There are at least twelve major virtues of good theories: evidential accuracy, causal adequacy, explanatory depth, internal consistency, internal coherence, universal coherence, beauty, simplicity, unification, durability, fruitfulness, and applicability. These virtues are best classified into four classes: evidential, coherential, aesthetic, and diachronic. Each virtue class contains at least three virtues that sequentially follow a repeating pattern of progressive disclosure and expansion. Systematizing the theoretical virtues in this manner clarifies each virtue and suggests how they might have a coordinated and cumulative (...) role in theory formation and evaluation across the disciplines—with allowance for discipline specific modification. An informal and flexible logic of theory choice is in the making here. Evidential accuracy, according to my systematization, is not a largely isolated trait of good theories, as some have made it out to be. Rather, it bears multifaceted relationships, constituting significant epistemic entanglements, with other theoretical virtues. (shrink)

One of Nancy Cartwright's arguments for entity realism focuses on the non-redundancy of causal explanation. In How the Laws of Physics Lie she uses an example from laser theory to illustrate how we can have a variety of theoretical treatments governing the same phenomena while allowing just one causal story. In the following I show that in the particular example Cartwright chooses causal explanation exhibits the same kind of redundancy present in theoretical explanation. In an attempt to salvage Cartwright's example (...) the causal explanation could be reinterpreted as a capacity claim, as outlined in her recent work Nature's Capacities and Their Measurement. However, I argue that capacities cannot be isolated in the way that Cartwright suggests and consequently these capacity claims also fail to provide a unique causal story. We can, however, make sense of capacities by characterizing them in a relational way and I offer some ideas as to how this approach would retain our intuitions about capacities while denying their ontological priority as dormant powers. (shrink)

Alexander Bird argues for an epistemic account of scientific progress, whereas Darrell Rowbottom argues for a semantic account. Both appeal to intuitions about hypothetical cases in support of their accounts. Since the methodological significance of such appeals to intuition is unclear, I think that a new approach might be fruitful at this stage in the debate. So I propose to abandon appeals to intuition and look at scientific practice instead. I discuss two cases that illustrate the way in which scientists (...) make judgments about progress. As far as scientists are concerned, progress is made when scientific discoveries contribute to the increase of scientific knowledge of the following sorts: empirical, theoretical, practical, and methodological. I then propose to articulate an account of progress that does justice to this broad conception of progress employed by scientists. I discuss one way of doing so, namely, by expanding our notion of scientific knowledge to include both know-that and know-how. (shrink)

We argue that the logical outcome of the cladistics revolution in biological systematics, and the move towards rankless phylogenetic classification of nested monophyletic groups as formalized in the PhyloCode, is to eliminate the species rank along with all the others and simply name clades. We propose that the lowest level of formally named clade be the SNaRC, the Smallest Named and Registered Clade. The SNaRC is an epistemic level in the classification, not an ontic one. Naming stops at that level (...) because there is no currently acceptable evidence for clades within it, not because no smaller clades exist. Later, included clades may be named. They would then become the SNaRCs, while the original SNaRC would keep its original name. We argue that all theoretical tasks of biology, in evolution and ecology, as well as practical tasks such as conservation assessment, are better approached using this rankless phylogenetic approach. (shrink)

In 1792 Dugald Stewart published Elements of the philosophy of the human mind. In its section on abstraction he declared himself to be a nominalist. Although a few scholars have made brief reference to this position, no sustained attention has been given to the central role that it played within Stewart’s early philosophy of mind. It is therefore the purpose of this essay to unpack Stewart’s nominalism and the intellectual context that fostered it. In the first three sections I aver (...) that his nominalism emanated from his belief that objects of the mind—qualities, ideas and words—were signs that bore no necessary relation to the external objects that they were meant to represent. More specifically, it was these signs that were arranged into systems of thought by the ‘operations of the mind’. The next three sections suggest that his treatment of words as signs most probably originated in his views on language and medicine and that his nominalistic philosophy of mind could also be extended to systems that sought to classify the natural world. I conclude by suggesting several avenues of enquiry that could be pursued by future scholars interested in excavating Stewart’s thought. (shrink)

This paper addresses the general problem of how to rationally choose an algorithm for phylogenetic inference. Specifically, the controversy between maximum likelihood (ML) and maximum parsimony (MP) perspectives is reframed within the philosophical issue of theory choice. A Kuhnian approach in which rationality is bounded and value-laden is offered and construed through the notion of a Style of Modeling. A Style is divided into four stages: collecting remnant models, constructing models of taxonomical identity, implementing modeling algorithms, and finally inferring and (...) confirming evolutionary trees or cladograms. The identification and investigation of styles is useful for exploring sociological and epistemological issues such as individuating scientific communities and assessing the rationality of algorithm choice. Regarding the last point, this paper suggests that the values motivating ML and MP perspectives are justified but only contextually; these algorithms also have normative force because they can be therapeutic by allowing us to rationally choose among several competing trees, nonetheless this force is limited and cannot be used in order to decide the controversy tout court. (shrink)

With the careful use of the polywater episode in the history of chemistry as a case study, I will show that the distinction recently made in the philosophy of science between experimenting on an entity and manipulating that entity is best seen as a distinction between experimenting on, and experimenting with, that entity. The polywater case also reveals that Ian Hacking's 1983 manipulability criterion is not a necessary condition for realism, and that scientists can, and do, justifiably change their minds (...) as to the reality of theoretical entities. (shrink)

(1988). The explanative recourse to realism. International Studies in the Philosophy of Science: Vol. 3, No. 1, pp. 2-18. doi: 10.1080/02698598808573321.

Thought experiment acquires evidential significance only on particular metaphysical assumptions. These include the thesis that science aims at uncovering "phenomena"universal and stable modes in which the world is articulatedand the thesis that phenomena are revealed imperfectly in actual occurrences. Only on these Platonically inspired assumptions does it make sense to bypass experience of actual occurrences and perform thought experiments. These assumptions are taken to hold in classical physics and other disciplines, but not in sciences that emphasize variety and contingency, such (...) as Aristotelian natural philosophy and some forms of historiography. This explains why thought experiments carry weight in the former but not the latter disciplines. (shrink)

The ArgumentIn the controversy in 1989 over the reported achievement of cold nuclear fusion, parts of the physics and chemistry communities were opposed in both a theoretic and a professional competition. Physicists saw the chemists' announcement as an incursion into territory allocated to their own discipline and strove to restore the interdisciplinary boundaries that had previously held. The events that followed throw light on the manner in which scientists' knowledge claims and metascientific beliefs are affected by their membership of disciplinary (...) communities. In particular, the controversy offers evidence for a constructivist reinterpretation of the “division of nature into levels,” which is customarily held to underpin the division of science into disciplines. (shrink)

In seeking general accounts of evidence, confirmation, or inference, philosophers have looked to logical relationships between evidence and hypotheses. Such logics of evidential relationship, whether hypothetico-deductive, Bayesian, or instantiationist fail to capture or be relevant to scientific practice. They require information that scientists do not generally have (e.g., an exhaustive set of hypotheses), while lacking slots within which to include considerations to which scientists regularly appeal (e.g., error probabilities). Building on my co-symposiasts contributions, I suggest some directions in which a (...) new and more adequate philosophy of evidence can move. (shrink)

Experimental realism aims at striking a middle ground between scientific realism and anti-realism, between the success of experimental physics it would explain and the realism about scientific theories it would supplant. This middle ground reinstates the engineering idea that belief in scientific entities is justified on purely experimental grounds, without any commitment to scientific theories and laws. This paper argues that there is no defensible middle ground to be staked out when it comes to justifying physicists' belief in colored quarks, (...) and that experimental realism shifts, under analysis, into scientific realism. (shrink)

In this article, I introduce the notion of horizon for scientific practice (HSP), representing limits or boundaries within which scientists ply their trade, to facilitate analysis of scientific discovery and progress. The notion includes not only constraints that delimit scientific practice, e.g. of bringing experimentation to a temporary conclusion, but also possibilities that open up scientific practice to additional scientific discovery and to further scientific progress. Importantly, it represents scientific practice as a dynamic and developmental integration of activities to investigate (...) and analyze the natural world. I use the discovery of the clotting factor, thrombin, and the experiments conducted by the Johns Hopkins physiologist, William Howell, on the enzymatic nature of thrombin to illustrate the notion of HSP. In a concluding section, I compare the notion of HSP to other notions for scientific practice proposed in the history and philosophy of science literature. (shrink)

The purpose of this paper is to show how the degree of experimental validity of scientific procedures is crucially involved in determining two typical pragmatic modes in science, namely, the preservation of useful procedures and the disposal of useless ideas. The term 'pragmatic' will here be used following Schurz's characterisation of being internally pragmatic, as referring to that which proves useful for scientific or epistemic goals. The first part of the paper consists in a characterisation of the notion of experimental (...) validity. The second part is focused on several historical examples illustrating how the above pragmatic modes relate to the question of experimental validity. The Michelson-Morley experiment is presented as a case of a highly valid and useful experiment preserved through the development of different theories (like, on the one hand, the ether theory, upheld by Fitzgerald and Lorentz, and, on the other hand, Einstein's special theory of relativity). The concept of caloric will be discussed as an example of an idea that was discarded once it became useless, after heat was understood as a form of energy within the new frame provided by the kinetic theory of heat towards the middle of the 19th century. (shrink)

La tesis de la subdeterminación empírica representa uno de los mayores desafíos contemporáneos en contra del realismo científico, sin embargo, frecuentemente se le ha considerado como un reto coherente y se ha buscado una forma de atenuar su impacto ya sea mitigando alguna posición realista, o bien, atacando alguno de sus presupuestos más problemáticos. En este ensayo defiendo un argumento en su contra, a saber, que es una tesis que nos conduce a una reductio y que semejante resultado echa por (...) tierra su supuesta plausibilidad como una tesis antirrealista. (shrink)

The scientific realism debate has now reached an entirely new level of sophistication. Faced with increasingly focused challenges, epistemic scientific realists have appropriately revised their basic meta-hypothesis that successful scientific theories are approximately true: they have emphasized criteria that render realism far more selective and, so, plausible. As a framework for discussion, I use what I take to be the most influential current variant of selective epistemic realism, deployment realism. Toward the identification of new case studies that challenge this form (...) of realism, I break away from the standard list and look to the history of celestial mechanics, with an emphasis on twentieth century advances. I then articulate two purely deductive arguments that, I argue, properly capture the historical threat to realism. I contend that both the content and form of these novel challenges seriously threaten selective epistemic realism. I conclude on a positive note, however, arguing for selective realism at a higher level. Even in the face of threats to its epistemic tenet, scientific realism need not be rejected outright: concern with belief can be bracketed while nonetheless advocating core realist tenets. I show that, in contrast with epistemic deployment realism, a purely axiological scientific realism can account for key scientific practices made salient in my twentieth century case studies. And embracing the realists favored account of inference, inference to the best explanation, while pointing to a set of the most promising alternative selective realist meta-hypothesis, I show how testing the latter can be immensely valuable to our understanding of science. (shrink)

The ArgumentThere can be no doubt about the moral and epistemological significance of what Shapin calls the “physical place” of the scientific laboratory. The physical place is defined by the locales, barriers, ports of entry, and lines of sight that bound the laboratory and separate it from other urban and architectural environments. Shapin's discussion of the emergence of the scientific laboratory in seventeenth-century England provides a convincing demonstration that credible knowledge is situated at an intersection between physical locales and social (...) distinctions. In this paper I take up Shapin's theme of the “siting of knowledge production,” but I give it a different treatment – one based on ethnomethodological studies of work. Without denying all that can be witnessed in the spectacle of the scientist at the bench and of the architectural habitat of the bench, I argue that the “place” of scientific work is defined by locally organizedtopical contextures. The paper describes two examples of such spatial orders – “opticism” and “digitality” – associated with distinct complexes of equipment and practice. These topical spaces might initially be viewed as “ideal” or “symbolic” spaces, but I argue that they are no less material than the “physical setting” of the laboratory; indeed, they are the physical setting. (shrink)

I argue that although Ockham’s Razor (OR) has its origins in a-priorist ontological mandates according to the purposes of natural theology and natural philosophy as influenced by it, the principle has taken on significant empirical and contingent materialist connotations and conceptual content since the scientific revolution. I briefly discuss the pluralism of the concept of OR historically and in contemporary science and philosophy. I then attempt to align scientific metaphysics with contemporary conceptions of OR, and to demonstrate that ontic parsimony (...) is an indispensable element of scientific (contingent and anti-a-priorist) metaphysics. I then further deploy that scientific metaphysics to propose a contingently grounded semi-formal approach, with set theoretic features, and then with information theoretic features, to provide a way of assessing when a scientific theory and its ontology are aligned with OR appropriately in the context of the proposed scientific metaphysics. (shrink)

This essay argues that nano-images would be best understood with an aesthetical approach rather than with an epistemological critique. For this aim, I propose a ‘techno-aesthetical’ approach: an enquiry into the way instruments and machines transform the logic of the sensible itself and not just the way by which it represents something else. Unlike critical epistemology, which remains self-evidently grounded on a representationalist philosophy, the approach developed here presents the advantage of providing a clear-cut distinction between image-as-representation and other modes (...) of existence of images, such as the one of ‘ imaginaction ’ that I draw from a comparison between far-field and near-field microscopies. Once this regime of imaginaction is distinguished from representation, I focus on nanotechnological percepts and argue that they follow a transmodal logic. I then draw the implications of this enquiry in terms of a new sensible condition that changes the way we think of non-living objects. Finally, I conclude that if techno-aesthetics dares to posit and articulate sensibility beyond the privileged sphere of subject/object relationships, it simultaneously engages us to consider the political character of our responsibilities towards the design of nano-engineered sensorial spaces. (shrink)

This is my first professional philosophical essay. I wrote "The twofold meaning of being" in 1996 when I was a student of Nunzio Incardona at University of Palermo (Italy) and before my degree thesis, "The difference in Aristotle’s Metaphysics". It still waits to be published.

Today, mechanisms and mechanistic explanation are very popular in philosophy of science and are deemed a welcome alternative to laws of nature and deductive‐nomological explanation. Starting from Mitchell's pragmatic notion of laws, I cast doubt on their status as a genuine alternative. I argue that (1) all complex‐systems mechanisms ontologically must rely on stable regularities, while (2) the reverse need not hold. Analogously, (3) models of mechanisms must incorporate pragmatic laws, while (4) such laws themselves need not always refer to (...) underlying mechanisms. Finally, I show that Mitchell's account is more encompassing than the mechanistic account *Received August 2008; revised January 2010. †To contact the author, please write to: Centre for Logic and Philosophy of Science, Ghent University, Blandijnberg 2, B‐9000 Belgium; e‐mail: [email protected]. (shrink)

New accents in the philosophy of technology and philosophy of science amounting, e.g., to the so-called schools of the “New Experimentalism”, “New Instrumentalism” and, recently, “New Mechanism” emphasize the impact of instruments, experiments, and “mechanisms” of the respective technologies opened up by the progress of ever-improving measuring instruments, procedures etc. In addition, it would be necessary to accentuate the process- and action-orientation including practical responsibility problems and dynamic systems models from an epistemological perspective of the methodological scheme-interpretationist approach developed by (...) the author since the seventies of last century. The necessity of multi-disciplinary mutual influences was already time and again stressed regarding philosophy of science. But relatively new is not only the methodological turn involved but also the necessity to go to higher levels of abstraction, metatheories, action- and value-orientation. Therefore, we have to go more interdisciplinary, systems-oriented, and higher-level. That implies notable consequences for an ethics, or rather, meta-ethics for philosophy of science. Practice-oriented philosophers of science will have to go more methodological, multidisciplinary and even responsible. (shrink)

It is usually believed that science goes with things like theoria, ‘knowing that’, ontology and representing, and that techne, know-how, technology and intervening are only instrumental to science or its beneficial but nonetheless accidental side effect. In this context to be instrumental means also to be eliminable, or at least transparent, something that leaves no trace. Following the historical development of experimentation, from simple observation to modern microscopic experiments. I try to show how that view loses its ground. To produce (...) an artefact, scientific or other, is to be engaged in a complex dynamics, both ontological and epistemological in which at least two component processes, that of bringing forth and that of bringing into, are intertwined. The old dictum: ‘Science discovers, technology invents’, should be replaced by: science discovers because it invents. As a consequence scientific theory becomes an instrument of design. (shrink)

This paper discusses the connection between the actual history of mathematics and Lakatos's philosophy of mathematics, in three parts. The first points to studies by Lakatos and others which support his conception of mathematics and its history. In the second I suggest that the apparent poverty of Lakatosian examples may be due to the way in which the history of mathematics is usually written. The third part argues that Lakatos is right to hold philosophy accountable to history, even if Lakatos's (...) own view of mathematics fails that test. (shrink)

We claim that the process of theoretical model refinement in economics is best characterised as robustness analysis: the systematic examination of the robustness of modelling results with respect to particular modelling assumptions. We argue that this practise has epistemic value by extending William Wimsatt's account of robustness analysis as triangulation via independent means of determination. For economists robustness analysis is a crucial methodological strategy because their models are often based on idealisations and abstractions, and it is usually difficult to tell (...) which idealisations are truly harmful. (shrink)

The concept of observability of entities in physical science is typically analysed in terms of the nature and significance of a dichotomy between observables and unobservables. In the present work, however, this categorization is resisted and observability is analysed in a descriptive way in terms of the information which one can receive through interaction with objects in the world. The account of interaction and the transfer of information is done using applicable scientific theories. In this way, the question of observability (...) of scientific entities is put to science itself. The result is a demonstration that observability has many dimensions, some more epistemically significant than others. (shrink)

I consider three aspects in which machine learning and philosophy of science can illuminate each other: methodology, inductive simplicity and theoretical terms. I examine the relations between the two subjects and conclude by claiming these relations to be very close.

In this essay, I provide normative guidelines for developing a philosophically interesting and plausible version of social constructivism as a philosophy of science, wherein science aims for social-epistemic values rather than for truth or empirical adequacy. This view is more plausible than the more radical constructivist claim that scientific facts are constructed. It is also more interesting than the modest constructivist claim that representations of such facts emerge in social contexts, as it provides a genuine rival to the scientific axiologies (...) of scientific realists and constructive empiricists. I further contrast my view with positions holding that the aims of science are context dependent, that the unit of normative analysis is the scientific community, and that the aims of science are non-epistemic social values. (shrink)

In the traditional conception of science one assumes that science produces results which are certain and precise. It is argued that this picture is flawed and needs to be replaced with a view where uncertainty and imprecision are an integral part of the scientific enterprise. Uncertainty is still poorly understood by many practising scientists. However, several developments in science indicate that some epistemological uncertainty, e.g. due to processes of abstraction and idealization, will always follow advances in scientific knowledge. There are (...) also other developments that indicate some principal ontological uncertainties, i.e. uncertainties that are due to how the world is. Complexity is one such example. Remarks on post-normal science are thus included. This paper argues, therefore, that scientific uncertainty is a multi-dimensional concept, and that it is unavoidable because it is often the result as much as the cause of new knowledge. (shrink)

This paper points out the need for an analytical and ontological reorientation of the field of computer-supported cooperative work (CSCW). It is argued that even though this field is heterogeneous it is marred by general problems of conceptualising the co-constitutive relations between humans and technologies. This is demonstrated through readings of several recent CSCW analyses. It is then suggested that a conceptual improvement can be facilitated by paying attention to newer scientific studies, here exemplified by Pickering, Haraway and Latour.

In this paper a critique to philosophical approaches that presuppose invariant knowledge for policy purposes is carried out. It is shown that socioeconomic processes do not fit to the logic of stable causal factors, but they are more suited to the logic of "open-ended results". On the basis of this ontological variation it is argued that ex-ante interventions are not appropriate in the socioeconomic realm. On the contrary, they must be understood in a “dynamic” sense. Finally, derivational robustness analysis is (...) proposed as a useful tool for overcoming the problem of “overconstraint”, a typical problem of economic models. (shrink)

This paper argues for a position of ‘dark pessimism’ towards introspective reports playing a strong justificatory role in consciousness science, based on the application of frameworks and concepts of measurement. I first show that treating introspective reports as measurements fits well within current discussions of the reliability of introspection, and argue that introspective reports must satisfy at least a minimal definition of measurement in order to play a justificatory role in consciousness science. I then show how treating introspective reports as (...) measurements makes it possible to identify the foundational methodological problems that underlie much of the current philosophical and scientific debate about the status of introspective evidence in studying consciousness. I argue that these problems prevent introspective reports from playing a strong justificatory role and resolving long-standing debates in consciousness science, both in contemporary work and in the future. (shrink)

Given that visualisations via medical imaging have tremendously increased over the last decades, the overall presence of colour-coded brain slices generated on the basis of functional imaging, i.e. neuroimaging techniques, have led to the assumption of so-called kinds of brains or cognitive profiles that might be especially related to non-healthy humans affected by neurological, neuropsychological or psychiatric syndromes or disorders. In clinical contexts especially, one must consider that visualisations through medical imaging are suggestive in a twofold way. Imaging data not (...) only visually render pathological entities, but also tend to represent objective and concrete evidence for these psychophysical states in question. This article aims to identify key issues in visually rendering psychiatric disorders via functional approaches of imaging within the neurosciences from an epistemological point of view. (shrink)

Since early modernity, it has often been assumed that miracles are incompatible with the existence of the natural laws utilized in the sciences. This paper argues that this assumption is largely an artifact of empiricist accounts of laws that should be rejected for reasons internal to philosophy of science, and that no such incompatibility arises on the most important alternative interpretations, which treat laws as expressions of forces, dispositions, or causal powers.

The ArgumentVisible colleges, in contrast to the “invisible colleges” familiar to historians of science, are the collective places of science, the places where the “creation of phenomena” and theoretical speculation proceed side by side. To understand their spatial form, we must understand first how buildings can structure space to both conserve and generate social forms, depending on how they relate structure in space to randomness. Randomness is shown to play a crucial role in morphogenetic models of many kinds, especially in (...) spatial forms and in social networks. We argue here that it can also play a crucial role in the advance of science. (shrink)

Thought about fictional characters is special, and needs to be distinguished from ordinary world-directed thought. On my interpretation, Kendall Walton and Gareth Evans have tried to show how this serious fiction-directed thought can arise from engagement with a kind of pretending. Many criticisms of their account have focused on the methodological presupposition, that fiction-directed thought is the appropriate explanandum. In the first part of this paper, I defend the methodological claim, and thus the existence of the problem to which pretense (...) is supposed to be a solution. In the second part, I elaborate and defend the pretense theory as a solution to this problem. (shrink)

Can a naturalist earn the right to talk of a shared empirical world? Hume famously thought not, and contemporary stipulative naturalists infer from this inability that the demand is somehow unnatural. The critical naturalist, by contrast, claims to earn that right. In this paper, I motivate critical naturalism, arguing first that stipulative naturalism is question begging, and second, that the pessimism it inherits from Hume about whether the problem can be solved is misplaced. Hume's mistake was to mis-identify exemplary contexts (...) of thought: thought is a kind of action, better exemplified at the backgammon table or the dinner party than in the study. By earning the right to this environment-involving conception of thought, the critical naturalist can address, rather than avoid, the explanatory problem Hume uncovered. (shrink)

Laudan famously argued that neither truth nor approximate truth can be part of an explanation of a scientific theory's predictive success because in the history of science there were theories that enjoyed some limited success but now are considered outright false. The power of his argument lay in the many historic examples he listed . Realists have disputed that all theories on Laudan's list can be regarded as predictively successful but let's suppose momentarily that at least some exist that support (...) his point. In this case, there are historic false theories that made some true predictions. We are aiming for a general explanation of a theory's predictive success and hence these false theories necessarily are on board. Now, Laudan also argues that historic false theories – the downright false ones and the ones we nowadays judge as strictly false, but approximately true – do not in any principled sense differ from the ones we presently accept. These theories seem to present a good basis for inductively inferring that any presently accepted scientific theory is actually false. Many presently accepted theories certainly are predictively successful to a great extent and certainly their success should be covered by an acceptable explanation. Since there seems to be inductive support for the conclusion that …. (shrink)

Researchers in the biological and biomedical sciences, particularly those working in laboratories, use a variety of artifacts to help them perform their cognitive tasks. This paper analyses the relationship between researchers and cognitive artifacts in terms of integration. It first distinguishes different categories of cognitive artifacts used in biological practice on the basis of their informational properties. This results in a novel classification of scientific instruments, conducive to an analysis of the cognitive interactions between researchers and artifacts. It then uses (...) a multidimensional framework in line with complementarity-based extended and distributed cognition theory to conceptualize how deeply instruments in different informational categories are integrated into the cognitive systems of their users. The paper concludes that the degree of integration depends on various factors, including the amount of informational malleability, the intensity and kind of information flow between agent and artifact, the trustworthiness of the information, the procedural and informational transparency, and the degree of individualisation. (shrink)

The concept of the cortical column refers to vertical cell bands with similar response properties, which were initially observed by Vernon Mountcastle’s mapping of single cell recordings in the cat somatic cortex. It has subsequently guided over 50 years of neuroscientific research, in which fundamental questions about the modularity of the cortex and basic principles of sensory information processing were empirically investigated. Nevertheless, the status of the column remains controversial today, as skeptical commentators proclaim that the vertical cell bands are (...) a functionally insignificant by-product of ontogenetic development. This paper inquires how the column came to be viewed as an elementary unit of the cortex from Mountcastle’s discovery in 1955 until David Hubel and Torsten Wiesel’s reception of the Nobel Prize in 1981. I first argue that Mountcastle’s vertical electrode recordings served as criteria for applying the column concept to electrophysiological data. In contrast to previous authors, I claim that this move from electrophysiological data to the phenomenon of columnar responses was concept-laden, but not theory-laden. In the second part of the paper, I argue that Mountcastle’s criteria provided Hubel Wiesel with a conceptual outlook, i.e. it allowed them to anticipate columnar patterns in the cat and macaque visual cortex. I argue that in the late 1970s, this outlook only briefly took a form that one could call a ‘theory’ of the cerebral cortex, before new experimental techniques started to diversify column research. I end by showing how this account of early column research fits into a larger project that follows the conceptual development of the column into the present. (shrink)

Farmers all over the world perform experiments, and have done so since long before modern experimental science and its recognized forerunners. There is a rich anthropological literature on these experiments, but the philosophical issues that they give rise to have not received much attention. Based on the anthropological literature, this study investigates methodological and philosophical issues pertaining to farmers’ experiments, including the choice of interventions to be tested, the planning of experiments, and the use of control fields and other means (...) to deal with confounding factors. Farmers’ experiments have some advantages over the field trials of agricultural scientists, but also some comparative disadvantages. The two experimental traditions are complementary, and neither of them can replace the other. Several aspects of farmers’ experiments are shown to have a direct bearing on central topics in the philosophy of science. (shrink)

Philosophical discussions of biological classification have failed to recognise the central role of homology in the classification of biological parts and processes. One reason for this is a misunderstanding of the relationship between judgments of homology and the core explanatory theories of biology. The textbook characterisation of homology as identity by descent is commonly regarded as a definition. I suggest instead that it is one of several attempts to explain the phenomena of homology. Twenty years ago the ‘new experimentalist’ movement (...) in philosophy of science drew attention to the fact that many experimental phenomena have a ‘life of their own’: the conviction that they are real is not dependent on the theories used to characterise and explain them. I suggest that something similar can be true of descriptive phenomena, and that many homologies are phenomena of this kind. As a result the descriptive biology of form and function has a life of its own—a degree of epistemological independence from the theories that explain form and function. I also suggest that the two major ‘homology concepts’ in contemporary biology, usually seen as two competing definitions, are in reality complementary elements of the biological explanation of homology. (shrink)