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  1. Explanation: a mechanist alternative.William Bechtel & Adele Abrahamsen - 2005 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):421-441.
    Explanations in the life sciences frequently involve presenting a model of the mechanism taken to be responsible for a given phenomenon. Such explanations depart in numerous ways from nomological explanations commonly presented in philosophy of science. This paper focuses on three sorts of differences. First, scientists who develop mechanistic explanations are not limited to linguistic representations and logical inference; they frequently employ diagrams to characterize mechanisms and simulations to reason about them. Thus, the epistemic resources for presenting mechanistic explanations are (...)
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  • Discovering Cell Mechanisms: The Creation of Modern Cell Biology.William Bechtel - 2005 - Cambridge University Press.
    Between 1940 and 1970 pioneers in the new field of cell biology discovered the operative parts of cells and their contributions to cell life. They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. Cell biology was a revolutionary science but in this book it also provides fuel for yet another revolution, one that focuses on (...)
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  • (1 other version)What Is a Mechanism? A Counterfactual Account.James Woodward - 2002 - Philosophy of Science 69 (S3):S366-S377.
    This paper presents a counterfactual account of what a mechanism is. Mechanisms consist of parts, the behavior of which conforms to generalizations that are invariant under interventions, and which are modular in the sense that it is possible in principle to change the behavior of one part independently of the others. Each of these features can be captured by the truth of certain counterfactuals.
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  • Discovering Complexity.William Bechtel, Robert C. Richardson & Scott A. Kleiner - 1996 - History and Philosophy of the Life Sciences 18 (3):363-382.
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  • Inferring causation in epidemiology: mechanisms, black boxes, and contrasts.Alex Broadbent - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press. pp. 45--69.
    This chapter explores the idea that causal inference is warranted if and only if the mechanism underlying the inferred causal association is identified. This mechanistic stance is discernible in the epidemiological literature, and in the strategies adopted by epidemiologists seeking to establish causal hypotheses. But the exact opposite methodology is also discernible, the black box stance, which asserts that epidemiologists can and should make causal inferences on the basis of their evidence, without worrying about the mechanisms that might underlie their (...)
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  • Mechanistic theories of causality.Jon Williamson - unknown
    After introducing a range of mechanistic theories of causality and some of the problems they face, I argue that while there is a decisive case against a purely mechanistic analysis, a viable theory of causality must incorporate mechanisms as an ingredient. I describe one way of providing an analysis of causality which reaps the rewards of the mechanistic approach without succumbing to its pitfalls.
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  • Dynamic mechanistic explanation: computational modeling of circadian rhythms as an exemplar for cognitive science.William Bechtel & Adele Abrahamsen - 2010 - Studies in History and Philosophy of Science Part A 41 (3):321-333.
    Two widely accepted assumptions within cognitive science are that (1) the goal is to understand the mechanisms responsible for cognitive performances and (2) computational modeling is a major tool for understanding these mechanisms. The particular approaches to computational modeling adopted in cognitive science, moreover, have significantly affected the way in which cognitive mechanisms are understood. Unable to employ some of the more common methods for conducting research on mechanisms, cognitive scientists’ guiding ideas about mechanism have developed in conjunction with their (...)
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  • Across the boundaries: extrapolation in biology and social science.Daniel Steel (ed.) - 2007 - New York: Oxford University Press.
    Inferences like these are known as extrapolations.
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  • Mechanisms and the nature of causation.Stuart S. Glennan - 1996 - Erkenntnis 44 (1):49--71.
    In this paper I offer an analysis of causation based upon a theory of mechanisms-complex systems whose internal parts interact to produce a system's external behavior. I argue that all but the fundamental laws of physics can be explained by reference to mechanisms. Mechanisms provide an epistemologically unproblematic way to explain the necessity which is often taken to distinguish laws from other generalizations. This account of necessity leads to a theory of causation according to which events are causally related when (...)
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  • What is psychological explanation?William Bechtel & Cory Wright - 2009 - In Sarah Robins, John Symons & Paco Calvo (eds.), The Routledge Companion to Philosophy of Psychology. New York, NY: Routledge. pp. 113--130.
    Due to the wide array of phenomena that are of interest to them, psychologists offer highly diverse and heterogeneous types of explanations. Initially, this suggests that the question "What is psychological explanation?" has no single answer. To provide appreciation of this diversity, we begin by noting some of the more common types of explanations that psychologists provide, with particular focus on classical examples of explanations advanced in three different areas of psychology: psychophysics, physiological psychology, and information-processing psychology. To analyze what (...)
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  • When mechanistic models explain.Carl F. Craver - 2006 - Synthese 153 (3):355-376.
    Not all models are explanatory. Some models are data summaries. Some models sketch explanations but leave crucial details unspecified or hidden behind filler terms. Some models are used to conjecture a how-possibly explanation without regard to whether it is a how-actually explanation. I use the Hodgkin and Huxley model of the action potential to illustrate these ways that models can be useful without explaining. I then use the subsequent development of the explanation of the action potential to show what is (...)
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  • Thinking about mechanisms.Peter Machamer, Lindley Darden & Carl F. Craver - 2000 - Philosophy of Science 67 (1):1-25.
    The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.
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  • Rethinking Mechanistic Explanation.Lindley Darden - 2002 - Philosophy of Science 69 (S3):342-353.
    Philosophers of science typically associate the causal‐mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon’s account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex‐systems approach avoids certain (...)
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  • (1 other version)Reasoning in Biological Discoveries: Essays on Mechanisms, Interfield Relations, and Anomaly Resolution.Lindley Darden - 2006 - New York: Cambridge University Press.
    Reasoning in Biological Discoveries brings together a series of essays, which focus on one of the most heavily debated topics of scientific discovery. Collected together and richly illustrated, Darden's essays represent a groundbreaking foray into one of the major problems facing scientists and philosophers of science. Divided into three sections, the essays focus on broad themes, notably historical and philosophical issues at play in discussions of biological mechanism; and the problem of developing and refining reasoning strategies, including interfield relations and (...)
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  • Modeling mechanisms.Stuart Glennan - 2005 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):443-464.
    Philosophers of science increasingly believe that much of science is concerned with understanding the mechanisms responsible for the production of natural phenomena. An adequate understanding of scientific research requires an account of how scientists develop and test models of mechanisms. This paper offers a general account of the nature of mechanical models, discussing the representational relationship that holds between mechanisms and their models as well as the techniques that can be used to test and refine such models. The analysis is (...)
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  • (1 other version)Rethinking Mechanistic Explanation.Stuart Glennan - 2002 - Philosophy of Science 69 (S3):S342-S353.
    Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids certain (...)
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  • Discovering Cell Mechanisms: The Creation of Modern Cell Biology.William Bechtel - 2007 - Journal of the History of Biology 40 (1):185-187.
    Between 1940 and 1970 pioneers in the new field of cell biology discovered the operative parts of cells and their contributions to cell life. They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. Cell biology was a revolutionary science but in this book it also provides fuel for yet another revolution, one that focuses on (...)
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  • Singular and General Causal Relations: A Mechanist Perspective.Stuart Glennan - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
    My aim in this paper is to make a case for the singularist view from the perspective of a mechanical theory of causation, and to explain what, from this perspective, causal generalizations mean, and what role they play within the mechanical theory.
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  • Large cardinals and definable counterexamples to the continuum hypothesis.Matthew Foreman & Menachem Magidor - 1995 - Annals of Pure and Applied Logic 76 (1):47-97.
    In this paper we consider whether L(R) has “enough information” to contain a counterexample to the continuum hypothesis. We believe this question provides deep insight into the difficulties surrounding the continuum hypothesis. We show sufficient conditions for L(R) not to contain such a counterexample. Along the way we establish many results about nonstationary towers, non-reflecting stationary sets, generalizations of proper and semiproper forcing and Chang's conjecture.
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  • (1 other version)Explaining the Brain.Carl F. Craver - 2007 - Oxford, GB: Oxford University Press.
    Carl F. Craver investigates what we are doing when we use neuroscience to explain what's going on in the brain. When does an explanation succeed and when does it fail? Craver offers explicit standards for successful explanation of the workings of the brain, on the basis of a systematic view about what neuroscientific explanations are.
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  • Function and organization: comparing the mechanisms of protein synthesis and natural selection.Phyllis McKay Illari & Jon Williamson - 2010 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 41 (3):279-291.
    In this paper, we compare the mechanisms of protein synthesis and natural selection. We identify three core elements of mechanistic explanation: functional individuation, hierarchical nestedness or decomposition, and organization. These are now well understood elements of mechanistic explanation in fields such as protein synthesis, and widely accepted in the mechanisms literature. But Skipper and Millstein have argued that natural selection is neither decomposable nor organized. This would mean that much of the current mechanisms literature does not apply to the mechanism (...)
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  • Looking down, around, and up: Mechanistic explanation in psychology.William Bechtel - 2009 - Philosophical Psychology 22 (5):543-564.
    Accounts of mechanistic explanation have emphasized the importance of looking down—decomposing a mechanism into its parts and operations. Using research on visual processing as an exemplar, I illustrate how productive such research has been. But once multiple components of a mechanism have been identified, researchers also need to figure out how it is organized—they must look around and determine how to recompose the mechanism. Although researchers often begin by trying to recompose the mechanism in terms of sequential operations, they frequently (...)
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  • Thinking again about biological mechanisms.Lindley Darden - 2008 - Philosophy of Science 75 (5):958-969.
    The new research program to understand mechanisms in biology has developed rapidly in the last 10 years. Reconsideration of the characterization of mechanisms in biology in the light of this recent work is now in order. This article discusses the perspectival aspect of the characterization of mechanisms, refinements in claims about working entities and kinds of activities, challenges and responses to claims about regularity, productive continuity, and the organizational aspects of a mechanism, and issues about representations of mechanisms in schemas (...)
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  • (1 other version)Explaining the brain: mechanisms and the mosaic unity of neuroscience.Carl F. Craver - 2007 - New York : Oxford University Press,: Oxford University Press, Clarendon Press.
    Carl Craver investigates what we are doing when we sue neuroscience to explain what's going on in the brain.
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  • Causality and causal modelling in the social sciences.Federica Russo - 2009 - Springer, Dordrecht.
    The anti-causal prophecies of last century have been disproved. Causality is neither a ‘relic of a bygone’ nor ‘another fetish of modern science’; it still occupies a large part of the current debate in philosophy and the sciences. This investigation into causal modelling presents the rationale of causality, i.e. the notion that guides causal reasoning in causal modelling. It is argued that causal models are regimented by a rationale of variation, nor of regularity neither invariance, thus breaking down the dominant (...)
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  • (1 other version)What is a mechanism? A counterfactual account.Jim Woodward - 2002 - Proceedings of the Philosophy of Science Association 2002 (3):S366-S377.
    This paper presents a counterfactual account of what a mechanism is. Mechanisms consist of parts, the behavior of which conforms to generalizations that are invariant under interventions, and which are modular in the sense that it is possible in principle to change the behavior of one part independently of the others. Each of these features can be captured by the truth of certain counterfactuals.
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  • (1 other version)Rethinking mechanistic explanation.Stuart Glennan - 2002 - Proceedings of the Philosophy of Science Association 2002 (3):S342-353.
    Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids certain (...)
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  • (1 other version)Reasoning in biological discoveries.Lindley Darden - manuscript
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  • Synthesizing activities and interactions in the concept of a mechanism.James G. Tabery - 2004 - Philosophy of Science 71 (1):1-15.
    Stuart Glennan, and the team of Peter Machamer, Lindley Darden, and Carl Craver have recently provided two accounts of the concept of a mechanism. The main difference between these two versions rests on how the behavior of the parts of the mechanism is conceptualized. Glennan considers mechanisms to be an interaction of parts, where the interaction between parts can be characterized by direct, invariant, change-relating generalizations. Machamer, Darden, and Craver criticize traditional conceptualizations of mechanisms which are based solely on parts (...)
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  • (2 other versions)Mental mechanisms: Philosophical perspectives on the sciences of cognition and the brain.William P. Bechtel - manuscript
    1. The Naturalistic Turn in Philosophy of Science 2. The Framework of Mechanistic Explanation: Parts, Operations, and Organization 3. Representing and Reasoning About Mechanisms 4. Mental Mechanisms: Mechanisms that Process Information 5. Discovering Mental Mechanisms 6 . Summary.
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  • Biological Complexity and Integrative Pluralism.Sandra D. Mitchell - 2003 - Cambridge University Press.
    This fine collection of essays by a leading philosopher of science presents a defence of integrative pluralism as the best description for the complexity of scientific inquiry today. The tendency of some scientists to unify science by reducing all theories to a few fundamental laws of the most basic particles that populate our universe is ill-suited to the biological sciences, which study multi-component, multi-level, evolved complex systems. This integrative pluralism is the most efficient way to understand the different and complex (...)
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  • Ephemeral Mechanisms and Historical Explanation.Stuart Glennan - 2010 - Erkenntnis 72 (2):251-266.
    While much of the recent literature on mechanisms has emphasized the superiority of mechanisms and mechanistic explanation over laws and nomological explanation, paradigmatic mechanisms—e.g., clocks or synapses—actually exhibit a great deal of stability in their behavior. And while mechanisms of this kind are certainly of great importance, there are many events that do not occur as a consequence of the operation of stable mechanisms. Events of natural and human history are often the consequence of causal processes that are ephemeral and (...)
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  • A Modified Conception of Mechanisms.Phillip J. Torres - 2009 - Erkenntnis 71 (2):233-251.
    In this paper, I critique two conceptions of mechanisms, namely those put forth by Stuart Glennan (Erkenntnis 44:49–71, 1996; Philosophy of Science 69:S342–S353, 2002) and Machamer et al. (Philosophy of Science 67:1–25, 2000). Glennan’s conception, I argue, cannot account for mechanisms involving negative causation because of its interactionist posture. MDC’s view encounters the same problem due to its reificatory conception of activities—this conception, I argue, entails an onerous commitment to ontological dualism. In the place of Glennan and MDC, I propose (...)
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  • Capacities, Universality, and Singularity.Stuart M. Glennan - 1997 - Philosophy of Science 64 (4):605-626.
    In this paper I criticize Cartwright's analysis of capacities and offer an alternative analysis. I argue that Cartwright's attempt to connect capacities to her condition CC fails because individuals can exercise capacities only in certain contexts. My own analysis emphasizes three features of capacities: 1) Capacities belong to individuals; 2) Capacities are typically not metaphysically fundamental properties of individuals, but can be explained by referring to structural properties of individuals; and 3) Laws are best understood as ascriptions of capacities.
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  • Mechanisms.Stuart Glennan - 2009 - In Helen Beebee, Christopher Hitchcock & Peter Menzies (eds.), The Oxford Handbook of Causation. Oxford University Press UK.
    Mechanism is undoubtedly a causal concept, in the sense that ordinary definitions and philosophical analyses explicate the concept in terms of other causal concepts such as production and interaction. Given this fact, many philosophers have supposed that analyses of the concept of mechanism, while they might appeal to philosophical theories about the nature of causation, could do little to inform such theories. On the other hand, methods of causal inference and explanation appeal to mechanisms. Discovering a mechanism is the gold (...)
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  • The Russo-Williamson thesis and the question of whether smoking causes heart disease.Donald Gillies - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press. pp. 110--125.
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  • Mechanistic Theories of Causality Part I.Jon Williamson - 2011 - Philosophy Compass 6 (6):421-432.
    Part I of this paper introduces a range of mechanistic theories of causality, including process theories and the complex-systems theories, and some of the problems they face. Part II argues that while there is a decisive case against a purely mechanistic analysis, a viable theory of causality must incorporate mechanisms as an ingredient, and describes one way of providing an analysis of causality which reaps the rewards of the mechanistic approach without succumbing to its pitfalls.
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  • Activities and causation: The metaphysics and epistemology of mechanisms.Peter Machamer - 2004 - International Studies in the Philosophy of Science 18 (1):27 – 39.
    This article deals with mechanisms conceived as composed of entities and activities. In response to many perplexities about the nature of activities, a number of arguments are developed concerning their epistemic and ontological status. Some questions concerning the relations between cause and causal explanation and mechanisms are also addressed.
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  • The Downs and Ups of Mechanistic Research: Circadian Rhythm Research as an Exemplar. [REVIEW]William Bechtel - 2010 - Erkenntnis 73 (3):313 - 328.
    In the context of mechanistic explanation, reductionistic research pursues a decomposition of complex systems into their component parts and operations. Using research on the mechanisms responsible for circadian rhythms, I consider both the gains that have been made by discovering genes and proteins that figure in these intracellular oscillators and also highlight the increasingly recognized need to understand higher-level integration, both between cells in the central oscillator and between the central and peripheral oscillators. This history illustrates a common need to (...)
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  • Difference mechanisms: Explaining variation with mechanisms.James Tabery - 2009 - Biology and Philosophy 24 (5):645-664.
    Philosophers of science have developed an account of causal-mechanical explanation that captures regularity, but this account neglects variation. In this article I amend the philosophy of mechanisms to capture variation. The task is to explicate the relationship between regular causal mechanisms responsible for individual development and causes of variation responsible for variation in populations. As it turns out, disputes over this relationship have rested at the heart of the nature–nurture debate. Thus, an explication of the relationship between regular causal mechanisms (...)
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  • Productivity, relevance and natural selection.Stuart Glennan - 2009 - Biology and Philosophy 24 (3):325-339.
    Recent papers by a number of philosophers have been concerned with the question of whether natural selection is a causal process, and if it is, whether the causes of selection are properties of individuals or properties of populations. I shall argue that much confusion in this debate arises because of a failure to distinguish between causal productivity and causal relevance. Causal productivity is a relation that holds between events connected via continuous causal processes, while causal relevance is a relationship that (...)
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  • The IARC and Mechanistic Evidence.Bert Leuridan & Erik Weber - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press. pp. 91--109.
    The International Agency for Research on Cancer (IARC) is an organization which seeks to identify the causes of human cancer. Per agent, such as betel quid or Human Papillomaviruses, they review the available evidence deriving from epidemiological studies, animal experiments and information about mechanisms (and other data). The evidence of the different groups is combined such that an overall assessment of the carcinogenicity of the agent in question is obtained. In this paper, we critically review the IARC’s carcinogenicity evaluations. First (...)
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  • Decomposing, recomposing, and situating circadian mechanisms: Three tasks in developing mechanistic explanations.William Bechtel & Adele Abrahamsen - 2009 - In Alexander Hieke & Hannes Leitgeb (eds.), Reduction: Between the Mind and the Brain. Frankfurt: Ontos Verlag. pp. 12--177.
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  • From reduction back to higher levels.William Bechtel & Adele Abrahamsen - 2008 - In B. C. Love, K. McRae & V. M. Sloutsky (eds.), Proceedings of the 30th Annual Conference of the Cognitive Science Society. Cognitive Science Society. pp. 559--564.
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  • Contextual unanimity and the units of selection problem.Stuart Glennan - 2002 - Philosophy of Science 69 (1):118-137.
    Sober and Lewontin's critique of genic selectionism is based upon the principle that a unit of selection should make a context‐independent contribution to fitness. Critics have effectively shown that this principle is flawed. In this paper I show that the context independence principle is an instance of a more general principle for characterizing causes,called the contextual unanimity principle. I argue that this latter principle, while widely accepted, is erroneous. What is needed is to replace the approach to causality characterized by (...)
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