What is life? For four centuries, it has been believed that the only possible scientific approach to this question proceeds from the Cartesian metaphor -- organism as machine. Therefore, organisms are to be studied and characterized the same way "machines" are; the same way any inorganic system is. Robert Rosen argues that such a view is neither necessary nor sufficient to answer the question. He asserts that life is not a specialization of mechanism, but rather a sweeping generalization of it. (...) Above all, Rosen argues that renouncing mechanism does not mean abandoning science. A radical alternative is proposed, drawn equally from experience in biology, physics, and mathematics; an alternative which draws attention to a new class of complex systems, which are radically different from mechanism. (shrink)

The mathematical theory of communication.

Stephen Cole Kleene was one of the greatest logicians of the twentieth century and this book is the influential textbook he wrote to teach the subject to the next generation. It was first published in 1952, some twenty years after the publication of Godel's paper on the incompleteness of arithmetic, which marked, if not the beginning of modern logic. The 1930s was a time of creativity and ferment in the subject, when the notion of computable moved from the realm of (...) philosophical speculation to the realm of science. This was accomplished by the work of Kurt Gode1, Alan Turing, and Alonzo Church, who gave three apparently different precise definitions of computable. When they all turned out to be equivalent, there was a collective realization that this was indeed the right notion. Kleene played a key role in this process. One could say that he was there at the beginning of modern logic. He showed the equivalence of lambda calculus with Turing machines and with Godel's recursion equations, and developed the modern machinery of partial recursive functions. This textbook played an invaluable part in educating the logicians of the present. It played an important role in their own logical education.". (shrink)

Continuing his exploration of the organization of complexity and the science of design, this new edition of Herbert Simon's classic work on artificial ...

Process and Reality, Whitehead’s magnum opus, is one of the major philosophical works of the modern world, and an extensive body of secondary literature has developed around it. Yet surely no significant philosophical book has appeared in the last two centuries in nearly so deplorable a condition as has this one, with its many hundreds of errors and with over three hundred discrepancies between the American and the English editions, which appeared in different formats with divergent paginations. The work itself (...) is highly technical and far from easy to understand, and in many passages the errors in those editions were such as to compound the difficulties. The need for a corrected edition has been keenly felt for many decades. (shrink)

In the Critique of Judgement, Kant offers a penetrating analysis of our experience of the beautiful and the sublime. He discusses the objectivity of taste, aesthetic disinterestedness, the relation of art and nature, the role of imagination, genius and originality, the limits of representation, and the connection between morality and the aesthetic. He also investigates the validity of our judgements concerning the degree in which nature has a purpose, with respect to the highest interests of reason and enlightenment. The work (...) profoundly influenced the artists, writers, and philosophers of the classical and romantic period, including Hegel, Schelling, Schopenhauer, and Nietzsche. In addition, it has remained a landmark work in fields such as phenomenology, hermeneutics, the Frankfurt School, analytical aesthetics, and contemporary critical theory. Today it remains an essential work of philosophy, and required reading for all with an interest in aesthetics. (shrink)

Kurt Godel was the most outstanding logician of the twentieth century, famous for his work on the completeness of logic, the incompleteness of number theory, and the consistency of the axiom of choice and the continuum hypothesis. He is also noted for his work on constructivity, the decision problem, and the foundations of computation theory, as well as for the strong individuality of his writings on the philosophy of mathematics. Less well-known is his discovery of unusual cosmological models for Einstein's (...) equations, permitting "time-travel" into the past. This second volume of a comprehensive edition of Godel's works collects together all his publications from 1938 to 1974. Together with Volume I (Publications 1929-1936), it makes available for the first time in a single source all of his previously published work. Continuing the format established in the earlier volume, the present text includes introductory notes that provide extensive explanatory and historical commentary on each of the papers, a facing English translation of the one German original, and a complete bibliography. Succeeding volumes are to contain unpublished manuscripts, lectures, correspondence, and extracts from the notebooks. Collected Works is designed to be accessible and useful to as wide an audience as possible without sacrificing scientific or historical accuracy. The only complete edition available in English, it will be an essential part of the working library of professionals and students in logic, mathematics, philosophy, history of science, and computer science. These volumes will also interest scientists and all others who wish to be acquainted with one of the great minds of the twentieth century. (shrink)

A monumental work by an important modern philosopher, Matter and Memory (1896) represents one of the great inquiries into perception and memory, movement and time, matter and mind. Nobel Prize-winner Henri Bergson surveys these independent but related spheres, exploring the connection of mind and body to individual freedom of choice. Bergson’s efforts to reconcile the facts of biology to a theory of consciousness offered a challenge to the mechanistic view of nature, and his original and innovative views exercised a profound (...) influence on other philosophers--including James, Whitehead, and Santayana--as well as novelists such as Dos Passos and Proust. Matter and Memory is essential to an understanding of Bergson’s philosophy and its legacy. (shrink)

A controversial scientific vision predicts a time in which humans and machines will merge and create a new form of non-biological intelligence, explaining how the occurrence will solve such issues as pollution, hunger, and aging.

NOW IN PAPERBACK"€"Starting from a collection of simple computer experiments"€"illustrated in the book by striking computer graphics"€"Stephen Wolfram shows how their unexpected results force a whole new way of looking at the operation of our universe.

One of the most influential physics books of the twentieth century was actually about biology. In a series of lectures, Erwin Schrödinger described how he believed that quantum mechanics, or some variant of it, would soon solve the riddle of life. These lectures were published in 1944 under the title What is life? and are credited by some as ushering in the age of molecular biology. In the nineteenth century, many scientists thought they knew the answer to Schrödinger’s rhetorical question. (...) Life, they maintained, was some sort of magic matter. The continued use of the term ‘organic chemistry’ is a hangover from that era. The belief that there is a chemical recipe for life led to the hope that, if only we knew what it was, we could mix up the right stuff in a test tube and make life in the lab. Most research on biogenesis has followed that tradition, by assuming that chemistry was a bridge — and a long one at that — linking matter with life. Elucidating this chemical pathway has been a tantalizing goal, spurred on by the famous Miller–Urey experiment of 1952, in which amino acids were made by sparking electricity through a mixture of water and common gases. But the concept has turned out to be something of a blind alley, and further progress with prebiotic chemical synthesis has been frustratingly slow. The origin of life remains one of the great outstanding mysteries of science. To take up Schrödinger’s suggestion, a radical solution to the problem, ‘What is life?’ could be that quantum mechanics enabled life to emerge directly from the atomic world, without the need for complex intermediate chemistry. Life must have a chemical basis: organic molecules provide the hardware for biology. But what about the software? When Schrödinger asked, ‘What is life?’ he could already glimpse the central significance of the cell’s information storage and replication processes, even though the role of DNA and the genetic code was yet to be discovered.. (shrink)

Compiling twenty articles on the nature of life and on the objective of the natural sciences, this remarkable book complements Robert Rosen's groundbreaking Life Itself--a work that influenced a wide range of philosophers, biologists, linguists, and social scientists. In Essays on Life Itself, Rosen takes to task the central objective of the natural sciences, calling into question the attempt to create objectivity in a subjective world and forcing us to reconsider where science can lead us in the years to come.

... Difficulty of distinguishing between Varieties and Species — Origin of Domestic ... and Origin— Principle of Selection anciently followed, its Effects— ...

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Wilhelm Dilthey: Einleitung in die Geisteswissenschaften. Versuch einer Grundlegung für das Studium der Gesellschaft und ihrer Geschichte Lesefreundlicher Großdruck in 16-pt-Schrift Großformat, 210 x 297 mm Berliner Ausgabe, 2020 Durchgesehener Neusatz mit einer Biographie des Autors bearbeitet und eingerichtet von Theodor Borken Erstdruck: Leipzig (Duncker & Humblot) 1883. Textgrundlage ist die Ausgabe: Wilhelm Dilthey: Gesammelte Schriften. Herausgegeben von Bernhard Groethuysen u. a., Leipzig u. a.: B. G. Teubner u. a., 1914 ff. Umschlaggestaltung von Thomas Schultz-Overhage. Gesetzt aus der Minion Pro, (...) 16 pt. Henricus Edition Deutsche Klassik UG (haftungsbeschränkt). (shrink)

In der Schrift "Jenseits von Gut und Böse" erreicht Nietzsches philosophische Entlarvung des Nihilismus der überkommenen Werte ihre höchste und reifste Gestalt; als ›Vorspiel der Philosophie der Zukunft‹ konzipiert, inspiriert sie Nietzsche zu einer Neubewertung seiner frühen Schrift über "Die Geburt der Tragödie aus den Geiste der Musik", nun mit dem Vorwort: ›Versuch einer Selbstkritik‹._1885 faßte Friedrich Nietzsche den Entschluß, eine Neue Ausgabe seiner Schriften erscheinen zu lassen, die »das Eigene und Unvergleichliche in diesen Werken« herausstellen sollte. Diesem Konzept folgt (...) auch die von Claus-Artur Scheier neu herausgegebene Ausgabe der philosophischen Werke in sechs in Bänden.BAND 1 Jenseits von Gut und Böse Die Geburt der Tragödie X, 414 SeitenBAND 2 Menschliches, Allzumenschliches 1 VI, 358 SeitenBAND 3 Menschliches, Allzumenschliches 2 VI, 330 SeitenBAND 4 Morgenröthe VI, 330 SeitenBAND 5 Die fröhliche Wissenschaft / Wir Furchtlosen VI, 338 SeitenBAND 6 Zur Genealogie der Moral Götzen-Dämmerung VI, 314 SeitenDiese erste Ausgabe der philosophischen Werke Friedrich Nietzsches in der »Philosophischen Bibliothek« folgt dem 1885 von Nietzsche selbst gefaßten und begründeten Konzept einer Neuen Ausgabe seiner im eigentlichen Sinne »philosophischen« Schriften und bietet den Text nach den Originalausgaben von 1886/1887, ergänzt um die 1889 erschienene Götzen-Dämmerung.Eine »vollständige Ausgabe letzter Hand« nach dem Vorbild Goethes hat Friedrich Nietzsche nicht vorlegen können, denn am Ende war er nicht mehr Herr seiner Sinne. Doch gibt das wirklich Grund zur Klage? Oder anders gefragt: Hätte Nietzsche eine solche Ausgabe, die einfach alles versammelt, was er geschrieben hat, überhaupt gewollt und gutgeheißen? Die Frage muß offen bleiben. Doch es gibt gewiß Gründe, Nietzsche nicht mit jenen gleichzustellen, denen es auf diese Weise nur darum zu tun war, ihren Nachruhm zu sichern und nach eigenen Vorstellungen zu steuern. Denn es gibt sie ja, die von Nietzsche selbst gewollte und kritisch kommentierte Ausgabe ganz eigener Art: nämlich die durch Jenseits von Gut und Böse und die Genealogie der Moral eingerahmte Neue Ausgabe von 1886/87, die die vor dem Zarathustra veröffentlichten, mit neuen Vorreden versehenen philosophischen Schriften enthält, von denen der Autor selber sagte: »Sie werden bemerken, daß Menschliches, Allzumenschliches, die Morgenröte, die fröhliche Wissenschaft einer Vorrede ermangeln: es hatte gute Gründe, daß ich damals, als diese Werke entstanden, mir ein Stillschweigen auferlegte – ich stand noch zu nahe, noch zu sehr ›drin‹ und wußte kaum, was mit mir geschehen war. Jetzt, wo ich selber am besten und genauesten sagen kann, was das Eigene und Unvergleichliche in diesen Werken ist und inwiefern sie eine für Deutschland neue Literatur inaugurieren, würde ich mich zu solchen zurückblickenden und nachträglichen Vorreden gerne entschließen. Meine Schriften stellen eine fortlaufende Entwicklung dar, welche nicht nur mein persönliches Erlebnis und Schicksal sein wird: – ich bin nur der Erste, eine heraufkommende Generation wird das, was ich erlebt habe, von sich aus verstehn und eine feine Zunge für meine Bücher haben. Die Vorreden könnten das Notwendige im Gange einer solchen Entwicklung deutlich machen.« Mit der 1990 unter dem Titel ›Friedrich Nietzsche: Ecce auctor‹ vorgelegten Edition der Vorreden von 1886 hatte Claus-Artur Scheier zum ersten Mal darauf aufmerksam gemacht, daß Nietzsche die für die Neue Ausgabe seiner im eigentlichen Sinne »philosophischen« Schriften verfaßten Vorreden als in sich geschlossenen, genealogisch angelegten Versuch einer selbstkritischen Neubewertung und Einordnung seines Werkes ansah: »Von der Vorrede zur Geburt der Tragödie bis zur Vorrede des letztgenannten Buchs [der ›Genealogie der Moral‹] – das gibt eine Art ›Entwicklungsgeschichte‹«. Jetzt sah sich Nietzsche im Zenit seiner Schaffenskraft, und die Neue Ausgabe sollte den Mitte 1885 gefaßten Plan vorantreiben, »eine große Schul-Tätigkeit als Philosoph auszuüben […]. Die Bücher heraus aus diesem Winkel!!! Es sind meine Angelhaken; wenn sie mir keine Menschen fangen, so haben sie keinen Sinn!«. (shrink)