Pain in consciousness, between Stoicism and Analytic Philosophy My essay will discuss how the so-called “Spartan mirage” has influenced the philosophical tradition about “pain”. Stoicism and later Christian moral thought have focused on the primacy of conscience among human mind’s faculties. The general approach will be analytical, because I am going to argue that the concept of pain is introduced into the ancient philosophical debate together with what I would call a “sparring partner”. Within this linguistic game, the constant confrontation (...) of “pain” with a “double”, namely conscience, has produced a drift, a prejudice with evident social consequences. The mode of introduction and its longstanding effects on ethics are examined and compared to the contemporary debate on pain’s neurophysiology. (shrink)

The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of a (...) chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. (shrink)

The interview focuses on specific aspects of Giuseppe Cacciatore's philosophy, with particular emphasis on the connection between theoretical speculation and civil practice. As highlighted by philosopher Giuseppe Cantillo, Cacciatore' s works strive to combine thought and history at every point, starting with Pietro Piovani's 'critical-problematic historicism'. The outcome is a theoretical system that is aimed at civil and political commitment, while at the same time maintaining a genuinely ideal motivation.