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  1. Strategies in the interfield discovery of the mechanism of protein synthesis.Lindley Darden & Carl Craver - 2002 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 33 (1):1-28.
    In the 1950s and 1960s, an interfield interaction between molecular biologists and biochemists integrated important discoveries about the mechanism of protein synthesis. This extended discovery episode reveals two general reasoning strategies for eliminating gaps in descriptions of the productive continuity of mechanisms: schema instantiation and forward chaining/backtracking. Schema instantiation involves filling roles in an overall framework for the mechanism. Forward chaining and backtracking eliminate gaps using knowledge about types of entities and their activities. Attention to mechanisms highlights salient features of (...)
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  • Interfield theories.Lindley Darden & Nancy Maull - 1977 - Philosophy of Science 44 (1):43-64.
    This paper analyzes the generation and function of hitherto ignored or misrepresented interfield theories , theories which bridge two fields of science. Interfield theories are likely to be generated when two fields share an interest in explaining different aspects of the same phenomenon and when background knowledge already exists relating the two fields. The interfield theory functions to provide a solution to a characteristic type of theoretical problem: how are the relations between fields to be explained? In solving this problem (...)
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  • When mechanistic models explain.Carl F. Craver - 2006 - Synthese 153 (3):355-376.
    Not all models are explanatory. Some models are data summaries. Some models sketch explanations but leave crucial details unspecified or hidden behind filler terms. Some models are used to conjecture a how-possibly explanation without regard to whether it is a how-actually explanation. I use the Hodgkin and Huxley model of the action potential to illustrate these ways that models can be useful without explaining. I then use the subsequent development of the explanation of the action potential to show what is (...)
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  • Mechanisms and the Evidence Hierarchy.Brendan Clarke, Donald Gillies, Phyllis Illari, Federica Russo & Jon Williamson - 2014 - Topoi 33 (2):339-360.
    Evidence-based medicine (EBM) makes use of explicit procedures for grading evidence for causal claims. Normally, these procedures categorise evidence of correlation produced by statistical trials as better evidence for a causal claim than evidence of mechanisms produced by other methods. We argue, in contrast, that evidence of mechanisms needs to be viewed as complementary to, rather than inferior to, evidence of correlation. In this paper we first set out the case for treating evidence of mechanisms alongside evidence of correlation in (...)
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  • Saving the phenomena.James Bogen & James Woodward - 1988 - Philosophical Review 97 (3):303-352.
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  • Explaining Engineered Computing Systems’ Behaviour: the Role of Abstraction and Idealization.Nicola Angius & Guglielmo Tamburrini - 2017 - Philosophy and Technology 30 (2):239-258.
    This paper addresses the methodological problem of analysing what it is to explain observed behaviours of engineered computing systems, focusing on the crucial role that abstraction and idealization play in explanations of both correct and incorrect BECS. First, it is argued that an understanding of explanatory requests about observed miscomputations crucially involves reference to the rich background afforded by hierarchies of functional specifications. Second, many explanations concerning incorrect BECS are found to abstract away from descriptions of physical components and processes (...)
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  • Explanatory unification.Philip Kitcher - 1981 - Philosophy of Science 48 (4):507-531.
    The official model of explanation proposed by the logical empiricists, the covering law model, is subject to familiar objections. The goal of the present paper is to explore an unofficial view of explanation which logical empiricists have sometimes suggested, the view of explanation as unification. I try to show that this view can be developed so as to provide insight into major episodes in the history of science, and that it can overcome some of the most serious difficulties besetting the (...)
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  • Computing as a Science: A Survey of Competing Viewpoints. [REVIEW]Matti Tedre - 2011 - Minds and Machines 21 (3):361-387.
    Since the birth of computing as an academic discipline, the disciplinary identity of computing has been debated fiercely. The most heated question has concerned the scientific status of computing. Some consider computing to be a natural science and some consider it to be an experimental science. Others argue that computing is bad science, whereas some say that computing is not a science at all. This survey article presents viewpoints for and against computing as a science. Those viewpoints are analyzed against (...)
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  • Which Scientific Knowledge is a Common Good?Hans Radder - 2017 - Social Epistemology 31 (5):431-450.
    In this article, I address the question of whether science can and should be seen as a common good. For this purpose, the first section focuses on the notion of knowledge and examines its main characteristics. I discuss and assess the core view of analytic epistemology, that knowledge is, basically, justified true belief. On the basis of this analysis, I then develop an alternative, multi-dimensional theory of the nature of knowledge. Section 2 reviews and evaluates several answers to the question (...)
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  • On malfunctioning software.Giuseppe Primiero, Nir Fresco & Luciano Floridi - 2015 - Synthese 192 (4):1199-1220.
    Artefacts do not always do what they are supposed to, due to a variety of reasons, including manufacturing problems, poor maintenance, and normal wear-and-tear. Since software is an artefact, it should be subject to malfunctioning in the same sense in which other artefacts can malfunction. Yet, whether software is on a par with other artefacts when it comes to malfunctioning crucially depends on the abstraction used in the analysis. We distinguish between “negative” and “positive” notions of malfunction. A negative malfunction, (...)
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  • Computing mechanisms.Gualtiero Piccinini - 2007 - Philosophy of Science 74 (4):501-526.
    This paper offers an account of what it is for a physical system to be a computing mechanism—a system that performs computations. A computing mechanism is a mechanism whose function is to generate output strings from input strings and (possibly) internal states, in accordance with a general rule that applies to all relevant strings and depends on the input strings and (possibly) internal states for its application. This account is motivated by reasons endogenous to the philosophy of computing, namely, doing (...)
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  • Pragmatic laws.Sandra D. Mitchell - 1997 - Philosophy of Science 64 (4):479.
    Beatty, Brandon, and Sober agree that biological generalizations, when contingent, do not qualify as laws. Their conclusion follows from a normative definition of law inherited from the Logical Empiricists. I suggest two additional approaches: paradigmatic and pragmatic. Only the pragmatic represents varying kinds and degrees of contingency and exposes the multiple relationships found among scientific generalizations. It emphasizes the function of laws in grounding expectation and promotes the evaluation of generalizations along continua of ontological and representational parameters. Stability of conditions (...)
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  • Thinking about mechanisms.Peter Machamer, Lindley Darden & Carl F. Craver - 2000 - Philosophy of Science 67 (1):1-25.
    The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.
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  • What is a mechanism? Thinking about mechanisms across the sciences.Phyllis Illari & Jon Williamson - 2012 - European Journal for Philosophy of Science 2 (1):119-135.
    After a decade of intense debate about mechanisms, there is still no consensus characterization. In this paper we argue for a characterization that applies widely to mechanisms across the sciences. We examine and defend our disagreements with the major current contenders for characterizations of mechanisms. Ultimately, we indicate that the major contenders can all sign up to our characterization.
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  • In Defence of Activities.Phyllis Illari & Jon Williamson - 2013 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 44 (1):69-83.
    In this paper, we examine what is to be said in defence of Machamer, Darden and Craver’s (MDC) controversial dualism about activities and entities (Machamer, Darden and Craver’s in Philos Sci 67:1–25, 2000). We explain why we believe the notion of an activity to be a novel, valuable one, and set about clearing away some initial objections that can lead to its being brushed aside unexamined. We argue that substantive debate about ontology can only be effective when desiderata for an (...)
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  • Mechanistic Evidence: Disambiguating the Russo–Williamson Thesis.Phyllis McKay Illari - 2011 - International Studies in the Philosophy of Science 25 (2):139-157.
    Russo and Williamson claim that establishing causal claims requires mechanistic and difference-making evidence. In this article, I will argue that Russo and Williamson's formulation of their thesis is multiply ambiguous. I will make three distinctions: mechanistic evidence as type vs object of evidence; what mechanism or mechanisms we want evidence of; and how much evidence of a mechanism we require. I will feed these more precise meanings back into the Russo–Williamson thesis and argue that it is both true and false: (...)
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  • Mechanistic Explanation: Integrating the Ontic and Epistemic.Phyllis Illari - 2013 - Erkenntnis 78 (2):237-255.
    Craver claims that mechanistic explanation is ontic, while Bechtel claims that it is epistemic. While this distinction between ontic and epistemic explanation originates with Salmon, the ideas have changed in the modern debate on mechanistic explanation, where the frame of the debate is changing. I will explore what Bechtel and Craver’s claims mean, and argue that good mechanistic explanations must satisfy both ontic and epistemic normative constraints on what is a good explanation. I will argue for ontic constraints by drawing (...)
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  • Exploring a Mechanistic Approach to Experimentation in Computing.Eric Hatleback & Jonathan M. Spring - 2014 - Philosophy and Technology 27 (3):441-459.
    The mechanistic approach in philosophy of science contributes to our understanding of experimental design. Applying the mechanistic approach to experimentation in computing is beneficial for two reasons. It connects the methodology of experimentation in computing with the methodology of experimentation in established sciences, thereby strengthening the scientific reputability of computing and the quality of experimental design therein. Furthermore, it pinpoints the idiosyncrasies of experimentation in computing: computing deals closely with both natural and engineered mechanisms. Better understanding of the idiosyncrasies, which (...)
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  • Modeling mechanisms.Stuart Glennan - 2005 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):443-464.
    Philosophers of science increasingly believe that much of science is concerned with understanding the mechanisms responsible for the production of natural phenomena. An adequate understanding of scientific research requires an account of how scientists develop and test models of mechanisms. This paper offers a general account of the nature of mechanical models, discussing the representational relationship that holds between mechanisms and their models as well as the techniques that can be used to test and refine such models. The analysis is (...)
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  • Ephemeral Mechanisms and Historical Explanation.Stuart Glennan - 2010 - Erkenntnis 72 (2):251-266.
    While much of the recent literature on mechanisms has emphasized the superiority of mechanisms and mechanistic explanation over laws and nomological explanation, paradigmatic mechanisms—e.g., clocks or synapses—actually exhibit a great deal of stability in their behavior. And while mechanisms of this kind are certainly of great importance, there are many events that do not occur as a consequence of the operation of stable mechanisms. Events of natural and human history are often the consequence of causal processes that are ephemeral and (...)
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  • Capacities, Universality, and Singularity.Stuart M. Glennan - 1997 - Philosophy of Science 64 (4):605-626.
    In this paper I criticize Cartwright's analysis of capacities and offer an alternative analysis. I argue that Cartwright's attempt to connect capacities to her condition CC fails because individuals can exercise capacities only in certain contexts. My own analysis emphasizes three features of capacities: 1) Capacities belong to individuals; 2) Capacities are typically not metaphysically fundamental properties of individuals, but can be explained by referring to structural properties of individuals; and 3) Laws are best understood as ascriptions of capacities.
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  • Explanation and scientific understanding.Michael Friedman - 1974 - Journal of Philosophy 71 (1):5-19.
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  • Concealment and Discovery: The Role of Information Security in Biomedical Data Re-Use.N. Tempini & Leonelli Sabina - forthcoming - Social Studies of Science.
    This paper analyses the role of information security in shaping the dissemination and re-use of biomedical data, as well as the embedding of such data in the material, social and regulatory landscapes of research. We consider the data management practices adopted by two UK-based data linkage infrastructures: the Secure Anonymised Information Linkage, a Welsh databank that facilitates appropriate re-use of health data derived from research and routine medical practice in the region; and the Medical and Environmental Data Mash-up Infrastructure, a (...)
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  • Computability and Logic.George S. Boolos, John P. Burgess & Richard C. Jeffrey - 2003 - Bulletin of Symbolic Logic 9 (4):520-521.
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