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  1. Crick's Adaptor Hypothesis and the Discovery of Transfer RNA: Experiment Surpassing Theoretical Prediction.Michael Fry - 2022 - Philosophy, Theory, and Practice in Biology 14 (11):1-31.
    Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they bind to complementary protein-coding nucleic acid, and their liberated amino acids are (...)
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  • Disagreement in discipline-building processes.David Anzola - 2019 - Synthese 198 (Suppl 25):6201-6224.
    Successful instances of interdisciplinary collaboration can eventually enter a process of disciplinarisation. This article analyses one of those instances: agent-based computational social science, an emerging disciplinary field articulated around the use of computational models to study social phenomena. The discussion centres on how, in knowledge transfer dynamics from traditional disciplinary areas, practitioners parsed several epistemic resources to produce new foundational disciplinary shared commitments, and how disagreements operated as a mechanism of differentiation in their production. Two parsing processes are examined to (...)
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  • Predictivism and avoidance of ad hoc-ness: An empirical study.Samuel Schindler - 2024 - Studies in History and Philosophy of Science Part A 104 (C):68-77.
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  • Methodological reflections on the MOND/dark matter debate.Patrick M. Duerr & William J. Wolf - 2023 - Studies in History and Philosophy of Science Part A 101 (C):1-23.
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  • The Virtues of Pursuit-Worthy Speculation: The Promises of Cosmic Inflation.William J. Wolf & Patrick M. Duerr - forthcoming - British Journal for the Philosophy of Science.
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  • Model-Selection Theory: The Need for a More Nuanced Picture of Use-Novelty and Double-Counting.Katie Steele & Charlotte Werndl - 2016 - British Journal for the Philosophy of Science:axw024.
    This article argues that common intuitions regarding (a) the specialness of ‘use-novel’ data for confirmation and (b) that this specialness implies the ‘no-double-counting rule’, which says that data used in ‘constructing’ (calibrating) a model cannot also play a role in confirming the model’s predictions, are too crude. The intuitions in question are pertinent in all the sciences, but we appeal to a climate science case study to illustrate what is at stake. Our strategy is to analyse the intuitive claims in (...)
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  • Theoretical Virtues: Do Scientists Think What Philosophers Think They Ought to Think?Samuel Schindler - 2022 - Philosophy of Science 89 (3):542-564.
    Theoretical virtues play an important role in the acceptance and belief of theories in science and philosophy. Philosophers have well-developed views on which virtues ought and ought not to influence one’s acceptance and belief. But what do scientists think? This paper presents the results of a quantitative study with scientists from the natural and social sciences and compares their views to those held by philosophers. Some of the more surprising results are: all three groups have a preference order regarding theoretical (...)
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  • The Costs of HARKing.Mark Rubin - 2022 - British Journal for the Philosophy of Science 73 (2):535-560.
    Kerr coined the term ‘HARKing’ to refer to the practice of ‘hypothesizing after the results are known’. This questionable research practice has received increased attention in recent years because it is thought to have contributed to low replication rates in science. The present article discusses the concept of HARKing from a philosophical standpoint and then undertakes a critical review of Kerr’s twelve potential costs of HARKing. It is argued that these potential costs are either misconceived, misattributed to HARKing, lacking evidence, (...)
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  • Exploratory hypothesis tests can be more compelling than confirmatory hypothesis tests.Mark Rubin & Chris Donkin - 2022 - Philosophical Psychology.
    Preregistration has been proposed as a useful method for making a publicly verifiable distinction between confirmatory hypothesis tests, which involve planned tests of ante hoc hypotheses, and exploratory hypothesis tests, which involve unplanned tests of post hoc hypotheses. This distinction is thought to be important because it has been proposed that confirmatory hypothesis tests provide more compelling results (less uncertain, less tentative, less open to bias) than exploratory hypothesis tests. In this article, we challenge this proposition and argue that there (...)
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  • Prediction versus accommodation in economics.Robert Northcott - 2019 - Journal of Economic Methodology 26 (1):59-69.
    Should we insist on prediction, i.e. on correctly forecasting the future? Or can we rest content with accommodation, i.e. empirical success only with respect to the past? I apply general considerations about this issue to the case of economics. In particular, I examine various ways in which mere accommodation can be sufficient, in order to see whether those ways apply to economics. Two conclusions result. First, an entanglement thesis: the need for prediction is entangled with the methodological role of orthodox (...)
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  • The Problem of New Evidence: P-Hacking and Pre-Analysis Plans.Zoe Hitzig & Jacob Stegenga - 2020 - Diametros 17 (66):10-33.
    We provide a novel articulation of the epistemic peril of p-hacking using three resources from philosophy: predictivism, Bayesian confirmation theory, and model selection theory. We defend a nuanced position on p-hacking: p-hacking is sometimes, but not always, epistemically pernicious. Our argument requires a novel understanding of Bayesianism, since a standard criticism of Bayesian confirmation theory is that it cannot represent the influence of biased methods. We then turn to pre-analysis plans, a methodological device used to mitigate p-hacking. Some say that (...)
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  • On the Individuation of Choice Options.Roberto Fumagalli - 2020 - Philosophy of the Social Sciences 50 (4):338-365.
    Decision theorists have attempted to accommodate several violations of decision theory’s axiomatic requirements by modifying how agents’ choice options are individuated and formally represented. In recent years, prominent authors have worried that these modifications threaten to trivialize decision theory, make the theory unfalsifiable, impose overdemanding requirements on decision theorists, and hamper decision theory’s internal coherence. In this paper, I draw on leading descriptive and normative works in contemporary decision theory to address these prominent concerns. In doing so, I articulate and (...)
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  • Prediction in epidemiology and medicine.Jonathan Fuller, Alex Broadbent & Luis J. Flores - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 54:45-48.
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  • Prediction in epidemiology and medicine.Jonathan Fuller, Alex Broadbent & Luis J. Flores - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences.
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  • Predictive hypotheses are ineffectual in resolving complex biochemical systems.Michael Fry - 2018 - History and Philosophy of the Life Sciences 40 (2):25.
    Scientific hypotheses may either predict particular unknown facts or accommodate previously-known data. Although affirmed predictions are intuitively more rewarding than accommodations of established facts, opinions divide whether predictive hypotheses are also epistemically superior to accommodation hypotheses. This paper examines the contribution of predictive hypotheses to discoveries of several bio-molecular systems. Having all the necessary elements of the system known beforehand, an abstract predictive hypothesis of semiconservative mode of DNA replication was successfully affirmed. However, in defining the genetic code whose biochemical (...)
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  • Predictivism and old evidence: a critical look at climate model tuning.Mathias Frisch - 2015 - European Journal for Philosophy of Science 5 (2):171-190.
    Many climate scientists have made claims that may suggest that evidence used in tuning or calibrating a climate model cannot be used to evaluate the model. By contrast, the philosophers Katie Steele and Charlotte Werndl have argued that, at least within the context of Bayesian confirmation theory, tuning is simply an instance of hypothesis testing. In this paper I argue for a weak predictivism and in support of a nuanced reading of climate scientists’ concerns about tuning: there are cases, model-tuning (...)
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  • Externalismo semántico y subdeterminación empírica. Respuesta a un desafío al realismo científico.Marc Jiménez Rolland - 2017 - Dissertation, Universidad Autónoma Metropolitana
    I offer an explicit account of the underdetermination thesis as well as of the many challenges it poses to scientific realism; a way to answer to these challenges is explored and outlined, by shifting attention to the content of theories. I argue that, even if we have solid grounds (as I contend we do) to support that some varieties of the underdetermination thesis are true, scientific realism can still offer an adequate picture of the aims and achievements of science.
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  • HARKing: From Misdiagnosis to Mispescription.Aydin Mohseni - unknown
    The practice of HARKing---hypothesizing after results are known---is commonly maligned as undermining the reliability of scientific findings. There are several accounts in the literature as to why HARKing undermines the reliability of findings. We argue that none of these is right and that the correct account is a Bayesian one. HARKing can indeed decrease the reliability of scientific findings, but it can also increase it; which effect HARKing produces depends on the difference of the prior odds of hypotheses characteristically selected (...)
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