In this paper I argue that it is finally time to move beyond the Nagelian framework and to break new ground in thinking about epistemic reduction in biology. I will do so, not by simply repeating all the old objections that have been raised against Ernest Nagel’s classical model of theory reduction. Rather, I grant that a proponent of Nagel’s approach can handle several of these problems but that, nevertheless, Nagel’s general way of thinking about epistemic reduction in terms of (...) theories and their logical relations is entirely inadequate with respect to what is going on in actual biological research practice. (shrink)

In 1768 Immanuel Kant presented an argument showing the necessity of absolute space, i.e. substantivalism in contrast to relationalism, based on the property of handedness. While there is large consensus about the fallacy of Kant’s argument, a more recent debate exists – mainly stimulated by John Earman – about the status of the Kantian argument in view of modern physics and its fundamentally built-in parity violation, which leads to a preferred handedness. According to Earman the relationalist has no means to (...) distinguish one handedness in the cosmos without reference to an absolute structure of space. After recapitulating the historical background of the Newton/Leibniz debate on the ontological status of space as well as the Kantian argument, this paper offers a systematic consideration of arguments about handedness in modern physics. The goal is to show that “Earman’s challenge” can be rejected. (shrink)

One of the most important questions in epistemology and the philosophy of science is: what is a good theory and when is a theory better than another theory, given some observational data? The coherentist‟s answer would be the following twofold conjecture: A theory is a good theory given some observational data iff that theory coheres with the observational data and a theory is better than another theory given some observational data iff the first theory coheres more with the observational data (...) than the second theory. In this paper we show that this answer is a good answer. More precisely, we argue that the coherence measures of Olsson and Shogenji are good measures for the purpose of comparing and evaluating theories, i.e. assessing theories. We do so by clarifying the sufficient and necessary conditions every assessment function must satisfy for being a good measure of the goodness of theories. Afterwards we will show that the coherence measures of Olsson and Shogenji are indeed good assessment functions for assessing theories. (shrink)

The old antagonism between the Quinean and the Duhemian view on underdetermination is reexamined. In this respect, two theses will be defended. First, it is argued that the main differences between Quine's and Duhem's versions of underdetermination derive from a different attitude towards the history of science. While Quine considered underdetermination from an ahistorical, a logical point of view, Duhem approached it as a distinguished historian of physics. On this basis, a logical and a historical version of the underdetermination thesis (...) can be distinguished. The second thesis of the article is that the main objections against underdetermination are fatal only to the logical rendering. Taken together, the two theses constitute a defence of underdetermination. (shrink)

We examine possible causal structures of experiments with entangled quantum objects. Previously, these structures have been obscured by assuming a misleading probabilistic analysis of quantum non locality as 'Outcome Dependence or Parameter Dependence' and by directly associating these correlations with influences. Here we try to overcome these shortcomings: we proceed from a recent stronger Bell argument, which provides an appropriate probabilistic description, and apply the rigorous methods of causal graph theory. Against the standard view that there is only an influence (...) between the measurement outcomes, we show that there must be an influence from one setting to its distant outcome: EPR correlations can only come about if one of the outcomes is a common effect of both settings. Our discussion makes explicit under which assumptions similar conclusions from information theoretic considerations can be interpreted causally. (shrink)

The paper has three parts. In the first part ExtOSR, an extended version of Ontic Structural Realism, will be introduced. ExtOSR considers structural properties as ontological primitives, where structural properties are understood as comprising both relational and structurally derived intrinsic properties or structure invariants. It is argued that ExtOSR is best suited to accommodate gauge symmetry invariants and zero value properties. In the second part, ExtOSR will be given a Humean shape by considering structures as categorical and global. It will (...) be laid out how such structures serve to reconstruct non-essential structural kinds and laws. In the third part Humean structural realism will be defended against the threat of quidditism. (shrink)

It is widely accepted that the violation of Bell inequalities excludes local theories of the quantum realm. In this paper I present a stronger Bell argument which even forbids certain non-local theories. The remaining non-local theories, which can violate Bell inequalities, are characterised by the fact that at least one of the outcomes in some sense probabilistically depends both on its distant as well as on its local parameter. While this is not to say that parameter dependence in the usual (...) sense necessarily holds, it shows that the received analysis of quantum non-locality as “outcome dependence or parameter dependence” is deeply misleading about what the violation of Bell inequalities implies. (shrink)

In the contemporary life sciences more and more researchers emphasize the “limits of reductionism” (e.g. Ahn et al. 2006a, 709; Mazzocchi 2008, 10) or they call for a move “beyond reductionism” (Gallagher/Appenzeller 1999, 79). However, it is far from clear what exactly they argue for and what the envisioned limits of reductionism are. In this paper I claim that the current discussions about reductionism in the life sciences, which focus on methodological and explanatory issues, leave the concepts of a reductive (...) method and a reductive explanation too unspecified. In order to fill this gap and to clarify what the limits of reductionism are I identify three reductive methods that are crucial in the current practice of the life sciences: decomposition, focusing on internal factors, and studying parts in isolation. Furthermore, I argue that reductive explanations in the life sciences exhibit three characteristics: first, they refer only to factors at a lower level than the phenomenon at issue, second, they focus on internal factors and thus ignore or simplify the environment of a system, and, third, they cite only the parts of a system in isolation. (shrink)

Systems biology is largely tributary to genomics and other “omic” disciplines that generate vast amounts of structural data. “Omics”, however, lack a theoretical framework that would allow using these data sets as such (rather than just tiny bits that are extracted by advanced data-mining techniques) to build explanatory models that help understand physiological processes. Systems biology provides such a framework by adding a dynamic dimension to merely structural “omics”. It makes use of bottom-up and top-down models. The former are based (...) on data about systems components, the latter on systems-level data. We trace back both modeling strategies (which are often used to delineate two branches of the field) to the modeling of metabolic and signaling pathways in the bottom-up case, and to biological cybernetics and systems theory in the top-down case. We then argue that three roots of systems biology must be discerned to account adequately for the structure of the field: pathway modeling, biological cybernetics, and “omics”. We regard systems biology as merging modeling strategies (supplemented by new mathematical procedures) from data-poor fields with data supply from a field that is quite deficient in explanatory modeling. After characterizing the structure of the field, we address some epistemological and ontological issues regarding concepts on which the top-down approach relies and that seem to us to require clarification. This includes the consequences of identifying modules in large networks without relying on functional considerations, the question of the “holism” of systems biology, and the epistemic value of the “systeome” project that aspires to become the cutting edge of the field. (shrink)

Modeling mechanisms is central to the biological sciences – for purposes of explanation, prediction, extrapolation, and manipulation. A closer look at the philosophical literature reveals that mechanisms are predominantly modeled in a purely qualitative way. That is, mechanistic models are conceived of as representing how certain entities and activities are spatially and temporally organized so that they bring about the behavior of the mechanism in question. Although this adequately characterizes how mechanisms are represented in biology textbooks, contemporary biological research practice (...) shows the need for quantitative, probabilistic models of mechanisms, too. In this paper we argue that the formal framework of causal graph theory is well-suited to provide us with models of biological mechanisms that incorporate quantitative and probabilistic information. On the ba-sis of an example from contemporary biological practice, namely feedback regulation of fatty acid biosynthesis in Brassica napus, we show that causal graph theoretical models can account for feedback as well as for the multi-level character of mechanisms. However, we do not claim that causal graph theoretical representations of mechanisms are advantageous in all respects and should replace common qualitative models. Rather, we endorse the more balanced view that causal graph theoretical models of mechanisms are useful for some purposes, while being insufficient for others. (shrink)

This article investigates the question of why there is emotional resistance to research results such as the theory of evolution and to philosophical naturalism. A depiction of how this emotional resistance expresses itself is followed by a brief account of the core theses of philosophical naturalism. The emotional reactions to research results then are differentiated from reactions to philosophical naturalism and a first overview of the irritant positions of naturalism is given. Finally two misunderstandings about the aims of philosophical naturalism (...) are addressed. (shrink)

Der Artikel diskutiert Niklas Luhmanns Konzeption von Kommunikation als emergentem Phänomen. Erstens soll gezeigt werden, dass sich Luhmann, entgegen jüngster Einwände, in der Tat als sozialer Emergentist rekonstruieren und als solcher in die aktuelle Debatte um Reduktion und Emergenz des Sozialen einordnen lässt. Zweitens soll dadurch Licht auf die generellen Probleme und Voraussetzungen einer emergentistischen Soziologie geworfen werden. Um diese Ziele zu erreichen, wird zunächst geklärt, welche Positionen sich in der Soziologie grundsätzlich gegenüber stehen und auf welcher Grundlage Luhmann als (...) Emergentist einzuordnen ist. Anschließend soll die Emergenz der Kommunikation als eigenständiges soziales Phänomen erläutert und ins Verhältnis zum Individuum gesetzt werden. Schließlich wird Luhmanns Konzeption mit Hilfe einiger Adäquatheitsbedingungen aus der allgemeinen Wissenschaftsphilosophie als unzureichend kritisiert. Ziel ist dabei auch die Klärung der Bedingungen für eine plausible Emergenztheorie innerhalb der Soziologie. Nach einer abschließenden Zusammenfassung der wesentlichen Ergebnisse soll ein Ausblick auf eine aussichtsreiche soziologische Emergenzkonzeption geboten werden. (shrink)

The completeness of quantum mechanics is generally interpreted to be or entail the following conditional statement ): If a QM system S is in a pure non-eigenstate of observable A, then S does not have value ak of A at t. QM itself can be assumed to contain two elements: a formula generating probabilities; Hamiltonians that can be time-dependent due to a time-dependent external potential. It is shown that, given and, QM and SC are incompatible. Hence, SC is not the (...) appropriate interpretation of the completeness of QM. (shrink)

The different versions of the Kochen-Specker Theorem show that quantum mechanics cannot be supplemented by hidden variables given two constraints. These results are generally interpreted as showing that QM is complete in the following way. A QM system S has only those values of observables for which the state yields probability 1. For all other probabilities S adopts a value during the measurement interaction. But this interpretation is fundamentally problematic. In fact it cannot yield a general and coherent interpretation of (...) the trace formula. I present an argument to this effect, discuss a possible objection and sketch implications. (shrink)

In den Wissenschaften finden Bilder der unterschiedlichsten Art ihre Verwendung in unserem Streben nach Erkenntnis. Ein Merkmal vieler Arten wissenschaftlicher Visualisierungen besteht darin, dass sie bis dato nur theoretisch erfasste Entitäten sichtbar machen. Sie scheinen daher die Grenze zwischen Beobachtbarem und Unbeobachtbarem in entscheidender Weise zu verschieben. Vor diesem Hintergrund wird vielfach die konstruktivistische These vertreten, die Visualisierungen führten erst in ihrem Produktionsprozess zur Erschaffung des Forschungsobjekts, dieses existiere folglich nicht unabhängig von ihnen in der Welt. Mit dieser These setzt (...) sich der Beitrag kritisch auseinander, indem erstens nachgezeichnet wird, inwiefern konstruktivistische Deutungen in diesem Kontext naheliegen, und zweitens dieser Auffassung die Überlegungen des wissenschaftlichen Realismus als Alternative für die Interpretation der Rolle wissenschaftlicher Visualisierungen im Erkenntnisprozess gegenübergestellt werden. (shrink)

Fotografien können als paradigmatische Instanzen des Bildbegriffs aufgefasst werden. Sie finden umfangreiche Verwendung in den Wissenschaften. Die kausale Relation zum abgebildeten Objekt sowie die vermeintliche Ähnlichkeit des Bildes mit seinem Gegenstand scheinen ihren Gebrauch als Belege im Forschungsprozess zu legitimieren. Anhand einer Fallstudie zur Oberflächenerfassung des Planeten Mars mit Hilfe einer digitalen Spezialkamera soll in diesem Beitrag untersucht werden, inwiefern Fotografien der Status eines wissenschaftlichen Datums tatsächlich zugesprochen werden kann oder nicht.

This article opens with general and historical remarks on philosophy of science's problems with the concept of discovery. Then, drawing upon simple examples of Watson's and Crick's non-philosophical usage, I characterize phrases of the type "x discovers y" semantically. It will subsequently be shown how widespread philosophical discussion on discovery violates the semantic constraints of phrases of the type "x discovers y." Then I provide a philosophical reconstruction of "x discovers y" that is in keeping with the "folk" notion of (...) discovery. The philosophical ingredients of this approach are taken from a certain aspect of action theory and from epistemological reliabilism. The approach draws upon the concept of superior action and connects this concept to progressive research. In contrast to normal actions, superior actions are primarily explained by competencies. This perspective includes reminders of what some nineteenth-century philosopher-scientists had advocated as a competence-oriented view on scientific research. Finally, this approach is applied to the case of Watson's and Crick's discovery. (shrink)

The purpose of this work is to outline a new approach to the debate on structural realism. This position has been criticized in the recent literature. First, the two arguments which led to the introduction of structural realism into the debate on scientific realism are introduced, namely, the “no-miracles Second, argument” the and framework the of “pessimistic structuralist meta induction”. meta-theory is introduced in order to argue as follows. Once this framework is adapted, it is possible to respond to the (...) critiques that have been made to structural realism and to clarify this position, especially the notion of structural continuity. (shrink)