The problem analysed in this paper is whether we can gain knowledge by using valid inferences, and how we can explain this process from a model-theoretic perspective. According to the paradox of inference (Cohen & Nagel 1936/1998, 173), it is logically impossible for an inference to be both valid and its conclusion to possess novelty with respect to the premises. I argue in this paper that valid inference has an epistemic significance, i.e., it can be used by an agent to (...) enlarge his knowledge, and this significance can be accounted in model-theoretic terms. I will argue first that the paradox is based on an equivocation, namely, it arises because logical containment, i.e., logical implication, is identified with epistemological containment, i.e., the knowledge of the premises entails the knowledge of the conclusion. Second, I will argue that a truth-conditional theory of meaning has the necessary resources to explain the epistemic significance of valid inferences. I will explain this epistemic significance starting from Carnap’s semantic theory of meaning and Tarski’s notion of satisfaction. In this way I will counter (Prawitz 2012b)’s claim that a truth-conditional theory of meaning is not able to account the legitimacy of valid inferences, i.e., their epistemic significance. (shrink)

This undergraduate textbook introduces some fundamental issues in philosophy of science for students of philosophy and science students. The book is divided into two parts. Part 1 deals with knowledge and values. Chap. 1 presents the classical conception of knowledge as initiated by the ancient Greeks and elaborated during the development of science, introducing the central concepts of truth, belief and justification. Aspects of the quest for objectivity are taken up in the following two chapters. Moral issues are broached in (...) Chap. 4, which discusses some aspects of the use and abuse of science, taking up the responsibilities of scientists in properly conducting their business and decision-makers in their concerns with the import of science for society. Part 2 contrasts the view of scientific progress as the rejecting of old hypotheses and theories and replacing them with new ones, represented by Karl Popper, with the conception of progress as accumulating knowledge, saving as much as possible from older theories, represented by Pierre Duhem. A concluding chapter defends the natural attitude of taking the theories of modern science to be literally true, i.e. realism, in the face of arguments drawn partly from the history of scientific progress in criticism of this stance. (shrink)

During the past few decades, a radical shift has occurred in how philosophers conceive of the relation between science and philosophy. A great number of analytic philosophers have adopted what is commonly called a ‘naturalistic’ approach, arguing that their inquiries ought to be in some sense continuous with science. Where early analytic philosophers often relied on a sharp distinction between science and philosophy—the former an empirical discipline concerned with fact, the latter an a priori discipline concerned with meaning—philosophers today largely (...) follow Willard Van Orman Quine (1908-2000) in his seminal rejection of this distinction. -/- This book offers a comprehensive study of Quine’s naturalism. Building on Quine’s published corpus as well as thousands of unpublished letters, notes, lectures, papers, proposals, and annotations from the Quine archives, this book aims to reconstruct both the nature (chapters 2-4) and the development (chapter 5-7) of his naturalism. As such, this book aims to contribute to the rapidly developing historiography of analytic philosophy, and to provide a better, historically informed, understanding of what is philosophically at stake in the contemporary naturalistic turn. (shrink)

No one has a well developed solution to Duhem's problem, the problem of how experimental evidence warrants revision of our theories. Deborah Mayo proposes a solution to Duhem's problem in route to her more ambitious program of providing a philosophical account of inductive inference and experimental knowledge. This paper is a response to Mayo's Error Statistics (ES) program, paying particular attention to her response to Duhem's problem. It turns out that Mayo's purported solution to Duhem's problem is very significant to (...) her project, for the epistemic license claimed by ES and the philosophical underpinnings to her account of experimental knowledge depend on this solution. By introducing the partition problem, I argue that ES fails to solve Duhem's problem and therefore fails to provide an adequate account of experimental knowledge. (shrink)

Scientists often respond to failures to replicate by citing differences between the experimental components of an original study and those of its attempted replication. In this paper, we investigate these purported mismatch explanations. We assess a body of failures to replicate in neuroscience studies on spinal cord injury. We argue that a defensible mismatch explanation is one where a mismatch of components is a difference maker for a mismatch of outcomes, and the components are relevantly different in the follow-up study, (...) given the scope of the original study. With this account, we argue that not all differences between studies are meaningful, even if they are difference makers. As our examples show, focusing only on these differences results in disregarding the representativeness of the original experiment’s components and the scope of its outcomes, undercutting other epistemic aims, such as translation, in the process. (shrink)

Quine is routinely perceived as having changed his mind about the scope of the Duhem-Quine thesis, shifting from what has been called an 'extreme holism' to a more moderate view. Where the Quine of 'Two Dogmas of Empiricism' argues that “the unit of empirical significance is the whole of science” (1951, 42), the later Quine seems to back away from this “needlessly strong statement of holism” (1991, 393). In this paper, I show that the received view is incorrect. I distinguish (...) three ways in which Quine's early holism can be said to be wide-scoped and show that he has never changed his mind about any one of these aspects of his early view. Instead, I argue that Quine's apparent change of mind can be explained away as a mere shift of emphasis. (shrink)

In the reflection on organisations there is a tradition that focuses on the dimensions of power within organisations. Generally in that tradition, organisations are interpreted as complex unities of individuals and coalitions who try to influence the functioning of organisations with a view to their values and interests. This tradition presents itself in opposition to mainstream thinking about organisations in which they are interpreted as technical systems for making profits through efficient ways of production. This dichotomy of tradition reflects more (...) or less Habermas's dichotomy of communicative and instrumental reason. In this article I develop a perspective that goes beyond this dichotomy. I try to show by means of a critical analysis of organisations from a "technological" perspective that organisations are necessarily open to democratic actions. This can be considered as an unforeseen application or example of the Habermasian communicative reason. (shrink)

The high point of the falsification of physical theories in a standard view of the philosophy of science is the so-called crucial experiment. This experiment is a kind of manipulated empirical test, which provides the criterion for distinguishing between two rival hypotheses, where one is an acceptable theory due to passing the test, and the other turns out to be an unacceptable theory as it does not pass the test. The crucial experiment was supposed to play a significant role because, (...) in virtue of an empirical disconfirmation of one theory, the experiment was assumed to confirm the other as true. However, in 1906, in La théorie physique, son object et la structure (hereafter quoted in English translation as The Aim and Structure of Physical Theory (1906/1954)), Pierre Duhem famously argued against this view and stated that crucial experiments in physics are impossible as they are necessarily ambiguous and logically incomplete. His contention rested on the claim that, “[a] physical theory is not an explanation [of true reality in itself in virtue of some broad metaphysical ramification of physics]. It is a system of mathematical propositions, deduced from a small number of principles, which aim to represent as simply, as completely, and as accurately as possible a set of experimental laws” (ibid., p. 19). Furthermore, different theories could be equally suitable to represent a given group of experimental laws. And, assuming holism, no hypothesis could be tested in isolation, but merely as a part of a set of an entire scientific theory. The problem which Duhem identified in 1906 was slightly overshadowed and neglected in mainstream philosophy of science until the appearance of a challenging paper by Willard Van Orman Quine published in 1951 and entitled “Two Dogmas of Empiricism”. Quine’s paper caused a revival of interest in Duhem’s original formulation and gave a new impulse towards the problem in the form of the so-called Duhem-Quine thesis. The aim of this paper is to reconsider whether Duhem was right to argue that there are no crucial experiments in physics. In order to assess the validity of the thesis, first, this paper makes an exposition of Duhem’s arguments in their favour, and analyses the major criticisms of this position offered in the subject-literature of Adolf Grünbaum, who explicitly attacked the arguments for the thesis as inconclusive and false. Then, this paper presents possible modes of defence of the Duhem-Quine thesis and argues that the original formulation of the thesis is well qualified and plausible. Finally, this paper offers a pragmatic interpretation of the theory choice. (shrink)

ABSTRACT The emerging consensus in the secondary literature on Duhem is that his notion of ‘good sense’ is a virtue of individual scientists that guides them choosie between empirically equal rival theories : 149–159; Ivanova 2010. “Pierre Duhem’s Good Sense as a Guide to Theory Choice.” Studies in History and Philosophy of Science Part A 41 : 58–64; Fairweather 2011. “The Epistemic Value of Good Sense.” Studies in History and Philosophy of Science Part A 43 : 139–146; Bhakthavatsalam. “Duhemian Good (...) Sense and Agent Reliabilism.” Studies in History and Philosophy of Science Part A 64: 22–29). In this paper, I argue that good sense is irrelevant for theory choice within Duhem’s conception of scientific methodology. Theory choice, for Duhem, is either a pseudo-problem or addressed purely by empirical and formal desiderata depending on how it is understood. I go on to provide a positive interpretation of good sense as a feature of scientific communities that undergo particular forms of education that allow scientists to abandon theory pursuit. I conclude by suggesting that this interpretation entails that virtue epistemological readings of Duhem are insufficient for understanding good sense; we must employ a social epistemological perspective. (shrink)

Quine’s thesis of underdetermination is significantly weaker than it has been taken to be in the recent literature, for the following reasons: (i) it does not hold for all theories, but only for some global theories, (ii) it does not require the existence of empirically equivalent yet logically incompatible theories, (iii) it does not rule out the possibility that all perceived rivalry between empirically equivalent theories might be merely apparent and eliminable through translation, (iv) it is not a fundamental thesis (...) within Quine’s philosophy, and (v) it does not carry with it the anti-realistic consequences often associated with the thesis in recent debates. The paper analyzes Quine’s views on the matter and the changes they underwent over the years. A conjecture is put forth about why Quine’s thesis has been so widely misrepresented: Quine’s writings up to 1975 tackled primarily the formulation and justification of the thesis, but afterwards were concerned mostly with the question whether empirically equivalent rivals to the theory we hold are to be considered true also. When this latter discussion is read without bearing in mind Quine’s earlier formulation and justification of the thesis, his thesis seems to have stronger epistemic consequences than it actually does. A careful reading of his later writings shows, however, that the formulation of the thesis remained unchanged after 1975, and that his mature and considered views supported only a very mitigated version of the thesis. (shrink)

Whereas there is much discussion about Thomas Kuhn’s notion of methodological incommensurability and many have seen his ideas as an attempt to allow for rational disagreement in science, so far no serious analysis of how exactly Kuhn aims to account for rational disagreement has been proposed. This paper provides the first in-depth analysis of Kuhn’s account of rational disagreement in science—an account that can be seen as the most prominent attempt to allow for rational disagreement in science. Three things will (...) be shown: First, we find not one, but two accounts of rational disagreements in science in Kuhn’s writings: one stemming from methodological incommensurability and one stemming from Kuhn-underdetermination, which are not only fundamentally different—the first purports to explain how disagreeing scientists can nevertheless be rational, while the second attempts to show how rational scientists can nevertheless disagree—but appear to be incompatible with each other. Second, I will assess both accounts. Kuhn’s account from methodological incommensurability is not convincing since it cannot explain rational disagreement in science. Whereas, on the other hand, Kuhn’s account from Kuhn-underdetermination allows for rational disagreement, his argument why we should accept it is not convincing. Third, I present a tentative sketch of an alternative to Kuhn’s account that emphasizes the fallibility of epistemic justification in order to show that Kuhn’s argument founders. In sum, the paper shows that focusing not on the muchly debated consequences of methodological incommensurability, but on Kuhn’s treatment of rational disagreement gives new insight into the adequate interpretation of his thought as well as the cogency of his ideas. (shrink)

“What data will show the truth?” is a fundamental question emerging early in any empirical investigation. From a statistical perspective, experimental design is the appropriate tool to address this question by ensuring control of the error rates of planned data analyses and of the ensuing decisions. From an epistemological standpoint, planned data analyses describe in mathematical and algorithmic terms a pre-specified mapping of observations into decisions. The value of exploratory data analyses is often less clear, resulting in confusion about what (...) characteristics of design and analysis are necessary for decision making and what may be useful to inspire new questions. This point is addressed here by illustrating the Popper-Miller theorem in plain terms and using a graphical support. Popper and Miller proved that probability estimates cannot generate hypotheses on behalf of investigators. Consistently with Popper-Miller, we show that probability estimation can only reduce uncertainty about the truth of a merely possible hypothesis. This fact clearly identifies exploratory analysis as one of the tools supporting a dynamic process of hypothesis generation and refinement which cannot be purely analytic. A clear understanding of these facts will enable stakeholders, mathematical modellers and data analysts to better engage on a level playing field when designing experiments and when interpreting the results of planned and exploratory data analyses. (shrink)

Duhem-Quine’s thesis provides plausibility for Feyerabend’s methodological anarchism by showing that the empirical refutation of a theoretical system is as chimerical as its verification. Grünbaum argues against this that such a thesis is untenable. They both agree in the formulation of Duhem’s argument as it was exposed by Quine. However, the exegesis carried out by Quinn, Laudan and Ariew makes it clear that it is a mistake to identify the Duhem-Quine thesis with the Duhem thesis. I argue that, if this (...) is so, then a refutation that can be accepted as such only in retrospect is logically possible. (shrink)

This paper is meant to link the philosophical debate concerning the underdetermination of theories by evidence with a rather significant socio-political issue that has been taking place in Canada over the past few years: the so-called ‘death of evidence’ controversy. It places this debate within a broader philosophical framework by discussing the connection between evidence and theory; by bringing out the role of epistemic values in the so-called scientific method; and by examining the role of social values in science. While (...) it should be admitted that social values play an important role in science, the key question for anyone who advocates this view is: what and whose values? The way it is answered makes an important epistemic difference to how the relation between evidence and theory is appraised. I first review various arguments for the claim that evidence underdetermines theory and shows their presuppositions and limitations, using conceptual analysis and historical examples. After broaching the relation between evidence and method in science by highlighting the need to incorporate epistemic values into the scientific method, my discussion focuses on recent arguments for the role of social values in science. Finally, I address the implications of the approach outlined for the current ‘death of evidence’ debate in Canada. (shrink)

The concept of burden of proof is used in a wide range of discourses, from philosophy to law, science, skepticism, and even in everyday reasoning. This paper provides an analysis of the proper deployment of burden of proof, focusing in particular on skeptical discussions of pseudoscience and the paranormal, where burden of proof assignments are most poignant and relatively clear-cut. We argue that burden of proof is often misapplied or used as a mere rhetorical gambit, with little appreciation of the (...) underlying principles. The paper elaborates on an important distinction between evidential and prudential varieties of burdens of proof, which is cashed out in terms of Bayesian probabilities and error management theory. Finally, we explore the relationship between burden of proof and several (alleged) informal logical fallacies. This allows us to get a firmer grip on the concept and its applications in different domains, and also to clear up some confusions with regard to when exactly some fallacies (ad hominem, ad ignorantiam, and petitio principii) may or may not occur. (shrink)

Exploratory factor analysis is a statistical method widely used in quantitative psychology for the construction of scales and measurement instruments. It aims to reduce the complexity of a data set and explain the common and unique variance using latent variables. In introductory textbooks, exploratory factor analysis is generally presented in contrast to confirmatory factor analysis as a theory- or a hypothesis-generating process that does not require prior background, theory or hypothesis to be performed. The aim of the present paper is (...) to analyze this claim and clarify in which sense exploratory factor analysis is theory-laden. We provide a careful examination of the concepts it involves and thereby establish a clear limitation of the epistemic scope of exploratory factor analysis. (shrink)

Philosophers of science have often favoured reductive approaches to how-possibly explanation. This article identifies three alternative conceptions making how-possibly explanation an interesting phenomenon in its own right. The first variety approaches “how possibly X?” by showing that X is not epistemically impossible. This can sometimes be achieved by removing misunderstandings concerning the implications of one’s current belief system but involves characteristically a modification of this belief system so that acceptance of X does not result in contradiction. The second variety offers (...) a potential how-explanation of X. It is usually followed by a range of further potential how-explanations of the same phenomenon. In recent literature the factual claims implied by the second variety have been downplayed whereas the heuristic role of mapping the space of conceptual possibilities has been emphasized. I will focus especially on this truth-bracketing sense of potentiality when looking closer at the second variety in the paper. The third variety has attracted less interest. It presents a partial how-explanation of X. Typically it aims to establish the existence of a mechanism by which X could be and was generated. The third conception stands out as the natural alternative for the advocate of ontic how-possibly explanations. This article transfers Salmon’s view that explanation-concepts can be broadly divided into epistemic, modal, and ontic to the context of how-possibly explanations. Moreover, it is argued that each of the three above-mentioned varieties of how-possibly explanation occurs in science. To recognize this may be especially relevant for philosophers. We are often misled by the promises of various why-explanation accounts, and seem to have forgotten nearly everything about the diversity of how-possibly explanations. (shrink)

Duhem is often described as an anti-realist or instrumentalist. A contrary view has recently been expressed by Martin (1991) (Pierre Duhem: Philosophy and History in the Work of a Believing Physicist (La Salle, IL: Open Court)), who suggests that this interpretation makes it difficult to understand the vantage point from which Duhem argues in La science allemande (1915) that deduction, however impeccable, cannot establish truths unless it begins with truths. In the same spirit, the present paper seeks to establish that (...) Duhem is at any rate not the kind of anti-realist he is often presented as being, and that his views are like those Quine sees fit to call realist. An interpretation of Duhem's views on explanation and precision in science, and their bearing on the epistemological status of theory, is advanced which leads naturally into his critique of conventionalism. His attitude towards atomism, which should not be judged from a post-1925 perspective, is considered part of the unified view he strove after and appropriately called Duhem's physicalism, standing in contrast to the kind of reductionist conception usually associated with atomism. (shrink)

The rejection of the idea that the so‐called Duhem‐Quine thesis in fact expresses a thesis upheld by either Duhem or Quine invites a more detailed comparison of their views. It is suggested that the arguments of each have a certain impact on the positions maintained by the other. In particular, Quine's development of his notion of ontological commitment is enlisted in the interpretation of Duhem's position. It is argued that this counts against the instrumentalist construal usually put on what Duhem (...) says about approximation and historical continuity. (shrink)

Evidential holism begins with something like the claim that “it is only jointly as a theory that scientific statements imply their observable consequences.” This is the holistic claim that Elliott Sober tells us is an “unexceptional observation”. But variations on this “unexceptional” claim feature as a premise in a series of controversial arguments for radical conclusions, such as that there is no analytic or synthetic distinction that the meaning of a sentence cannot be understood without understanding the whole language of (...) which it is a part and that all knowledge is empirical knowledge. This paper is a survey of what evidential holism is, how plausible it is, and what consequences it has. Section 1 will distinguish a range of different holistic claims, Sections 2 and 3 explore how well motivated they are and how they relate to one another, and Section 4 returns to the arguments listed above and uses the distinctions from the previous sections to identify holism's role in each case. (shrink)

This paper is a detailed critical study of Adolf Grünbaum's work on the Duhemian thesis. I show that (a) Grünbaum's geometrical counterexample to the (D1) subthesis is unsuccessful, even with minimal claims made for what the counterexample is supposed to show, and (b) the (D2) subthesis is not a reasonable one (and cannot correctly be attributed to Duhem). The paper concludes with an argument about the relation between the Duhemian thesis, concerning component hypotheses of a scientific theory, and the view (...) that it is impossible to falsify entire theories conclusively. (shrink)

Duhem's discussion of physical theories as natural classifications is neither antithetical nor incidental to the main thrust of his philosophy of science. Contrary to what is often supposed, Duhem does not argue that theories are better thought of as economically organizing empirical laws than as providing information concerning the nature of the world. What he is primarily concerned with is the character and justification of the scientific method, not the logical status of theoretical entities. The crucial point to notice is (...) that he took the principle of the autonomy of physics to be of paramount importance and he developed the conception of natural classification in opposition to accounts of physical theories that contravened it. (shrink)

The publication of this volume appears to be the most recent in a group of works whose appearance marks renewed interest in Duhem. Over the past ten years, attention has been focused on Duhem's life (Jaki 1984), his physics (Jaki 1984; Nye 1986, 208–23), his philosophy of science (Jaki 1984, chap. 9; Paul 1979, chap. 5; Ariew 1984),' and his history of science (Jaki 1984, chap. 10; Martin 1976). But the significance of this translation is that - leaving asideTo Save (...) the Phenomena– for the first time we have a partial translation into English of one of the two great historical works that revitalized the study of medieval science. (shrink)

The waning popularity of logical empiricism and the supposed discovery of insurmountable technical difficulties led most philosophers to abandon the project to formulate a formal criterion of empirical significance. Such a criterion would delineate claims that observation can confirm or disconfirm from those it cannot. Although early criteria were clearly inadequate, criticisms made of later, more sophisticated criteria were often indefensible or easily answered. Most importantly, Carnap’s last criterion was seriously misinterpreted and an amended version of it remains tenable.

What makes a high-quality biomarker experiment? The success of personalized medicine hinges on the answer to this question. In this paper, I argue that judgment about the quality of biomarker experiments is mediated by the problem of theoretical underdetermination. That is, the network of biological and pathophysiological theories motivating a biomarker experiment is sufficiently complicated that it often frustrates valid interpretation of the experimental results. Drawing on a case-study in biomarker diagnostic development from neurooncology, I argue that this problem of (...) underdetermination can be overcome with greater coordination across the biomarker research trajectory. I then sketch an account for how coordination across a research trajectory can be evaluated. I ultimate conclude that what makes a high-quality biomarker experiment must be judged by the epistemic contribution it makes to this coordinated research effort. (shrink)

Pierre Duhem rejected unambiguously the strong version of realism that he believed was held by Copernicus. In fact, although Copernicus believed that his theory was clearly superior to Ptolemy's, he seems to have recognized that his theory was at best only approximately true. Accordingly, he recognized that his arguments were not demonstrative in the traditional sense but probable and persuasive. Duhem regarded even the belief in probably true explanations as misguided. Nevertheless, Duhem recognized that, even if metaphysical intuition does not (...) enter into the content of physical theories, the rejection of hypotheses could be explained only by appeal to common sense. Hence, Duhem held a qualified instrumentalism according to which physical theories are not realist, but the terms of ordinary experience and empirical laws are realist. Accordingly, Duhem rejected the complete subordination of science to philosophy as well as the complete separation of science from philosophy. Duhem's history of cosmological doctrines reflects his belief in the origin of the subordination of science to philosophy and of the struggle to achieve the proper balance without being driven to the opposite extreme of their complete separation. (shrink)

In recent years, several authors have reconstructed the relationship between 20th-century economic theory and neuro-psychological research in terms of a three-stage narrative of initial unity, increasing separation, and ongoing reunification. In this article, I draw on major developments in economic theory and neuro-psychological research to provide a descriptive and normative critique of this reconstruction. Moreover, I put forward a reconstruction of the relationship between economics and neuro-psychology that, I claim, better fits both the available empirical evidence and the methodological foundations (...) of these disciplines. In doing so, I argue that recent calls to develop a unified interdisciplinary framework for modeling choice are premised on disputable presuppositions concerning both the domain of economic theory and the relationship between this theory’s axiomatic foundations and empirical findings about the neuro-psychological substrates of choice. (shrink)

Do accounts of scientific theory formation and revision have implications for theories of everyday cognition? We maintain that failing to distinguish between importantly different types of theories of scientific inference has led to fundamental misunderstandings of the relationship between science and everyday cognition. In this article, we focus on one influential manifestation of this phenomenon which is found in Fodor's well-known critique of theories of cognitive architecture. We argue that in developing his critique, Fodor confounds a variety of distinct claims (...) about the holistic nature of scientific inference. Having done so, we outline more promising relations that hold between theories of scientific inference and ordinary cognition. (shrink)

This article revisits Karl Popper’s falsificationist methodology with respect to three tasks. The first is to illuminate and systematize Popper’s methodological views in light of his core epistemological commitments. A second and related objective is to gauge which aspects of falsificationism should be identified as “conventionalist”—a label that Popper himself uses (albeit with qualifications) but that is compromised by and, thus, stands in need of elucidation because of Popper’s idiosyncratic understanding of conventionalism. Third, by elaborating Popper’s virtue-epistemological, dialogical model of (...) rationality, I show how Popper’s conventionalism, fallibilism, and critical rationalism form a coherent system. This system allows Popper to accord science the status of a privileged source of knowledge—without naïve appeal to authority. My systematization of Popper’s views yields an intrinsically and exegetically more satisfactory reading of Popper’s falsificationism than usual presentations. Thanks to its marked flexibility and methodological liberalism, it bypasses many standard objections but still offers sound and relevant methodological advice. With its “virtue-methodological” thrust, Popper sketches an original and promising approach to methodology, the fertility of which deserves further exploration for contemporary debates. (shrink)

The first part of this paper consists of an exposition of the views expressed by Pierre Duhem in his Aim and Structure of Physical Theory concerning the philosophy and historiography of mathematics. The second part provides a critique of these views, pointing to the conclusion that they are in need of reformulation. In the concluding third part, it is suggested that a number of the most important claims made by Duhem concerning physical theory, e.g., those relating to the Newtonian method, (...) the limited falsifiability of theories, and the restricted role of logic, can be meaningfully applied to mathematics. (shrink)

in this paper i assess Pierre Duhem’s criticism of crucial experiments, and argue that we have reasons to vindicate their existence. i then analize the experiments carried out by Fizeau and Foucault in 1850, and criticize Duhem’s interpretation of their results. i contend that the results of crucial experiences can be described in terms that are neutral with respect to the competing theories. For that reason an experimental result is relatively stable and open to different interpretations in the light of (...) new theories. i conclude by distinguishing successful crucial experiments from decisive experiments. The former are meant to provide evidence that confirms one theory and disconfirms its rivals, but not necessarily to provide sufficient reasons for accepting or rejecting one of those theories. (shrink)

Duhem's and Quine's holistic theses, when properly understood, allow methodologically responsible ways of resolving a conflict between a theoretical system and experience; they only deny the possibility of doing it in an epistemically persuasive way. By developing a "string" model of scientific tests I argue that the pattern of interaction between the elements of a theoretical system arising in response to multiple adverse data can be helpful in locating a "weak spot" in it. Combining this model with anti-holistic arguments of (...) Popper, Greenwood, and Lakatos significantly reinforces their joint power. (shrink)

In this chapter I investigate the prospects of integrated history and philosophy of science, by examining how philosophical issues raised by “hidden entities”, entities that are not accessible to unmediated observation, can enrich the historical investigation of their careers. Conversely, I suggest that the history of those entities has important lessons to teach to the philosophy of science. Hidden entities have played a crucial role in the development of the natural sciences. Despite their centrality to past scientific practice, however, several (...) of them (e.g., phlogiston, caloric, and the ether) turned out to be fictitious. For this reason, they have figured prominently in recent debates on scientific realism. The issues I explore in this paper are entangled with those debates. I argue that our understanding of hidden entities and their role in experimental practice can be enhanced by adopting an integrated historical-cum-philosophical approach. On the one hand, philosophical reflection on the reality of those entities has a lot to gain by examining historically how they were ntroduced and investigated. On the other hand, the historical reconstruction of the careers of those entities may profit from philosophical reflection on their existence. (shrink)

The authors' commentary on Bruno Latour's "Technology is society made durable" provides the reader with an opportunity to become acquainted with actor-network theory.

Although Duhem’s thesis that in physics crucial experiments are impossible contains some grains of truth in it, its effects have been greatly exaggerated. In this talk I argue against this and other associated theses by pointing out the various ways in which these theses can be curtailed. In the process of doing so, I examine a few recent attempts to overcome the problems posed by these theses and identify their strengths and weaknesses.

La tesis del holismo de la confirmación aparece por primera vez presentada de manera explícita y extensa en los escritos de Duhem. Años después, es defendida por Quine, pero no en base a la discusión de teorías científicas particulares, sino en relación con su posición semántica. Desde entonces las relaciones entre el holismo semántico y el holismo de la contrastación han sido discutidas, aunque generalmente de un modo algo despegado del análisis de teorías específicas y sus relaciones. Pretendo mostrar a (...) partir del análisis de un caso, el de las relaciones entre la genética de poblaciones y la teoría de la selección natural, un sentido en el que el holismo de la confirmación puede ser derivado del holismo semántico. The thesis of the confirmation holism appears for the first time explicitly and extensively in the writings of Duhem. Years later, it is defended by Quine, but not based on the discussion of particular scientific theories, but in relation to its semantic position. Since then, the relations between semantic holism and confirmation holism have been discussed, although generally somewhat detached from the analysis of specific theories and their relations. I intend to show from the analysis of a case, that of the relations between population genetics and the theory of natural selection, a sense in which the holism of confirmation can be derived from semantic holism. (shrink)

What makes a high-quality biomarker experiment? The success of personalized medicine hinges on the answer to this question. Unfortunately, as many commentators have now emphasized, the quality of most biomarker experiments to date has been quite low. Although the technical side of this problem has received considerable attention, the philosophical issues remain largely unexplored. In this paper, I argue that understanding what constitutes a high-quality biomarker experiment requires some fundamental shifts in how we think about the epistemology, ontology, and methodology (...) of clinical translation. (shrink)

This monographic chapter explains how expected utility (EU) theory arose in von Neumann and Morgenstern, how it was called into question by Allais and others, and how it gave way to non-EU theories, at least among the specialized quarters of decion theory. I organize the narrative around the idea that the successive theoretical moves amounted to resolving Duhem-Quine underdetermination problems, so they can be assessed in terms of the philosophical recommendations made to overcome these problems. I actually follow Duhem's recommendation, (...) which was essentially to rely on the passing of time to make many experiments and arguments available, and evebntually strike a balance between competing theories on the basis of this improved knowledge. Although Duhem's solution seems disappointingly vague, relying as it does on "bon sens" to bring an end to the temporal process, I do not think there is any better one in the philosophical literature, and I apply it here for what it is worth. In this perspective, EU theorists were justified in resisting the first attempts at refuting their theory, including Allais's in the 50s, but they would have lacked "bon sens" in not acknowledging their defeat in the 80s, after the long process of pros and cons had sufficiently matured. This primary Duhemian theme is actually combined with a secondary theme - normativity. I suggest that EU theory was normative at its very beginning and has remained so all along, and I express dissatisfaction with the orthodox view that it could be treated as a straightforward descriptive theory for purposes of prediction and scientific test. This view is usually accompanied with a faulty historical reconstruction, according to which EU theorists initially formulated the VNM axioms descriptively and retreated to a normative construal once they fell threatened by empirical refutation. From my historical study, things did not evolve in this way, and the theory was both proposed and rebutted on the basis of normative arguments already in the 1950s. The ensuing, major problem was to make choice experiments compatible with this inherently normative feature of theory. Compability was obtained in some experiments, but implicitly and somewhat confusingly, for instance by excluding overtly incoherent subjects or by creating strong incentives for the subjects to reflect on the questions and provide answers they would be able to defend. I also claim that Allais had an intuition of how to combine testability and normativity, unlike most later experimenters, and that it would have been more fruitful to work from his intuition than to make choice experiments of the naively empirical style that flourished after him. In sum, it can be said that the underdetermination process accompanying EUT was resolved in a Duhemian way, but this was not without major inefficiencies. To embody explicit rationality considerations into experimental schemes right from the beginning would have limited the scope of empirical research, avoided wasting resources to get only minor findings, and speeded up the Duhemian process of groping towards a choice among competing theories. (shrink)

With resources hinted at in different ways by both Duhem and Quine, it is argued that some of their misgivings about empirical confirmation, or crucial experiments, may be exaggerated or unfounded; and that such experiments, suitably conceived, can give good meaning to empirical sentences. With appropriate meanings one can then wonder about synonymy and analyticity.

“Naturalized epistemology” is a recent attempt to transform the theory of knowledge into a branch of natural science. Traditional epistemologists object to this proposal on the grounds that it eliminates the distinctively philosophical content of epistemology. In this thesis, I argue that traditional philosophers are justified in their reluctance to accept naturalism, but that their ongoing inability to refute it points to deeper problems inherent in traditional epistemology. I establish my thesis first by critiquing three versions of naturalism, showing that (...) each version either fails to implement its objectives consistently or starts from dubious objectives. “Optimistic naturalism” attempts to use naturalistic methods to give positive answers to traditional epistemological questions (such as by affirming that our beliefs can be justified). This fails because the form of traditional questions requires the concept “belief,” a concept that I argue naturalistic methodology cannot countenance (because of the severe constraints of naturalistic semantic theory). “Pessimistic naturalism,” the version advocated by Quine, is more consistent with naturalistic methodology, but fails because hidden behind its conclusions are assumptions (such as the underdetermination thesis) that cannot themselves be naturalized in the full context of scientific evidence. A final attempt to naturalize epistemology, deflationary naturalism, dispenses with traditional questions entirely, urging that the terms “knowledge” and “justification” be taken as mere pragmatic devices whose use can, nevertheless, be studied scientifically. Curiously, this view fails to take account of important facts about the actual use of those terms, as studied by psychologists. In the end, despite problems with each of these versions, traditional philosophers can learn something from their encounter with naturalism. In the course of showing how various naturalistic doctrines cannot themselves be naturalized, I identify the flaws in traditional epistemology (such as its reliance on a priorism, and its resulting inability to articulate a workable empirical foundationalist theory of justification) that make naturalism harder to challenge. These flaws must be corrected if philosophers are to preserve the autonomy of their discipline. (shrink)

The main aims of the article are as follows: to indicate that cognition may be satisfactorily modelled from a constructivist perspective; to reconstruct the latest tendencies within science and technology studies encapsulated in the term constructivism rather than in the notion of social constructivism; to show how technoscience is conceptualised from the constructivist standpoint.

The old antagonism between the Quinean and the Duhemian view on underdetermination is reexamined. In this respect, two theses will be defended. First, it is argued that the main differences between Quine's and Duhem's versions of underdetermination derive from a different attitude towards the history of science. While Quine considered underdetermination from an ahistorical, a logical point of view, Duhem approached it as a distinguished historian of physics. On this basis, a logical and a historical version of the underdetermination thesis (...) can be distinguished. The second thesis of the article is that the main objections against underdetermination are fatal only to the logical rendering. Taken together, the two theses constitute a defence of underdetermination. (shrink)

In the first half of this dissertation, I develop a heuristic methodology for analyzing scientific solutions to the problem of underdetermination. Heuristics are rough-and-ready procedures used by scientists to construct models, design experiments, interpret evidence, etc. But as powerful as they are, heuristics are also error-prone. Therefore, I argue that they key to prudently using a heuristic is the articulation of meta-heuristics---guidelines to the kinds of problems for which a heuristic is well- or ill-suited. Given that heuristics will introduce certain (...) errors into our scientific investigations, I emphasize the importance of a particular category of meta-heuristics involving the search for robust evidence. Robustness is understood to be the epistemic virtue bestowed by agreement amongst multiple modes of determination. The more modes we have at our disposal, and the more these confirm the same result, the more confident can we be that a result is not a mere artifact of some heuristic simplification. Through an analysis of case-studies in the philosophy of biology and clinical trials, I develop a principled method for modeling and evaluating heuristics and robustness claims in a qualitative problem space. The second half of the dissertation deploys the heuristic methodology to address ethical and epistemological issues in the science of clinical trials. To that end, I develop a network model for the problem space of clinical research, capable of representing the various kinds of experiments, epistemic relationships, and ethical justifications intrinsic to the domain. I then apply this model to ongoing research with the antibacterial agent, moxifloxacin, for the treatment of tuberculosis, tracking its development from initially successful and promising in vitro and animal studies to its disappointing and discordant performance across five human efficacy trials. Given this failure to find a robust result with moxifloxacin across animal and human studies, what should researchers now do? While my final analysis of this case does not definitively answer that question, I demonstrate how my methodology, unlike a statistical meta-analysis, helps to clarify the directions for further research. (shrink)