This paper aims to propose an inferential and dynamic approach to understanding with models in biology. Understanding plays a central role in the practice of modeling. From its links with the other two central elements of scientific research, experimentation, and explanation, we show its epistemic relevance to the case of explanation in biology. Furthermore, by including the notion of understanding, we propose a non-referentialist perspective on scientific models, which is determined by their use.

In this paper, I argue that recent sociological theory has become increasingly bifurcated into two mutually incompatible styles of theorizing that I label formalist and behavioral-realist. Formalism favors mathematization and proposes an instrumentalist ontology of abstract processes while behavioral-realist theory takes at its basis the "real" physical individual endowed with concrete biological, cognitive and neurophysiological capacities and constraints and attempts to derive the proper conceptualization of social behavior from that basis. Formalism tends to lead toward a conceptually independent sociology that (...) in principle requires only minimal reference to the empirical and ontological storehouse of other disciplines, while behavioral-realist theory leads to an interdisciplinary sociology that can be located within a hierarchy of behavioral sciences, leading to questions regarding the relationship between sociology and other disciplines as well as issues of transdisciplinary unification and possible interdisciplinary reduction. I explore the consequences of this split for the project of explanatory sociological theory within the context of how it has manifested itself in sociological network theory and social psychology. I close with a critique and assessment of formalist tendencies in sociological theorizing. (shrink)

This is my first professional philosophical essay. I wrote "The twofold meaning of being" in 1996 when I was a student of Nunzio Incardona at University of Palermo (Italy) and before my degree thesis, "The difference in Aristotle’s Metaphysics". It still waits to be published.

Today, mechanisms and mechanistic explanation are very popular in philosophy of science and are deemed a welcome alternative to laws of nature and deductive‐nomological explanation. Starting from Mitchell's pragmatic notion of laws, I cast doubt on their status as a genuine alternative. I argue that (1) all complex‐systems mechanisms ontologically must rely on stable regularities, while (2) the reverse need not hold. Analogously, (3) models of mechanisms must incorporate pragmatic laws, while (4) such laws themselves need not always refer to (...) underlying mechanisms. Finally, I show that Mitchell's account is more encompassing than the mechanistic account *Received August 2008; revised January 2010. †To contact the author, please write to: Centre for Logic and Philosophy of Science, Ghent University, Blandijnberg 2, B‐9000 Belgium; e‐mail: [email protected]. (shrink)

Bas van Fraassen’s recent book Scientific Representation: Paradoxes of Perspective modifies and refines the “constructive empiricism” of The Scientific Image in a number of ways. This paper investigates the changes concerning one of the most controversial aspects of the overall position, that is, van Fraassen’s agnosticism concerning the veridicality of microscopic observation. The paper tries to make plausible that the new formulation of this agnosticism is an advance over the older rendering. The central part of this investigation is an attempt (...) to answer Marc Alspector-Kelly’s 2004-criticism of an early version of van Fraassen’s new position. Alspector-Kelly’s contribution it is to date the most extensive attack on van Fraassen’s twenty-first-century work on the topic of microscopic observation. One of the central ideas emerging from the present discussion is a link between the debate over the veridicality of microscopic observation and the issue of the theory-ladenness of experience. (shrink)

Several prominent voices have called for a democratization of science through deliberative processes that include a diverse range of perspectives and values. We bring these scholars into conversation with extant research on democratic deliberation in political theory and the social sciences. In doing so, we identify systematic barriers to the effectiveness of inclusive deliberation in both scientific and political settings. We are particularly interested in what we call misidentified dissent, where deliberations are starkly framed at the outset in terms of (...) dissenting positions without properly distinguishing the kinds of difference and disagreement motivating dissent. (shrink)

This study explores the history of nanotechnology from the perspective of protein engineering, which differs from the history of nanotechnology that has arisen from mechanical and materials engineering; it also demonstrates points of convergence between the two. Focusing on directed evolution—an experimental system of molecular biomimetics that mimics nature as an inspiration for material design—this study follows the emergence of an evolutionary experimental system from the 1960s to the present, by detailing the material culture, practices, and techniques involved. Directed evolution, (...) as an aspect of nanobiotechnology, is also distinct from the dominant biotechnologies of the 20th century. The experimental systems of directed evolution produce new ways of thinking about molecular diversity that could affect concepts concerning both biology and life. (shrink)

In this essay, I provide normative guidelines for developing a philosophically interesting and plausible version of social constructivism as a philosophy of science, wherein science aims for social-epistemic values rather than for truth or empirical adequacy. This view is more plausible than the more radical constructivist claim that scientific facts are constructed. It is also more interesting than the modest constructivist claim that representations of such facts emerge in social contexts, as it provides a genuine rival to the scientific axiologies (...) of scientific realists and constructive empiricists. I further contrast my view with positions holding that the aims of science are context dependent, that the unit of normative analysis is the scientific community, and that the aims of science are non-epistemic social values. (shrink)

The ways in which the various activities of synthetic biology connect to those of conventional biology display both a multiplicity and variety that reflect the multiplicity and variety of meanings for which the term synthetic biology has been invoked, today as in the past. Central to this variety, as well as to the connection itself, is the complex relationship between knowing and making that has prevailed in the life sciences. That relationship is the focus of this article. More specifically, my (...) aim is to explore the different assumptions about how knowing is related to making that have prevailed, implicitly or explicitly in the various activities—now or in the past—subsumed under the name synthetic biology. (shrink)

Within the realm of nano-, bio-, info- and cogno- (or NBIC) technosciences, the ‘power to change the world’ is often invoked. One could dismiss such formulations as ‘purely rhetorical’, interpret them as rhetorical and self-fulfilling or view them as an adequate depiction of one of the fundamental characteristics of technoscience. In the latter case, a very specific nexus between science and technology, or, the epistemic and the constructionist realm is envisioned. The following paper focuses on this nexus drawing on theoretical (...) conceptions as well as empirical material. It presents an overview of different technoscientific ways to ‘change the world’—via contemplation and representation, intervention and control, engineering, construction and creation. It further argues that the hybrid character of technoscience makes it difficult (if not impossible) to separate knowledge production from real world interventions and challenges current science and technology policy approaches in fundamental ways. (shrink)

Probing technoscience Content Type Journal Article Category Editorial Pages 61-65 DOI 10.1007/s10202-011-0103-0 Authors Karen Kastenhofer, Institute of Technology Assessment, Austrian Academy of Sciences, Strohgasse 45/5, 1030 Wien, Austria Astrid Schwarz, Department of Philosophy, TU Darmstadt, Schloss, 64283 Darmstadt, Germany Journal Poiesis & Praxis: International Journal of Technology Assessment and Ethics of Science Online ISSN 1615-6617 Print ISSN 1615-6609 Journal Volume Volume 8 Journal Issue Volume 8, Numbers 2-3.

ArgumentIn the theory-dominated view of scientific experimentation, all relations of theory and experiment are taken on a par; namely, that experiments are performed solely to ascertain the conclusions of scientific theories. As a result, different aspects of experimentation and of the relations of theory to experiment remain undifferentiated. This in turn fosters a notion of theory-ladenness of experimentation (TLE) that is toocoarse-grainedto accurately describe the relations of theory and experiment in scientific practice. By contrast, in this article, I suggest that (...) TLE should be understood as anumbrella conceptthat has different senses. To this end, I introduce a three-fold distinction among the theories of high-energy particle physics (HEP) as background theories, model theories, and phenomenological models. Drawing on this categorization, I contrast two types of experimentation, namely, “theory-driven” and “exploratory” experiments, and I distinguish between the “weak” and “strong” senses of TLE in the context of scattering experiments from the history of HEP. This distinction enables identifying the exploratory character of the deep-inelastic electron-proton scattering experiments – performed at the Stanford Linear Accelerator Center (SLAC) between the years 1967 and 1973 – thereby shedding light on a crucial phase of the history of HEP, namely, the discovery of “scaling,” which was the decisive step towards the construction of quantum chromo-dynamics as a gauge theory of strong interactions. (shrink)

ABSTRACTThis article responds to McWherter’s detailed critique of my assessment of Roy Bhaskar’s method of transcendental argumentation in chapter four of my Naturalizing Critical Realist Social Ontology. I begin by describing some naturalist ontological and epistemological views defended in my book, thereby showing that my naturalist challenge to the original version of critical realism is not only methodological but also substantial. I also indicate that this point is effectively downplayed in McWherter’s framing of the debate in terms of competing metaphilosophies. (...) I then consider how the doctrine of transcendental idealism is presupposed in Kant’s transcendental deduction and question the consistency of McWherter’s various descriptions of Bhaskar’s transcendental arguments. Finally, I provide detailed responses to McWherter’s objectives to my views. My conclusion is that naturalized critical realism is a more coherent and scientifically viable position than the neo-Kantian version of critical realism defended by McWherter. Nevertheless, I think that there is enough overlap between original and naturalized critical realism to regard the latter as a revised and elaborated version of the former. (shrink)

Over the last two decades, Science Studies has produced a fascinating body of literature on visual representation. A crucial part of that literature has explored the materiality of visual representation, primarily the “rendering practices” that make visual representations possible and embody epistemic virtues attached to the scientific self. This essay explores the practices and capacities that support visual representation, but it looks to a seemingly unlikely place for inspiration—the growing literature on the uses of sound in science. My interest here (...) is to see how that literature points us to a view of sound as an epistemic resource that supports the visual. If there is a visual emphasis in modern science, it is made possible by a set of material practices that are only partly visual. As such, this essay suggests how the history of visual representations in science might be bound up with a history of scientific aurality. (shrink)

It is often said that computer simulations generate new knowledge about the empirical world in the same way experiments do. My aim is to make sense of such a claim. I first show that the similarities between computer simulations and experiments do not allow them to generate new knowledge but invite the simulationist to interact with simulations in an experimental manner. I contend that, nevertheless, computer simulations and experiments yield new knowledge under the same epistemic circumstances, independently of any features (...) they may share. (shrink)

Can a naturalist earn the right to talk of a shared empirical world? Hume famously thought not, and contemporary stipulative naturalists infer from this inability that the demand is somehow unnatural. The critical naturalist, by contrast, claims to earn that right. In this paper, I motivate critical naturalism, arguing first that stipulative naturalism is question begging, and second, that the pessimism it inherits from Hume about whether the problem can be solved is misplaced. Hume's mistake was to mis-identify exemplary contexts (...) of thought: thought is a kind of action, better exemplified at the backgammon table or the dinner party than in the study. By earning the right to this environment-involving conception of thought, the critical naturalist can address, rather than avoid, the explanatory problem Hume uncovered. (shrink)

The concept of the cortical column refers to vertical cell bands with similar response properties, which were initially observed by Vernon Mountcastle’s mapping of single cell recordings in the cat somatic cortex. It has subsequently guided over 50 years of neuroscientific research, in which fundamental questions about the modularity of the cortex and basic principles of sensory information processing were empirically investigated. Nevertheless, the status of the column remains controversial today, as skeptical commentators proclaim that the vertical cell bands are (...) a functionally insignificant by-product of ontogenetic development. This paper inquires how the column came to be viewed as an elementary unit of the cortex from Mountcastle’s discovery in 1955 until David Hubel and Torsten Wiesel’s reception of the Nobel Prize in 1981. I first argue that Mountcastle’s vertical electrode recordings served as criteria for applying the column concept to electrophysiological data. In contrast to previous authors, I claim that this move from electrophysiological data to the phenomenon of columnar responses was concept-laden, but not theory-laden. In the second part of the paper, I argue that Mountcastle’s criteria provided Hubel Wiesel with a conceptual outlook, i.e. it allowed them to anticipate columnar patterns in the cat and macaque visual cortex. I argue that in the late 1970s, this outlook only briefly took a form that one could call a ‘theory’ of the cerebral cortex, before new experimental techniques started to diversify column research. I end by showing how this account of early column research fits into a larger project that follows the conceptual development of the column into the present. (shrink)

J.L. Austin is regarded as having an especially acute ear for fine distinctions of meaning overlooked by other philosophers. Austin employs an informal experimental approach to gathering evidence in support of these fine distinctions in meaning, an approach that has become a standard technique for investigating meaning in both philosophy and linguistics. In this paper, we subject Austin's methods to formal experimental investigation. His methods produce mixed results: We find support for his most famous distinction, drawn on the basis of (...) his `donkey stories', that `mistake' and `accident' apply to different cases, but not for some of his other attempts to distinguish the meaning of philosophically significant terms (such as `intentionally' and `deliberately'). We critically examine the methodology of informal experiments employed in ordinary language philosophy and much of contemporary philosophy of language and linguistics, and discuss the role that experimenter bias can play in influencing judgments about informal and formal linguistic experiments. (shrink)

Farmers all over the world perform experiments, and have done so since long before modern experimental science and its recognized forerunners. There is a rich anthropological literature on these experiments, but the philosophical issues that they give rise to have not received much attention. Based on the anthropological literature, this study investigates methodological and philosophical issues pertaining to farmers’ experiments, including the choice of interventions to be tested, the planning of experiments, and the use of control fields and other means (...) to deal with confounding factors. Farmers’ experiments have some advantages over the field trials of agricultural scientists, but also some comparative disadvantages. The two experimental traditions are complementary, and neither of them can replace the other. Several aspects of farmers’ experiments are shown to have a direct bearing on central topics in the philosophy of science. (shrink)

It is commonly accepted that thewestern view of humanity's place in nature isdominated by a dualistic opposition between nature andculture. Historically this has arisen fromexternalization of nature in both productive andcognitive practices; instances of such externalizationhave become generalized. I think the dualism can bedecomposed by identifying dominant elements in eachparticular instantiation and showing that their strictseparation evaporates under close scrutiny. The philosophical challenge this perspective presents isto substitute concrete socioecological analysis forfoundational metaphysics. A review of majorinterpretations of the history of (...) the dualism inWestern thought indicates that the legacy is moremultistranded than is usually admitted. Modern scienceis often assumed to lie squarely within the dualism,but this is unfounded. In contrast, science providestools for contextual analysis on how human activitiesand natural processes merge. The dualism thusevaporates in actual research practice. Nevertheless,the foundational metaphysics needs to be challenged,primarily because of its paralyzing effect onenvironmental philosophy. (shrink)

Several advocates of the lively field of “metaphysics of science” have recently argued that a naturalistic metaphysics should be based solely on current science, and that it should replace more traditional, intuition-based, forms of metaphysics. The aim of the present paper is to assess that claim by examining the relations between metaphysics of science and general metaphysics. We show that the current metaphysical battlefield is richer and more complex than a simple dichotomy between “metaphysics of science” and “traditional metaphysics”, and (...) that it should instead be understood as a three dimensional “box”, with one axis distinguishing “descriptive metaphysics” from “revisionary metaphysics”, a second axis distinguishing a priori from a posteriori metaphysics, and a third axis distinguishing “commonsense metaphysics”, “traditional metaphysics” and “metaphysics of science”. We use this three-dimensional figure to shed light on the project of current metaphysics of science, and to demonstrate that, in many instances, the target of that project is not defined with enough precision and clarity. (shrink)

Experiments are generally thought of as actions or operations undertaken to test a scientific hypothesis in settings detached from the rest of society. In this paper a different notion of experiment will be discussed. It is an understanding that has been developed in the classical tradition of the Chicago School of Sociology since the 1890s, but has so far remained unexplored. This sociological understanding of experiment does not model itself strictly on the natural sciences. Rather, it implies a process of (...) societal self-experimentation without a fixed setting of a sociological experimenter. The paper discusses this notion of experiment in relation to the recursive dependency of the application and the production of sociological knowledge. It is contended that this concept of a self-experimental society offers theoretical insights that could well prove fruitful for a sociological concept of experiment beyond the realm of the laboratory. (shrink)

Philosophical discussions of biological classification have failed to recognise the central role of homology in the classification of biological parts and processes. One reason for this is a misunderstanding of the relationship between judgments of homology and the core explanatory theories of biology. The textbook characterisation of homology as identity by descent is commonly regarded as a definition. I suggest instead that it is one of several attempts to explain the phenomena of homology. Twenty years ago the ‘new experimentalist’ movement (...) in philosophy of science drew attention to the fact that many experimental phenomena have a ‘life of their own’: the conviction that they are real is not dependent on the theories used to characterise and explain them. I suggest that something similar can be true of descriptive phenomena, and that many homologies are phenomena of this kind. As a result the descriptive biology of form and function has a life of its own—a degree of epistemological independence from the theories that explain form and function. I also suggest that the two major ‘homology concepts’ in contemporary biology, usually seen as two competing definitions, are in reality complementary elements of the biological explanation of homology. (shrink)

The aim of this paper is to grasp the relevant distinctions between various ways in which models and simulations in Artificial Intelligence (AI) relate to cognitive phenomena. In order to get a systematic picture, a taxonomy is developed that is based on the coordinates of formal versus material analogies and theory-guided versus pre-theoretic models in science. These distinctions have parallels in the computational versus mimetic aspects and in analytic versus exploratory types of computer simulation. The proposed taxonomy cuts across the (...) traditional dichotomies between symbolic and embodied AI, general intelligence and symbol and intelligence and cognitive simulation and human/non-human-like AI. -/- According to the taxonomy proposed here, one can distinguish between four distinct general approaches that figured prominently in early and classical AI, and that have partly developed into distinct research programs: first, phenomenal simulations (e.g., Turing’s “imitation game”); second, simulations that explore general-level formal isomorphisms in pursuit of a general theory of intelligence (e.g., logic-based AI); third, simulations as exploratory material models that serve to develop theoretical accounts of cognitive processes (e.g., Marr’s stages of visual processing and classical connectionism); and fourth, simulations as strictly formal models of a theory of computation that postulates cognitive processes to be isomorphic with computational processes (strong symbolic AI). -/- In continuation of pragmatic views of the modes of modeling and simulating world affairs, this taxonomy of approaches to modeling in AI helps to elucidate how available computational concepts and simulational resources contribute to the modes of representation and theory development in AI research—and what made that research program uniquely dependent on them. (shrink)

Philip Pettit has argued that all semantically basic terms are learned in response to ostended examples and all non-basic terms are defined via them. Michael Smith and Daniel Stoljar maintain that this “global response-dependence” entails noumenalism, the thesis that reality possesses an unknowable, intrinsic nature. Surprisingly Pettit acknowledges this, contending instead that his noumenalism, like Kant’s, can be construed ontologically or epistemically. Moreover, Pettit insists, construing his noumenalism epistemically renders it unproblematic. The article shows that construing noumenalism epistemically prevents Pettit (...) from knowing whether members of different communities respond to different properties in the world or the same properties differently. Pettit then faces a trilemma. He can construe noumenalism ontologically and confront Smith and Stoljar’s charge. He can construe noumenalism epistemically and confront the author’s charge. Or he can reject global response-dependence. After explaining why Pettit should choose the middle horn, the article closes with lessons about global response-dependence generally. (shrink)

Abstract Thomas Kuhn is the most famous historian and philosopher of science of the last century. He is also among the most controversial. Since Kuhn's death, his corpus has been interpreted, systematized, and defended. Here I add to this endeavor in a novel way by arguing that Kuhn can be interpreted as a global response-dependence theorist. He can be understood as connecting all concepts and terms in an a priori manner to responses of suitably situated subjects to objects in the (...) world. Further, I claim, this interpretation is useful for three reasons. First, it allows us to systematize and defend Kuhn's views. We can therefore better appreciate him as a thinker in his own right. Second, it deepens our understanding of both the uniqueness of Kuhn's views and the continuity of those views with those of others. We can therefore better appreciate his place in history. And third, as I explain in the paper, my interpretation affords us the only example of an ethnocentric global response-dependence theory. We can therefore better appreciate the versatility of response-dependence itself. (shrink)

In this paper, I elaborate on the very political dimension of epistemology that is opened up by the radical change of focus initiated by constructivism: from science as knowledge to science as practice. In a first step, this brings me to claim that science is political in its own right, thereby drawing on Mouffe and Laclau’s framework of radical democracy and its central notion of antagonism to make explicit what is meant by ‘the political.’ Secondly, I begin to explore what (...) this intrinsic political dimension of science might entail for democratic thought. I do so by connecting my preliminary explorations in the field of science with Andrew Feenberg’s elaborate frame of thought on the democratization of technology. Interestingly, Feenberg is one of the few thinkers who have connected questions of power and ideology, typically treated of within the field of political theory, with a constructivist approach to technological progress. In this sense, this paper can be seen as a first attempt to expand Feenberg’s framework of democratic rationalization from the world of technology to the world of science. (shrink)

An interpretation is given of John Dewey's views about “realism” in metaphysics, and of how these views relate to contemporary debates. Dewey rejected standard formulations of realism as a general metaphysical position, and interpreters have often been taken him to be sympathetic to some form of verificationism or constructivism. I argue that these interpretations are mistaken, as Dewey's unease with standard formulations of realism comes from his philosophical emphasis on intelligent control of events, by means of ordinary action. Because of (...) his views about relations, Dewey's views in this area do risk collapsing into an overly holistic position. I discuss how these problems might be avoided, and consider also how Dewey's views about naturalism and realism might usefully inform ongoing work. (shrink)

South Korean high school students are being taught Einstein’s Special Theory of Relativity. In this article, I examine the portrayal of this theory in South Korean high school physics textbooks and discuss an alternative method used to solve the analyzed problems. This examination of how these South Korean textbooks present this theory has revealed two main flaws: First, the textbooks’ contents present historically fallacious backgrounds regarding the origin of this theory because of a blind dependence on popular undergraduate textbooks, which (...) ignore the revolutionary aspects of the theory in physics. And second, the current ingredients of teaching this theory are so simply enumerated and conceptually confused that students are not provided with good opportunities to develop critical capacities for evaluating scientific theories. Reviewing textbooks used in South Korea, I will, first, claim that the history of science contributes to understand not merely the origins but also two principles of this theory. Second, in addition to this claim, I argue that we should distinguish not only hypotheses from principles but also phenomena from theoretical consequences and evidence. Finally, I suggest an alternative way in which theory testing occurs in the process of evaluation among competitive theories on the basis of data, not in the simple relation between a hypothesis and evidence. (shrink)

Most recent philosophical thought about the scientific representation of the world has focused on dyadic relationships between language-like entities and the world, particularly the semantic relationships of reference and truth. Drawing inspiration from diverse sources, I argue that we should focus on the pragmatic activity of representing, so that the basic representational relationship has the form: Scientists use models to represent aspects of the world for specific purposes. Leaving aside the terms "law" and "theory," I distinguish principles, specific conditions, models, (...) hypotheses, and generalizations. I argue that scientists use designated similarities between models and aspects of the world to form both hypotheses and generalizations. (shrink)

: Bereft of the illusion of an epistemic vantage point external to science, what should be our commitment towards the categories, concepts and terms of that very science? Should we, despaired of the possibility to found these concepts on rock bottom, adopt empiricist skepticism? Or perhaps the inexistence of external foundations implies, rather, immunity for scientific ontology from epistemological criticism? Philosophy's "realism debate" died out without providing a satisfactory answer to the dilemma, which was taken over by the neighboring disciplines. (...) The "symmetry principle" of the "StrongProgramme" for the sociology of science-the requirement that truth and error receive the same kind of causal explanations-offered one bold metaphysical answer, under the guise of a methodological decree. Recently, however, it has been argued that this solution is not bold enough, that the social constructivists replaced the naïve presumption of an independent nature which adjudicates our beliefs with a mirror-image presumption of a sui generis society which furnishes these beliefs autonomously. The proper metaphysics for a foundationless epistemology, argues Bruno Latour, is one which grants nature and society, object and subject, equal roles in the success and failure of science and technology; one in which history of society merges with a history of things-in-themselves. The paper analyzes the philosophical and methodological motivations and ramifications of this extraordinary suggestion. (shrink)

In this paper we explore the constraints that our preferred account of scientific representation places on the ontology of scientific models. Pace the Direct Representation view associated with Arnon Levy and Adam Toon we argue that scientific models should be thought of as imagined systems, and clarify the relationship between imagination and representation.

Everything you always wanted to know about structural realism but were afraid to ask Content Type Journal Article Pages 227-276 DOI 10.1007/s13194-011-0025-7 Authors Roman Frigg, Department of Philosophy, Logic and Scientific Method, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE UK Ioannis Votsis, Philosophisches Institut, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Geb. 23.21/04.86, 40225 Düsseldorf, Germany Journal European Journal for Philosophy of Science Online ISSN 1879-4920 Print ISSN 1879-4912 Journal Volume Volume 1 Journal Issue Volume 1, Number 2.

Supported by Ian Hacking’s concept of “intervention,” and Charles Taylor’s concept of “intentionality,” this article argues that doubting is acting, and that doubting is therefore subject to the same demands of responsibility as any other action. The argument is developed by using medical practice as a test-case. The central suggestion is that the demand of acting responsibly limits doubt in medicine. The article focuses on two such limitations to doubt. Firstly, the article argues that it is irresponsible to doubt that (...) our actions can harm other people. Secondly, the article argues that it is irresponsible not to strive for coherence between our utterances of doubt and our other actions. Incoherence here can cause “cultural impoverishment.” In a larger context this article also argues that medicine can enrich our epistemology, because medical knowledge displays important traits of knowledge that are downplayed in traditional epistemology derived from mathematics and physics. In particular, medicine makes it possible to get the relation between ethics and epistemology into sharper focus. The endpoint in medical epistemology is “responsible action,” and not certainty in and of itself. (shrink)

It has become apparent that the debate between scientific realists and constructive empiricists has come to a stalemate. Neither view can reasonably claim to be the most rational philosophy of science, exclusively capable of making sense of all scientific activities. On one prominent analysis of the situation, whether we accept a realist or an anti-realist account of science actually seems to depend on which values we antecedently accept, rather than our commitment to “rationality” per se. Accordingly, several philosophers have attempted (...) to argue in favour of scientific realism or constructive empiricism by showing that one set of values is exclusively best, for anyone and everyone, and that the downstream choice of the philosophy of science which best serves those values is therefore best, for anyone and everyone. These efforts, however, seem to have failed. In response, I suggest that philosophers of science should suspend the effort to determine which philosophy of science is best for everyone, and instead begin investigating which philosophy of science is best for specific people, with specific values, in specific contexts. I illustrate how this might be done by briefly sketching a single case study from the history of science, which seems to show that different philosophies of science are better at motivating different forms of scientific practice. (shrink)

Although scientific realism is the default position in the life sciences, philosophical accounts of realism are geared towards physics and run into trouble when applied to fields such as biology or neuroscience. In this paper, I formulate a new robustness-based version of entity realism, and show that it provides a plausible account of realism for the life sciences that is also continuous with scientific practice. It is based on the idea that if there are several independent ways of measuring, detecting (...) or deriving something, then we are justified in believing that it is real. I also consider several possible objections to robustness-based entity realism, discuss its relationship to ontic structural realism, and show how it has the potential to provide a novel response to the pessimistic induction argument. (shrink)

This paper examines the relationship between simulation and experiment. Many discussions of simulation, and indeed the term "numerical experiments," invoke a strong metaphor of experimentation. On the other hand, many simulations begin as attempts to apply scientific theories. This has lead many to characterize simulation as lying between theory and experiment. The aim of the paper is to try to reconcile these two points of viewto understand what methodological and epistemological features simulation has in common with experimentation, while at the (...) same time keeping a keen eye on simulation's ancestry as a form of scientific theorizing. In so doing, it seeks to apply some of the insights of recent work on the philosophy of experiment to an aspect of theorizing that is of growing philosophical interest: the construction of local models. (shrink)

This paper discusses essential elements of the philosophical works of Ludwik Fleck and their potential interpretation for the teaching and learning of science. In the early twentieth century, Fleck made substantial contributions to understanding the sociological character of the nature of science and explaining the embedding of science in society. His works have several parallels to the later and very popular work, The Structure of Scientific Revolutions, by Thomas S. Kuhn, although Kuhn only indirectly referred to the influence of Fleck (...) on his own theories. Starting from a short review of the life of Ludwik Fleck, his philosophical work and its connections to Kuhn, this paper elaborates upon and illustrates how his theories can be considered for science education in order to provide learners with a better understanding of the nature of scientific endeavor and the bi-directional science-to-society links. (shrink)