Results for 'J. Räikkä'

983 found
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  1. (1 other version)Is endurantism the folk friendly view of persistence?Sam Baron, Andrew J. Latham, Jordan Veng Oh & Kristie Miller - 2024 - Philosophical Studies 181 (10).
    Many philosophers have thought that our folk, or pre-reflective, view of persistence is one on which objects endure. This assumption not only plays a role in disputes about the nature of persistence itself, but is also put to use in several other areas of metaphysics, including debates about the nature of change and temporal passage. In this paper, we empirically test three broad claims. First, that most people (i.e. most non-philosophers) believe that, and it seems to them as though, objects (...)
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  2. Autonomy and Community in Kant's Theory of Taste.Jessica J. Williams - forthcoming - The Journal of Aesthetics and Art Criticism.
    In this paper, I argue that Kant has a far more communitarian theory of aesthetic life than is usually acknowledged. I focus on two aspects of Kant’s theory that might otherwise be taken to support an individualist reading, namely, Kant’s emphasis on aesthetic autonomy and his characterization of judgments of taste as involving demands for agreement. I argue that the full expression of autonomy in fact requires being a member of an aesthetic community and that within such a community, judgments (...)
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  3. Is Health the Absence of Disease?Somogy Varga & Andrew J. Latham - forthcoming - Inquiry: An Interdisciplinary Journal of Philosophy.
    While philosophical questions about health and disease have attracted much attention in recent decades, and while opinions are divided on most issues, influential accounts seem to embrace negativism about health, according to which health is the absence of disease. Some subscribe to unrestricted negativism, which claims that negativism applies not only to the concepts of health and disease as used by healthcare professionals but also to the lay concept that underpins everyday thinking. Whether people conceptualize health in this manner has (...)
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  4. Paying attention to attention: psychological realism and the attention economy.Dylan J. White - 2024 - Synthese 203 (2):1-22.
    In recent years, philosophers have identified a number of moral and psychological harms associated with the attention economy (Alysworth & Castro, 2021; Castro & Pham, 2020; Williams, 2018). Missing from many of these accounts of the attention economy, however, is what exactly attention is. As a result of this neglect of the cognitive science of attention, many of these accounts are not empirically credible. They rely on oversimplified and unsophisticated accounts of not only attention, but self- control, and addiction as (...)
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  5. Imagination, Mereotopology, and Topic Expansion.Aybüke Özgün & A. J. Cotnoir - forthcoming - Review of Symbolic Logic.
    In the topic-sensitive theory of the logic of imagination due to Berto (2018a), the topic of the imaginative output must be contained within the imaginative input. That is, imaginative episodes can never expand what they are about. We argue, with Badura (2021), that this constraint is implausible from a psychological point of view, and it wrongly predicts the falsehood of true reports of imagination. Thus the constraint should be relaxed; but how? A number of direct approaches to relaxing the controversial (...)
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  6. How to be a realist about computational neuroscience.Danielle J. Williams - 2025 - Synthese 205 (3):1-27.
    Recently, a version of realism has been offered to address the simplification strategies used in computational neuroscience. According to this view, computational models provide us with knowledge about the brain, but they should not be taken literally in _any_ sense, even rejecting the idea that the brain performs computations (computationalism). I acknowledge the need for considerations regarding simplification strategies in neuroscience and how they contribute to our interpretations of computational models; however, I argue that whether we should accept or reject (...)
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  7. Pictorial syntax.Kevin J. Lande - 2024 - Mind and Language 39 (4):518-539.
    It is commonly assumed that images, whether in the world or in the head, do not have a privileged analysis into constituent parts. They are thought to lack the sort of syntactic structure necessary for representing complex contents and entering into sophisticated patterns of inference. I reject this assumption. “Image grammars” are models in computer vision that articulate systematic principles governing the form and content of images. These models are empirically credible and can be construed as literal grammars for images. (...)
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  8. Gorgias on Speech and the Soul.R. J. Barnes - 2022 - In S. Montgomery Ewegen & Colleen P. Zoller, Gorgias/Gorgias: The Sicilian Orator and the Platonic Dialogue. Parnassos Press. pp. 87-106.
    In his Encomium of Helen and On Not Being, Gorgias of Leontinoi discusses the nature and function of speech more extensively than any other surviving author before Plato. His discussions are not only surprising in the way they characterize the power of logos and its effects on a listener but also in how the two descriptions of speech seem to contradict one another. In the Helen, Gorgias claims that logos is a very powerful entity, capable of affecting a listener in (...)
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  9.  95
    "They Had It Coming!" The Effect of Moral Character on Somatic and Mental Health Judgments.Somogy Varga, Andrew J. Latham & Edouard Machery - forthcoming - Royal Institute of Philosophy Supplement.
    Prior research has unveiled a pathologization effect where individuals perceived as having bad moral character are more likely to have their conditions labeled as diseases and are less often considered healthy compared to those viewed as having a good moral character. Moreover, these individuals are perceived as less unlucky in their affliction and more deserving of it. This study explores the broader impacts of moral character on such judgments, hypothesizing that these effects reach deeper and extend to both negative and (...)
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  10. (1 other version)Kant against the cult of genius: epistemic and moral considerations.Jessica J. Williams - 2021 - In Camilla Serck-Hanssen & Beatrix Himmelmann, Proceedings of the 13th International Kant Congress: The Court of Reason (Oslo, 6–9 August 2019). De Gruyter. pp. 919-926.
    In the Critique of Judgment, Kant claims that genius is a talent for art, but not for science. Despite his restriction of genius to the domain of fine art, several recent interpreters have suggested that genius has a role to play in Kant’s account of cognition in general and scientific practice in particular. In this paper, I explore Kant’s reasons for excluding genius from science as well as the reasons that one might nevertheless be tempted to think that his account (...)
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  11. Hill on perceptual relativity and perceptual error.E. J. Green - 2024 - Mind and Language 39 (1):80-88.
    Christopher Hill's Perceptual experience is a must‐read for philosophers of mind and cognitive science. Here I consider Hill's representationalist account of spatial perception. I distinguish two theses defended in the book. The first is that perceptual experience does not represent the enduring, intrinsic properties of objects, such as intrinsic shape or size. The second is that perceptual experience does represent certain viewpoint‐dependent properties of objects—namely, Thouless properties. I argue that Hill's arguments do not establish the first thesis, and then I (...)
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  12. When do parts form wholes? Integrated information as the restriction on mereological composition.Kelvin J. McQueen & Naotsugu Tsuchiya - forthcoming - Neuroscience of Consciousness.
    Under what conditions are material objects, such as particles, parts of a whole object? This is the composition question and is a longstanding open question in philosophy. Existing attempts to specify a non-trivial restriction on composition tend to be vague and face serious counterexamples. Consequently, two extreme answers have become mainstream: composition (the forming of a whole by its parts) happens under no or all conditions. In this paper, we provide a self-contained introduction to the integrated information theory of consciousness (...)
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  13. Disagreement and alienation.Berislav Marušić & Stephen J. White - 2023 - Philosophical Perspectives 37 (1):210-227.
    This paper proposes to reorient the philosophical debate about peer disagreement. The problem of peer disagreement is normally seen as a problem about the extent to which disagreement provides one with evidence against one's own conclusions. It is thus regarded as a problem for individual inquiry. But things look different in more collaborative contexts. Ethical norms relevant to those contexts make a difference to the epistemology. In particular, we argue that a norm of mutual answerability applies to us when we (...)
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  14. Automated Influence and Value Collapse: Resisting the Control Argument.Dylan J. White - forthcoming - American Philosophical Quarterly.
    Automated influence is one of the most pervasive applications of artificial intelligence in our day-to-day lives, yet a thoroughgoing account of its associated individual and societal harms is lacking. By far the most widespread, compelling, and intuitive account of the harms associated with automated influence follows what I call the control argument. This argument suggests that users are persuaded, manipulated, and influenced by automated influence in a way that they have little or no control over. Based on evidence about the (...)
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  15. Automated Influence and Value Collapse.Dylan J. White - 2024 - American Philosophical Quarterly 61 (4):369-386.
    Automated influence is one of the most pervasive applications of artificial intelligence in our day-to-day lives, yet a thoroughgoing account of its associated individual and societal harms is lacking. By far the most widespread, compelling, and intuitive account of the harms associated with automated influence follows what I call the control argument. This argument suggests that users are persuaded, manipulated, and influenced by automated influence in a way that they have little or no control over. Based on evidence about the (...)
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  16. Fine-Tuning, Multiple Universes, and Self-Locating Beliefs.Christopher J. G. Meacham - forthcoming - In Daniel Rubio & Klaas J. Kraay, The Blackwell Companion to Philosophy and the Multiverse. Blackwell.
    Does the evidence that our universe contains fine-tuned life confirm the multiverse hypothesis? The answer depends on our approach to self-locating beliefs. In a recent paper, Isaacs, Hawthorne, and Russell (2022) offer two arguments for thinking that such evidence does confirm the multiverse hypothesis. First, they argue that the three leading approaches to self-locating beliefs all entail that such evidence confirms the multiverse hypothesis. Second, they present a pair of theorems showing that any approach to self-locating beliefs that satisfies certain (...)
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  17. Can We Perceive the Past?E. J. Green - forthcoming - In Lynn Nadel & Sara Aronowitz, Space, Time, and Memory. Oxford University Press.
    A prominent view holds that perception and memory are distinguished at least partly by their temporal orientation: Perception functions to represent the present, while memory functions to represent the past. Call this view perceptual presentism. This chapter critically examines perceptual presentism in light of contemporary perception science. I adduce evidence for three forms of perceptual sensitivity to the past: (i) shaping perception by past stimulus exposure, (ii) recruitment of mnemonic representations in perceptual processing, and (iii) perceptual representation of present objects (...)
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  18. What is Mental Health and Disorder? Philosophical Implications from Lay Judgments.Somogy Varga & Andrew J. Latham - 2024 - Synthese (5).
    How do people understand the concepts of mental health and disorder? The objective of this paper is to examine the impact of several factors on people’s judgments about whether a condition constitutes a mental disorder or a healthy state. Specifically, this study examines the impact of the source of the condition, its outcome, individual valuation (i.e., the value the individual attaches to the condition), and group valuation (i.e., the value the relevant group attaches to the condition). While we find that (...)
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  19. (1 other version)Health, Disease, and the Medicalization of Low Sexual Desire: A Vignette-Based Experimental Study.Somogy Varga, Andrew J. Latham & Jacob Stegenga - forthcoming - Ergo.
    Debates about the genuine disease status of controversial diseases rely on intuitions about a range of factors. Adopting tools from experimental philosophy, this paper explores some of the factors that influence judgments about whether low sexual desire should be considered a disease and whether it should be medically treated. Drawing in part on some assumptions underpinning a divide in the literature between viewing low sexual desire as a genuine disease and seeing it as improperly medicalized, we investigate whether health and (...)
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  20. Routledge Handbook of Philosophy of Disagreement.Maria Baghramian, J. Adam Carter & Rach Cosker-Rowland (eds.) - 2024 - New York, NY: Routledge.
    Disagreement is one of the deepest and most pervasive topics in philosophy, arguably its very bedrock, and is an ever-increasing feature of politics, ethics, public policy, science and many other areas. Despite the omnipresence of disagreement, the topic itself has received relatively little sustained examination. In this outstanding handbook a team of international contributors examines the philosophy of disagreement and how it extends to debates in public policy and science. Comprising forty-one chapters by an international team of contributors, the Handbook (...)
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  21.  34
    Patient Moral Luck.Preston J. Werner - 2025 - In Timmons Mark, Oxford Studies in Normative Ethics vol. 14.
    In this paper, I argue for a fundamentally different kind of moral luck, Patient Moral Luck (PML). Unlike traditional moral luck, PML concerns the amount of moral consideration that different moral patients — that is, creatures (including human beings) with moral status — will be owed, independent of factors in their control. PML, I argue, entails that morality itself appears to sanction and even obligate actions which, along predictable patterns, involve repeatedly failing to equally consider certain moral patients - and (...)
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  22. Undetermined: Free will in real time and through time.Kevin J. Mitchell - manuscript
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  23. Memory, Anticipation, and Future Bias.Andrew J. Latham, Kristie Miller, James Norton, Shen Pan & Rasmus Pedersen - forthcoming - Philosophical Psychology.
    One proposed explanation for a particular kind of temporal preference lies in a disparity between the emotional intensity of memory compared to anticipation. According to the memory/anticipation disparity explanation, the utility of anticipation of a particular event if that event is future, whether positive or negative, is greater than the utility of retrospection of that same event if it is past, whether positive or negative, and consequently, overall utility is maximised when we prefer negative events to be located in the (...)
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  24. Constructing a Naturalistic Theory of Intentionality.J. H. van Hateren - 2021 - Philosophia 49 (1):473-493.
    A naturalistic theory of intentionality is proposed that differs from previous evolutionary and tracking theories. Full-blown intentionality is constructed through a series of evolvable refinements. A first, minimal version of intentionality originates from a conjectured internal process that estimates an organism’s own fitness and that continually modifies the organism. This process produces the directedness of intentionality. The internal estimator can be parsed into intentional components that point to components of the process that produces fitness. It is argued that such intentional (...)
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  25. Civic Identity Consisting of Moral and Political Identity among Young Adults.Hyemin Han & Kelsie J. Dawson - forthcoming - Personality and Individual Differences.
    In the present study, we tested whether civic identity consisting of moral and political identity via the bifactor model of civic identity with the Stanford Civic Purpose dataset. Previous research in youth development proposed that civic identity consists of two closely related identity constructs, i.e., moral and political identity. Given the bifactor model in factor analysis assumes the presence of both the general and specific factors, we hypothesized that the bifactor model would better fit the data than conventional alternative models. (...)
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  26. Mental Time Travel in Animals: The “When” of Mental Time Travel.Andrew J. Latham, Kristie Miller & Rasmus Pedersen - 2024 - Philosophical Transactions of the Royal Society B: Biological Sciences 379 (1913).
    While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an (...)
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  27. (1 other version)Temporal Dynamism and the Persisting Stable Self.Andrew J. Latham, Kristie Miller & Shira Yechimovitz - forthcoming - The Philosophical Quarterly.
    Empirical evidence suggests that a majority of people believe that time robustly passes, and that many also report that it seems to them, in experience, as though time robustly passes. Non-dynamists deny that time robustly passes, and many contemporary non-dynamists—deflationists—even deny that it seems to us as though time robustly passes. Non-dynamists, then, face the dual challenge of explaining why people have such beliefs and make such reports about their experiences. Several philosophers have suggested the stable-self explanation, according to which (...)
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  28. Global Democracy Theories: Reshaping Political Authority.Karel J. Leyva - 2024 - Politics and Rights Review 1.
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  29. Aesthetics in Biodiversity Conservation.Jukka Mikkonen & Kaisa J. Raatikainen - 2024 - Journal of Aesthetics and Art Criticism 82 (2):174-190.
    Biodiversity loss is an immense ecological crisis of our time. But while “biodiversity” has become a buzzword in media and policy, conservationists have found it difficult to build a common understanding on the nature and severity of biodiversity loss and the means to tackle it. Perhaps surprisingly, many biologists and philosophers have proposed that biodiversity might be best defended with reference to its aesthetic value. This article explores whether aesthetic values could provide strong support for biodiversity conservation. By exploring the (...)
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  30. Painting and Dancing: Scales of Virtue and Inspiration in Late Ancient Platonism.Michael J. Griffin - manuscript
    This paper explores two related questions in late Athenian and Alexandrian Neoplatonism. First, how can a philosopher contemplate the eternal Forms while engaging in practical agency in the world? Second, do Neoplatonists provide a consistent account of the philosopher’s progress through the ‘stages of virtue’ (βαθμοί τῶν ἀρετῶν), the conceptual structure that underpins late antique philosophical curricula and hagiography? These questions interact, I suggest, because later Platonists appeal to the stages of virtue and divine maniai (βαθμοί τῶν μανίων) to explain (...)
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  31. Rethinking Sovereignty: A Path to Cosmopolitan Democracy.Karel J. Leyva - 2024 - Politics and Rights Review 2.
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  32. When is Climate-Change Related Internal Displacement of International Concern?Matthew J. Lister - 2024 - In Jamie Draper & David Owen, The Political Philosophy of Internal Displacement. Oxford University Press. pp. 179-195.
    It is now widely expected that climate change will be serious enough that a very large number of people will be displaced from their homes because of events relating to or resulting from climate change. Such events may include rising sea levels (and resulting increased salination of ground water), stronger hurricanes and tropical storms, drought, floods, increased and more intense wildfires, and other extreme or (previously) unusual weather events. Although estimates vary widely, it seems very likely that many millions of (...)
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  33. The role of causal manipulability in the manifestation of time biases.Batoul Hodroj, Andrew J. Latham, Kristie Miller, Rasmus Pedersen & Danqi Wang - 2024 - Synthese 204 (4):1-34.
    We investigate the causal manipulability hypothesis, according to which what partly explains (a) why people tend to prefer negative events to be in their further future rather than their nearer future and positive events to be in their nearer future rather than their further future and (b) why people tend to prefer that negative events be located in their past not their future and that positive events be located in their future not their past, is that people tend to discount (...)
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  34. The Short and the Long of It: A Political Phenomenology of Pandemic Time.Cressida J. Heyes - 2020 - Philosophy Today 64 (4):859-863.
    Drawing on Françoise Dastur’s suggestion that the event is a permanent possibility that shapes lived experience, but also, when it occurs, a distinctive temporal rupture, I argue that the initial weeks of the COVID-19 epidemic constitute an event, in her sense. Connecting this phenomenological point to literatures on the politics of temporality, I suggest that the distinction between event and normal experience maps to that between epidemic and endemic. Understanding some of the political and ethical erasures of death and debility (...)
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  35. Episodic Imagining, Temporal Experience, and Beliefs about Time.Anthony Bigg, Andrew J. Latham, Kristie Miller & Shira Yechimovitz - 2024 - Philosophy and Phenomenological Research 109 (2):528-547.
    We explore the role of episodic imagining in explaining why people both differentially report that it seems to them in experience as though time robustly passes, and why they differentially report that they believe that time does in fact robustly pass. We empirically investigate two hypotheses, the differential vividness hypothesis, and the mental time travel hypothesis. According to each of these, the degree to which people vividly episodically imagine past/future states of affairs influences their tendency to report that it seems (...)
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  36. Philosophical Foundations for Complementary Protection.Matthew J. Lister - 2019 - In David Miller & Christine Straehle, The Political Philosophy of Refuge. Cambridge University Press. pp. 211-231.
    A Significant percentage of the people outside their country of citizenship or residence who are unable to meet their basic needs on their own, and need international protection, do not fall under the definition set out in the UN Refugee Convention. This has led many - both academic commentators and activists - to call for a new, expanded refugee definition, preferably backed up by a new, binding, international convention. In earlier work I have resisted this call, arguing that there is (...)
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  37. Building a Fair Future: Transforming Immigration Policy for Refugees and Families.Matthew J. Lister - 2024 - In Matteo Bonotti & Narelle Miragliotta, Australian Politics at a Crossroads: Prospects for Change. Routledge. pp. 149-16`.
    In this chapter I focus on two problems facing immigration systems around the world, and Australia in particular. The topics addressed are chosen because each one involves important fundamental rights and because significant improvement in these areas is possible even if each state acts alone, without significant coordination with others. First, I examine refugee programmes, focussing specifically on the ‘two- tier’ refugee programmes pioneered by Australia with the introduction of Temporary Protection Visas by the Howard Government in 1999. Next, I (...)
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  38. Robots, Eldercare and Meaningful Lives.Russell J. Woodruff & Cholavardan Kondeti - 2023 - Humana Mente 16 (44):123-137.
    In this paper we examine how the use of robots in caring for elders can impact the meaningfulness of elders’ lives. We present a framework for understanding ‘meaningfulness in life’, and then apply that framework in discussing ways in which the use of robots to assist in activities of daily living can preserve, enhance or undermine the meaningfulness of elders’ lives. We conclude with a discussion of if and how having false beliefs about companion robots can affect meaningfulness in the (...)
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  39. On Being the Right Size, Revisited: The Problem with Engineering Metaphors in Molecular Biology.Daniel J. Nicholson - 2020 - In Sune Holm & Maria Serban, Philosophical Perspectives on the Engineering Approach in Biology: Living Machines? New York: Routledge. pp. 40-68.
    In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, macroscopic (...)
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  40. It takes two to make a view go right. [REVIEW]Danielle J. Williams - 2024 - The Brains Blog.
    The Physical Signature of Computation is the most “robust” mapping view that’s ever hit the market. It is impressive in its detail and the careful attention paid to its characterization of both the physical system and the formal computational description—a true service to the philosophical literature. The book promises a “unified account of artifact and biological computation,” but here’s where things take a turn: after handling artifacts, the Robust Mapping Account fades from view and the Mechanistic Account of Physical Computation (...)
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  41. On the Properties of Composite Objects.Michael J. Duncan - manuscript
    What are the properties of composite objects, and how do the properties of composite objects and the properties of their proper parts relate to one another? The answers to these questions depend upon which view of composition one adopts. One view, which I call the orthodox view, is that composite objects are numerically distinct from their proper parts, individually and collectively. Another view, known as composition as identity, is that composite objects are numerically identical to their proper parts, taken together. (...)
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  42. BCI-Mediated Behavior, Moral Luck, and Punishment.Daniel J. Miller - 2020 - American Journal of Bioethics Neuroscience 11 (1):72-74.
    An ongoing debate in the philosophy of action concerns the prevalence of moral luck: instances in which an agent’s moral responsibility is due, at least in part, to factors beyond his control. I point to a unique problem of moral luck for agents who depend upon Brain Computer Interfaces (BCIs) for bodily movement. BCIs may misrecognize a voluntarily formed distal intention (e.g., a plan to commit some illicit act in the future) as a control command to perform some overt behavior (...)
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  43. Extended Simples and the Argument from Heterogeneity.Michael J. Duncan - manuscript
    Perhaps the most commonly discussed argument against the possibility of extended simples is the argument from heterogeneity. The argument states that, if extended simples are possible, then extended simples which exhibit intrinsic qualitative variation across space (or spacetime) are also possible [Premise 1]. But, the argument goes, it is impossible for an extended simple to exhibit intrinsic qualitative variation across space (or spacetime) [Premise 2]. Thus, extended simples are impossible. I argue that there is a serious problem with the argument (...)
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  44. A Parsimonious Solution to the Hard Problem of Consciousness: Complexity and Narrative.Maxson J. McDowell - manuscript
    Three decades after Chalmers named it, the ‘hard problem’ remains. I suggest a parsimonious solution. Biological dynamic systems interact according to simple rules (while the environment provides simple constraints) and thus self-organize to become a new, more complex dynamic system at the next level. This spiral repeats several times generating a hierarchy of levels. A leap to the next level is frequently creative and surprising. From ants, themselves self-organized according to physical/chemical laws, may emerge an ant colony self-organized according to (...)
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  45. Assurance Views of Testimony.Philip J. Nickel - 2019 - In Miranda Fricker, Peter Graham, David Henderson & Nikolaj Jang Pedersen, The Routledge Handbook of Social Epistemology. New York, USA: Routledge. pp. 96-102.
    Assurance theories of testimony attempt to explain what is distinctive about testimony as a form of epistemic warrant or justification. The most characteristic assurance theories hold that a distinctive subclass of assertion (acts of “telling”) involves a real commitment given by the speaker to the listener, somewhat like a promise to the effect that what is asserted is true. This chapter sympathetically explains what is attractive about such theories: instead of treating testimony as essentially similar to any other kind of (...)
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  46. How Philosophers Have Influenced the Way You Think About Race.Jennifer Mensch & Michael J. Olson - 2023 - Futurumcareers.Com.
    Problematic perceptions about race damage our society. These attitudes can seem impossible to overcome, but philosophers Dr Jennifer Mensch, at Western Sydney University in Australia, and Dr Michael Olson, at Marquette University in the US, beg to differ. They are compiling a collection of 18th-century philosophical and scientific texts that helped shape the way people saw race across the Western world, and were used to justify colonisation. They believe that by exposing these historical roots of racism, opportunities to improve societal (...)
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  47. Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study.Timothy J. Lane - 2018 - Neuroscience 379:142-151.
    Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and (...)
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  48. Indication of dynamic neurovascular coupling from inconsistency between EEG and fMRI indices across sleep–wake states.Timothy J. Lane - 2019 - Sleep and Biological Rhythms 17:423-431.
    Neurovascular coupling (NVC), the transient regional hyperemia following the evoked neuronal responses, is the basis of blood oxygenation level-dependent techniques and is generally adopted across physiological conditions, including the intrinsic resting state. However, the possibility of neurovascular dissociations across physiological alterations is indicated in the literature. To examine the NVC stability across sleep–wake states, we used electroencephalography (EEG) as the index of neural activity and functional magnetic resonance imaging (fMRI) as the measure of cerebrovascular response. Eight healthy adults were recruited (...)
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  49. Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder.Timothy J. Lane - 2020 - Schizophrenia Bulletin 46 (1):163–174.
    Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. -/- Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD (...)
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  50. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.Timothy J. Lane - 2021 - Psychiatry Research: Neuroimaging 308.
    The neurotransmitters GABA and glutamate have been suggested to play a role in Major Depressive Disorder (MDD) through an imbalance between cortical inhibition and excitation. This effect has been highlighted in higher brain areas, such as the prefrontal cortex, but has also been posited in basic sensory cortices. Based on this, magnetic resonance spectroscopy (MRS) was used to investigate potential changes to GABA+ and glutamate+glutamine (Glx) concentrations within the occipital cortex in MDD patients (n = 25) and healthy controls (n (...)
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