The new research program to understand mechanisms in biology has developed rapidly in the last 10 years. Reconsideration of the characterization of mechanisms in biology in the light of this recent work is now in order. This article discusses the perspectival aspect of the characterization of mechanisms, refinements in claims about working entities and kinds of activities, challenges and responses to claims about regularity, productive continuity, and the organizational aspects of a mechanism, and issues about representations of mechanisms in schemas (...) and sketches. †To contact the author, please write to: Committee for Philosophy and the Sciences, Department of Philosophy, 1125A Skinner Building, University of Maryland, College Park, MD 20742 USA; e‐mail: [email protected]. (shrink)

In the 1950s and 1960s, an interfield interaction between molecular biologists and biochemists integrated important discoveries about the mechanism of protein synthesis. This extended discovery episode reveals two general reasoning strategies for eliminating gaps in descriptions of the productive continuity of mechanisms: schema instantiation and forward chaining/backtracking. Schema instantiation involves filling roles in an overall framework for the mechanism. Forward chaining and backtracking eliminate gaps using knowledge about types of entities and their activities. Attention to mechanisms highlights salient features of (...) this historical episode while providing general reasoning strategies for mechanism discovery. (shrink)

Not all models are explanatory. Some models are data summaries. Some models sketch explanations but leave crucial details unspecified or hidden behind filler terms. Some models are used to conjecture a how-possibly explanation without regard to whether it is a how-actually explanation. I use the Hodgkin and Huxley model of the action potential to illustrate these ways that models can be useful without explaining. I then use the subsequent development of the explanation of the action potential to show what is (...) required of an adequate mechanistic model. Mechanistic models are explanatory. (shrink)

This paper shows that grounded dispositions are necessarily coextensive with disjunctive properties. It responds to several objections against this thesis, and then shows how to construct a disjunctive property necessarily coextensive with an arbitrary grounded disposition.

This paper shows that grounded dispositions are necessarily coextensive with disjunctive properties. It responds to several objections against this thesis, and then shows how to construct a disjunctive property necessarily coextensive with an arbitrary grounded disposition.

Some explanations are relatively abstract: they abstract away from the idiosyncratic or messy details of the case in hand. The received wisdom in philosophy is that this is a virtue for any explanation to possess. I argue that the apparent consensus on this point is illusory. When philosophers make this claim, they differ on which of four alternative varieties of abstractness they have in mind. What’s more, for each variety of abstractness there are several alternative reasons to think that the (...) variety of abstractness in question is a virtue. I identify the most promising reasons, and dismiss some others. The paper concludes by relating this discussion to the idea that explanations in biology, psychology and social science cannot be replaced by relatively micro explanations without loss of understanding. (shrink)

Eliminative materialism is the thesis that our common-sense conception of psychological phenomena constitutes a radically false theory, a theory so fundamentally defective that both the principles and the ontology of that theory will eventually be displaced, rather than smoothly reduced, by completed neuroscience. Our mutual understanding and even our introspection may then be reconstituted within the conceptual framework of completed neuroscience, a theory we may expect to be more powerful by far than the common-sense psychology it displaces, and more substantially (...) integrated within physical science generally. My purpose in this paper is to explore these projections, especially as they bear on (1) the principal elements of common-sense psychology: the propositional attitudes (beliefs, desires, etc.), and (2) the conception of rationality in which these elements figure. (shrink)

The independence problems for functionalism stem from the worry that if functional properties are defined in terms of their causes and effects then such functional properties seem to be too intimately connected to these purported causes and effects. I distinguish three different ways the independence problems can be filled out – in terms of necessary connections, analytic connections and vacuous explanations. I argue that none of these present serious problems. Instead, they bring out some important and over-looked features of functionalism.

This paper concerns what Jerry Fodor calls a 'metaphysical mystery': How can there by macroregularities that are realized by wildly heterogeneous lower level mechanisms? But the answer to this question is not as mysterious as many, including Jaegwon Kim, Ned Block, and Jerry Fodor might think. The multiple realizability of the properties of the special sciences such as psychology is best understood as a kind of universality, where 'universality' is used in the technical sense one finds in the physics literature. (...) It is argued that the same explanatory strategy used by physicists to provide understanding of universal behavior in physics can be used to explain how special science properties can be heterogeneously multiply realized. (shrink)

This paper aims to draw attention to an explanatory problem posed by the existence of multiply realized or universal behavior exhibited by certain physical systems. The problem is to explain how it is possible that systems radically distinct at lower-scales can nevertheless exhibit identical or nearly identical behavior at upper-scales. Theoretically this is reflected by the fact that continuum theories such as fluid mechanics are spectacularly successful at predicting, describing, and explaining fluid behaviors despite the fact that they do not (...) recognize the discrete nature of fluids. A standard attempt to reduce one theory to another, is shown to fail to answer the appropriate question about autonomy. (shrink)

In a recent book on applied mathematics A. C. Fowler offers the following description of what is involved in mathematical modeling.

It is common to hear talk of the aim of belief and to find philosophers appealing to that aim for numerous explanatory purposes. What belief 's aim explains depends, of course, on what that aim is. Many hold that it is somehow related to truth, but there are various ways in which one might specify belief 's aim using the notion of truth. In this article, by considering whether they can account for belief 's standard of correctness and the epistemic (...) norms governing belief, I argue against certain prominent specifications of belief 's aim given in terms of truth, and advance a neglected alternative. (shrink)

This book, based on Jaegwon Kim's 1996 Townsend Lectures, presents the philosopher's current views on a variety of issues in the metaphysics of the mind...

As a leading member of the Vienna Circle, Rudolph Carnap's aim was to bring about a "unified science" by applying a method of logical analysis to the empirical data of all the sciences. This work, first published in English in 1934, endeavors to work out a way in which the observation statements required for verification are not private to the observer. The work shows the strong influence of Wittgenstein, Russell, and Frege.

Comparisons of rival explanations or theories often involve vague appeals to explanatory power. In this paper, we dissect this metaphor by distinguishing between different dimensions of the goodness of an explanation: non-sensitivity, cognitive salience, precision, factual accuracy and degree of integration. These dimensions are partially independent and often come into conflict. Our main contribution is to go beyond simple stipulation or description by explicating why these factors are taken to be explanatory virtues. We accomplish this by using the contrastive-counterfactual approach (...) to explanation and the view of understanding as an inferential ability. By combining these perspectives, we show how the explanatory power of an explanation in a given dimension can be assessed by showing the range of answers it provides to what-if-things-had-been-different questions and the theoretical and pragmatic importance of these questions. Our account also explains intuitions linking explanation to unification or to exhibition of a mechanism. (shrink)

Woodward's long awaited book is an attempt to construct a comprehensive account of causation explanation that applies to a wide variety of causal and explanatory claims in different areas of science and everyday life. The book engages some of the relevant literature from other disciplines, as Woodward weaves together examples, counterexamples, criticisms, defenses, objections, and replies into a convincing defense of the core of his theory, which is that we can analyze causation by appeal to the notion of manipulation.

Woodward's long awaited book is an attempt to construct a comprehensive account of causation explanation that applies to a wide variety of causal and explanatory claims in different areas of science and everyday life. The book engages some of the relevant literature from other disciplines, as Woodward weaves together examples, counterexamples, criticisms, defences, objections, and replies into a convincing defence of the core of his theory, which is that we can analyse causation by appeal to the notion of manipulation.

I defend an account of explanatory depth according to which explanations in the non-fundamental sciences can be deeper than explanations in fundamental physics.

Inference to the Best Explanation (IBE) and Bayesianism are our two most prominent theories of scientific inference. Are they compatible? Van Fraassen famously argued that they are not, concluding that IBE must be wrong since Bayesianism is right. Writers since then, from both the Bayesian and explanationist camps, have usually considered van Fraassen’s argument to be misguided, and have plumped for the view that Bayesianism and IBE are actually compatible. I argue that van Fraassen’s argument is actually not so misguided, (...) and that it causes more trouble for compatibilists than is typically thought. Bayesianism in its dominant, subjectivist form, can only be made compatible with IBE if IBE is made subservient to conditionalization in a way that robs IBE of much of its substance and interest. If Bayesianism and IBE are to be fit together, I argue, a strongly objective Bayesianism is the preferred option. I go on to sketch this objectivist, IBE-based Bayesianism, and offer some preliminary suggestions for its development. (shrink)

The two major modern accounts of explanation are the causal and unification accounts. My aim in this paper is to provide a kind of unification of the causal and the unification accounts, by using the central technical apparatus of the unification account to solve a central problem faced by the causal account, namely, the problem of determining which parts of a causal network are explanatorily relevant to the occurrence of an explanandum. The end product of my investigation is a causal (...) account of explanation that has many of the advantages of the unification account. (shrink)

It is widely held that the size of a probability makes no difference to the quality of a probabilistic explanation. I argue that explanatory practice in statistical physics belies this claim. The claim has gained currency only because of an impoverished conception of probabilistic processes and an unwarranted assumption that all probabilistic explanations have a single form.

Reductionism is often understood to include two theses: (1) every singular occurrence that the special sciences can explain also can be explained by physics; (2) every law in a higher-level science can be explained by physics. These claims are widely supposed to have been refuted by the multiple realizability argument, formulated by Putnam (1967, 1975) and Fodor (1968, 1975). The present paper criticizes the argument and identifies a reductionistic thesis that follows from one of the argument's premises.

Since the appearance of a widely influential book, Self-Knowledge and Self-ldentity, Sydney Shoemaker has continued to work on a series of interrelated issues in the philosophy of mind and metaphysics. This volume contains a collection of the most important essays he has published since then. The topics that he deals with here include, among others, the nature of personal and other forms of identity, the relation of time to change, the nature of properties and causality and the relation between the (...) two, dualism and immortality, and the nature of mental states. All the essays show the same care and precision in argument as the earlier book, but they also reveal a substantial shift in Professor Shoemaker's position to a form of materialism. In fact, a number of papers together constitute what is probably the most subtle and rigourous defence yet of a sophisticated functionalism in the account of the mind. (shrink)

Causation is widely assumed to be a binary relation: c causes e. I will argue that causation is a quaternary, contrastive relation: c rather than C* causes e rather than E*, where C* and E* are nonempty sets of contrast events. Or at least, I will argue that treating causation as contrastive helps resolve some paradoxes.

The author draws on arguments from contemporary philosophy of mind to provide an argument for sociological collectivism. This argument for nonreductive individualism accepts that only individuals exist but rejects methodological individualism. In Part I, the author presents the argument for nonreductive individualism by working through the implications of supervenience, multiple realizability, and wild disjunction in some detail. In Part II, he extends the argument to provide a defense for social causal laws, and this account of social causation does not require (...) any commitment to intentionality or agency on the part of individuals. (shrink)

During the 'sixties and 'seventies, Hilary Putnam, Jerry Fodor, and Richard Boyd, among others, developed a type of materialism that eschews reductionist claims.¹ In this view, explana- tions, natural kinds, and properties in psychology do not reduce to counterparts in more basic sciences, such as neurophysiology or physics. Nevertheless, all token psychological entities-- states, processes, and faculties--are wholly constituted of physical entities, ultimately out of entities over which microphysics quantifies. This view quickly became the standard position in philosophy of mind, (...) and reductionism fell out of favor. Recently, however, reductionism has been experiencing a rebirth, and many have suggested that the non-reductive approach was accepted too quickly and too uncritically. In this paper, we attempt to provide a more thorough account of the anti-reductionist position, and, in the process, to defend it against its recent critics. (shrink)

The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.

Proponents of mechanistic explanation all acknowledge the importance of organization. But they have also tended to emphasize specificity with respect to parts and operations in mechanisms. We argue that in understanding one important mode of organization—patterns of causal connectivity—a successful explanatory strategy abstracts from the specifics of the mechanism and invokes tools such as those of graph theory to explain how mechanisms with a particular mode of connectivity will behave. We discuss the connection between organization, abstraction, and mechanistic explanation and (...) illustrate our claims by looking at an example from recent research on so-called network motifs. (shrink)