In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, macroscopic (...) and microscopic entities inhabit different “worlds”: the former is ruled by gravity and inertia, whereas the latter is governed by Brownian motion. One implication is that we should be extremely skeptical of models and analogies that seek to explain properties of microscopic entities by appealing to properties of macroscopic ones. Unfortunately, this is precisely what the appeal to engineering metaphors in molecular biology attempts to do. Molecular biologists routinely resort to such metaphors because they are familiar and intuitively intelligible. But if our machines were the size of molecules it would be impossible for them to function the way they do. It follows that we should avoid distorting biological reality by construing it in engineering terms. In this chapter I examine four key metaphors in molecular biology – “genetic program,” “cellular circuitry,” “molecular machine,” and “molecular motor” – and I argue that their deficiencies derive from their neglect of scale. I also try to explain why many biologists today appear to have forgotten the importance of scale that Haldane drew attention to in his essay. I suggest that the reason has to do with the influence of Schrödinger’s argument in 'What is Life?' regarding the stability of the gene. (shrink)

This paper explores the functional role of noise in synthetic biology and its relation to the concept of randomness. Ongoing developments in the field of synthetic biology are pursuing the re-organisation and control of biological components to make functional devices. This paper addresses the distinction between noise and randomness in reference to the functional relationships that each may play in the evolution of living and/or synthetic systems. The differentiation between noise and randomness in its constructive role, that is, between noise (...) as a perturbation in routine behaviours and noise as a source of variability that cells may exploit, indicates the need for a clarification and rectification of the conflicting uses of the notion of noise in the studies of the so-called noise biology. (shrink)

This paper uses a game-theoretic framework to formalize the Hayekian notion of equilibrium as the compatibility of plans. To do so, it imposes more structure on the conventional model of strategic games. For each player, it introduces goals, goal-oriented strategies, and the goals’ probabilities of success, from which players’ payoffs are derived. The differences between the compatibility of plans and Nash equilibrium are identified and discussed. Furthermore, it is shown that the notion of compatibility of plans, in general, differs from (...) the notion of Pareto efficiency. Since the compatibility of plans across all players can rarely be achieved in reality, a measurement is introduced to determine various degrees of plan compatibility. Several possible extensions and applications of the model are discussed. (shrink)

This article highlights the mathematical structure of Henri Bergson’s method. While Bergson has been historically interpreted as an anti-scientific and irrationalist philosopher, he modeled his philosophical methodology on the infinitesimal calculus developed by Leibniz and Newton in the seventeenth century. His philosophy, then, rests on the science of number, at least from a methodological standpoint. By looking at how he conscripted key mathematical concepts into his philosophy, this article invites us to re-imagine Bergson’s place in the history of Western philosophy.

This chapter draws on insights from non-equilibrium thermodynamics to demonstrate the ontological inadequacy of the machine conception of the organism. The thermodynamic character of living systems underlies the importance of metabolism and calls for the adoption of a processual view, exemplified by the Heraclitean metaphor of the stream of life. This alternative conception is explored in its various historical formulations and the extent to which it captures the nature of living systems is examined. Following this, the chapter considers the metaphysical (...) implications of reconceptualizing the organism from complex machine to flowing stream. What do we learn when we reject the mechanical and embrace the processual? Three key lessons for biological ontology are identified. The first is that activity is a necessary condition for existence. The second is that persistence is grounded in the continuous self-maintenance of form. And the third is that order does not entail design. (shrink)

A notion of delegated causality is introduced here. This subtle kind of causality is dual to interventional causality. Delegated causality elucidates the causal role of dynamical systems at the “edge of chaos”, explicates evident cases of downward causation, and relates emergent phenomena to Gödel’s incompleteness theorem. Apparently rich implications are noticed in biology and Chinese philosophy. The perspective of delegated causality supports cognitive interpretations of self-organization and evolution.

The Ethical Dimension of Science According to Mariano Artigas: Many authors have written, from different approaches, about the relationships between ethics and science. In this work, we analyze how Mariano Artigas did it. He gives great importance to ethics, which he considers a philosophical presupposition of scientific activity. A detailed analysis of his work allows to understand to what extent ethics is important for science. Specifically, we consider the relationships of ethics with humans and with science; the interweaving and the (...) distinction between both of them; the importance of ethics as a hermeneutical key in Popper; and the emergence of ethics before, during, and after scientific activity. (shrink)

Contemporary theories of consciousness are based on widely different concepts of its nature, most or all of which probably embody aspects of the truth about it. Starting with a concept of consciousness indicated by the phrase “the feeling of what happens” (the title of a book by Antonio Damásio), we attempt to build a framework capable of supporting and resolving divergent views. We picture consciousness in terms of Reality experiencing itself from the perspective of cognitive agents. Each conscious experience is (...) regarded as composed of momentary feeling events that are combined by recognition and evaluation into extended conscious episodes that bind cognitive contents with a wide range of apparent durations (0.1 secs to 2 or more secs, for us humans, depending on circumstances and context). Three necessary conditions for the existence of consciousness are identified: a) a ground of Reality, envisaged as an universal field of potentiality encompassing all possible manifestations, whether material or 'mental'; b) a transitional zone, leading to; c) a manifest world with its fundamental divisions into material, 'informational' and quale-endowed aspects. We explore ideas about the nature of these necessary conditions, how they may relate to one another and whether our suggestions have empirical implications. (shrink)

Our commonsense notion of reality is supported by two critical assumptions for which we have little understanding: The conscious experience which underpins the observations integral to the scientific method and language, which is the method by which all theories, scientific or otherwise, are communicated. This book examines both of these matters in detail and arrives at a new theoretical foundation for understanding how nature undertakes the task of building the universe. -/- Creating Reality is a synthesis of Darwin’s The Origin (...) of Species and Douglas Hofstadter’s Gödel, Escher, Bach (GEB). It is an intellectual journey that addresses the most profound questions facing science and philosophy today and delivers the greatest transformation in the way we view the world since Darwin’s masterpiece. The book is targeted at anyone up for the cerebral challenge of thinking deeply about how we make sense of the world and our existence. The book is thoroughly researched and referenced, drawing from the most highly credential sources. -/- When we take stock of where we are in our understanding of nature, it seems that three important questions stand out for which we have few answers. More than just questions, they represent gaps in our comprehension of what makes the universe tick. These are the thematic focal points of this book: -/- • What is the nature of belief? (An examination of truth as a function of language). • What is consciousness? • What is the relationship between mathematics and the physical world? -/- The exploration of these three questions unravels the mystery behind the principal means by which we come to have knowledge of the world. So our journey begins by asking the more generic question: How do we come to know the world? The book makes no assumptions about this thing called ‘reality’ and takes a fresh look at the presuppositions underlying commonsense notions of reality. (shrink)

In this chapter we examine the relationship between biological information, the key biological concept of specificity, and recent philosophical work on causation. We begin by showing how talk of information in the molecular biosciences grew out of efforts to understand the sources of biological specificity. We then introduce the idea of ‘causal specificity’ from recent work on causation in philosophy, and our own, information theoretic measure of causal specificity. Biological specificity, we argue, is simple the causal specificity of certain biological (...) processes. This, we suggest, means that causal relationships in biology are ‘informational’ relationships simply when they are highly specific relationships. Biological information can be identified with the storage, transmission and exercise of biological specificity. It has been argued that causal relationships should not be regarded as informational relationship unless they are ‘arbitrary’. We argue that, whilst arbitrariness is an important feature of many causal relationships in living systems, it should not be used in this way to delimit biological information. Finally, we argue that biological specificity, and hence biological information, is not confined to nucleic acids but distributed among a wide range of entities and processes. (shrink)

partial review of Thomas Nagel’s book, Mind and Cosmos: Why the Materialist Neo-Darwinian Conception of Nature Is Almost Certainly False is used to articulate some systems-theoretic ideas about the challenge of understanding subjective experience. The article accepts Nagel’s view that reductionist materialism fails as an approach to this challenge, but argues that seeking an explanation of mind based on emergence is more plausible than seeking one based on pan-psychism, which Nagel favors. However, the article proposes something similar to Nagel’s neutral (...) monism by positing a hierarchy of information processes that spans the domains of matter, life, and mind. As depicted in this hierarchy, subjective experience is emergent, but also continuous with informational phenomena at lower levels. (shrink)

Homo deceptus is a book that brings together new ideas on language, consciousness and physics into a comprehensive theory that unifies science and philosophy in a different kind of Theory of Everything. The subject of how we are to make sense of the world is addressed in a structured and ordered manner, which starts with a recognition that scientific truths are constructed within a linguistic framework. The author argues that an epistemic foundation of natural language must be understood before laying (...) claim to any notion of reality. This foundation begins with Ludwig Wittgenstein’s Tractatus Logico-Philosophicus and the relationship of language to formal logic. Ultimately, we arrive at an answer to the question of why people believe the things they do. This is effectively a modification of Alfred Tarski’s semantic theory of truth. The second major issue addressed is the ‘dreaded’ Hard Problem of Consciousness as first stated by David Chalmers in 1995. The solution is found in the unification of consciousness, information theory and notions of physicalism. The physical world is shown to be an isomorphic representation of the phenomenological conscious experience. New concepts in understanding how language operates help to explain why this relationship has been so difficult to appreciate. The inclusion of concepts from information theory shows how a digital mechanics resolves heretofore conflicting theories in physics, cognitive science and linguistics. Scientific orthodoxy is supported, but viewed in a different light. Mainstream science is not challenged, but findings are interpreted in a manner that unifies consciousness without contradiction. Digital mechanics and formal systems of logic play central roles in combining language, consciousness and the physical world into a unified theory where all can be understood within a single consistent framework. (shrink)

The ArgumentThe paper is divided into the two parts. In the first, I examine the relations among molecular biology, gene technology, and medicine as some aspect of the consequences of these relations with respect to the human genome project of the consequences of these relations with respect to the human genome project. I argue that the prevailing momentum of early molecular biology resided in argue that the prevailing momentum of relay molecular biology resided in crating the technical means for an (...) extracellular representation of intracellular configurations. Assuch, its medical impact was rather limited. With the advent of recombinant DNA technology is based on the prospects of an intracellular representation of extracellular projects—the “rewriting” of life. Its medical impact is potentially unlimited. In the second part, I question the very opposition between nature and culture that implicitly underlies the notion of medicine as a “cultural system.” I argue that both on a macroscopic level and on a microscopic level, the “natural” and the “social” are no longer to be seen as ontologically different.In its uncanny oscillation between retrospection and foresight, between description and proclamation, and between assertion and hesitation, this essay translates an uneasiness that I have not been able to overcome while writing it. The essay conveys the tangled views of a hybrid author who himself cannot but oscillate between the perspectives of an actor in the field of molecular biology, a participant in the field of science studies, and a citizen. (shrink)

Emotionality is a basic feature of behavior. The argument over whether the expression of emotions is based primarily on culture (constructivism, nurture) or biology (natural forms, nature) will never be resolved because both alternatives are untenable. The evidence is overwhelming that at all ages and all levels of organization, the development of emotionality is epigenetic: The organism is an active participant in its own development. To ascribe these effects to “experience” was the best that could be done for many years. (...) With the rapid acceleration of information on how changes in organization are actually brought about, it is a good time to review, update, and revitalize our views of experience in relation to the concept of basic emotion. (shrink)

Although biological autonomy is widely discussed, its description in scientific terms remains elusive. I present here a series of recent evidences on the existence of genuine biological autonomy. Nevertheless, nowadays it seems that the only acceptable ground to account for any natural phenomena, including biological autonomy, is physics. But if this were the case, then arguably there would be no way to account for genuine biological autonomy. The way out of such a situation is to build up an exact theoretical (...) biology, and one of the first steps is to clarify the basic concepts of biology, among them biological aim, function and autonomy. We found a physical mechanism to realize biological autonomy, namely, biologically initiated vacuum processes. In the newly emerging picture, biological autonomy shows up as a new, fundamental and inevitable element in our scientific world picture. It offers new perspectives for solving problems regarding the origin and nature of life, connecting ancient Greek philosophy with modern science. Namely, our proposal sheds light in what sense can the God as conceived by Xenophanes can move the material objects of the Universe by its thoughts without toil. (shrink)

Researchers report that people who are asked to give their reason for converting to Creationism often say that they have done so because they see it as the only possible alternative to ‘Darwinism’ – something which they find intolerable and equate with scientific atheism.

This article is an extended commentary inspired by Alan Drengson's paper “Shifting Paradigms: From Technocrat to Planetary Person” (Drengson 2011). In this article Susan Greenwood and I echo Drengson's criticism that Euro-American science is incomplete, having committed what Thomas Roberts calls “The Singlestate Fallacy: the erroneous assumption that all worthwhile abilities reside in our normal, awake mindbody state” (Roberts 2006:105). This singlestate fallacy is vividly portrayed in Mary Shelley's novel Frankenstein, whose critique of Euro-American science is revisited in this article. (...) Alternatively, Greenwood and I suggest that what is needed is a multimodel framework “that allows for in-depth analysis of the different modes of consciousness.” Roberts refers to this alternative attitude toward science as the Multistate Paradigm. An awareness of the transformational character of shamanism is also explored in this article as a means to overcome the oppositions between the technocratic and person planetary perspective, and their related gender associations. (shrink)

I propose that, in addition to the commonly recognized increase of entropy, two more time arrows influence living beings. The increase of damage reactions, which produce aging and genetic variation, and the decrease of the rate of entropy production involved in natural selection are neglected arrows of time. Although based on the statistical theory of the arrow of time, they are distinguishable from the general arrow of the increase of entropy. Physiology under healthy conditions only obeys the increase of entropy (...) arrow. But aging, death, and evolution are determined by the other time arrows as well. Paradoxes emerge from conflicts among the specific determinisms associated with each arrow. These conflicts, along with uncertainties intrinsic to the low-number statistics of the arrows of damage reactions and decrease of the rate of production of entropy, highlight the limits of determinism at different levels of biology and its dependence on time span and number of organisms. The recognition of the three time arrows opens new perspectives for the problem of compatibility of the flow of time in physics and psychology. (shrink)

I will discuss some of the implications of the ongoing Darwinian revolution for theology as a constructor and interpreter of human meaning. Focus will be directed toward the following issues: How should we best understand ourselves in the new, evolutionary cosmos? What are the problems with the kind of genetic reductionism espoused by neo‐Darwinism? How are those problems resolved by the “relational” understanding of life made available by thermodynamics and ecology? How do we generate meaning‐structures in this relationally‐constituted cosmos? Finally, (...) how do these developments enrich our understandings of responsibility—to each other and to our private conceptions of God? (shrink)

Popper's thesis that the growth of knowledge lies in the emergence of problems out of criticism and takes place in an autonomous world of products of the human mind (his so-called world-3) raises two questions: (1) Why does criticism lead to new problems, and (2) Why can only a limited number of tentative solutions arise at a given time? I propose the following answer: Criticism entails an overlooked evolutionary world-3 mechanism, namely, the migration of piece meal conceptual schemes from one (...) research tradition to another. Popper by passed the questions above because he relied very heavily on the selective power of criticism. (shrink)

Charles Clark; Child-centred Education and the ‘Growth’ Metaphysic, Journal of Philosophy of Education, Volume 22, Issue 1, 30 May 2006, Pages 75–88, https://do.

Six "divine conjectures" frame the place of Theóne (The One to Whom we pray) in the creation of our universe and for its continuing development in five subsequent stages into a loving universe. The first stage, the cosmological universe, establishes the laws of nature, understood by scientists as the "standard model". The second stage introduces life and death into the universe by a process we are only now beginning to understand. Stage 3 requires certain life forms to become conscious with (...) a subset of those life-forms acquiring language that results in that subset becoming self-conscious. The next stage, Conjecture 4, identifies certain persons who become addicted to learning in their unrelenting effort to learn as much of what can be known as possible. The fifth conjecture requires individual persons to act as agents of Theóne in achieving Conjecture 6—a universe that is both loving and lawful. During the course of the exposition subsidiary discussions of the concepts of conjecture and hypothesis explicate the function of each in the advancement of knowledge and understanding. There are brief discussions of prayer and purpose in relation to the Divine. (shrink)

This disagreement extends to the fundamental details of physical and biochemical theories. On the other hand, (2) There is almostuniversal agreementthatlife did notfirstcome aboutmerely by chance. This is not to say that all scientists think that life’s existence was inevitable. The common view is that given a fuller understanding of the physical and biological conditions and processes involved, the emergence of life should be seen to be quite likely, or at least not very surprising. The view which is almost universally (...) rejected by researchers in the field is that the numerous and prima facie improbable physical and biological requirements for life all fell together just by a fluke, like so many dice tumbling out of a bag and landing all sixes. Most importantly, for the purposes of the following discussion, (3) The conviction that life did not arise largely by chance is treated as epistem- ically prior to the development of alternative theories. C 2007, Copyright the Authors Journal compilation C 2007, Blackwell Publishing, Inc. (shrink)

For many years, biology was largely descriptive (natural history), but with its emergence as a scientific discipline in its own right, a reductionist approach began, which has failed to be matched by adequate understanding of function of cells, organisms and species as whole entities. Every effort was made to explain biological phenomena in physico-chemical terms.It is argued that there is and always has been a clear distinction between life sciences and physical sciences, explicit in the use of the word biology. (...) If this distinction is real, it implies that biological phenomena can never be entirely satisfactorily explained in terms of extant physicochemical laws. One notable manifestation of this is that living organisms appear to -- actually do -- behave in purposeful ways, and the inanimate universe does not. While this fundamental difference continues to be suppressed, the purposiveness (or teleology) which pervades biology remains anathema to almost all scientists (including most biologists) even to the present day. We argue here that it can, however, become a perfectly tenable position when the Theory of Natural Selection is accepted as the main foundation, the essential tenet, of biology that distinguishes it from the realm of physical sciences. In accepting this position, it remains quite legitimate to expect that in many but not all circumstances, extant physical laws (and presumably others still to be discovered) are in no way breached by biological systems, which cannot be otherwise since all organisms are composed of physical material. (shrink)

This article investigates the origins of the experiences involved in the diagnostics (detection and normative evaluation) of biological entities in image-based medical praxis. Our specific research aim presupposes a vast discussion regarding the origins of knowledge in general, but is narrowed down to the alternatives of anthropomorphism and biomorphism. Accordingly, in the subsequent chapters we will make an attempt to investigate and illustrate what holds the diagnostic experiential situation together—biological regularities, manifestation via movement, conscious synthesis, causal categories, or something else. (...) We argue that as long as knowledge originates out of practices, a promising way forward is to oscillate between the prominent although controversial ideas of the history of philosophy and observations of concrete human practices, such as, in our chosen example, image-based medical diagnostics of biological pathologies. Although a number of thinkers are involved in the discussion, Aristotle and Husserl are most important here as the representatives of historical paradigms on the matter. The body in this research was not taken solely as the physical entity (Körper) but rather as a transcendental, constitutive structure where diagnostic and biological processes synchronize in teleological movement (Leib). However, philosophical speculations are illustrated by actual radiograms, the interpretation of which brings us back to the aforementioned question of primacy regarding cognition. (shrink)

In this paper the authors provide an epistemological view on the old controversial random-necessity. It has been considered that either one or the other form part of the structure of reality. Chance and indeterminism are nothing but a disorderly efficiency of contingency in the production of events, phenomena, processes, i.e., in its causality, in the broadest sense of the word. Such production may be observed in natural and artificial processes or in human social processes (in history, economics, society, politics, etc.). (...) Here we touch the object par excellence of all scientific research whether natural or human. In this work, is presented a hypothesis whose practical result satisfies the Hegelian dialectic, with the consequent implication of their mutual reciprocal integration_._ Producing abstractions, without which, there is no thought or knowledge of any kind, from the concrete, that is, the real problem, which in this case is a given Ontological System or Reality. (shrink)

Příspěvek se zabývá možností filozofické definice života a kritickým rozborem definice navržené Markem A. Bedauem. Podle Bedaua je vytvoření definice života nejen možné, ale i užitečné z hlediska mnoha vědních oborů. Bedau odmítá pokusy definovat život za pomoci výčtu charakteristických vlastností. Navrhuje model minimálního chemického života, který nazývá Program-Metabolism-Container model (PMC model). Ten je charakterizován jako systém tří vzájemně se podporujících prvků: 1. programu v podobě dědičné informace, 2. látkové výměny, 3. obalu, zajišťujícího izolaci systému od vnějšího prostředí a zároveň (...) identitu jednotlivého organismu. Pomocí PMC modelu minimálního chemického života lze úspěšně vyřešit otázky spjaté s charakterem a počátkem života, při jejichž řešení selhávají pokusy vycházející z jiných definic. (shrink)

The development of the genome editing system called CRISPR–Cas9 has opened a huge debate on the possibility of modifying the human germline. But the types of changes that could and/or ought to be made have not been discussed. To cast some light on this debate, I will describe the story of the CRISPR–Cas9 system. Then, I will briefly review the projects for modification of the human species that were discussed by biologists throughout the twentieth century. Lastly, I will show that (...) for plenty of reasons, both scientific and societal, germline modification is no longer a priority for our societies. (shrink)

Following the development of the selectionist theory of the immune system, there was an attempt to characterize many biological mechanisms as being "selectionist" as juxtaposed to "instructionist." But this broad definition would group Darwinian evolution, the immune system, embryonic development, and Chomsky's language-acquisition mechanism as all being "selectionist." Yet Chomsky's mechanism (and embryonic development) are significantly different from the selectionist mechanisms of biological evolution or the immune system. Surprisingly, there is a very abstract way using two dual mathematical logics to (...) make the distinction between genuinely selectionist mechanisms and what are better called "generative" mechanisms. This note outlines that distinction. (shrink)

The development of computers as ‘mind tools’ has generated intriguing and provocative views about their potential human-like qualities. In this paper an attempt is made to explore the ‘real’ nature of computers by an examination of three widely different perspective, (1) the common-sense view of computers as tools; (2) the provocative view of computers as persons; and (3) the challenging view of computers as texts. In the course of the discussion an extended critique of the use of anthropomorphic terms in (...) relation to machines is conducted and the fundamental differences between human persons and machines is reasserted. (shrink)

Two decades ago, Rolf Landauer (1991) argued that “information is physical” and ought to have a role in the scientific analysis of reality comparable to that of matter, energy, space and time. This would also help to bridge the gap between biology and mathematics and physics. Although it can be argued that we are living in the ‘golden age’ of biology, both because of the great challenges posed by medicine and the environment and the significant advances that have been made—especially (...) in genetics and molecular and cell biology—we feel that information as an essential aspect of life has been neglected, or at least misunderstood. We therefore summon Maxwell’s Demon and its distant relative the ratchet, and apply these to biology. (shrink)

ABSTRACT: With a view to suggesting the possible relevance of Aristotelian thought to current notions of complexity and self-organization, studies Aristotlenard cells, and the theories of Schneider, Kay, and D. Sagan.