_Brute Science_ investigates whether biomedical research using animals is, in fact, scientifically justified. Hugh LaFollette and Niall Shanks examine the issues in scientific terms using the models that scientists themselves use. They argue that we need to reassess our use of animals and, indeed, rethink the standard positions in the debate.

Do animals have moral rights? In contrast to the philosophical gurus of the animal rights movement, whose opinion has held moral sway in recent years, Peter Carruthers here claims that they do not. He explores a variety of moral theories, arguing that animals lack direct moral significance. This provocative but judiciously argued book will appeal to all those interested in animal rights, whatever their initial standpoint. It will also serve as a lively introduction to ethics, demonstrating why theoretical issues in (...) ethics actually matter. (shrink)

First-in-human clinical trials represent a critical juncture in the translation of laboratory discoveries. However, because they involve the greatest degree of uncertainty at any point in the drug development process, their initiation is beset by a series of nettlesome ethical questions [1]: has clinical promise been sufficiently demonstrated in animals? Should trial access be restricted to patients with refractory disease? Should trials be viewed as therapeutic? Have researchers adequately minimized risks? The resolution of such ethical questions inevitably turns on claims (...) about future events like harms, therapeutic response, and clinical translation. Recurrent failures in clinical translation, like Eli Lilly's Alzheimer candidate semagacestat, highlight the severe limitations of current methods of prediction. In this case, patients in the active arm of the placebo-controlled trial had earlier onset of dementia and elevated rates of skin cancer [2]. Various authoritative accounts of human research ethics state that decision-making about risk and benefit should be careful, systematic, and non-arbitrary [3]–[5]. Yet, these sources provide little guidance about what kinds of evidence stakeholders should use to ensure their estimates of such events ground responsible ethical decisions. In this article, we suggest that investigators, oversight bodies, and sponsors often base their predictions on a flawed and inappropriately narrow preclinical evidence base. (shrink)

The Singer-Regan debate -- Reciprocity -- Frey's challenge -- The criticisms of Leahy and Carruthers -- The great ape project and slavery -- The Nozick-Rachels debate.

Offers a forthright approach to the many disquieting questions surrounding the emotional debate over animal rights. This book includes a chapter on animal agriculture, and additional discussions of animal law, companion animal issues, genetic engineering, animal pain, animal research, and other topics.

Research that includes non-human animal experimentation is fundamentally a dilemmatic enterprise. Humans use other animals in research to improve life for their own species. Ethical principles are established to deal with this dilemma. But despite this ethical apparatus, people who in one way or another work with animal experimentation have to interpret and understand the principles from their individual points of view. In interviews with members of Swedish animal ethics committees, different views on what the term ethics really means were (...) articulated. For one member, the difficult ethical dilemma of animal experimentation is the lack of enriched cages for mice. For another, the ethical problem lies in regulations restraining research. A third member talks about animals’ right not to be used for human interests. These different views on “ethics” intersect once a month in the animal ethics committee meetings. There is no consensus on what constitutes the ethical problem that the members should be discussing. Therefore, personal views on what ethics means, and hierarchies among committee members, characterise the meetings. But committee traditions and priorities of interpretation as well are important to the decisions. The author discusses how “ethics” becomes situated and what implications this may have for committees’ decisions. (shrink)

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically (...) analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics. (shrink)

In Executive Order No. 10521, March 17, 1954, President Eisenhower stated: “…only a small fraction of the Federal Funds is being used to stimulate and support the vital basic research which makes possible our practical scientific progress. I believe strongly that this Nation must extend its support of research in basic science.”.

: Implicit instruction about values occurs throughout scientific communication, whether in the university classroom or in the larger public forum. The concern of this paper is that the kind of values education that occurs includes "reverse moral education," the idea that moral considerations are at best extra scientific if not simply irrational. The (a)moral education that many scientists unwittingly foist on their "students" undergirds the scientific establishment's typical responses to larger social issues: "Huff!" In this paper I explain the nature (...) of moral education which occurs in the "science classroom" and argue that it is wrongheaded--though there are remedies for its negative effects. (shrink)

Critics of animal modeling have advanced a variety of arguments against the validity of the practice. The point of one such form of argument is to establish that animal modeling is pointless and therefore immoral. In this article, critical arguments of this form are divided into three types, the pseudoscience argument, the disanalogy argument, and the predictive validity argument. I contend that none of these criticisms currently succeed, nor are they likely to. However, the connection between validity and morality is (...) important, suggesting that critical efforts would be instructive if they addressed it in a more nuanced way. (shrink)

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised.

Animal models of human disease play a central role in modern biomedical science. Developing animal models for human mental illness presents unique practical and philosophical challenges. In this article we argue that existing animal models of psychiatric disease are not valid, attempts to model syndromes are undermined by current nosology, models of symptoms are rife with circular logic and anthropomorphism, any model must make unjustified assumptions about subjective experience, and any model deemed valid would be inherently unethical, for if an (...) animal adequately models human subjective experience, then there is no morally relevant difference between that animal and a human. (shrink)

The argument from species overlap has been widely used in the literature on animal ethics and speciesism. However, there has been much confusion regarding what the argument proves and what it does not prove, and regarding the views it challenges. This article intends to clarify these confusions, and to show that the name most often used for this argument (‘the argument from marginal cases’) reflects and reinforces these misunderstandings. The article claims that the argument questions not only those defences of (...) anthropocentrism that appeal to capacities believed to be typically human, but also those that appeal to special relations between humans. This means the scope of the argument is far wider than has been thought thus far. Finally, the article claims that, even if the argument cannot prove by itself that we should not disregard the interests of nonhuman animals, it provides us with strong reasons to do so, since the argument does prove that no defence of anthropocentrism appealing to non-definitional and testable criteria succeeds. (shrink)