Driven by technological innovations, newborn screening (NBS) panels have been expanded and the development of genomic NBS pilot programs is rapidly progressing. Decisions on disease selection for NBS are still based on the Wilson and Jungner (WJ) criteria published in 1968. Despite this uniform reference, interpretation of the WJ criteria and actual disease selection for NBS programs are highly variable. A systematic literature search [PubMED search “Wilson” AND “Jungner”; last search 16.07.22] was performed to evaluate the applicability of the WJ (...) criteria for current and future NBS programs and the need for adaptation. By at least two reviewers, 105 publications (systematic literature search, N = 77; manual search, N = 28) were screened for relevant content and, finally, 38 publications were evaluated. Limited by the study design of qualitative text analysis, no statistical evaluation was performed, but a structured collection of reported aspects of criticism and proposed improvements was instead collated. This revealed a set of general limitations of the WJ criteria, such as imprecise terminology, lack of measurability and objectivity, missing pediatric focus, and absent guidance on program management. Furthermore, it unraveled specific aspects of criticism on clinical, diagnostic, therapeutic, and economical aspects. A major obstacle was found to be the incompletely understood natural history and phenotypic diversity of rare diseases prior to NBS implementation, resulting in uncertainty about case definition, risk stratification, and indications for treatment. This gap could be closed through the systematic collection and evaluation of real-world evidence on the quality, safety, and (cost-)effectiveness of NBS, as well as the long-term benefits experienced by screened individuals. An integrated NBS public health program that is designed to continuously learn would fulfil these requirements, and a multi-dimensional framework for future NBS programs integrating medical, ethical, legal, and societal perspectives is overdue. (shrink)

This paper considers the problem of assigning meanings to empty natural kind terms. It does so in the context of the Twin-Earth externalist-internalist debate about whether the meanings of natural kind terms are individuated by the external physical environment of the speakers using these terms. The paper clarifies and outlines the different ways in which meanings could be assigned to empty natural kind terms. And it argues that externalists do not have the semantic resources to assign them meanings. The paper (...) ends on a sceptical note concerning the fruitfulness of using the Twin-Earth setting in debates about the semantics of empty natural kind terms. (shrink)

Many philosophers claim that understanding a logical constant (e.g. ‘if, then’) fundamentally consists in having dispositions to infer according to the logical rules (e.g. Modus Ponens) that fix its meaning. This paper argues that such dispositionalist accounts give us the wrong picture of what understanding a logical constant consists in. The objection here is that they give an account of understanding a logical constant which is inconsistent with what seem to be adequate manifestations of such understanding. I then outline an (...) alternative account according to which understanding a logical constant is not to be understood dispositionally, but propositionally. I argue that this account is not inconsistent with intuitively correct manifestations of understanding the logical constants. (shrink)

A paradigmatic case of rigidity for singular terms is that of proper names. And it would seem that a paradigmatic case of rigidity for general terms is that of natural kind terms. However, many philosophers think that rigidity cannot be extended from singular terms to general terms. The reason for this is that rigidity appears to become trivial when such terms are considered: natural kind terms come out as rigid, but so do all other general terms, and in particular all (...) descriptive general terms. This paper offers an account of rigidity for natural kind terms which does not trivialise in this way. On this account, natural kind terms are de jure obstinately rigid designators and other general terms, such as descriptive general terms, are not. (shrink)

I address a type of circularity threat that arises for the view that we employ general basic logical principles in deductive reasoning. This type of threat has been used to argue that whatever knowing such principles is, it cannot be a fully cognitive or propositional state, otherwise deductive reasoning would not be possible. I look at two versions of the circularity threat and answer them in a way that both challenges the view that we need to apply general logical principles (...) in deductive reasoning and defuses the threat to a cognitivist account of knowing basic logical principles. (shrink)

It is disputed what norm, if any, governs assertion. We address this question by looking at assertions of future contingents: statements about the future that are neither metaphysically necessary nor metaphysically impossible. Many philosophers think that future contingents are not truth apt, which together with a Truth Norm or a Knowledge Norm of assertion implies that assertions of these future contingents are systematically infelicitous. In this article, we argue that our practice of asserting future contingents is incompatible with the view (...) that they are not truth apt. We consider a range of norms of assertion and argue that the best explanation of the data is provided by the view that assertion is governed by the Knowledge Norm. (shrink)

This paper considers the question of what knowing a logical rule consists in. I defend the view that knowing a logical rule is having propositional knowledge. Many philosophers reject this view and argue for the alternative view that knowing a logical rule is, at least at the fundamental level, having a disposition to infer according to it. To motivate this dispositionalist view, its defenders often appeal to Carroll’s regress argument in ‘What the Tortoise Said to Achilles’. I show that this (...) dispositionalist view, and the regress that supposedly motivates it, operate with the wrong picture of what is involved in knowing a logical rule. In particular I show that it gives us the wrong picture of the relation between knowing a logical rule and actions of inferring according to it, as well as of the way in which knowing a logical rule might be a priori. (shrink)

John MacFarlane has recently argued that his brand of truth relativism – Assessment Sensitivity – provides the best solution to the puzzle of future contingents: statements about the future that are metaphysically neither necessary nor impossible. In this paper, we show that even if we grant all of the metaphysical, semantic and pragmatic assumptions in terms of which MacFarlane sets and solves the puzzle, Assessment Sensitivity is ultimately self-refuting.

Classical logic counts sentences such as ‘Alice is identical with Alice’ as logically true. A standard objection to classical logic is that Alice’s self-identity, for instance, is not a matter of logic because the identity of particular objects is not a matter of logic. For this reason, many philosophers argue that classical logic is not the right logic, and that it should be abandoned in favour of free logic — logic free of existential commitments with respect to singular terms. In (...) most standard free logics, sentences such as ‘Alice is identical with Alice’ are not logically true. This paper argues that this objection from existential commitments is some- what superficial and that there is a deeper reason why ‘Alice is identical with Alice’ should not be considered a logical truth. Indeed, a key fundamental thought about the nature of logic is that a logical truth is true in virtue of its logical form. The fundamental problem I raise is that a sentence such as ‘Alice is identical with Alice’ appears to not even be true in virtue of its logical form. Thus this paper argues that given that such a sentence is not true in virtue of its logical form, it should not be counted as logically true. It moreover argues, on the same grounds, that even the sentences which free logicians regard as logically true shouldn’t be regarded as logically true. So in this sense free logic is no repair to classical logic. (shrink)

On Fred Dretske’s account of knowledge, the Epistemic Closure Principle for knowledge is not valid. Dretske takes this to be a virtue since the account is thus able to saves ordinary knowledge from skepticism. On it, you may know that you have hands, although you do not know that you are not a handless brain in a vat. As a correlate, the account also has to countenance the existence of what has come to be known as ‘abominable conjunctions’ – conjunctions (...) of the form ‘I know I have hands but I do not know that I am not a handless brain in a vat’. These conjunctions are abominable in that they look false or in some way incoherent. Dretske suggests that the abomination is merely pragmatic and can be explain in terms of conversational features, more precisely, in terms of the Gricean Conversation Principles and its associated Maxims of Conversation. I argue that no such Gricean explanation is forthcoming, and that the abomination cannot be thought of as a merely pragmatic or conversational phenomenon. As I show, the abomination goes deeper, into the semantics. (shrink)

Des lecteurs dune récente livraison de Monist, The Relevance of Charles Peirce, pourraient chercher l'actualité de Peirce chez des philosophes contemporains influencés par lui. J'essaie de montrer que Peirce est actuel parce que son apport principal, le pragmatisme, se rattache profondément à des sujets qui nous sont familiers. Formé dans la tradition cartésienne et kantienne de l'epistemologie, l'oeuvre de Peirce intéresse les héritiers de cette tradition.Cependant, son pragmatisme fait apparaître les hésitations de cette tradition qui offre à ses héritiers une (...) incertitude epistemologic ue générale dont l'effet est de les engager vers un fondationalisme égocentrique qui isole plusieurs philosophes de l'actualité. Readers of the recent Monist publication, The Relevance of Charles Peirce (La Salle, Illinois, 1983) may seek to locate Peirce's « relevance » in the number of contemporary philosophers influenced by any aspect of his work.I argue, instead, that Peirce is relevant because his central work, pragmatism, relates deeply to matters immediately at hand. Since he is trained in Cartesian-Kantian tradition of epistemology, Peirce's work interests disciples of that tradition. In the end, however, his pragmatism discloses the errent tendency of that tradition : to offer its disciples over-generalized epistemological uncertainty and, therefore, the compensatory need to engage in egocentric foundationalisms. These foundationalisms isolate many contemporary philosophers from « mutters immediately at hand ». (shrink)

The Fifth Element (1997) is a French science-fiction film in English, directed and co-written by Luc Besson. The title and the plot of the film refer to a central notion of Greek philosophy, that is, pemptousia, or quintessence. Pre-Socratic philosophers such as Thales, Anaxagoras, Anaximenes and others, were convinced that all natural beings – in fact, nature itself – consist in four primary imperishable elements or essences (ousiai), i.e., fire, earth, water, and air. To these four, Aristotle added aether, (...) a fifth essence (pemptousia). The introduction of aether gave birth to a great tradition in late Antique and Medieval philosophy, and eventually it came to signify not an additional primary element, but the core-essence of all beings, their fundamental ontological structure. Besson’s film draws its inspiration on this philosophical tradition but its cinematographic rendering of the concept of Quintessence is typical of the contemporaneous views on the core characteristics of matters. The modernity that stimulates the film is equally anti-transcendentalist and anti-essentialist. Thus, the fifth element of the film is existentially personified and genderized making the traditional philosophical significance of the term to be adjusted by modernity in an immanent and temporal context where in addition aesthetics plays a crucial role. (shrink)

A discussion of a collection of essays by French scholars on Adam Smith, mainly but not exclusively, on his political theory.

Heidegger, Philosophy, and Politics: The Heidelberg Conference Autor: Jacques Derrida, Hans-Georg Gadamer, and Philippe Lacoue-Labarthe, Edited by Mireille Calle-Gruber, Translated by Jeff Fort, Foreword by Jean-Luc Nancy, Editorial: Fordham University Press, Fecha de Publicación: 2016, Formato: Hardback $85.00, Páginas: 116, Reviewed by: Facundo Bey (Universidad Nacional de General San Martín / CONICET-Universidad de Buenos Aires).