textbook will enable scientists to be better scientists by offering them a deeper understanding of the scientific method.

Observation and conceptual interpretation constitute the two major ways through which human beings engage the world. _The World Observed/The World Conceived _presents an innovative analysis of the nature and role of observation and conceptualization. While these two actions are often treated as separate, Hans Radder shows that they are inherently interconnected-that materially realized observational processes are always conceptually interpreted and that the meaning of concepts depends on the way they structure observational processes and abstract from them. He examines the role (...) of human action and conceptualization in realizing observational processes and develops a detailed theory of the relationship between observation, abstraction, and the meaning of concepts. This book provides a critical analysis of the work of various other philosophers and their accounts of scientific and ordinary-life observation and conceptualization. Radder discusses the formation and nature of concepts and demonstrates how concepts structure the phenomenal world. He then introduces and defines the notions of extensible concepts, abstraction and nonlocal meanings and explores the philosophical implications of his theory. _The World Observed/The World Conceived_ offers fresh insights in practices of observation and conceptualization, that will prove useful to many areas of scholarly study including ontology, epistemology, philosophy of language, philosophy of science, science studies, and cognitive science. (shrink)

The "War" in science is largely the discussion between those who believe that science is above criticism and those who do not. After the Science Wars is a collection of essays by leading philosophers and scientists, all attempting to bridge interdisciplinary gulfs in this discussion.

Chapter 1 FROM ORDER TO DISORDER 5 mins. John enters and goes into his office. He says something very quickly about having made a bad mistake. He had sent the review of a paper. . . . The rest of the sentence is inaudible. 5 mins.

Churchland proposes a radically new way of representing theories and their acquisition in the terms of connectionist neuro- science. ...

Models as Mediators discusses the ways in which models function in modern science, particularly in the fields of physics and economics. Models play a variety of roles in the sciences: they are used in the development, exploration and application of theories and in measurement methods. They also provide instruments for using scientific concepts and principles to intervene in the world. The editors provide a framework which covers the construction and function of scientific models, and explore the ways in which they (...) enable us to learn about both theories and the world. The contributors to the volume offer their own individual theoretical perspectives to cover a wide range of examples of modelling, from physics, economics and chemistry. These papers provide ideal case-study material for understanding both the concepts and typical elements of modelling, using analytical approaches from the philosophy and history of science. (shrink)

Originally published in 1974. Scientific Knowledge and Sociological Theory centres on the problem of explaining the manifest variety and contrast in the beliefs about nature held in different groups and societies. It maintains that the sociologist should treat all beliefs symmetrically and must investigate and account for allegedly "correct" or "scientific" beliefs just as he would "incorrect" or "unscientific" ones. From this basic position a study of scientific beliefs is constructed. The sociological interest of such beliefs is illustrated and a (...) sociological perspective upon scientific change is developed. (shrink)

Especially troublesome in this dispute is the status of the natural sciences, and this is where Hacking finds some of his most telling cases, from the conflict ...

The central theme running throughout this outstanding new survey is the nature of the philosophical debate created by modern science's foundation in experimental and mathematical method. More recently, recognition that reasoning in science is probabilistic generated intense debate about whether and how it should be constrained so as to ensure the practical certainty of the conclusions drawn. These debates brought to light issues of a philosophical nature which form the core of many scientific controversies today. _Scientific Method: A Historical and (...) Philosophical Introduction_ presents these debates through clear and comparative discussion of key figures in the history of science. Key chapters critically discuss * Galileo's demonstrative method, Bacon's inductive method, and Newton's rules of reasoning * the rise of probabilistic `Bayesian' methods in the eighteenth century * the method of hypotheses through the work of Herschel, Mill and Whewell * the conventionalist views of Poincaré and Duhem * the inductivism of Peirce, Russell and Keynes * Popper's falsification compared with Reichenbach's enumerative induction * Carnap's scientific method as Bayesian reasoning The debates are brought up to date in the final chapters by considering the ways in which ideas about method in the physical and biological sciences have affected thinking about method in the social sciences. This debate is analyzed through the ideas of key theorists such as Kuhn, Lakatos, and Feyerabend. (shrink)