Eyal et al have recently argued that researchers should consider conducting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human challenge studies to hasten vaccine development. We have conducted (J. L.) and overseen (L. D.) human challenge studies and agree that they can be useful in developing anti-infective agents. We also agree that adults can autonomously choose to undergo risks with no prospect of direct benefit to themselves. However, we disagree that SARS-CoV-2 challenge studies are ethically appropriate at this time, for (...) 3 reasons: (1) current scientific knowledge of SARS-CoV-2 infection is insufficient to manage risks; (2) autonomous decision making, while necessary, does not override concerns about risk; and (3) undertaking challenge studies now would imperil confidence in the research enterprise, potentially undermining the global response to the coronavirus disease 2019 (COVID-19) pandemic. (shrink)

Ang mga pelikula ng viva max ay namayagpag mula ng magkaroon ng lockdown sa Pilipinas. Sa yugtong ito, nagpalabas ang viva films ng mga pelikula sa pamamagitan ng aplikasyong viva max. Sa panonood ng mga pelikula rito, kailangan mag-subscribe ng manonood. Ang pinakamababng subscription nito ay 149.00. Sa plan na ito, isang buwan ng makakapanood ang subscriber ng lahat ng pelikula ng viva max. Nilalayon ng pananaliksik na ito na talakayin ang kalagayan ng kababaihang gumaganap sa mga piling pelikula ng (...) viva max batay sa kanilang katangian at maging ang papel sa lipunan gamit ang lenteng feminismo. Gumamit ang mananaliksik ng thematic analysis. Sa paggamit ng metodong ito, masusing pinag-aralan at binigyang-kahulugan ang mga impormasyon at datos na susuriin. Naging sandigan din ng pananaliksik na ito ang teoryang feminismo kung saan sinuri ang katangian at papel na ginampanan ng bawat tauhang babae sa mga piling pelikula ng viva max upang mabigyang-linaw ang pagbabagong naganap sa kanilang katauhan. Maging ang dahilan nang patuloy na pagtangkilik ng mga manonood sa ganitong uri ng palabas sa kabila ng iba-ibang palabas na matatagpuan sa ilang aplikasyong katulad ng Netflix, Iflix at Disney. Hindi maikakaila na malaki pa rin ang hatak ng mga pelikula na mapapanood sa viva max. Makikita rin sa pananaliksik na ito ang iba-ibang katangian at kakayahan ng mga kababaihan na tiyak na hahangaan ng sinumang manonood. Mga katangiang hindi binibigyang pansin ng ilang manonood lalo na ng mga kalalakihan ngunit kung susuriin, ito ay nagpapakita ng mahahalagang aral na tiyak na kapupulutan ng aral. Mahalagang talakayin ang ganitong uri ng pananaliksik upang magbigay- linaw kung bakit patuloy itong tinatangkilik sa paglipas ng panahon sa kabila ng paglabas ng mga bagong panoorin. (shrink)

The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of a (...) chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. (shrink)

In [3], Quentin Smith claims that `the Hartle-Hawking cosmology' is inconsistent with classical theism in a way which redounds to the discredit of classical theism; and, moreover, that the truth of `the Hartle- Hawking cosmology' would undermine reasonsed belief in any other varieties of theism which hold that the universe is created.

In her book Michel de Montaigne: Accidental Philosopher, Ann Hartle argues that Montaigne’s thought is dialectical in the Hegelian sense. Unlike Hegel’s progressive dialectic, however, Montaigne’s thought is, according to Hartle, circular in that the reconciliation of opposed terms comes not in the form of a newly emergent term, but in a return to the first term, where the meaning of the first is transformed as a result of its dialectical interaction with the second. This analysis motivates Hartle’s claim that (...) Montaigne is not a skeptic at all, let alone a Pyrrhonian skeptic. In this paper, I argue that Hartle’s circular-dialectical interpretation of Montaigne is not only compatible with Pyrrhonism, but is in fact an ideal model for understanding Sextus Empiricus’s skeptical therapy. (shrink)

Gruber et al. (2022) and Buonomano and Rovelli (Forthcoming) aim to render Q18 consistent the picture of time delivered to us by physics, with the way time seems to us in experience. Their general approach is similar; they take the picture of our world given to us in physics, a picture on which there is no global “moving” present and hence no robust temporal flow, and attempt to explain why things nevertheless seem to us as they do, given that our (...) world is that way. In this, they follow in the footsteps of Hartle (2005), Callender (2017), and Ismael (2017), who argue that any information gathering system (an IGUS) will, in learning to navigate our world, represent the distinctions between past, present, and future, and represent their own changing trajectory through spacetime. While we are generally very sympathetic to this approach, there are several places where we disagree. (shrink)

Gruber and Smith (2019) have conducted some interesting virtual reality (VR) experiments, but we think that these experiments fail to illuminate why people think that the present is special. Their experiments attempted to test a suggestion by Hartle (2005) that with VR one might construct scenarios in which people experience the same present twice. If that’s possible, then it could give us a reason to think that when we experience the present as being special, that’s not because it’s objectively so. (...) Instead, our experience of the present being special is a feature of having a psychology like ours. While we are sympathetic to the thought that there is no objective present, we do not think that these experiments give us a reason to think this. That said, VR experiments, such as Gruber and Smith’s, hold much promise for being able to illuminate various aspects of our temporal psychology.According to Hartle’s (2005) IGUS model (which is meant to resemble entities like us) sensory information is routed to two kinds of processes: conscious processes C, which cause behavior, and unconscious processes, U, which construct a schematic representation of the environment. Hartle proposed that we experience the present as being special because of the sensory information at a time entering into C. For Gruber et al. (2020), the succession of sensory information entering into C underpins our experience of time passing. Our experience of time passing is illusory because it fails to be verid... (shrink)

Philosophers of literature do not take much of an interest in autobiography.1 In one sense this is not surprising. As a certain prejudice has it, autobiography is, along with biography, the preferred reading of people who do not really like to read. The very words can conjure up images of what one finds on bookshelves in Florida retirement communities and in underfunded public libraries, books with titles like Under the Rainbow: The Real Liza Minnelli or Me: Stories of My (...) Life (Katharine Hepburn).2 Hardly rousing material, at least from the philosophical point of view. But on a moment’s reflection, it becomes clear that the initial prejudice is unfounded. Never mind the fact that there are obviously .. (shrink)

The consistent histories reformulation of quantum mechanics was developed by Robert Griffiths, given a formal logical systematization by Roland Omn\`{e}s, and under the label `decoherent histories', was independently developed by Murray Gell-Mann and James Hartle and extended to quantum cosmology. Criticisms of CH involve issues of meaning, truth, objectivity, and coherence, a mixture of philosophy and physics. We will briefly consider the original formulation of CH and some basic objections. The reply to these objections, like the objections themselves, involves a (...) mixture of physics and philosophy. These replies support an evaluation of the CH formulation as a replacement for the measurement, or orthodox, interpretation. (shrink)