Weisberg (2006) and Godfrey-Smith (2006, 2009) distinguish between two forms of theorising: data-driven ‘abstract direct representation’ and modeling. The key difference is that when using a data-driven approach, theories are intended to represent specific phenomena, so directly represent them, while models may not be intended to represent anything, so represent targets indirectly, if at all. The aim here is to compare and analyse these practices, in order to outline an account of model-based theorising that involves direct representational relationships. This is (...) based on the way that computational templates Humphreys (2002, 2004) are now used in cognitive neuroscience, and draws on the dynamic and tentative process of any kind of theory construction, and the idea of partial, purpose-relative representation. (shrink)

Scientific realists argue that a good track record of multi-agent, and multiple method, validation of empirical claims is itself evidence that those claims, at least partially and approximately, reflect ways nature actually is independent of the ways we conceptualize it. Constructivists contend that successes in validating empirical claims only suffice to establish that our ways of modelling the world, our “constructions,” are useful and adequate for beings like us. This essay presents a thought experiment in which beings like us intersubjectively (...) validate claims about properties of particular things in nature under conditions in which those beings have profoundly different personal phenomenological experiences of those properties. I submit that the thought experiment scenario parallels our actual situation, and argue that this shows that successes in intersubjectively validating empirical claims are indeed enough to claim victory for the realist. More specifically, I champion a variation of realism that marries Ronald Giere’s brand of ‘perspectival realism’ with Philip Kitcher’s ‘real realism,’ and posits that causal relations between ourselves and properties instantiated in nature ground our references to the relevant properties even though our conceptions of them are perspective relative. (shrink)

Many standard philosophical accounts of scientific practice fail to distinguish between modeling and other types of theory construction. This failure is unfortunate because there are important contrasts among the goals, procedures, and representations employed by modelers and other kinds of theorists. We can see some of these differences intuitively when we reflect on the methods of theorists such as Vito Volterra and Linus Pauling on the one hand, and Charles Darwin and Dimitri Mendeleev on the other. Much of Volterra's and (...) Pauling's work involved modeling; much of Darwin's and Mendeleev's did not. In order to capture this distinction, I consider two examples of theory construction in detail: Volterra's treatment of post-WWI fishery dynamics and Mendeleev's construction of the periodic system. I argue that modeling can be distinguished from other forms of theorizing by the procedures modelers use to represent and to study real-world phenomena: indirect representation and analysis. This differentiation between modelers and non-modelers is one component of the larger project of understanding the practice of modeling, its distinctive features, and the strategies of abstraction and idealization it employs. (shrink)

I review prominent historical arguments against scientific realism to indicate how they display a systematic overshooting in the conclusions drawn from the historical evidence. The root of the overshooting can be located in some critical, undue presuppositions regarding realism. I will highlight these presuppositions in connection with both Laudan’s ‘Old induction’ and Stanford’s New induction, and then delineate a minimal realist view that does without the problematic presuppositions.

Science advances by means of argument and debate. Based on a formal model of complex argumentation, this article assesses the interplay between evidential and inferential drivers in scientific controversy, and explains, in particular, why both evidence accumulation and argumentation are veritistically valuable. By improving the conditions for applying veritistic indicators , novel evidence and arguments allow us to distinguish true from false hypotheses more reliably. Because such veritistic indicators also underpin inductive reasoning, evidence accumulation and argumentation enhance the reliability of (...) inductive inference, for example, inference to the best explanation. 1 Introduction2 Theory of Dialectical Structures3 Debate Simulations4 From Evidence and Arguments to Truth: The First Route5 From Evidence to Truth: The Second Route6 Conclusion. (shrink)

I explore a type of computational social simulation known as artificial societies. Artificial society simulations are dynamic models of real-world social phenomena. I explore the role that these simulations play in social explanation, by situating these simulations within contemporary philosophical work on explanation and on models. Many contemporary philosophers have argued that models provide causal explanations in science, and that models are necessary mediators between theory and data. I argue that artificial society simulations provide causal mechanistic explanations. I conclude that (...) in their current form, these simulations are based on methodologically individualist assumptions that could limit their potential scope of social explanation. (shrink)

I present a new definition of verisimilitude, framed in terms of causes. Roughly speaking, according to it a scientific model is approximately true if it captures accurately the strengths of the causes present in any given situation. Against much of the literature, I argue that any satisfactory account of verisimilitude must inevitably restrict its judgments to context-specific models rather than general theories. We may still endorse—and only need—a relativized notion of scientific progress, understood now not as global advance but rather (...) as the mastering of particular problems. This also sheds new light on longstanding difficulties surrounding language-dependence and models committed to false ontologies. (shrink)

In this paper, I briefly present the regularity and necessity views and assess their difficulties. I construe scientific laws as universal propositions satisfied by empirically successful scientific models and made — approximately — true by the real systems represented, albeit partially, by these models. I also conceive a scientific theory as a set of models together with a set of propositions, some of which are laws. A scientific law is a universal proposition or statement that belongs to a scientific theory. (...) Scientific laws also are laws of nature since we can provide arguments in favour of natural causal powers that ground the truth of laws. I argue that the truth of counterfactual conditional statements and the occurrence of regularities in nature provide good reasons to believe that real causal powers exist in nature and that the truth of scientific laws is based on a metaphysics of nature. (shrink)

This article deals with the problematic concepts of the rational and the social, which have been typically seen as dichotomous in the history and philosophy of science literature. I argue that this view is mistaken and that the social can be seen as something that enables rationality in science, and further, that a scientific community as well as an individual can be taken as an epistemic subject. Furthermore, I consider how scientific communities could be seen as freely acting and choosing (...) agents. Fundamentally, this boils down to the question whether we accept the voluntarist conception of human beings, one consequence of which is that scientists possess, in principle, the capacity for deliberative reflection and choice. If this is accepted, we can talk about the degrees of autonomy that communities possess. I also examine what kinds of decisions an autonomous community should make in order to produce objective knowledge. My suggestion is that objectivity be understood as intersubjectivity: a view is objective when it has been exposed to critical reflection from various points of view, and due to this, transcends subjective idiosyncrasies. (shrink)

In this paper I analyze the difficult question of the truth of mature scientific theories by tackling the problem of the truth of laws. After introducing the main philosophical positions in the field of scientific realism, I discuss and then counter the two main arguments against realism, namely the pessimistic metainduction and the abstract and idealized character of scientific laws. I conclude by defending the view that well-confirmed physical theories are true only relatively to certain values of the variables that (...) appear in the laws. (shrink)

In this essay, I shall show that the so-called inferential (Suárez 2003 and 2004 ) and interpretational (Contessa 2007 ) accounts of scientific representation are respectively unsatisfactory and too weak to account for scientific representation ( pars destruens ). Along the way, I shall also argue that the pragmatic similarity (Giere 2004 and Giere 2010 ) and the partial isomorphism (da Costa and French 2003 and French 2003 ) accounts are unable to single out scientific representation. In the pars construens (...) I spell out a limiting case account which has explanatory surplus vis à vis the approaches which I have previously reviewed. My account offers an adequate treatment of scientific representation, or so I shall try to argue. Central to my account is the notion of a pragmatic limiting case, which will be characterized in due course. (shrink)

Recent philosophical attention to climate models has highlighted their weaknesses and uncertainties. Here I address the ways that models gain support through observational data. I review examples of model fit, variety of evidence, and independent support for aspects of the models, contrasting my analysis with that of other philosophers. I also investigate model robustness, which often emerges when comparing climate models simulating the same time period or set of conditions. Starting from Michael Weisberg’s analysis of robustness, I conclude that his (...) approach involves a version of reasoning from variety of evidence, enabling this robustness to be a confirmatory virtue.. (shrink)

The modern history of verisimilitude can be divided into three periods. The first began in 1960, when Karl Popper proposed his qualitative definition of what it is for one theory to be more truthlike than another theory, and lasted until 1974, when David Miller and Pavel Trichý published their refutation of Popper's definition. The second period started immediately with the attempt to explicate truthlikeness by means of relations of similarity or resemblance between states of affairs (or their linguistic representations); the (...) work within this similarity approach was summarized in the books of Graham Oddie [1986] and Ilkka Niiniluoto [1987]. During the subsequent third period, studies in verisimilitude have been actively continued, and interesting results and applications have been achieved, but not many dramatic novelties. While it is now obsolete to claim that truthlikeness with reasonable properties cannot be defined at all, there is still a lot of controversy about the best and least arbitrary approach to doing this. (shrink)

The philosophy of information (PI) is a new area of research with its own field of investigation and methodology. This article, based on the Herbert A. Simon Lecture of Computing and Philosophy I gave at Carnegie Mellon University in 2001, analyses the eighteen principal open problems in PI. Section 1 introduces the analysis by outlining Herbert Simon's approach to PI. Section 2 discusses some methodological considerations about what counts as a good philosophical problem. The discussion centers on Hilbert's famous analysis (...) of the central problems in mathematics. The rest of the article is devoted to the eighteen problems. These are organized into five sections: problems in the analysis of the concept of information, in semantics, in the study of intelligence, in the relation between information and nature, and in the investigation of values. (shrink)

In this paper we argue that structural explanations are an effective way of explaining well known relativistic phenomena like length contraction and time dilation, and then try to understand how this can be possible by looking at the literature on scientific models. In particular, we ask whether and how a model like that provided by Minkowski spacetime can be said to represent the physical world, in such a way that it can successfully explain physical phenomena structurally. We conclude by claiming (...) that a partial isomorphic approach to scientific representation can supply an answer only if supplemented by a robust injection of pragmatic factors. (shrink)

Scientists and laypeople alike use the sense of understanding that an explanation conveys as a cue to good or correct explanation. Although the occurrence of this sense or feeling of understanding is neither necessary nor sufficient for good explanation, it does drive judgments of the plausibility and, ultimately, the acceptability, of an explanation. This paper presents evidence that the sense of understanding is in part the routine consequence of two well-documented biases in cognitive psychology: overconfidence and hindsight. In light of (...) the prevalence of counterfeit understanding in the history of science, I argue that many forms of cognitive achievement do not involve a sense of understanding, and that only the truth or accuracy of an explanation make the sense of understanding a valid cue to genuine understanding. (shrink)

Naturalism implies unity of method--an application of the methods of science to the methodology of science itself and to value theory. Epistemological naturalists have tried to find a privileged discipline to be the methodological model of philosophy of science and epistemology. However, since science itself is not unitary, the use of one science as a model amounts to a reduction and distorts the philosophy of science just as badly as traditional philosophy of science distorted science, despite the fact that the (...) central theme of naturalized philosophy of science is that methodology should be true to science as practiced. I argue that naturalized philosophy of science must apply a plurality of methods to epistemological issues. (shrink)

This paper examines the nature of model-based reasoning in the interplay between theory and experiment in the context of biomedical engineering research laboratories, where problem solving involves using physical models. These "model systems" are sites of experimentation where in vitro models are used to screen, control, and simulate specific aspects of in vivo phenomena. As with all models, simulation devices are idealized representations, but they are also systems themselves, possessing engineering constraints. Drawing on research in contemporary cognitive science that construes (...) cognition as occurring in a complex distributed system comprising people and artifacts, I argue that reasoning with model systems is a constraint satisfaction process involving co-construction, manipulation, and revision of mental and physical models. (shrink)

I argue that everyday folk-psychological skill might best be explained in terms of the deployment of something like a model, in a specific sense drawn from recent philosophy of science. Theoretical models in this sense do not make definite commitments about the systems they are used to understand; they are employed with a particular kind of flexibility. This analysis is used to dissolve the eliminativism debate of the 1980s, and to transform a number of other questions about the status and (...) role of folk psychology. (shrink)

Most recent philosophical thought about the scientific representation of the world has focused on dyadic relationships between language-like entities and the world, particularly the semantic relationships of reference and truth. Drawing inspiration from diverse sources, I argue that we should focus on the pragmatic activity of representing, so that the basic representational relationship has the form: Scientists use models to represent aspects of the world for specific purposes. Leaving aside the terms "law" and "theory," I distinguish principles, specific conditions, models, (...) hypotheses, and generalizations. I argue that scientists use designated similarities between models and aspects of the world to form both hypotheses and generalizations. (shrink)

I argue against theories that attempt to reduce scientific representation to similarity or isomorphism. These reductive theories aim to radically naturalize the notion of representation, since they treat scientist's purposes and intentions as non-essential to representation. I distinguish between the means and the constituents of representation, and I argue that similarity and isomorphism are common but not universal means of representation. I then present four other arguments to show that similarity and isomorphism are not the constituents of scientific representation. I (...) finish by looking at the prospects for weakened versions of these theories, and I argue that only those that abandon the aim to radically naturalize scientific representation are likely to be successful. (shrink)

This article concerns whether Nietzsche is sympathetic to monism about concrete objects, the heterodox metaphysical view that there is exactly one concrete object. I first dispel prominent reasons for thinking that Nietzsche rejects monism. I then develop the most compelling arguments for monism in Nietzsche’s writings and check for soundness. The arguments seem to be supported by the texts, but they have not been developed in the literature. Despite such arguments, I suggest that Nietzsche is actually not sympathetic to monism (...) about objects—but his reasons for siding against monism are not at all obvious. The result should be a new understanding of some of Nietzsche’s fundamental ontological commitments. (shrink)

Scientific discourse is rife with passages that appear to be ordinary descriptions of systems of interest in a particular discipline. Equally, the pages of textbooks and journals are filled with discussions of the properties and the behavior of those systems. Students of mechanics investigate at length the dynamical properties of a system consisting of two or three spinning spheres with homogenous mass distributions gravitationally interacting only with each other. Population biologists study the evolution of one species procreating at a constant (...) rate in an isolated ecosystem. And when studying the exchange of goods, economists consider a situation in which there are only two goods, two perfectly rational agents, no restrictions on available information, no transaction costs, no money, and dealings are done immediately. Their surface structure notwithstanding, no competent scientist would mistake descriptions of such systems as descriptions of an actual system: we know very well that there are no such systems. These descriptions are descriptions of a model-system, and scientists use model-systems to represent parts or aspects of the world they are interested in. Following common practice, I refer to those parts or aspects as target-systems. What are we to make of this? Is discourse about such models merely a picturesque and ultimately dispensable façon de parler? This was the view of some early twentieth century philosophers. Duhem (1906) famously guarded against confusing model building with scientific theorizing and argued that model building has no real place in science, beyond a minor heuristic role. The aim of science was, instead, to construct theories, with theories understood as classificatory or representative structures systematically presented and formulated in precise symbolic.. (shrink)

This review of recent work in the philosophy of science motivated by a commitment to 'naturalism' begins by identifying three key axioms and one theorem shared by philosophers thus self-styled. Owing much to Quine and Ernest Nagel, these philosophers of science share a common agenda with naturalists elsewhere in philosophy. But they have disagreed among themselves about how the axioms and the theorems they share settle long-standing disputes in the philosophy of science. After expounding these disagreements in the work of (...) Boyd, Giere, Laudan, and Kitcher, I argue that naturalism needs to look for more than mere consistency in its foundations. (shrink)

Recently, a number of philosophers of biology have endorsed views about random drift that, we will argue, rest on an implicit assumption that the meaning of concepts such as drift can be understood through an examination of the mathematical models in which drift appears. They also seem to implicitly assume that ontological questions about the causality of terms appearing in the models can be gleaned from the models alone. We will question these general assumptions by showing how the same equation (...) — the simple 2 = p2 + 2pq + q2 — can be given radically different interpretations, one of which is a physical, causal process and one of which is not. This shows that mathematical models on their own yield neither interpretations nor ontological conclusions. Instead, we argue that these issues can only be resolved by considering the phenomena that the models were originally designed to represent and the phenomena to which the models are currently applied. When one does take those factors into account, starting with the motivation for Sewall Wright’s and R.A. Fisher’s early drift models and ending with contemporary applications, a very different picture of the concept of drift emerges. On this view, drift is a term for a set of physical processes, namely, indiscriminate sampling processes. (shrink)

This paper's purpose is to set forth the conditions of explanation in the domain of formal modelling of social action. Explanation is defined as an adequate account of the underlying factors bringing about a phenomenon. The modelling of a social phenomenon can claim explanatory value in this sense if the following two conditions are fulfilled. (1) The generative mechanisms involved translate the effects of real factors abstracted from their phenomenal context, not those of purely ideal ones. (2) The explanatory hypotheses, (...) which account for the effects of explanatory factors, and the purely descriptive hypotheses, which introduce conceptual simplifications and summarise complex secondary mechanisms, are relatively independent from each other with regard to the phenomenon represented. This condition subjects the model to testing by alternatives through the development of purely descriptive hypotheses in the sense of explanatory or analytical realism. (shrink)

The semantic, or model-theoretic, approach to theories has recently come under criticism on two fronts: (i) it is claimed that it cannot account for the wide diversity of models employed in scientific practice—a claim which has led some to propose a “deflationary” account of models; (ii) it is further contended that the sense of “model” used by the approach differs from that given in model theory. Our aim in the present work is to articulate a possible response to these claims, (...) drawing on recent developments within the semantic approach itself. Thus, the first is answered by utilizing the notion of a “partial structure”, first introduced in this context by da Costa and French in 1990. The second claim is undermined by consideration of van Fraassen's understanding of “model” which corresponds well with that evinced by modem mathematicians. This latter discussion, in particular, has an impact on the continuing debate regarding the relative merits of the semantic and syntactic views and the developments presented here can be taken to provide further support to the former. (shrink)

The concept of information has acquired a strikingly prominent role in contemporary biology. This trend is especially marked within genetics, but it has also become important in other areas, such as evolutionary theory and developmental biology, particularly where these fields border on genetics. The most distinctive biological role for informational concepts, and the one that has generated the most discussion, is in the description of the relations between genes and the various structures and processes that genes play a role in (...) causing. For many biologists, the causal role of genes should be understood in terms of their carrying information about their various products. That information might require the cooperation of various environmental factors before it can be "expressed," but the same can be said of other kinds of message. An initial response might be to think that this mode of description is entirely anchored in a set of well-established facts about the role of DNA and RNA within protein synthesis, summarized in the familiar chart representing the "genetic code," mapping DNA base triplets to amino acids. However, informational enthusiasm in biology predates even a rudimentary understanding of these mechanisms (Schrodinger 1944). And more importantly, current applications of informational concepts extend far beyond anything that can receive an obvious justification in terms of the familiar facts about the specification of protein molecules by DNA. This includes: 1 (i) The description of whole-organism phenotypic traits (including complex behavioral traits) as specified or coded for by information contained in the genes, (ii) The treatment of many causal processes within cells, and perhaps of the wholeorganism developmental sequence, in terms of the execution of a program stored in the genes, (iii) The idea that genes themselves, for the purpose of evolutionary theorizing, should be seen as, in some sense, "made" of information.. (shrink)

How is scientific knowledge used, adapted and extended in deriving real-world systems and technological devices? This paper aims at developing a general model of "applying science" based on the Exemplar-Based Explanation (EBE) model. EBE embodies the view that a real-world system is derived not by solving theoretical laws for specific boundary conditions but by constructing the system out of previously derived systems that function as exemplars. I will discuss a number of artifacts from hydraulics and language technology, and develop an (...) instantiation of EBE which generalizes over different disciplines. I argue that engineering practice is highly cumulative: new systems are almost literally built upon and constructed out of previous systems resulting into increasingly complex wholes. (shrink)

In this paper, a criticism of the traditional theories of approximation and idealization is given as a summary of previous works. After identifying the real purpose and measure of idealization in the practice of science, it is argued that the best way to characterize idealization is not to formulate a logical model – something analogous to Hempel's D-N model for explanation – but to study its different guises in the praxis of science. A case study of it is then made (...) in thermostatistical physics. After a brief sketch of the theories for phase transitions and critical phenomena, I examine the various idealizations that go into the making of models at three difference levels. The intended result is to induce a deeper appreciation of the complexity and fruitfulness of idealization in the praxis of model-building, not to give an abstract theory of it. (shrink)

A number of developmental psychologists have argued for a theory they call the theory theory - a theory of cognitive development that suggests that infants and small children make sense of their world by constructing cognitive representations that have many of the attributes of scientific theories. In this paper I argue that there are indeed close parallels between the activities of children and scientists, but that these parallels will be better understood if one recognizes that both scientists and children are (...) not so much theorists as model builders. (shrink)

Regarding the dichotomy between applied science and pure science, there are two apparently paradoxical facts. First, they are distinguishable. Second, the outcomes of pure sciences (e.g. scientific theories and models) are applicable to producing the outcomes of applied sciences (e.g. technological artefacts) and vice versa. Addressing the functional roles of applied and pure science, i.e. to produce design representation and science representation, respectively, I propose a new characterisation of the dichotomy that explains these two facts.

This paper aims (a) to provide characterizations of realism and instrumentalism that are philosophically interesting and applicable to economics; and (b) to defend instrumentalism against realism as a methodological stance in economics. Starting point is the observation that ‘all models are false’, which, or so I argue, is difficult to square with the realist's aim of truth, even if the latter is understood as ‘partial’ or ‘approximate’. The three cheers in favour of instrumentalism are: (1) Once we have usefulness, truth (...) is redundant. (2) There is something disturbing about causal structure. (3) It's better to do what one can than to chase rainbows. (shrink)

In this paper, the different theories about science and technology relationships are analyzed. All of them have some virtues, but also one main defect: these theories do not take into account other well-founded possible relationships. The origin of this problem is the narrow view about science and technology. In this paper another characterization about technology based on Ronald Giere’s perspective is suggested. In the light of this new description, six different relationships between science and technology arise. Some of these relations (...) had been explained in the before analyzed theories, but others emerge from the new portrayal. (shrink)

http://dx.doi.org/10.5007/1808-1711.2008v12n1p97 This paper defends the idea that there are three determinant elements in the identity of theories in accordance with the semantic approach of theories: the kind of theoretic models, the data models and the empirical claims, but with some exceptions in each case. I uphold this thesis in an analysis the Structuralist view and van Fraassen’s one about this respect.

While agreeing that cognition in the sciences is usefully thought of as involving processes encompassing both humans and artifacts, I object to attributing cognitive states to extended systems. I argue that cognitive states, such as ?knowing?, should be confined to the human components of cognitive systems. My argument appeals to the large dimensions, both spatial and temporal, of many scientific cognitive systems, the existence of epistemic norms, and the need for agents in science.

Part I Introduction The specific problem adressed in this thesis is: what is the rational use of theory and experiment in the process of scientific discovery, in theory and in the practice of drug research for Parkinson’s disease? The thesis aims to answer the following specific questions: what is: 1) the structure of a theory?; 2) the process of scientific reasoning?; 3) the route between theory and experiment? In the first part I further discuss issues about rationality in science as (...) introduction to part II, and I present an overview of my case-study of neuropharmacology, for which I interviewed researchers from the Groningen Pharmacy Department, as an introduction to part III. Part II Discovery In this part I discuss three theoretical models of scientific discovery according to studies in the fields of Logic, Cognition, and Computation. In those fields the structure of a theory is respectively explicated as: a set of sentences; a set of associated memory chunks; and as a computer program that can generate the observed data. Rationality in discovery is characterized by: finding axioms that imply observation sentences; heuristic search for a hypothesis, as part of problem solving, by applying memory chunks and production rules that represent skill; and finding the shortest program that generates the data, respectively. I further argue that reasoning in discovery includes logical fallacies, which are neccesary to introduce new hypotheses. I also argue that, while human subjects often make errors in hypothesis evaluation tasks from a logical perspective, these evaluations are rational given a probabilistic interpretation. Part III Neuropharmacology In this last part I discusses my case-study and a model of discovery in a practice of drug research for Parkinson’s disease. I discuss the dopamine theory of Parkinson’s disease and model its structure as a qualitative differential equation. Then I discuss the use and reasons for particular experiments to both test a drug and explore the function of the brain. I describe different kinds of problems in drug research leading to a discovery. Based on that description I distinguish three kinds of reasoning tasks in discovery, inference to: the best explanation, the best prediction and the best intervention. I further demonstrate how a part of reasoning in neuropharmacology can be computationally modeled as qualitative reasoning, and aided by a computer supported discovery system. (shrink)

Despite their best efforts, scientists may be unable to construct models that simultaneously exemplify every theoretical virtue. One explanation for this is the existence of tradeoffs: relationships of attenuation that constrain the extent to which models can have such desirable qualities. In this paper, we characterize three types of tradeoffs theorists may confront. These characterizations are then used to examine the relationships between parameter precision and two types of generality. We show that several of these relationships exhibit tradeoffs and discuss (...) what consequences those tradeoffs have for theoretical practice. (shrink)

A biochemical pathway is a sequence of chemical reactions in a biological organism. Such pathways specify mechanisms that explain how cells carry out their major functions by means of molecules and reactions that produce regular changes. Many diseases can be explained by defects in pathways, and new treatments often involve finding drugs that correct those defects. This paper presents explanation schemas and treatment strategies that characterize how thinking about pathways contributes to biomedical discovery. It discusses the significance of pathways for (...) understanding the nature of diseases, explanations, and theories. (shrink)

The aim of this paper is to explore the possibility that, at least, some metaphysical debates are ‘metalinguistic negotiations’. I will take the dispute between the dominant approaches of realism and the anti-realism ones about the ontological status of scientific models as a case-study. I will argue that such a debate may be better understood as a disagreement, at bottom normatively, motivated, insofar as a normative and non-factual question may be involved in it: how the relevant piece of language ought (...) to be used. Even though I will generally assess the prospects for a broadly deflationist approach, I shall outline a sense in which the dispute can be recast as ‘minimally substantive’. (shrink)

Microbial model systems have a long history of fruitful use in fields that include evolution and ecology. In order to develop further insight into modelling practice, we examine how the competitive exclusion and coexistence of competing species have been modelled mathematically and materially over the course of a long research history. In particular, we investigate how microbial models of these dynamics interact with mathematical or computational models of the same phenomena. Our cases illuminate the ways in which microbial systems and (...) equations work as models, and what happens when they generate inconsistent findings about shared targets. We reveal an iterative strategy of comparative modelling in different media, and suggest reasons why microbial models have a special degree of epistemic tractability in multimodel inquiry. (shrink)

I develop an account of scientific representations building on Charles S. Peirce's rich, and still underexplored, notion of iconicity. Iconic representations occupy a central place in Peirce's philosophy, in his innovative approach to logic and in his practice as a scientist. Starting from a discussion of Peirce's approach to diagrams, I claim that Peirce's own representations are in line with his formulation of iconicity, and that they are more broadly connected to the pragmatist philosophy he developed in parallel with his (...) scientific work. I then defend the contemporary relevance of Peirce's approach to iconic representations, and specifically argue that Peirce offers a useful ‘third way’ between what Mauricio Suárez has recently described as the ‘analytical’ and ‘practical’ inquiries into the concept of representation. As a philosophically minded scientist and an experimentally inclined philosopher, Peirce never divorced the practice of representing from questions about what counts as a representation... (shrink)

This paper provides a conceptual analysis of the notion of interests as it is used in the social studies of science. After describing the theoretical background behind the Strong Program's adoption of the concept of interest, the paper outlines a reconstruction of the everyday notion of interest and argues that this same notion is used also by the sociologists of scientific knowledge. However, there are a couple of important differences between the everyday use of this notion and the way in (...) which it used by the sociologists. The sociologists do not use the term in evaluative context and they do not regard interests as purely non-epistemic factors. Finally, it is argued that most of the usual critiques of interest explanations, by both philosophers and fellow sociologists, are misguided. (shrink)

This article defends a pragmatic and structuralist account of scientific representation of the kind recently proposed by Bas van Fraassen against criticisms of both the structuralist and the pragmatist plank of the account. I argue that the account appears to have the unacceptable consequence that the domain of a theory is restricted to phenomena for which we actually have constructed a model—a worry arising from the account’s pragmatism, which is exacerbated by its structuralism. Yet, the account has the resources, at (...) least partially, to address the worry. What remains as implication is a strong anti-foundationalism. 1 Introduction2 ‘No Representation without Representer’3 Representational Structuralism3.1 Do structural models need to be concretely fitted out?3.2 The triviality objection4 Anti-foundationalism5 Conclusion. (shrink)

The practice of model-building is very common in analytic philosophical theology. Yet many other theologians worry that any attempt to model God must be hubristic and idolatrous. A better understanding of scientific modeling can set the stage for a more fruitful engagement between analytic theologians and their critics. I first present an account of scientific modeling that draws on recent work in the philosophy of science. I then apply that account to a prominent analytic model of the trinity, Michael Rea (...) and Jeffrey Brower’s “material constitution model.” I argue that modeling – whether scientific or theological – need not be understood as a hubristic enterprise. A model does not always try to grasp its target at all, let alone grasp it fully and completely. Even theologians who are committed to a strong doctrine of divine mystery can therefore find value in analytic modeling. (shrink)

Roald Hoffmann and other theorists claim that we ought to use highly idealized chemical models (“qualitative models”) in order to increase our understanding of chemical phenomena, even though other models are available which make more highly accurate predictions. I assess this norm by examining one of the tradeoffs faced by model builders and model users—the tradeoff between precision and generality. After arguing that this tradeoff obtains in many cases, I discuss how the existence of this tradeoff can help us defend (...) Hoffmann's norm for modelling. (shrink)