Robustness arguments hold that hypotheses are more likely to be true when they are confirmed by diverse kinds of evidence. Robustness arguments require the confirming evidence to be independent. We identify two kinds of independence appealed to in robustness arguments: ontic independence —when the multiple lines of evidence depend on different materials, assumptions, or theories—and probabilistic independence. Many assume that OI is sufficient for a robustness argument to be warranted. However, we argue that, as typically construed, OI is not a (...) sufficient independence condition for warranting robustness arguments. We show that OI evidence can collectively confirm a hypothesis to a lower degree than individual lines of evidence, contrary to the standard assumption undergirding usual robustness arguments. We employ Bayesian networks to represent the ideal empirical scenario for a robustness argument and a variety of ways in which empirical scenarios can fall short of this ideal. (shrink)

The sceptical positions philosophers have adopted with respect to neuroimaging data are based on detailed evaluations of subtraction, which is one of many data analysis techniques used with neuroimaging data. These positions are undermined when the epistemic implications of the use of a diversity of data analysis techniques are taken into account. I argue that different data analysis techniques reveal different patterns in the data. Through the use of multiple data analysis techniques, researchers can produce results that are locally robust. (...) Thus, the epistemology of neuroimaging must take into consideration the details of the different data analysis techniques that are used to evaluate neuroimaging data, and the specific theoretical aims those techniques are deployed towards. _1_ Introduction _2_ Scepticism about Neuroimaging _3_ Data Analysis and Evidence _4_ Deconvolution and Pattern Classification Analysis _4.1_ Deconvolution analysis _4.2_ Region of interest selection _4.3_ Pattern classification analysis _5_ The Strength of Multiple Analyses _6_ Conclusion. (shrink)

A notion of experimental series is developed, in which experiments or experimental sets are connected through experimental suggestions arising from previous experimental outcomes. To that end, the justification of Howard Temin's DNA provirus hypothesis is examined. The hypothesis originated with evidence from two exploratory experimental sets on an oncogenic virus and was substantiated by including evidence from three additional experimental sets. Collectively these sets comprise an experimental series and the accumulative evidence from the series was adequate to justify the hypothesis (...) by persuading the virology community of its veracity. The notion of crucial experiment is also discussed in terms of experimental series. (shrink)

This paper addresses philosophical issues concerning whether mental disorders are natural kinds and how the DSM should classify mental disorders. I argue that some mental disorders (e.g., schizophrenia, depression) are natural kinds in the sense that they are natural classes constituted by a set of stable biological mechanisms. I subsequently argue that a theoretical and causal approach to classification would provide a superior method for classifying natural kinds than the purely descriptive approach adopted by the DSM since DSM-III. My argument (...) suggests that the DSM should classify natural kinds in order to provide predictively useful (i.e., projectable) diagnostic categories and that a causal approach to classification would provide a more promising method for formulating valid diagnostic categories. (shrink)

I propose a distinct type of robustness, which I suggest can support a confirmatory role in scientific reasoning, contrary to the usual philosophical claims. In model robustness, repeated production of the empirically successful model prediction or retrodiction against a background of independentlysupported and varying model constructions, within a group of models containing a shared causal factor, may suggest how confident we can be in the causal factor and predictions/retrodictions, especially once supported by a variety of evidence framework. I present climate (...) models of greenhouse gas global warming of the 20th Century as an example, and emphasize climate scientists’ discussions of robust models and causal aspects. The account is intended as applicable to a broad array of sciences that use complex modeling techniques. (shrink)

The thesis of theory-ladenness of observations, in its various guises, is widely considered as either ill-conceived or harmless to the rationality of science. The latter view rests partly on the work of the proponents of New Experimentalism who have argued, among other things, that experimental practices are efficient in guarding against any epistemological threat posed by theory-ladenness. In this paper I show that one can generate a thesis of theory-ladenness for experimental practices from an influential New Experimentalist account. The notion (...) I introduce for this purpose is the concept of ‘theory-driven data reliability judgments’, according to which theories which are sought to be tested with a particular set of data guide reliability judgments about those very same data. I provide various prominent historical examples to show that TDRs are used by scientists to resolve data conflicts. I argue that the rationality of the practices which employ TDRs can be saved if the independent support of the theories driving TDRs is construed in a particular way. (shrink)

In psychiatry, pharmacological drugs play an important experimental role in attempts to identify the neurobiological causes of mental disorders. Besides being developed in applied contexts as potential treatments for patients with mental disorders, pharmacological drugs play a crucial role in research contexts as experimental instruments that facilitate the formulation and revision of neurobiological theories of psychopathology. This paper examines the various epistemic functions that pharmacological drugs serve in the discovery, refinement, testing, and elaboration of neurobiological theories of mental disorders. I (...) articulate this thesis with reference to the history of antipsychotic drugs and the evolution of the dopamine hypothesis of schizophrenia in the second half of the twentieth century. I argue that interventions with psychiatric patients through the medium of antipsychotic drugs provide researchers with information and evidence about the neurobiological causes of schizophrenia. This analysis highlights the importance of pharmacological drugs as research tools in the generation of psychiatric knowledge and the dynamic relationship between practical and theoretical contexts in psychiatry. (shrink)

According to the "experimenter's regress", disputes about the validity of experimental results cannot be closed by objective facts because no conclusive criteria other than the outcome of the experiment itself exist for deciding whether the experimental apparatus was functioning properly or not. Given the frequent characterization of simulations as "computer experiments", one might worry that an analogous regress arises for computer simulations. The present paper analyzes the most likely scenarios where one might expect such a "simulationist's regress" to surface, and, (...) in doing so, discusses analogies and disanalogies between simulation and experimentation. I conclude that, on a properly broadened understanding of robustness, the practice of simulating mathematical models can be seen to have sufficient internal structure to avoid any special susceptibility to regress-like situations. (shrink)

When a technique purports to provide information that is not available to the unaided senses, it is natural to think that the only way to validate that technique is by appealing to a theory of the processes that lead from the object of study to the raw data. In fact, scientists have a variety of strategies for validating their techniques. Those strategies can yield multiple independent arguments that support the validity of the technique. Thus, it is possible to produce a (...) robust body of data with a single technique. I illustrate and support these claims with a historical case study. *Received September 2009; revised October 2009. †To contact the author, please write to: Department of History and Philosophy of Science, 1017 Cathedral of Learning, University of Pittsburgh, Pittsburgh, PA 15260; e‐mail: [email protected]. (shrink)

In recent years, pragmatism in general and John Dewey in particular have been of increasing interest to philosophers of science. Dewey's work provides an interesting alternative package of views to those which derive from the logical empiricists and their critics, on problems of both traditional and more recent vintage. Dewey's work ought to be of special interest to recent philosophers of science committed to the program of analyzing ``science in practice.'' The core of Dewey's philosophy of science is his theory (...) of inquiry---what he called ``logic.'' There is a major lacuna in the literature on this point, however: no contemporary philosophers of science have engaged with Dewey's logical theory, and scholars of Dewey's logic have rarely made connections with philosophy of science. This paper aims to fill this gap, to correct some significant errors in the interpretation of key ideas in Dewey's logical theory, and to show how Dewey's logic provides resources for a philosophy of science. (shrink)

The last two decades have seen a rising interest in (a) the notion of a scientific phenomenon as distinct from theories and data, and (b) the intricacies of experimentally producing and stabilizing phenomena. This paper develops an analysis of the stabilization of phenomena that integrates two aspects that have largely been treated separately in the literature: one concerns the skills required for empirical work; the other concerns the strategies by which claims about phenomena are validated. I argue that in order (...) to make sense of the process of stabilization, we need to distinguish between two types of phenomena: phenomena as patterns in the data ( surface regularities ) and phenomena as underlying (or hidden ) regularities. I show that the epistemic relationships that data bear to each of these types of phenomena are different: Data patterns are instantiated by individual data, whereas underlying regularities are indicated by individual data, insofar as they instantiate a data pattern. Drawing on an example from memory research, I argue that neither of these two kinds of phenomenon can be stabilized in isolation. I conclude that what is stabilized when phenomena are stabilized is the fit between surface regularities and hidden regularities. (shrink)

: Evidence claims depend on fallible assumptions. Three strategies for making true evidence claims in spite of this fallibility are strengthening the support for those assumptions, weakening conclusions, and using multiple independent tests to produce robust evidence. Reliability itself, understood in frequentist terms, does not explain the usefulness of all three strategies; robustness, in particular, sometimes functions in a way that is not well-characterized in terms of reliability. I argue that, in addition to reliability, the security of evidence claims is (...) of epistemic value, where an evidence claim is secure relative to an epistemic situation if it remains true in all scenarios that are epistemically possible relative to that epistemic situation. (shrink)

Scientific claims can be assessed epistemically in either of two ways: according to scientific standards, or by means of philosophical arguments such as the no-miracle argument in favor of scientific realism. This paper investigates the basis of this duality of epistemic assessments. It is claimed that the duality rests on two different notions of epistemic justification that are well-known from the debate on internalism and externalism in general epistemology: a deontological and an alethic notion. By discussing the conditions for the (...) scientific acceptability of empirical results, it is argued that intrascientific justification employs the deontological notion. Philosophical disputes such as those on scientific realism can by contrast be shown to rest on the alethic notion. The implications of these findings both for the nature of the respective epistemic projects and for their interrelation are explored. (shrink)

Culp (1994) provides a defense for a form of experimental reasoning entitled 'robustness'. Her strategy is to examine a recent episode in experimental microbiology--the case of the mistaken discovery of a bacterial organelle called a 'mesosome'--with an eye to showing how experimenters effectively used robust experimental reasoning (or could have used robust reasoning) to refute the existence of the mesosome. My plan is to criticize Culp's assessment of the mesosome episode and to cast doubt on the epistemic significance of robustness. (...) In turn, I present a different account of the experimental reasoning microbiologists used in arriving at the conclusion that mesosomes are artifacts. I call this form of reasoning 'reliable process reasoning', and close the paper with a brief discussion of how experimental microbiologists justify the claim that an experimental process is reliable. (shrink)

Multiple determination is the epistemic strategy of establishing the same result by means of multiple, independent procedures. It is an important strategy praised by both philosophers of science and practicing scientists. Despite the heavy appeal to multiple determination, little analysis has been provided regarding the specific grounds upon which its epistemic virtues rest. This article distinguishes between the various dimensions of multiple determination and shows how they can be used to evaluate the epistemic force of the strategy in particular cases. (...) Distinguishing between the various dimensions helps to resolve the disagreements regarding the relevance and epistemic import of multiple determination for scientific research. It also suggests a fruitful mode of interaction between the philosophy of science and (historical) accounts of scientific practice. (shrink)

We propose a new account of calibration according to which calibrating a technique shows that the technique does what it is supposed to do. To motivate our account, we examine an early twentieth-century debate about chlorophyll chemistry and Mikhail Tswett’s use of chromatographic adsorption analysis to study it. We argue that Tswett’s experiments established that his technique was reliable in the special case of chlorophyll without relying on either a theory or a standard calibration experiment. We suggest that Tswett broke (...) the experimenters’ regress by appealing to material facts in the common ground for chemists at the time. (shrink)

Multidisciplinary models aggregating ‘lower-level’ biological and ‘higher-level’ psychological and social determinants of a phenomenon raise a puzzle. How is the interaction between the physical, the psychological and the social conceptualized and explained? Using biopsychosocial models of pain as an illustration, I argue that these models are in fact level-neutral compilations of empirical findings about correlated and causally relevant factors, and as such they neither assume, nor entail a conceptual or ontological stratification into levels of description, explanation or reality. If inter-level (...) causation is deemed problematic or if debates about the superiority of a particular level of description or explanation arise, these issues are fueled by considerations other than empirical findings. (shrink)

In psychiatry, pharmacological research has played a crucial role in the formulation, revision, and refinement of neurobiological theories of psychopathology. Besides being utilized as potential treatments for various mental disorders, pharmacological drugs play an important epistemic role as experimental instruments that help scientists uncover the neurobiological underpinnings of mental disorders (Tsou, 2012). Interventions with psychiatric patients using pharmacological drugs provide researchers with information about the neurobiological causes of mental disorders that cannot be obtained in other ways. This important source of (...) evidence for the biological causes of mental disorder is often overlooked in philosophical analyses of psychiatry, especially in skeptical analyses that debase the biological aspects of psychopathology (e.g., Szasz, 1960; Scheff, 1963; Laing, 1967). In discussing pharmacological interventions as a form of evidence for the physical basis of mental disorders, this paper aims to clarify the nature, reliability, and limitations of this evidence. In addition, it illustrates the central role that pharmacological findings in applied clinical contexts play in the acquisition of neurobiological knowledge in research contexts. (shrink)

Neuroimaging technology is the most widely used tool to study human cognition. While originally a promising tool for mapping the content of cognitive theories onto the structures of the brain, recently developed tools for the analysis, handling and sharing of data have changed the theoretical landscape of cognitive neuroscience. Even with these advancements philosophical analyses of evidence in neuroimaging remain skeptical of the promise of neuroimaging technology. These views often treat the analysis techniques used to make sense of data produced (...) in a neuroimaging experiment as one, attributing the inferential limitations of analysis pipelines to the technology as a whole. Situated against the neuroscientists own critical assessment of their methods and the limitations of those methods, this skepticism appears based on a misunderstanding of the role data analysis techniques play in neuroimaging research. My project picks up here, examining how data analysis techniques, such as pattern classification analysis, are used to assess the evidential value of neuroimaging data. The project takes the form of three papers. In the first I identify the use of multiple data analysis techniques as an important aspect of the data interpretation process that is overlooked by critics. In the second I develop an account of inferences in neuroimaging research that is sensitive to this use of data analysis techniques, arguing that interpreting neuroimaging data is a process of isolating and explaining a variety of data patterns. In the third I argue that the development and uptake of new techniques for analyzing data must be accompanied by changes in research practices and standards of evidence if they are to promote knowledge generation. My approach to this work is both traditionally philosophical, insofar as it involves reading and analyzing the work of philosophers and neuroscientists, and embedded insofar as most of the research was conducted while engaged in attending lab meetings and participating in the work of those scientists whose work is the object of my research. (shrink)

An analysis is presented of published methods that have been used by experimenters to justify the reliability of the theory of invasion of microorganisms into cultured cells. The results show that, to demonstrate this invasion, many experimenters used two or more methods that were based on independent technical and theoretical principles, and by doing so improved the reliability of the theory. Subsequently I compare this strategy of 'multiple derivability' with other strategies, discussed in the literature in relation to the mesosome, (...) a bacterial organelle that had been detected with the electron microsope, but which appeared later to be an artifact. I propose that different strategies have been applied in this problem, and multiple derivability may have been the decisive one. Finally I discuss the idea that multiple derivability may help to anchor theories in a larger network of theories. (shrink)

According to the methodological principle called ‘robustness’, empirical evidence is more reliable when it is generated using multiple, independent (experimental) routes that converge on the same result. As it happens, robustness as a methodological strategy is quite popular amongst philosophers. However, despite its popularity, my goal here is to criticize the value of this principle on historical grounds. My historical reasons take into consideration some recent history of astroparticle physics concerning the search for WIMPs (weakly interacting massive particles), one of (...) the main candidates for cosmic dark matter. On the basis of these reasons, I assert that robustness, at least in this historical case we are considering, has less value than usually assumed by philosophers. (shrink)

Contemporary ways of understanding of science, especially in the philosophy of science, are beset by overly abstract and formal models of evidence. In such models, the only interesting feature of evidence is that it has a one-way ``support'' relation to hypotheses, theories, causal claims, etc. These models create a variety of practical and philosophical problems, one prominent example being the experimenter's regress. According to the experimenter's regress, good evidence is produced by good techniques, but which techniques are good is only (...) determined by whether they produce the evidence we expect. The best answer to this problem within the traditional approach relies on the concept of robust evidence, but this answer ultimately falls flat because it creates impossible requirements on good evidence. The problem can more easily be solved by rejecting abstract, formalistic models of evidence in favor of a model of inquiry which pays attention to the temporal complexity of the process of inquiry and the distinction between observational and experimental evidence. (shrink)

In a 1993 paper, I argued that empirical treatments of the epistemologyused by scientists in experimental work are too abstract in practice tocounter relativist efforts to explain the outcome of scientificcontroversies by reference to sociological forces. This was because, atthe rarefied level at which the methodology of scientists is treated byphilosophers, multiple mutually inconsistent instantiations of theprinciples described by philosophers are employed by contestingscientists. These multiple construals change within a scientificcommunity over short time frames, and these different versions ofscientific methodology (...) can determine the outcome of a controversy. Iillustrated with a comparatively detailed analysis of the methodologyused by biologists debating the existence of an entity called thebacterial mesosome between the mid-1950s and the mid-1970s. This 1993piece has drawn several critiques in the philosophical literature. Inthis present piece I respond to these critiques and argue that they failto address the core argument of the original paper, and I reflectfurther on the methodologies of philosophers of science pursuingempirical or `naturalistic' epistemology. (shrink)

The use of multiple means of determination to “triangulate” on the existence and character of a common phenomenon, object, or result has had a long tradition in science but has seldom been a matter of primary focus. As with many traditions, it is traceable to Aristotle, who valued having multiple explanations of a phenomenon, and it may also be involved in his distinction between special objects of sense and common sensibles. It is implicit though not emphasized in the distinction between (...) primary and secondary qualities from Galileo onward. It is arguably one of several conceptions involved in Whewell’s method of the “consilience of inductions” (Laudan 1971) and is to be found in several places in Peirce. (From M. Brewer and B. Collins, eds., (1981); Scientific Inquiry in the Social Sciences (a festschrift for Donald T. Campbell), San Francisco: Jossey-Bass, pp. 123–162.). (shrink)

Harry Collins' central argument about experimental practice revolves around the thesis that facts can only be generated by good instruments but good instruments can only be recognized as such if they produce facts. This is what Collins calls the experimenters' regress. For Collins, scientific controversies cannot be closed by the ‘facts’ themselves because there are no formal criteria independent of the outcome of the experiment that scientists can apply to decide whether an experimental apparatus works properly or not.No one seems (...) to have noticed that the debate is in fact a rehearsal of the ancient philosophical debate about skepticism. The present article suggests that the way out of radical skepticism offered by the so-called mitigated skeptics is a solution to the problem of consensus formation in science.Keywords: Argumentation; Skepticism; Sociology of science; Philosophy of science; Scientific controversies. (shrink)

In 1966 the population biologist Richard Levins gave a forceful and in?uential defence of a method called “robustness analysis” (RA). RA is a way of assessing the result of a model by showing that different but related models give the same result. As Levins put it, “our truth is the intersection of independent lies” (1966, 423). Steven Orzack and Elliott Sober (1993) responded with an equally forceful critique of this method, concluding that the idea of robustness “lacks proper de?nition and (...) that its bearing on the question of whether a proposition is true is highly problematic” (533). Replies to Orzack and Sober, from Levins (1993) and Weisberg (2006b), have rejected the idea that RA, on its own, can con?rm the results of models. I argue that these replies have not properly addressed Orzack and Sober’s real criticisms, which focus not on the role of empirical data in RA but on the problem of ensuring that the models used in RA are independent. By drawing on accounts of RA in experimental science, I argue that there is in fact a fallible but viable form of RA that can both con?rm the results of models and incorporate empirical data. However, for reasons other than those of Orzack and Sober, I conclude that RA may be of limited use in model-based science, as the example of ?shery biology can show. (shrink)

Scientists and philosophers generally agree that the replication of experiments is a key ingredient of good and successful scientific practice. “One-offs“ are not significant; experiments must be replicable to be considered valid and important. But the term “replication“ has been used in a number of ways, and it is therefore quite difficult to appraise the meaning and significance of replications. I consider how history may help - and has helped - with this task. I propose that: 1) Studies of past (...) scientific episodes in historical context and of recent philosophical contributions to the discussion are heuristic tools for exploring and clarifying the meaning of that concept. 2) The analysis of the development of the methodological imperative of replication sheds light on the significance scientists have attached to it, thereby contributing further to the clarification of the concept. 3) The analysis of the history of philosophical thought about methods and scientific methodology helps understand why philosophers have not paid much attention to the analysis of the concept of replication. (shrink)

H. B. D. Kettlewell's (1955, 1956) classic field experiments on industrial melanism in polluted and unpolluted settings using the peppered moth, Biston betularia, are routinely cited as establishing that the melanic (dark) form of the moth rose in frequency downwind of industrial centers because of the cryptic advantage dark coloration provides against visual predators in soot-darkened environments. This paper critiques three common myths surrounding these investigations: (1) that Kettlewell used a model that identified crypsis as the only selective force responsible (...) for the spread of the melanic gene, (2) that Kettlewell's field experiments alone established that selection for crypsis was the most important factor in the spread of melanic forms, and (3) that Kettlewell's investigations in an unpolluted wood near Dorset constituted a control for his earlier Birmingham studies (contra Hagen 1993, 1996). This analysis further identifies two features that distinguish manipulative experiments in evolutionary biology from experiments in other contexts. First, experiments in evolutionary biology rest on a wealth of information provided by strictly observational ecological studies; in the absence of such information experiments in evolutionary biology make no sense. Second, there is a trade-off between how much control investigators have over the conditions being studied and how informative the results of the experiment will be with regard to natural populations. (shrink)

Despite the fact that reproduction of experiments by peers has traditionally been regarded as of the utmost importance in enabling the intersubjectivity of scientific practice, reproductions may yield discordant results and deciding which result should be favored may not be an easy task. According to Harry Collins, experimental disagreement is resolved by the action of social, political and economic factors, but not by means of epistemic and scientific, or so-called internal reasons. His motivation for such a claim is the presence (...) of an infinite regress at the core of experimental activity that, according to him, cannot be stopped with scientific resources alone: the experimenters’ regress. The goal of this... (shrink)

Entre los estudios críticos que existen en torno a la obra de Paul Feyerabend predominan aquellos que subrayan una discontinuidad radical entre la versión temprana y tardía de su pensamiento. Todo ello contribuye a que dispongamos de una visión fragmentada e incompleta de un pensador que evoluciono hasta el 1994, año de su fallecimiento. Nuestro propósito es ofrecer una explicación de su itinerario intelectual de tal modo que quedé patente su continuidad en la clave de sus críticas contra los falsos (...) absolutos erigidos por el positivismo lógico y el racionalismo científico. Mostraremos las diversas cuestiones que Feyerabend aborda en las distintas épocas de su vida pero, al mismo tiempo, subrayaremos la unidad o coherencia lógica que existe en su revisión crítica de la racionalidad científica. Nos preocuparemos por entender las razones por las cuales nuestro filósofo de la ciencia va trasladando sus distintos focos de discusión o crítica. A common element in studies of Paul Karl Feyerabend is the distinction between five periods in his work. John Preston sees a radical discontinuity between the early and late versions of Feyerabend’s thought. All of this contributes our having a fragmented and incomplete view of a thinker who continued to evolve until 1994, the year of his death. We aim to provide an explanation of his intellectual journey that shows the evident continuity and unity of his thought. We will discuss the various issues he addressed in the different periods of his life, but at the same time we will emphasize the unity or logical coherence among them. Our aim is to understand the reasons why the philosopher of science changed his distinct foci of discussion and criticism. (shrink)

The paper addresses the evaluation of climate models and gives an overview of epistemic uncertainties in climate modeling; the uncertainties concern the data situation as well as the causal behavior of the climate system. In order to achieve reasonable results nonetheless, multimodel ensemble studies are employed in which diverse models simulate the future climate under different emission scenarios. The models jointly deliver a robust range of climate prognoses due to a broad plurality of theories, techniques, and methods in climate research; (...) the range reliably indicates the future development of the global climate. Nevertheless, the uncertainties are widely used by skeptics to challenge the IPCC’s prognoses. Such skeptical allegations can well be distinguished from points of fruitful epistemological criticism: in spite of the enduring range of prognoses, the epistemic uncertainties should not play a role in finding agreements on climate change mitigation. (shrink)

Abstract: The aim of this paper is to analyse and criticize the argument of the experimenters' regress proposed by Harry Collins in 1985. In order to do that, I begin with an introduction to the experiments that aimed to detect gravity waves performed by Joseph Weber during 1970, then I analyse and discuss both forms of the argument: the epistemological and the ontological. Finally, after giving an outline of a theory of experimental reproduction and an explication of the concept of (...) replication, I propose two ways of avoiding the experimenters' regress. (shrink)

Amalgamating evidence from heterogeneous sources and across levels of inquiry is becoming increasingly important in many pure and applied sciences. This special issue provides a forum for researchers from diverse scientific and philosophical perspectives to discuss evidence amalgamation, its methodologies, its history, its pitfalls, and its potential. We situate the contributions therein within six themes from the broad literature on this subject: the variety-of-evidence thesis, the philosophy of meta-analysis, the role of robustness/sensitivity analysis for evidence amalgamation, its bearing on questions (...) of extrapolation and external validity of experiments, its connection with theory development, and its interface with causal inference, especially regarding causal theories of cancer. (shrink)

Multidisciplinary models aggregating ‘lower-level’ biological and ‘higher-level’ psychological and social determinants of a phenomenon raise a puzzle. How is the interaction between the physical, the psychological and the social conceptualized and explained? Using biopsychosocial models of pain as an illustration, I argue that these models are in fact level-neutral compilations of empirical findings about correlated and causally relevant factors, and as such they neither assume, nor entail a conceptual or ontological stratification into levels of description, explanation or reality. If inter-level (...) causation is deemed problematic or if debates about the superiority of a particular level of description or explanation arise, these issues are fueled by considerations other than empirical findings. (shrink)

This article examines a metaphilosophical issue, namely existing disagreements in philosophy of science about the significance of using multiple means of determination in scientific practice. We argue that this disagreement can, in part, be resolved by separating different questions that can be asked about the use of multiple means of determination, including the following: what can be concluded from the convergence of data or the convergence of claims about phenomena? Are the conclusions drawn from the convergence of data and of (...) statements about phenomena of special importance to the debate about realism and antirealism? Do inferences based on multiple means of determination have stronger epistemic force than inferences that are secured in other ways? Is the epistemic goal of deploying multiple means of determination well entrenched within the scientific community? Most of these questions can be discussed both in a formal and in an empirical perspective. If the differences in perspective are taken into account, some disagreements can be easily resolved. In part, however, the disagreements reflect historiographical challenges that are very difficult, if not impossible to meet. (shrink)

Policy-makers face an uncertain world. One way of getting a handle on decision-making in such an environment is to rely on evidence. Despite the recent increase in post-fact figures in politics, evidence-based policymaking takes centre stage in policy-setting institutions. Often, however, policy-makers face large volumes of evidence from different sources. Robustness analysis can, prima facie, handle this evidential diversity. Roughly, a hypothesis is supported by robust evidence if the different evidential sources are in agreement. In this thesis, I strengthen the (...) case for the use of robustness analysis in evidence-based policymaking by answering open research questions about this inference technique. First, I argue that existing taxonomies miss a fruitful category of robustness reasoning, that is predictive stability. Second, I claim that derivational robustness analysis – the investigation of whether the results of different models are in agreement – can yield interesting insights even if not the entire relevant model space is covered by available models or if the model results are only partially in agreement. Third, I claim that expert knowledge is necessary to address questions that arise when one applies measurement robustness analysis – the investigation into whether multiple means of measurement yield the same result. Finally, I argue that, in situations where evidence from different measurements is not in agreement, it can be advisable to no longer take all of the evidence into account. This can be done in a rationally defensible way by choosing the most adequate theory or model underlying parts of the evidence set. I discuss examples from climate, medical, and economic policy-making to establish my claims. (shrink)

The past quarter century has seen an enormous growth of interest among scholars of science and technology in both particular experimental episodes and the process of experimentation. Among the most influential accounts have been those developed by Allan Franklin (1986, 1990), Deborah Mayo (1996) and Peter Galison (1987), each of which was developed primarily with reference to examples drawn from the history of physics. One useful way to access the generality of an account of experiment is to see how it (...) fares with reference to examples drawn from disciplines far removed from the context within which it was developed. In previous essays I examined and compared the adequacy of Franklin and Mayo’s views on experiment with reference to an episode drawn from the history of evolutionary biology, H.B.D. Kettlewell's classic studies of the phenomenon of industrial melanism (Rudge 1998, 2001). The present essay reanalyzes Kettlewell’s work once more, this time as a test of Peter Galison’s provocative account of experimentation in the sciences. Kettlewell’s investigations can indeed be interpreted within Galison’s perspective, but this appears to reflect the vagueness of many key distinctions Galison makes more than any special insights his views provide on the nature of experimentation in evolutionary biology. (shrink)

H. B. D. Kettlewell's (1955, 1956) classic field experiments on industrial melanism in polluted and unpolluted settings using the peppered moth, Biston betularia, are routinely cited as establishing that the melanic (dark) form of the moth rose in frequency downwind of industrial centers because of the cryptic advantage dark coloration provides against visual predators in soot-darkened environments. This paper critiques three common myths surrounding these investigations: (1) that Kettlewell used a model that identified crypsis as the only selective force responsible (...) for the spread of the melanic gene, (2) that Kettlewell's field experiments alone established that selection for crypsis was the most important factor in the spread of melanic forms, and (3) that Kettlewell's investigations in an unpolluted wood near Dorset constituted a control for his earlier Birmingham studies (contra Hagen 1993, 1996). This analysis further identifies two features that distinguish manipulative experiments in evolutionary biology from experiments in other contexts. First, experiments in evolutionary biology rest on a wealth of information provided by strictly observational ecological studies; in the absence of such information experiments in evolutionary biology make no sense. Second, there is a trade-off between how much control investigators have over the conditions being studied and how informative the results of the experiment will be with regard to natural populations. (shrink)

This article examines in detail a remarkable but short-lived cosmological theory of 1959. The theory depended crucially on a hypothesis that could be, and was, tested in the laboratory. I use the case to discuss the nature of testing in cosmology and to argue against ideas about astronomy suggested by Ian Hacking. The case of the electrical universe exemplifies how disagreements can be settled by good experiments and also how experiments of wide-ranging theoretical significance need not be biased by either (...) theory or the experimentalists’ predisposed ideas. I argue that the episode supports Allan Franklins “evidence model” and disputes accounts based on the sociology of scientific knowledge. (shrink)