In this thesis I examine the debate between John McDowell and Hubert Dreyfus. I narrow the debate down to what I believe is its most fundamental concern: the extent to which conceptual rationality plays a role in our skillful engagement with the world. I provide an exposition of the main arguments presented by each thinker in an attempt to lead the reader to a clearer understanding of the debate. I side with McDowell, I claim that his distinction between two (...) psychological states enables him to successfully rebut Dreyfus’ strongest critique, and provide a coherent account of the mind-world relation. (shrink)

Every metaphysic, according to Reiner Schürmann, involves the positing of a first principle for thinking and doing whereby the world becomes intelligible and masterable. What happens when such rules or norms no longer have the power they previously had? According to Cornelius Castoriadis, the world makes sense through institutions of imaginary significations. What happens when we discover that these significations and institutions truly are imaginary, without ground? Both thinkers begin their ontologies by acknowledging a radical finitude that threatens to destroy (...) meaning or order. For Schürmann it is the ontological anarchy revealed between epochs when principles governing modes of thinking and doing are foundering but new principles to take their place have not yet emerged. For Castoriadis it is chaos that names the indeterminationdetermination that governs the unfolding of the socio-historical with contingency and unpredictability. And yet for both thinkers their respective ontologies have political or ethical implications. On the basis of the anarchy of being, Schürmann unfolds an anarchic praxis or ethos of “living without why.” And on the basis of his notion of being as chaos, Castoriadis develops his political praxis of autonomy. The challenge for both is this move from ontology to practical philosophy, how to bridge theory and practice. The key for both seems to be a certain ontologically derived sense of freedom. In this paper, I analyze and compare their respective thoughts, and pursue the question of how anarchy or chaos and the implied sense of an ontological freedom might be made viable and sensible for human praxis, how radical finitude in the face of ontological groundlessness might nevertheless serve to situate a viable political praxis. (shrink)

In an attempt to resolve the problem or the marriage between law and morality, Dr. John Ezenwankwor publishes this book, Law and Morality: An Appraisal of Hart's Concept of Law. In it, he delves into a critical analysis of the works of a British legal philosopher, Herbert Lionel Adolphus Hart (1907-1992), who made landmark contributions to the moral and legal questions surrounding human actions or conducts. Incidentally, he surpasses his master, Hart, in this book, by correcting his mistaken and (...) poor consideration of the influence of morality in holding the society together and his dismissal of legal enforcement of morality. (shrink)

In this paper the author considers, by a careful reading of the Regula Benedicti (RB) and its sources, the claim by Michel de Certeau that some of Lacan’s ideas are based on Benedictine monasticism. As well as the four concepts that de Certeau identifies (analyst as monk; master; school; and work-as-speech) the author also considers whether four additional notions (desire; the uniqueness of the subject; nothingness; and empty speech)—the latter two of which may have been mediated to Lacan by Heidegger—which (...) come from the Regula Benedicti. (shrink)

This study sought to create a digital game-based physics lesson for seventh-grade students. It sought answers to respondents' least mastered competencies in physics by identifying their preferred game-based learning activity and determining their level of critical thinking, creative thinking, and problem-solving. A descriptive-developmental design was used in the study of selected learners from 129 grade 7 students, carried out at Bukal Sur National High School in Candelaria, Quezon, during the academic year 2022-2023. The study's findings revealed that the respondents' least (...) mastered competency in Physics was describing an object's motion in terms of distance or displacement, speed or velocity, and acceleration, as well as creating and interpreting visual representations of object motion such as tape charts and motion graphs and inferring that waves carry energy. Respondents prefer to play digital games, particularly puzzle games, on their mobile devices. The respondents' mean pre-test score indicated low critical thinking, creative thinking, and problem-solving, whereas the mean post-test score was very satisfactory. Finally, there is a significant difference between the respondents' pre-test and post-test scores for critical thinking, creative thinking, and problem-solving. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 42.2 (2004) 219-220 [Access article in PDF] Jack Zupko. John Buridan: Portrait of a Fourteenth-Century Arts Master. Notre Dame: University of Notre Dame Press, 2003. Pp. xix + 446. Cloth, $70.00. Paper, $40.00. What does the name "John Buridan" call to mind? For many, including medievalists, not much at all—at best, perhaps, a set of apparently unrelated ideas: nominalism; an impetus (...) theory of projectile motion; and a peculiar account of the will (although "Buridan's ass," the indecisive donkey caught between two equally appetizing bales of hay, is not found in Buridan's writing). In correcting this ignorance—an injustice to arguably the most famous and influential philosopher of the early-to-mid-fourteenth century—the temptation might have been to articulate Buridan's "positions" on "the big questions," allowing readers to fit Buridan into received categories. Thankfully, the present work, the first book-length study of Buridan in any language, resists this temptation. The John Buridan that emerges from Jack Zupko's skillful "exercise in philosophical portraiture" doesn't serve to simply fill gaps in our awareness of the historical record, but to enlighten and challenge our understanding of the practice of philosophy and the study of its history.Zupko emphasizes throughout that Buridan was a teacher, a master of arts in Paris. Buridan's pedagogical concerns help make sense of his central work in logic. As the basis for his arts lectures, Buridan chose Peter of Spain's Summulae Logicales, but in commenting on Peter, Buridan moves beyond creative exegisis to comprehensive renovation. Buridan (c. 1300-c. 1361) naturally wanted to accommodate terminist or via moderna supposition theory; but more importantly, he wanted a logic text that would set out a general plan of philosophical inquiry, "a compendium of methods, a 'how-to' book for the philosopher" (135). Buridan thus designed his own Summulae de Dialectica as a new authoritative logic text, and Zupko persuasively argues that its "nominalism" should be understood as less a set of doctrines in theoretical logic, than a program of logical practice, an education in logic as the ars artium, the universal intellectual tool.Zupko's portrait of "Buridan's vision of the philosophical enterprise" is thus appropriately divided into two parts. The first summarizes Buridan's method as described in the individual treatises of his Summulae. The second displays the method in practice, rehearsing and evaluating some of Buridan's arguments on various subjects. Many scholars will gravitate first to the latter part, where Zupko offers important interpretations and clarifications of Buridan's views. In these chapters, Zupko helps us to appreciate, among other things: how the problem of universals served to help Buridan define the scope of philosophy (ch. 10); the philosophical modesty of Buridan's account of the intellectual soul's presence in the body (ch. 11); the relationship between Buridan's epistemology and the skepticism of his Parisian contemporary Nicholas of Autrecourt (ch. 12); the sense in which Buridan is an "empiricist," viz an epistemic naturalist and reliabilist (ch. 13); how Buridan regarded moral psychology as applied physics, treating virtue as a kind of impetus (ch. 14); how Buridan's account of freedom can be regarded as a "perfection" of Thomistic intellectualism (ch. 15).Throughout these discussions, Zupko always keeps in sight his larger purpose of illustrating Buridan's conception of philosophical inquiry. Zupko makes much of the fact that [End Page 219] Buridan never wrote as a theologian, remaining his entire career in the arts faculty, where he wanted logic to organize secular inquiry. As Zupko notes, in this way Buridan's scholastic project seems to prefigure the "modern." But Buridan seems modern in another way as well. As Zupko points out in his "Introduction," though a cleric, Buridan never joined a religious order, so that his ideas developed independently of the Franciscan and Dominican traditions. He was, then, a teacher without a tradition—at least without deliberate allegiance to tradition, although he was in many ways the product of traditional scholastic intellectual discipline.Perhaps this... (shrink)

This article attempts to provide a summary of the European and Greek philosophy of the 16th century, so that the contribution of the two Zygomalas to philosophical education can be evaluated along with the philosophical preferences of their cycle. Contributions of this study would be considered the restoration of incorrect positions in the bibliography concerning the doctor-philosopher Leonardo Mindonios and the analysis of the philosophical corpus in Istanbul in the second half of the 16th century.

Although current educational priorities tend to avoid strong moral positions, one of the world's most venerable yet persistently influential moral traditions not only lays out a number of major moral principles but also incorporates them into its pedagogy. Confucius teaches us about the importance of seeking knowledge, learning how to learn, applying ancient wisdom to contemporary situations, valuing virtue over material gain, following the Golden Rule, and living by our principles. He also has ways of assessing his own students' progress (...) in these matters. Confucius' pedagogy is an interesting model to consider and contrast with contemporary models. This chapter introduces these principles and assessments from the Analects and draws out some comparisons to and contrasts with two alternative theories in western moral thought, Augustine and John Dewey. -/- The accepted version of the paper is included here. Pagination does not match the published version. (shrink)

It may come as a surprise to readers familiar with the life and work of the Arts Master that he discusses the Eucharist at all. As he likes to remind us, theological topics are generally out of his wheelhouse. Even so, in his Questions on the “Metaphysics” of Aristotle (QM) 4.6, Buridan takes the sacrament of the Eucharist as a key data point in his discussion of Aristotle’s Categories. In the Eucharist, the accidents of the bread and wine—their color, texture, (...) and so on—remain intact, but the underlying substance is transubstantiated into the body and blood of Christ. Accordingly, God can preserve accidents independent of their underlying substance. Therefore, for our part we can use accidental terms, like whiteness, without connoting any substances, like communion bread. Moreover, it follows that, contrary to Aristotle, substance and the accidental categories are not the most general genera. Instead, being (ens) is, as Buridan concludes. Here, I trace Buridan’s thought on the metaphysical and semantic matters of substance in light of the Eucharist. The Eucharist is for him not only a theological truth, but a metaphysical and semantic datum as well. I conclude by asking why Buridan did not take any and all questions about the Eucharist to be out of his ken. What does this tell us about his attitude toward theology? This paper also includes, as an appendix, the first ever English translation of the question under discussion (QM 4.6): “Does the term being (ens) signify substances and accidents by one single concept or notion?”. (shrink)

Materialism, reductionism, behaviorism, functionalism, dynamic systems theory and computationalism are popular views, but they were shown by Wittgenstein and more recently by Searle to be incoherent. The study of behavior encompasses all of human life but behavior is largely automatic and unconscious and even the conscious part, mostly expressed in language (which Wittgenstein equates with the mind), is not perspicuous, so it is critical to have a framework which Searle calls the Logical Structure of Rationality (LSR) and I call the (...) Descriptive Psychology of Higher Order Thought (DPHOT). After summarizing the framework worked out by Wittgenstein and Searle, as extended by myself and by modern reasoning research, I comment on this first book in a trilogy on Human Nature by P.M.S. Hacker, the leading authority on Wittgenstein and one of the best modern philosophers. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems view may consult my book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle’ 2nd ed (2019). Those interested in more of my writings may see ‘Talking Monkeys--Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet--Articles and Reviews 2006-2019 3rd ed (2019), The Logical Structure of Human Behavior (2019), and Suicidal Utopian Delusions in the 21st Century 4th ed (2019) . (shrink)

Materialism, reductionism, behaviorism, functionalism, dynamic systems theory and computationalism are popular views, but they were shown by Wittgenstein to be incoherent. The study of behavior encompasses all of human life but behavior is largely automatic and unconscious and even the conscious part, mostly expressed in language (which Wittgenstein equates with the mind), is not perspicuous, so it is critical to have a framework which Searle calls the Logical Structure of Rationality (LSR) and I call the Descriptive Psychology of Higher Order (...) Thought (DPHOT). After summarizing the framework worked out by Wittgenstein and Searle, as extended by modern reasoning research, I comment on this first book in a trilogy on Human Nature by the leading authority on Wittgenstein. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems view may consult my article The Logical Structure of Philosophy, Psychology, Mind and Language as Revealed in Wittgenstein and Searle 59p(2016). For all my articles on Wittgenstein and Searle see my e-book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Wittgenstein and Searle 367p (2016). Those interested in all my writings in their most recent versions may consult my e-book Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2016 662p (2016). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX . (shrink)

The paper presents a preliminary estimation of the extent of dissemination of optical texts, ideas, and issues among the masters connected with the Prague faculty of arts in the late 14th and early 15th century. Investigation of this topic, so far rather neglected, is based chiefly on manuscript research. The paper brings evidence that perspectiva was taught in Prague at least since the 1370s. It suggests that investigation of Prague quodlibetal disputations (ca. 1390s – 1410s) and consideration of perspectivist (...) authorities employed in these texts can also shed some light on the issue. However, the paper is mainly devoted to the question on the mechanism of vision disputed by Bohemian arts master John of Borotín (Iohannes de Borotin, 1378 – after 1458) in the quodlibet organised by John Hus in 1411. It is suggested that the single extant exemplar of the question (preserved in the codex Prague, National Library, X.H.18) probably is Borotín’s autograph. The structure and sources of the question are analysed, with the conclusion being that Borotín proposes a compromise between intromission and extramission influenced by John Peckham’s Perspectiva communis. A critical edition of Borotín’s question is appended to the paper. / / / Please note this article is published with Brepols Publishers as a Gold Open Access article under a Creative Commons CC 4.0: BY-NC license. The article is also freely available on the website of Brepols Publishers under this same license. (shrink)

This article examines an uncommon materialist argument preserved in late medieval Prague quodlibets by Matthias of Knín (1409) and Prokop of Kladruby (1417). The argument connects the Galenic claim that the human body has the noblest and best-balanced complexion possible with the Alexandrist claim that the human rational soul emerges from such well-balanced matter without any supernatural intervention. Of the various medieval renderings of these claims, John Wyclif’s De compositione hominis is singled out as the most probable source of (...) the argument. Far from attributing plain materialism to Wyclif, the article highlights a semimaterialist position, mentioned in two fifteenth-century De anima commentaries of Prague origin, grafting the immortal spirit postulate onto an Alexandrist-like doctrine of the intellect as educed from the harmoniously complexioned body. Finally, it is argued that this semimaterialist position may not only encapsulate how Bohemian masters read Wyclif, but also be close to Wyclif’s actual anthropological stance. (shrink)

This collection of articles was written over the last 10 years and the most important and longest within the last year. Also I have edited them to bring them up to date (2016). The copyright page has the date of this first edition and new editions will be noted there as I edit old articles or add new ones. All the articles are about human behavior (as are all articles by anyone about anything), and so about the limitations of having (...) a recent monkey ancestry (8 million years or much less depending on viewpoint) and manifest words and deeds within the framework of our innate psychology as presented in the table of intentionality. As famous evolutionist Richard Leakey says, it is critical to keep in mind not that we evolved from apes, but that in every important way, we are apes. If everyone was given a real understanding of this (i.e., human ecology and psychology) in school, maybe civilization would have a chance. -/- In my view these articles and reviews have many novel and highly useful elements, in that they use my own version of the recently (ca. 1980’s) developed dual systems view of our brain and behavior to lay out a logical system of rationality (personality, psychology, mind, language, behavior, thought, reasoning, reality etc.) that is sorely lacking in the behavioral sciences (psychology, philosophy, literature, politics, anthropology, history, economics, sociology etc.). The philosophy centers around the two writers I have found the most important, Ludwig Wittgenstein and John Searle, whose ideas I combine and extend within the dual system (two systems of thought) framework that has proven so useful in recent thinking and reasoning research. As I note, there is in my view essentially complete overlap between philosophy, in the strict sense of the enduring questions that concern the academic discipline, and the descriptive psychology of higher order thought (behavior). Once one has grasped Wittgenstein’s insight that there is only the issue of how the language game is to be played, one determines the Conditions of Satisfaction (what makes a statement true or satisfied etc.) and that is the end of the discussion. -/- Now that I think I understand how the games work I have mostly lost interest in philosophy, which of course is how Wittgenstein said it should be. But since they are the result of our innate psychology, or as Wittgenstein put, it due to the lack of perspicuity of language, the problems run throughout all human discourse, so there is endless need for philosophical analysis, not only in the ‘human sciences’ of philosophy, sociology, anthropology, political science, psychology, history, literature, religion, etc., but in the ‘hard sciences’ of physics, mathematics, and biology. It is universal to mix the language game questions with the real scientific ones as to what the empirical facts are. Scientism is ever present and the master has laid it before us long ago, i.e., Wittgenstein (hereafter W) beginning principally with the Blue and Brown Books in the early 1930’s. -/- "Philosophers constantly see the method of science before their eyes and are irresistibly tempted to ask and answer questions in the way science does. This tendency is the real source of metaphysics and leads the philosopher into complete darkness." (BBB p18) -/- Nevertheless, a real understanding of Wittgenstein’s work, and hence of how our psychology functions, is only beginning to spread in the second decade of the 21st century, due especially to P.M.S. Hacker (hereafter H) and Daniele Moyal-Sharrock (hereafter DMS),but also to many others, some of the more prominent of whom I mention in the articles. -/- When I read ‘On Certainty’ a few years ago I characterized it in an Amazon review as the Foundation Stone of Philosophy and Psychology and the most basic document for understanding behavior, and about the same time DMS was writing articles noting that it had solved the millennia old epistemological problem of how we can know anything for certain. I realized that W was the first one to grasp what is now characterized as the two systems or dual systems of thought, and I generated a dual systems (S1 and S2) terminology which I found to be very powerful in describing behavior. I took the small table that John Searle (hereafter S) had been using, expanded it greatly, and found later that it integrated perfectly with the framework being used by various current workers in thinking and reasoning research. -/- Since they were published individually, I have tried to make the book reviews and articles stand by themselves, insofar as possible, and this accounts for the repetition of various sections, notably the table and its explanation. I start with a short article that presents the table of intentionality and briefly describes its terminology and background. Next, is by far the longest article, which attempts a survey of the work of W and S as it relates to the table and so to an understanding or description (not explanation as W insisted) of behavior. -/- The key to everything about us is biology, and it is obliviousness to it that leads millions of smart educated people like Obama, Chomsky, Clinton and the Pope to espouse suicidal utopian ideals that inexorably lead straight to Hell On Earth. As W noted, it is what is always before our eyes that is the hardest to see. We live in the world of conscious deliberative linguistic System 2, but it is unconscious, automatic reflexive System 1 that rules. This is Searle’s The Phenomenological Illusion (TPI), Pinker’s Blank Slate and Tooby and Cosmides Standard Social Science Model. Democracy and equality are wonderful ideals, but without strict controls, selfishness and stupidity gain the upper hand and soon destroy any nation and any world that adopts them. The monkey mind steeply discounts the future, and so we sell our children’s heritage for temporary comforts. -/- The astute may wonder why we cannot see System 1 at work, but it is clearly counterproductive for an animal to be thinking about or second guessing every action, and in any case there is no time for the slow, massively integrated System 2 to be involved in the constant stream of split second ‘decisions’ we must make. As W noted, our ‘thoughts’ (T1 or the thoughts of System 1) must lead directly to actions. It is my contention that the table of intentionality (rationality, mind, thought, language, personality etc.) that features prominently here describes more or less accurately, or at least serves an heuristic for how we think and behave, and so it encompasses not merely philosophy and psychology but everything else (history, literature, mathematics, politics etc.). Note especially that intentionality and rationality as I (along with Searle, Wittgenstein and others) view it,includes both conscious deliberative System 2 and unconscious automated System 1 actions or reflexes. -/- Thus all the articles, like all behavior, are intimately connected if one knows how to look at them. As I note, The Phenomenological Illusion (oblivion to our automated System 1) is universal and extends not merely throughout philosophy but throughout life. I am sure that Chomsky, Obama, Zuckerberg and the Pope would be incredulous if told that they suffer from the same problem as Hegel, Husserl and Heidegger, but it’s clearly true. While the phenomenologists only wasted a lot of people’s time, they are wasting the earth. -/- My writings are available in updated versions as paperbacks and Kindles on Amazon. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) ASIN B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) ASIN B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) 2nd printing with corrections (Feb 2018) ASIN B0711R5LGX -/- Suicide by Democracy: an Obituary for America and the World (2018) ASIN B07CQVWV9C . (shrink)

In this paper we will explore how the action of signs underlying all human experience precludes the possibility that we are being systematically deceived in our perception of reality. The simulation hypothesis, as well as similarly motivated skeptical scenarios, such as the brain-in-a-vat hypothesis and Descartes’ evil demon thought experiment, wrongly presuppose a modern, dualistic theory of knowledge, as well as a neuroreductionist model of sensation. However, we will see how the action of signs in human cognition presupposes the existence (...) of a relational mode of being, namely, esse intentionale (“intentional being”), which is immaterial and incapable of subjection to technological manipulation. Furthermore, sensation, the origin of all human knowledge, and ens primum cognitum (“being as first known”), the condition of all human knowledge, both defy materialistic explanations. The doctrine of signs, as masterfully articulated by John Poinsot (John of St. Thomas), recognizes the triadic nature of relations underlying the full range of human experience. A proper understanding of the relationship between mind and world, as well as a recognition of the mistaken presuppositions underlying much of modern philosophy, will help to disillusion those who are convinced by the simulation hypothesis and other similarly motivated skeptical scenarios. (shrink)

The aim of the 17 original papers here is to summarize and analyze Wittgenstein's thought. At the time these were being written, the Oxford/Intelex CDROM ($2040 on Amazon but available thru interlibrary loan and steeply discounted on the net) with 20,000 some pages of W's nachlass was not yet available, and only those fluent in German and willing to find and slog thru the incomplete Cornell microfilm were able to examine it. To this day it much of it remains untranslated (...) from the German typescripts and handwritten manuscripts. I note this at the outset as W's untranslated or unpublished writings often shed crucial light on his thought and few to this day have made substantial use of them. In addition there are huge problems with translation of his early 20 th century Viennese German into modern English. One must be a master of English, German, and Wittgenstein in order to do this and very few are up to it. Several of the current authors note unfortunate translation errors in the only available English editions and I have seen similar comments countless times. As is well known, W's thought changed dramatically between the publication of the Tractatus (TLP) in 1922 and the Philosophical Investigations(1953). The continuity or lack thereof between his early and late work is the subject of a vast literature and is taken up here by several authors. Ishiguro on the picture theory and Mounce on the logical system in TLP are good, but for me the endless discussions of exactly how he was mistaken in his early work is of as little interest as the mistakes in most previous philosophy. Ammereller on Intentionality is a good, if prosaic, summary of (mostly) the early and middle W on belief and interpretation which, like virtually everyone, totally fails to give an adequate overview of W's pioneering work. In giving the general outline of our innate evolutionary psychology (ie, roughly our personality) and showing how this describes behavior, W represents a major milestone in human thought. There are unmistakeable indications of this even in his early writings (eg, see p 40, 49-58 here) and it has been documented by Hacker (eg, see his paper in The New Wittgenstein) and others but without any comprehensive account to date.Overall an exceptional book for introducing W to a general philosophical audience. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems view may consult my book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle’ 2nd ed (2019). Those interested in more of my writings may see ‘Talking Monkeys--Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet--Articles and Reviews 2006-2019 3rd ed (2019), The Logical Structure of Human Behavior (2019), and Suicidal Utopian Delusions in the 21st Century 4th ed (2019). (shrink)

In their pioneering, masterly research and survey on Bartolomeo Fonzio’s manuscripts, published in 1974, Stefano Caroti and Stefano Zamponi informed the reader that the Ms. Ricc. 152 of the Riccardiana Library in Florence was a huge amount of notebooks with notes taken by Fonzio while attending the Studium in Florence. Among them Caroti and Zamponi called the reader’s attention to the notes Fonzio took when he went to Argyropoulos’ lessons on the Posterior Analytics. In this essay the reader finds a (...) transcription of those notes, preceded by some comments on the sources from which the outstanding commentator is likely to have drawn and which can be picked out from the fragmentary notes, that is John Philoponus and Paul of Venice. (shrink)

Non-cognitivists claim that thick concepts can be disentangled into distinct descriptive and evaluative components and that since thick concepts have descriptive shape they can be mastered independently of evaluation. In Non-Cognitivism and Rule-Following, John McDowell uses Wittgenstein’s rule-following considerations to show that such a non-cognitivist view is untenable. In this paper I do several things. I describe the non-cognitivist position in its various forms and explain its driving motivations. I then explain McDowell’s argument against non-cognitivism and the Wittgensteinian considerations (...) upon which it relies, because this has been sufficiently misunderstood by critics and rarely articulated by commentators. After clarifying McDowell’s argument against non-cognitivism, I extend the analysis to show that commentators of McDowell have failed to appreciate his argument and that critical responses have been weak. I argue against three challenges posed to McDowell, and show that the case of thick concepts should lead us to reject non-cognitivism. (shrink)

The paper delves into manuscript sources connected with various disputations held at Prague University from around 1390 to 1420 and singles out a set of hitherto unknown quaestiones dealing with the nature of the human intellect and its relation to the body. Prague disputations from around 1400 arguably offer a unique vantage point on late medieval anthropological issues, since they encompass an entanglement of numerous doctrinal influences from Buridanian De anima commentaries to John Wyclif’s theories. The paper delineates several (...) conceptual tensions regarding the nature of the intellect, e.g., between materialism (entailed by the emphasis on the intellect’s inherence in the body) and personal immortality. It presents several strategies Prague masters employed to overcome these tensions. For example, an anonymous participant of the 1409 quodlibet develops the Buridanian distinction between the rationally demonstrable materialist tendency and the indemonstrable “catholic truth” about the intellect both inhering in and separable from the body. On the other hand, Wyclif’s adherents (Jacob of Mies and another anonymous master) postulate an immortal spirit hypostatically united to each human being beside the human soul educed from the potency of the matter. Yet, the boundaries between the doctrinal standpoints in question seem permeable, whereby a rigid definition of antagonistic groups in late medieval Prague intellectual milieu (e.g., Buridanians vs Wycliffites) is rendered ineffective. (shrink)

Consider a game of blind chess between two chess masters that is recorded in some standard chess notation. The recording is a representation of the game. But what is the game itself? This question is, we believe, central to the entire domain of social ontology. We argue that the recorded game is a special sort of quasi-abstract pattern, something that is: (i) like abstract entities such as numbers or forms, in that it is both nonphysical and nonpsychological; but at (...) the same time, (ii) through its association with specific players and a specific occasion, tied to time and history. We discover other abstract patterns of this sort especially in the domains of law and commerce. This essay draws on the work in social ontology, we of Hernando de Soto and of John Searle to develop an ontology of the social world based on an analysis of the peculiar interdependence between quasi-abstract patterns and their representations in documents of different sorts. (shrink)

This paper introduces a new, expanded range of relevant cognitive psychological research on collaborative recall and social memory to the philosophical debate on extended and distributed cognition. We start by examining the case for extended cognition based on the complementarity of inner and outer resources, by which neural, bodily, social, and environmental resources with disparate but complementary properties are integrated into hybrid cognitive systems, transforming or augmenting the nature of remembering or decision-making. Adams and Aizawa, noting this distinctive complementarity argument, (...) say that they agree with it completely: but they describe it as “a non-revolutionary approach” which leaves “the cognitive psychology of memory as the study of processes that take place, essentially without exception, within nervous systems.” In response, we carve out, on distinct conceptual and empirical grounds, a rich middle ground between internalist forms of cognitivism and radical anti-cognitivism. Drawing both on extended cognition literature and on Sterelny’s account of the “scaffolded mind” (this issue), we develop a multidimensional framework for understanding varying relations between agents and external resources, both technological and social. On this basis we argue that, independent of any more “revolutionary” metaphysical claims about the partial constitution of cognitive processes by external resources, a thesis of scaffolded or distributed cognition can substantially influence or transform explanatory practice in cognitive science. Critics also cite various empirical results as evidence against the idea that remembering can extend beyond skull and skin. We respond with a more principled, representative survey of the scientific psychology of memory, focussing in particular on robust recent empirical traditions for the study of collaborative recall and transactive social memory. We describe our own empirical research on socially distributed remembering, aimed at identifying conditions for mnemonic emergence in collaborative groups. Philosophical debates about extended, embedded, and distributed cognition can thus make richer, mutually beneficial contact with independently motivated research programs in the cognitive psychology of memory. (shrink)

Tradução para o português da "Dissertation on passions", de David Hume. Tradução realizada com base nas seguintes edições: 1. Four Dissertations/ David Hume, edited by John Immerwahr. (Facsimile da edição de 1757 publicada por A. Millar, Thoemmes Press, 1995); 2. A Dissertation on the passions ; The natural history of religion : a critical edition /David Hume; edited by Tom L. Be auchamp. (The Clarendon Edition of the Works of David Hume. Oxford: Ox ford University Press, 2007); 3. The (...) Complete Works of David Hume . 1882-1886, edited by Green T.H. & Grose, T. H. (Edição eletrônica in CD-ROM, Série “Past Masters”. Charlottesville : InteLex Corporation, 1992). A paginação entre // corresponde à paginação da edição de 1757, reproduzida na edição da Thoemmes Prees, 1995, editad a por John Immerwahr. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Newton's Metaphysics: Essays by Eric SchliesserMarius StanEric Schliesser. Newton's Metaphysics: Essays. Oxford: Oxford University Press, 2021. Pp. 328. Hardback, $99.90.Newton owes his high regard to the quantitative science he left us, but his overall picture of the world had some robustly metaphysical threads woven in as well. Posthumous judgment about the value of these threads has varied wildly. Christian Wolff thought him a metaphysical rustic, as did Hans (...) Reichenbach some two centuries later ("Die Bewegungslehre bei Newton, Leibniz und Huygens," Kant-Studien 29 [1924]: 416–38). In the 1960s, the tide would turn, as Howard Stein and James Edward McGuire separately began to show that Newton's metaphysics was not just sophisticated, but often more compelling than its early modern alternatives (see respectively "Newtonian Spacetime," Texas Quarterly 10 [1967]: 174–200; and Tradition and Innovation: Newton's Metaphysics of Nature [Dordrecht: Kluwer Academic Publishers, 1995]). Eric Schliesser's book unfolds in that same register of appreciative, high scholarship, and it attests to the enduring attraction of its subject.The book grew out of previous discrete papers, to which he added a few more for this occasion. Accordingly, it does not come with a master argument. Rather, it is an in-depth exploration of some key metaphysical themes in Newton. As such, it befits its subject figure, who reflected on themes and concepts while stopping short of working out systems.The first major theme is Newton and Spinozism. The latter does not denote Spinoza's metaphysics. In fact, Schliesser explains, Newton shared with Spinoza some weighty commitments, for example, to space being actually infinite, and to substance monism: "for Newton, there is strictly speaking only one genuine substance," namely, God (33). Rather, "Spinozism" is an interpreter's category for a bundle of three theses: identifying God and nature; denying final causation in the physical world; and the assumption of "blind" metaphysical necessity. Some counted Hobbes and John Toland as Spinozist in this sense, and even Epicurus, avant la lettre. Newton and his followers argued vehemently against this package, as Schliesser shows in chapters 4, 5, and 8. Their chief complaint was that Spinozism is unable to account for the "origin of motion," for a certain type of order, and for the stability of cosmological structure—and to do so in a way that "meets the standards of Newtonian mechanics" (122). This interpretive lens allows Schliesser to draw Kant in, by reading his youthful Theory of Heaven as a possible Spinozist reply to their objections (chapter 3). [End Page 157]A second theme is the metaphysics of mechanics, where Schliesser weaves together several strands. One is the ontology of gravity, for which he offers a novel construal: for Newton, gravity counts as real, but in a qualified sense. Namely, it is not essential and not intrinsic: "even after creation, a lonely partless particle of matter in the universe would not be said to gravitate." And gravity is relational: a "shared quality" of two or more bits of matter, which obtains in virtue of their sharing a nature (19). Another strand is Newton's ontology of time—really, a subtle, difficult topic long neglected. Famously, Newton in Principia defends absolute, true, and mathematical time. The question is what these three qualifiers denote, and whether Newton thought they were synonymous. Schliesser in chapter 7 argues for the provocative view that "absolute" and "true" time are not identical concepts; rather, they pick out different entities. These entities share a common structure, namely, metric and topological. That makes them species of "mathematical" time (179). But, Schliesser contends, Newton has unequal warrant for his two concepts of time.Yet another theme is formal causation. It comes to the fore in chapter 5, which grapples with Newton's opaque idea that space is an "emanative effect." Schliesser explains that here, "emanation picks out a species of formal causation" (147), but in a novel, early modern sense that comes from Bacon, not Aristotle. If space has a formal cause, then so has its twin brother, time, the topic of chapter 7. God is their common formal cause. Then in chapter 6 (coauthored with Zvi Biener) Schliesser adds that, for Newton, laws... (shrink)

Mark Johnston (2016, 2017) has argued on ethical grounds against a wide variety of "naturalistic" world views, which imply 'in our close vicinity, there are many persisting things all ontologically on a par, very similar in their features and such that they come into being and cease to exist at various times'—'personites', for short. Johnston argues that if personites exist, their intrinsic properties are compatible with their being people and thus having moral status; but since moral status is an intrinsic (...) matter, this implies that personites enjoy the same kind of moral status as people, a conclusion which leads to various bizarre ethical consequences. In response, we defend the view that although personites exist, they lack moral status, and have intrinsic properties (including modal properties) which no person could have. We also isolate a different argument for the moral status of certain personites, based on the claim that they instantiate properties which 'person' could very easily have expressed; we show how this argument can be resisted by adopting a pluralistic semantics, on which predicates like 'person' and 'being with moral status' express many properties even at the actual world. (shrink)

The modality of normality distinguishes states of affairs which are normal from those which are abnormal. Existing work on the modality of normality assumes that it is a restriction of metaphysical modality. In this paper, we argue that this assumption is inappropriate and explore the consequences of abandoning it. -/- After preliminary discussion (§1), we introduce the dominant framework for reasoning about normality (§2) and argue that it ascribes implausibly strong structural properties to the modality. In its place, we propose (...) a new framework, which avoids this commitment (§§3-5). This account has a number of interesting features, which we explore in both an informal and formal setting. If correct, it implies that the modality of normality occupies a distinctive place in the space of modalities. Before concluding, we consider some of the wider implications of our account (§6), focusing on the role normality has played in epistemic theorizing. (shrink)

Isaac Newton is best known as a mathematician and physicist. He invented the calculus, discovered universal gravitation and made significant advances in theoretical and experimental optics. His master-work on gravitation, the Principia, is often hailed as the crowning achievement of the scientific revolution. His significance for philosophers, however, extends beyond the philosophical implications of his scientific discoveries. Newton was an able and subtle philosopher, working at a time when science was not yet recognized as an activity distinct from philosophy. He (...) engaged with the work of Rene Descartes and G.W. Leibniz, and showed sensitivity to the work of John Locke, Francis Bacon, Pierre Gassendi and Henry More, to name just a few. In his time, Newton was not perceived as a scientific outsider, but as an active and knowledgeable participant in philosophical debates.... (shrink)

It is widely affirmed that human beings have irreplaceable valuable, and that we owe it to them to treat them accordingly. Many theorists have been drawn to Kantianism because they think that it alone can capture this intuition. One aim of this paper is to show that this is a mistake, and that Kantianism cannot provide an independent rational vindication, nor even a fully illuminating articulation, of irreplaceability. A further aim is to outline a broadly Aristotelian view that provides a (...) more fitting theoretical framework for this appealing conception of human value. This critique of Kantianism extends to contemporary theorists with a broadly Kantian orientation, including Christine Korsgaard, Stephen Darwall and John Rawls. The problem with these views, at heart, is that they attempt to ground morality in respect alone. Yet it is love, not respect, that brings irreplaceability into view. The paper closes with a sketch of a virtue-theoretic theory that follows Aquinas in taking love to be a master virtue that refines the other virtues so as to ensure a continuous and practically efficacious sensitivity to the irreplaceable value of fellow human beings. (shrink)

Edwards’s views on the nature of the human will demonstrate his unique ability to unite philosophical rigor and theological fervor. Edwards was a staunch defender of the Reformed doctrines of absolute divine sovereignty and meticulous providence, but he was also a proponent of the intellectual tools and methods of early modern philosophy (and of John Locke in particular). His ultimate statement of his doctrinal position, Freedom of the Will, is the masterful result of these dual commitments.

In order to determine whether current (or future) machines have a welfare that we as agents ought to take into account in our moral deliberations, we must determine which capacities give rise to interests and whether current machines have those capacities. After developing an account of moral patiency, I argue that current machines should be treated as mere machines. That is, current machines should be treated as if they lack those capacities that would give rise to psychological interests. Therefore, they (...) are moral patients only if they have non-psychological interests. I then provide an account of what I call teleo interests that constitute the most plausible type of non-psychological interest that a being might have. I then argue that even if current machines have teleo interests, they are such that agents need not concern themselves with these interests. Therefore, for all intents and purposes, current machines are not moral patients. (shrink)

Synthetic organisms are at the same time organisms and artifacts. In this paper we aim to determine whether such entities have a good of their own, and so are candidates for being directly morally considerable. We argue that the good of non-sentient organisms is grounded in an etiological account of teleology, on which non-sentient organisms can come to be teleologically organized on the basis of their natural selection etiology. After defending this account of teleology, we argue that there are no (...) grounds for excluding synthetic organisms from having a good also grounded in their teleological organization. However, this comes at a cost; traditional artifacts will also be seen as having a good of their own. We defend this as the best solution to the puzzle about what to say about the good of synthetic organisms. (shrink)

A Confederacy of Dunces (Confederacy) by John Kennedy Toole portrays an interplay between competing definitions of humanism. The one school of humanism—called by some the Modernist Paradigm—saw the Italian Renaissance as the origin of nineteenth- and twentieth-century modernist views that celebrated science, technology, and individual human freedom. The other school, led by Paul Oskar Kristeller, sought to historicize humanism by establishing that Renaissance writers and thinkers were generally conservative and preserved the philosophical ideas of the medieval era. Kristeller was (...) the President of the Renaissance Society of America and was at the height of his influence at Columbia University during the late 1950s, when Toole studied for his Master’s degree there. The main character in Confederacy, Ignatius J. Reilly, presents a parody of Kristeller’s position, which he uses to critique modern society. Ignatius also plays the part of a child of the planetary god Saturn, both by acting out the ancient astrological tradition of associating Saturn with misfortune and disorder and by being a parody of the Renaissance concept of the Genius as a Child of Saturn begun by the Renaissance philosopher whom Kristeller studied most, Marsilio Ficino. Ignatius’s worldview is an antithesis of the Modernist Paradigm. Confederacy is critical of both Modernist humanism with its attendant materialism and its antithesis—Ignatius’s dysfunctional version of Kristeller’s Renaissance philosophy. When the community expels Ignatius as a scapegoat, Toole appears to gesture toward a dialectical synthesis of the two concepts of humanism in the novel’s happy ending. (shrink)

This paper addresses the foundations of Teleological Individualism, the view that organisms, even non-sentient organisms, are goal-oriented systems while biological collectives, such as ecosystems or conspecific groups, are mere assemblages of organisms. Typical defenses of Teleological Individualism ground the teleological organization of organisms in the workings of natural selection. This paper shows that grounding teleological organization in natural selection is antithetical to Teleological Individualism because such views assume a view about the units of selection on which it is only individual (...) organisms that are units of selection. However, none of the Conventionalist, Reductionist, or Multi-Level Realist theories serve to justify such an assumption. Thus, Teleological Individualism cannot be grounded in natural selection. (shrink)

Recent claims that artificial intelligence (AI) systems demonstrate “emergent abilities” have fueled excitement but also fear grounded in the prospect that such systems may enable a wider range of parties to make unprecedented advances in areas that include the development of chemical or biological weapons. Ambiguity surrounding the term “emergent abilities” has added avoidable uncertainty to a topic that has the potential to destabilize the strategic landscape, including the perception of key parties about the viability of nonproliferation efforts. To avert (...) these problems in the future, scientists, developers, policymakers, and other parties should take credible steps to strengthen the health of the scientific ecosystem around AI. (shrink)

Robust technological enhancement of core cognitive capacities is now a realistic possibility. From the perspective of neutralism, the view that justifications for public policy should be neutral between reasonable conceptions of the good, only members of a subset of the ethical concerns serve as legitimate justifications for public policy regarding robust technological enhancement. This paper provides a framework for the legitimate use of ethical concerns in justifying public policy decisions regarding these enhancement technologies by evaluating the ethical concerns that arise (...) in the context of testing such technologies on nonhuman animals. Traditional issues in bioethics, as well as novel concerns such as the possibility of moral status enhancement, are evaluated from the perspective of neutralism. (shrink)

This essay is an inquiry into John McDowell’s thinking on ‘subjectivity.’ The project consists in two parts. On the one hand, I will discuss how McDowell understands and responds to the various issues he is tackling; on the other, I will approach relevant issues concerning subjectivity by considering different aspects of it: a subject as a perceiver, knower, thinker, speaker, agent, person and (self-) conscious being in the world. The inquiry begins by identifying and resolving a tension generated by (...) the very idea of ‘rational animal’: human beings are at the same time natural and rational. Later the inquiry proceeds by considering how McDowell’s notion of ‘second nature’ enables us to be human subjects with many faces. By going through the diagnoses and responses of McDowell, two central problems in modern and contemporary philosophy – the narrow conception of nature and the Cartesian inner space model – are identified and repelled. In Episode N I first urge that we should leave room for a certain notion of ‘world.’ I further argue that mentality has many aspects, and to understand those aspects is to understand the many faces of human subject. In Episode Ⅰ the Aristotelian notion of ‘second nature’ is discussed in order to resolve the tension in the very idea of ‘rational animal.’ Later I reply to some worries about this maneuver, including the objection from Crispin Wright. Hans-Georg Gadamer’s distinction between world and environment is introduced and related to McDowell’s thinking. Episode Ⅱ discusses perception and knowledge; McDowell’s main target – the Cartesian inner space – is introduced and criticized. Barry Stroud’s and Simon Blackburn’s positions are evaluated. Later I connect the main theme of Mind and World to the present context; in particular, I discuss McDowell’s invocation of Donald Davidson and Immanuel Kant. And then I discuss a common accusation of idealism, and Robert Brandom’s accusation of ‘residual individualism.’ Episode Ⅲ concentrates on Saul Kripke’s Wittgenstein, arguing that the master thesis behind the rule-following paradox is a version of the inner space model, and that Kripke’s Wittgenstein is not Wittgenstein. Martin Kusch’s objections are answered; Michael Dummett’s demand of reductionism is rebutted. After this, I turn to Davidson’s ‘no language’ claim, and discuss to what extent McDowell agrees with him. In Episode Ⅳ I evaluate objections from Hubert Dreyfus concerning action and agency. I discuss how Dreyfus and Maurice Merleau-Ponty commit ‘the Myth of the Disembodied Intellect’ identified by McDowell. I answer Michael Ayer’s charge of intellectualism in passing. Later I bring in McDowell’s objections to Derek Parfit on personhood and to Davidson on the mind-body relation. In Episode Ⅴ I focus on consciousness and self-consciousness. McDowell applies his argument against Parfit to Kant, but Maximilian de Gaynesford dissents. I reply to his objections on McDowell’s behalf. I further connect this to McDowell’s attacks on the dualism of scheme and content. This leads to my McDowellian rejection to the existence of qualia, and further brings me to the debate between intentionalism and disjunctivism in the context of the argument from illusion. I argue against Tim Crane’s ways of conceiving issues about intentionalism and the argument from illusion. Varieties of disjunctivism are also discussed. In my Epilogue, I express my worry about McDowell’s notion of ‘self-determining subjectivity.’ According to McDowell, human freedom consists in causations in the space of reason, but as Richard Gaskin points out, a satisfying story of it is yet to be provided. I close this essay with some rough ideas about how to fill in the details of the McDowellian picture. (shrink)

Our environmental wrongdoings result in a moral debt that requires restitution. One component of restitution is reparative and another is remediative. The remediative component requires that we remediate our characters in ways that alter or eliminate the character traits that tend to lead, in their expression, to environmental wrongdoing. Restitutive restoration is a way of engaging in ecological restoration that helps to meet the remediative requirement that accompanies environmental wrongdoing. This account of restoration provides a new motivation and justification for (...) engaging in restorative practices in addition to the standard pragmatist justification and motivations. (shrink)

The Projectability Challenge states that a metaethical view must explain how ordinary agents can, on the basis of moral experience and reflection, accurately and justifiably apply moral concepts to novel situations. In this paper, we argue for two primary claims. First, paradigm nonnaturalism can satisfactorily answer the projectability challenge. Second, it is unclear whether there is a version of moral naturalism that can satisfactorily answer the challenge. The conclusion we draw is that there is an important respect in which nonnaturalism (...) holds an advantage over its most prominent naturalist rivals. The conclusion is interesting if only because it is widely assumed that naturalism has an easier time handling thorny problems in moral epistemology. We argue that there is at least one such problem of which this assumption is not true. (shrink)

In a number of works, James M. Buchanan set out a proposal for a ‘demogrant’— a form of universal basic income that applied the principles of generality and non discrimination to the tax and the transfer sides of the scheme and was to be implemented as a constitutional rule outside the realm of day-to-day politics. The demogrant has received surprisingly little scholarly attention, but this article locates it in Buchanan’s broader constitutional political economy project and shows it was a logical (...) application of his theoretical framework to the problem of inefficient and unfair welfare systems when reform to the basic institutions of majoritarian democracy was not forthcoming. The demogrant aims to end the problems of majority cycling and rent seeking that plague contemporary welfare states and therefore offers a model of welfare without rent seeking—a constitutional welfare state. We compare Buchanan’s demogrant model to other universal basic income and negative income tax models and consider the most important criticisms. We conclude that rescuing the demogrant model from relative obscurity would be a fruitful future task of applied constitutional political economy and public choice. (shrink)

The ability to form „images“ of our experiences with the world (imaging effect) and to adjust our drive and determination in accordance with those images (action effect) is what characterises men, as stipulated by Cassirer and subsequently confirmed by Langer and Krois. Special techniques are required to communicate to others the images of life and how we interpret them. The art as a technique does this masterly by presenting us the views of others on their experiences and wishes through aesthetic (...) experience. Therefore, it is necessary to analyse images not only with respect to their historical aspects based on experiences with the world but to emphasise their power to shape the future by their potential to affect our actions. - / - Die Fähigkeit „Bilder“ unserer Erfahrungen mit der Welt zu formen (Bildkraft) und unser Streben und Wollen (Tatkraft) nach ihnen auszurichten, das ist es, was den Menschen nach Cassirer – und nachfolgend auch nach Langer und Krois – auszeichnet. Voraussetzung dafür die Bilder des Lebens und das, was wir von ihnen halten, zu objektivieren und Anderen zu kommunizieren, bilden Techniken. Die Kunst als Technik ist darin eine Meisterin, indem sie uns über die ästhetische Erfahrung Anschauungen Anderer von ihren Erfahrungen und Wünschen, lebendig vor Augen zu führen vermag. Bei der Analyse von Bildern gilt es insofern nicht nur deren geschichtsträchtigen, auf Erfahrungen mit der Welt beruhenden Aspekte zu untersuchen, sondern vor allem auch deren zukunftsprägendes und damit unsere Tatkraft ansprechendes Potential. (shrink)

Understanding comes in a variety of forms. This essay argues for the unity of these forms, against the common tendency to view them as fundamentally heteronomous, or disunified. After identifying ten core features of genuine understanding, which enable an argument for the existence of two distinct types of understanding, theoretical and practical, the essay poses a dilemma for theories that view them as disunified. Subsequently, it develops and defends a general account of understanding in terms of conceptions. What unifies diverse (...) forms of understanding, on this account, is a generic cognitive structure—given by the notion of a noetic conception—that is realized in different ways in various cases. (shrink)

According to QBism, quantum states, unitary evolutions, and measurement operators are all understood as personal judgments of the agent using the formalism. Meanwhile, quantum measurement outcomes are understood as the personal experiences of the same agent. Wigner’s conundrum of the friend, in which two agents ostensibly have different accounts of whether or not there is a measurement outcome, thus poses no paradox for QBism. Indeed the resolution of Wigner’s original thought experiment was central to the development of QBist thinking. The (...) focus of this paper concerns two very instructive modifications to Wigner’s puzzle: One, a recent no-go theorem by Frauchiger and Renner, and the other a thought experiment by Baumann and Brukner. We show that the paradoxical features emphasized in these works disappear once both friend and Wigner are understood as agents on an equal footing with regard to their individual uses of quantum theory. Wigner’s action on his friend then becomes, from the friend’s perspective, an action the friend takes on Wigner. Our analysis rests on a kind of quantum Copernican principle: When two agents take actions on each other, each agent has a dual role as a physical system for the other agent. No user of quantum theory is more privileged than any other. In contrast to the sentiment of Wigner’s original paper, neither agent should be considered as in “suspended animation.” In this light, QBism brings an entirely new perspective to understanding Wigner’s friend thought experiments. (shrink)

Fideism, as a philosophical and theological view, is defined in various manners. Sometimes it is defined as the priority of faith over accounts of all kinds of cognition based on human reason. The Geneva reformer John Calvin (1509–1564) was a fideist, and he simultaneously admired Saint Augustine — traces of that admiration can be found very easy in the chief Calvin’s work Institutio christianae religionis. However, this does not mean that he shared Augustinian views on faith‑reason relations. John (...) Calvin adopted late‑Augustinian interests, and was especially concerned with the issue of predestination. The Geneva reformer was the author of the double predestination doctrine. The chief claim of this doctrine is that: God intended one part of humanity for salvation; and the other one for damnation. This conclusion was supported with numerous quotations from the Old and the New Testament, and followed from the accepted exegetic principle that all words of the Holy Scripture are to be understood literally. Calvin also acted selectively and did not take into account other passages of the Bible contrary to them in sense. These different, even contradictory words and quotations create an incoherent image of God, which Calvin left unexplained as one of God’s mysteries. According to this image, God is a petulant despot, who by his irrational will treats people with unequal measure. God has settled a priori who would be saved and who would be damned, so the will of concrete man to act well or badly is without importance. In consequence, God is responsible for the evil and sins committed by people. Calvin’s God is unfair because he is merciful for one man, but not for other one. In approving a voluntaristic image of God, Calvin started becoming, particularly in the doctrine of double predestination, an extreme fideist, much more than his master Augustine. However, in later decades (especially in the seventeenth century), Calvin’s version of Christianity gaverise a rebellion against the double predestination doctrine, first in the ranks of the Dutch Calvinistic theologians (Armenians), and later in the circles of the English philosophers (Cambridge Platonics). In the end, Calvinism became a compromised Christianity and essentially contributed to the development of deism and atheism in Western European Countries in the eighteenth century. (shrink)

Till just few decades ago, scholars used to use the label ‘Ockhamism’ to mark a turning-point in the history of mediaeval philosophy, above all in the history of natural philosophy. That turning-point was exemplified by the once so-called ‘Buridanian school’, today known simply as ‘Parisian school of natural philosophy’, whose leading representative was for sure John Buridan. But looking carefully at some crucial points of the Picard master’s idea of ‘nature’, concerning specifically the relationship between God and secondary causes (...) on one side, and the role played by free will, both the divine and the human one, on the other side, one will find out that Buridan’s ‘Ockhamism’ is at least questionable: Scotus’ modal logic is the conceptual framework, within which he redetermines the boundaries of natural laws, but the ‘pure ockhamist’ idea of the prevalence of the will on the intellect in God’s nature is the source of an image of the world in which voluntary behaviours and natural laws are intertwined. Therefore, Buridan’s natural philosophy results as a peculiar synthesis of two of the main divergent lines of thinking of late mediaeval philosophy. (shrink)

HORMÔNIOS E SISTEMA ENDÓCRINO NA REPRODUÇÃO ANIMAL -/- OBJETIVO -/- As glândulas secretoras do corpo são estudadas pelo ramo da endocrinologia. O estudante de Veterinária e/ou Zootecnia que se preze, deverá entender os processos fisio-lógicos que interagem entre si para a estimulação das glândulas para a secreção de vários hormônios. -/- Os hormônios, dentro do animal, possuem inúmeras funções; sejam exercendo o papel sobre a nutrição, sobre a produção de leite e sobre a reprodução, os hormônios desempenham um primordial papel (...) quanto ao funcionamento do animal. -/- Nesse capítulo, o estudante identificará os hormônios relevantes para o controle reprodutivo, suas características e o uso clínico dos mesmos. -/- -/- INTRODUÇÃO -/- A endocrinologia é a ciência que se encarrega do estudo do sistema endócrino: um sistema de comunicação entre as células de um organismo; esse trabalho de comunicação é compartilhado com o sistema nervoso já que ambos sistemas possuem características distintas que lhes permite complementar-se para alcançar uma adequada coordenação das funções. Em algumas ocasiões o sistema nervoso e o sistema endócrino interagem direta-mente na transmissão de uma mensagem, pelo qual se conhece como sistema neuroendó-crino. -/- -/- OS HORMÔNIOS -/- A endocrinologia é a ciência que se encarrega do estudo dos hormônios e seus e-feitos. De maneira tradicional os hormônios são considerados como “substâncias secreta-das em direção a circulação pelas glândulas especializadas, e que exercem uma função sobre um órgão branco”. Essa definição, no entanto, é limitada e imprecisa. É necessário ser mais pontual, já que os hormônios não são produzidos em qualquer célula da glândula, senão nas células específicas. Por exemplo, o hormônio luteinizante (LH) é produzido pelos gonadotropos da adenohipófise e não por qualquer outro tipo de célula hipofisária. Da mesma maneira, falar de um “órgão branco” não é exato, já que os hormônios atuam somente nas células que tenham receptores específicos para esse hormônio, e não outras células do mesmo órgão; logo, falar de uma “célula branca” é mais apropriado que falar de um “órgão branco”. As células brancas do LH no testículo são as células de Leydig e as células brancas do hormônio folículo estimulante (FSH) no mesmo órgão são as células de Sertoli. -/- Mediante o supracitado, uma definição mais apropriada de hormônio é a seguinte: “Os hormônios são reguladores biológicos, produzidos e secretados em quantidades pe-quenas pelas células vivas, que depois de viajar pelo meio extracelular atuam sobre as cé-lulas brancas, onde exercem uma ação específica”. -/- É importante levar em conta que os hormônios somente regulam (estimulam ou inibem) funções que já existem na célula branca. Ademais, os hormônios são extraordina-riamente potentes, pelo qual se requerem quantidades muito pequenas para induzir uma resposta na célula. As concentrações circulantes da maioria dos hormônios estão na ordem de nanogramas (10-9 g) ou pictogramas (10-12 g) por mililitro. -/- Etimologicamente o termo “endócrino” significa “secretar em direção adentro”, já que os hormônios são secretados em direção ao interior do organismo (o sangue ou o espaço intracelular), em diferença das secreções exócrinas (em direção ao exterior), que são secretadas em direção a luz de um órgão, como o intestino no caso das enzimas pan-creáticas. -/- Algumas substâncias, sem deixar de ser hormônios, recebem uma classificação adicional em relação ao seu local de ação, ao tipo de células que lhes produzem, ou a al-guma outra característica. Agora, serão descritas algumas dessas características (figura 1). -/- -/- Parahormônio ou hormônio local -/- A maioria dos hormônios são transportados pela circulação desde seu local de se-creção até a célula branca. No entanto, alguns hormônios exercem seu efeito em células adjacentes aquelas que foram produzidos, ao qual não é necessário seu transporte através da circulação geral. Esse tipo de substâncias são chamadas de parahormônios ou hormô-nios locais, e sua liberação é denominada como secreção parácrina. Um exemplo é a pros-taglandina F2 alfa (PGF₂α), que é produzida no epitélio uterino (endométrio) e provoca as contrações nas células musculares do mesmo órgão (miométrio). Deve-se tomar em conta que a mesma substância poderia se comportar em outros casos como um hormônio clássico, atuando em um órgão distinto ao local de sua produção; é o caso da mesma PGF₂α de origem endometrial quando atua sobre as células do corpo lúteo do ovário, pro-vocando sua regressão. A classificação de uma substância como hormônio ou parahormô-nio não depende de sua estrutura química, senão da relação espacial existente entre a célu-la que o produz e a célula branca. -/- -/- Neurohormônio -/- A maioria dos hormônios são produzidos pelas células de origem epitelial, porém, muitos deles são produtos pelos neurônios, logo denominados como neurohormônios. To-dos os neurônios segregam alguma substância, porém tratam-se dos neurohormônios quando o neurônio que os produz despeja-os diretamente em direção a circulação geral, através da qual chegam aos órgãos para exercer seu efeito, sejam na indução, inibição ou estimulação do mesmo. -/- Esse processo é diferente dos neurotransmissores, os quais também são secretados por um neurônio, mas exercem seu efeito em uma célula adjacente com o qual o neurônio estabelece uma sinapse (neuroma com neurônio, neurônio com célula muscular, neurônio com célula glandular). A classificação de uma substância como hormônio ou como neuro-hormônio não depende de sua estrutura química, senão do tipo de célula que o produz. Uma mesma substância é um hormônio quando ele é produzido por uma célula epitelial e um neurohormônio se é produzido por um neurônio. A ocitocina, por exemplo, é secre-tada na neurohipófise por neurônios hipotalâmicos, nesse caso se trata de um neurohor-mônio, mas também é secretada por células do corpo lúteo dos ruminantes, e se trata nesse caso, de um hormônio. A distinção entre um neurohormônio e um hormônio é um neuro-transmissor, da mesma forma, não depende de sua estrutura química, e sim do local onde é secretado. Por exemplo, a dopamina atua como neurotransmissor quando se libera em sinapse da substância negra do mesencéfalo z mas atua como neurohormônio quando é liberada por neurônios hipotalâmicos em direção a circulação do eixo hipotálamo-hipofisário. -/- -/- Pré-hormônio -/- Em alguns casos, os hormônios são secretados em forma inativa (pré-hormônio), que requer uma transformação posterior para converter-se na forma ativa de hormônio. O angiotensinógeno circulante somente cobrará atividade biológica ao se transformar em angiotensina por ação da enzima renina. Algumas substâncias podem atuar como hormô-nios m alguns casos e como pré-hormônios em outros. A testosterona, por exemplo, atua como hormônio nas células musculares, aos quais possui um efeito anabólico direto. O certo é que para a testosterona induzir a masculinização dos órgãos genitais externos em um efeito macho é necessário que seja transformada previamente em 5α-di-hidrotes-tosterona pela enzima 5α-redutase presente nas células de tecido branco, por onde, nesse caso a testosterona é um pré-hormônio de di-hidrotestosterona. -/- -/- Feromônio -/- Os hormônios são mensagens químicas que comunicam a células distintas dentro do mesmo organismo, embora existam casos aos que requerem uma comunicação quími-ca entre organismos diferentes, em geral da mesma espécie. As substâncias empregadas para esse fim denominam-se feromônios. Essas substâncias devem possuir a capacidade de dispersão sobre o ambiente, pelo que nos organismos terrestres geralmente trata-se de substâncias voláteis, enquanto que os feromônios de organismos aquáticos geralmente são substâncias hidrossolúveis. Embora muitos feromônios possuam uma função sexual ou reprodutiva como é o caso de muitas espécies como a canina em que a fêmea em cio dispersa grandes quantidades de feromônios que são captados de longe pelos machos, todavia esse não é sempre o caso, e eles podem ser utilizados para outros tipos de comunicação, como é o caso dos feromônios utilizados pelas formigas para sinalização da rota em direção a fonte de alimentação. E como as abelhas no sentido de orientação da fonte de pólen até a colmeia. Muitos desses feromônios podem ser artificializados, isto é, elaborados pelo homem em laboratório para o estudo ou manipulação de algum animal. -/- -/- O SISTEMA ENDÓCRINO COMO UM SISTEMA DE COMUNICAÇÃO -/- O sistema endócrino é um sistema de comunicação que tem como objetivo coor-denar as funções das células de diferentes órgãos para mantença da homeostase do orga-nismo e promover seu desenvolvimento, crescimento e reprodução. Também ajuda os or-ganismos a adaptarem-se as mudanças de ambiente e ao habitat. O sistema endócrino representa um sistema de comunicação do tipo sem fio, diferentemente do sistema nervo-so que é um sistema de comunicação com fio. -/- Em todo o sistema de comunicação existe uma série de elementos que são necessá-rios para a realização da comunicação de forma efetiva. Esses elementos incluem o emis-sor, a mensagem, o sinal, o meio de transporte do sinal, o receptor, o efetor, a resposta e o feedback ou retroalimentação (figura 1). Todos os elementos são igualmente importan-tes e uma deficiência em qualquer deles pode interromper ou alterar a comunicação. -/- -/- Figura 1: componentes do sistema endócrino de comunicação. Fonte: ZARCO, 2018. -/- -/- Emissor ou transmissor -/- É o elemento responsável pela transmissão de uma mensagem; poderíamos com-pará-lo com a redação de notícias de um canal de televisão. Antes de decidir quais serão as notícias que serão transmitidas esse dia, em que ordem se apresentarão e que ênfase lhes darão, as pessoas da redação analisa rodas as informações disponíveis: provenientes de seus repórteres, de agências de notícias internacionais, publicada em jornais do dia, a existente na internet ou disponíveis através de redes sociais; isso significa que as mensa-gens transmitidas pelo emissor não são aleatórias, e sim respondem a uma análise respon-sável das necessidades de informação. -/- No sistema endócrino o emissor é a célula que produz e secreta um hormônio. Co-mo todo emissor responsável, a mesma célula analisa toda a informação relevante dispo-nível, tal como a concentração de diversos metabólitos no sangue, a concentração de ou-tros hormônios, e as mensagens que recebem por via nervosa, antes de decidir se secretará seu hormônio, em que quantidade o fará e com que frequência. Por essa razão, ao estudar o sistema endócrino não somente devemos conhecer a célula transmissora, e sim qual é a informação que a célula pode receber, e como a analisa e a prioriza para construir sua mensagem. -/- -/- Mensagem -/- É a informação transmitida pelo emissor. No caso de um sistema de notícias tele-visivas a mensagem é a notícia, por exemplo “Vaca dá a luz trigêmeos, um caso raro no Brasil”. No sistema endócrino a mensagem que se transmite é uma instrução para que em outra célula se realize determinadas ações. Por exemplo, os neurônios produtores de GnRH no hipotálamo de uma coelha, ao analisar as concentrações de estradiol circulantes e a informação nervosa procedente de neurônios sensoriais nós órgãos genitais da fêmea, podem “saber” que nos ovários existam folículos lisos para ovularem e que a coelha está copulando, pelo qual decidem transmitir a mensagem “Solicita-se os gonadotropos da adenohipófise a liberação de LH em quantidade suficiente para provocar a ovulação”. -/- -/- Sinal -/- É a forma a qual se codifica a mensagem para permitir sua difusão. No caso de um jornal, a mensagem (por exemplo a notícia da vaca que deu a luz trigêmeos) se codifi-ca em forma de ondas de rádio de uma determinada frequência, amplitude e intensidade; no caso do sistema endócrino a mensagem (a necessidade de realizar uma função celular) é codificada em forma de hormônio secretado em determinada quantidade, frequência e amplitude. Para o exemplo descrito supra, a mensagem se codifica na forma de uma grande elevação nas concentrações de GnRH no sangue do sistema porta hipotálamo-hipofisário. -/- É necessário tomar em conta que o emissor codifica a mensagem de forma tal que quando o receptor decifre o sinal obtenha a informação originalmente contida na mensa-gem. No entanto, o sinal pode ser interpretado de diferentes formas por receptores distintos, o que pode provocar respostas contrárias as esperadas. A notícia transmitida por um jornal de rádio, por exemplo, poderia estar codificada em forma de ondas de rádio que, casualmente, para o sistema eletrônico de um avião signifiquem “baixe a altitude e acelere”, razão pela qual é proibido utilizar aparelhos eletrônicos durante a decolagem e aterrissagem desses aparelhos. -/- Do mesmo modo, a mensagem codificada na forma de secreção de estradiol por parte dos ovários pode ser interpretado pelo sistema nervoso de uma ovelha como uma ordem para apresentar conduta de estro, pelas células do folículo ovariano como uma instrução para sofrer mitose e secretar o líquido folicular, pelos gonadotropos como uma ordem para a secreção de um pico pré-ovulatório de LH, e pelas células do endométrio como uma instrução para sintetizar receptores para a ocitocina. Dessa forma, o mesmo sinal (secreção de estradiol) pode conter diferentes mensagens para diferentes células do organismo. -/- Em alguns casos, pode-se apresentar uma resposta patológica devido as diversas formas de interpretação de uma mensagem, por exemplo, a repetição da secreção de adrenalina em um indivíduo estressado pode resultar no desenvolvimento de um proble-ma de hipertensão arterial. Por isso é necessário conhecer a maneira em que cada célula endócrina codifica suas mensagens, assim como a forma em que esses sinais podem ser interpretados em diferentes órgãos e tecidos, em diferentes momentos da vida do animal, em animais com diferentes antecedentes de espécies diferentes. -/- -/- Meio de transporte do sinal -/- O sinal tem que viajar ou difundir-se desde o emissor até o receptor, e em seu ca-minho pode ser modificado de diversas formas. Os sinais de rádio, por exemplo, viajam através da atmosfera e durante esse trajeto podem ser bloqueados por uma barreira física (como ocorre com as ondas de rádio AM em um túnel), ampliadas por uma estação repeti-dora, alteradas por um campo eletromagnético (uma aspiradora funcionando ao lado da sala de transmissão), entre outros. Da mesma forma, os sinais endócrinos que geralmente viajam no sangue, podem ser modificados ao longo do seu caminho. -/- A PGF₂α é inativada ao passar pelo pulmão, o angiotensinógeno é ativado pela re-nina na circulação, e a testosterona pode ser transformada em di-hidrotestosterona nas células da pele e na próstata, ou em estrógenos nos adipócitos e nos neurônios. Por tudo isso, o sinal que finalmente chega ao receptor pode ser diferente do transmitido pelo emissor. -/- Portanto, ao estudar qualquer sistema hormonal devemos conhecer as possíveis modificações que o hormônio pode sofrer desde o momento em que é secretado até que se uma ao seu receptor na célula branca. -/- -/- Receptor -/- É o elemento que recebe o sinal e interpreta a mensagem contida nele. No caso de um jornal de TV, o receptor é o canal correspondente (por exemplo o canal 2) em um aparelho de televisão. É importante ressaltar que um aparelho de TV possui muitos canais distintos, mas somente receberá mensagens se estiver ligado e sintonizado no canal que está transmitindo a mensagem de interesse. Ou seja, o receptor tem que estar ativo. -/- No caso das mensagens endócrinas os receptores são moléculas específicas nas células brancas. Essas moléculas são proteínas membranais ou citoplasmáticas (segundo o tipo de hormônio), que possui uma alta afinidade por seu hormônio, o que lhes permite registrar a mensagem apenas das baixíssimas concentrações em que os hormônios circu-lam. Os receptores possuem uma alta especificidade, o que significa que somente se unem a seu próprio hormônio, e não a outras substâncias. Em algumas ocasiões um receptor pode receber diversos hormônios do mesmo tipo; por exemplo o receptor de andrógenos pode unir testosterona, androstenediona, di-hidrotestosterona e diversos andrógenos sin-téticos. Apesar disso, cada um desses hormônios pode possuir uma afinidade diferente pelo receptor, pelo qual alguns serão mais potentes que outros para estimulação. -/- Em geral existe um número limitado de moléculas receptoras em cada célula, logo diz-se que os receptores são “saturáveis”, o qual significa que uma vez que todos sejam ocupados a célula não pode receber mais moléculas desse hormônio. Por essa razão a magnitude da resposta de um determinado hormônio vai aumentando conforme se aumen-tam suas concentrações, porém ao saturar-se os receptores alcançam um ponto em que a resposta já não aumenta embora sigam incrementando as concentrações hormonais já que os receptores não permanecem livres para unirem-se ao excesso de moléculas do hormô-nio. -/- As células, em contrapartida, podem regular tanto o número de receptores presen-tes como a afinidade destes por seu hormônio; isso significa que a magnitude da resposta antes um determinado sinal endócrino pode ser distinta em diferentes momentos da vida de um animal; depende do estado dos receptores presentes nos tecidos, pelo qual é impor-tante conhecer quais são os fatores que podem aumentar ou reduzir o número de recepto-res em uma célula, assim como aqueles que podem aumentar ou diminuir a afinidade des-ses receptores por seus hormônios. -/- -/- Efetor -/- É o elemento encarregado de responder a uma mensagem realizando uma ação, e é um elemento diferente do receptor. Vale ressaltar que no caso de uma transmissão de televisão o receptor é o aparelho sintonizado no canal de interesse, porém o efetor é o te-lespectador que está exposto as notícias. Esse telespectador sofrerá mudanças que podem resultar em uma ação. A mudança pode ser evidente (e auxiliar as vítimas de um desastre), ou simplesmente uma mudança potencial (ao se inteirar de uma notícia não se pode produ-zir nenhuma mudança aparente até que alguém lhe pergunte: já se interessou?, E nesse caso a resposta será: “sim” em lugar do “não”). Deve-se tomar em conta que o efetor pode estar ausente embora o receptor esteja presente (um televisor ligado em uma sala vazia). O efetor também pode estar inativado (o telespectador encontra-se dormindo); quando assim ocorre não irá produzir uma resposta embora o receptor esteja presente. -/- No sistema endócrino o efetor é, em geral, um sistema celular encarregado de rea-lizar uma determinada função. Na maioria dos casos trata-se de sistemas enzimáticos cuja função é estimulada pela união do hormônio ao seu receptor. Alguns hormônios, por exemplo, atuam através do sistema AMP cíclico (AMPc) logo, a união do hormônio ao seu receptor resulta na ativação de uma proteína chamada Proteína Gs, que ativa a enzima Adenil-ciclase (ou adenilato ciclase), a qual transforma ATP em AMPc. A presença de AMPc resulta na ativação de uma enzima cinese de proteínas que fosforiza outras enzi-mas, o que pode ativá-las ou inativá-las; nesses casos, é gerada uma cascata de eventos que resulta em uma mudança na atividade celular; por exemplo, a cadeia de eventos que produz-se em resposta ao AMPc quando a célula de Leydig do testículo é estimulada pela união do LH a seu receptor resulta na produção de testosterona, enquanto que a estimula-ção de um adipócito provocada pela união da adrenalina a seu receptor, que também atua através do sistema AMPc, resulta em uma série de eventos que provocam, finalmente, a liberação de ácidos graxos livres em direção a circulação. -/- Nos exemplos supra, o AMPc é considerado um mensageiro intracelular, já que o receptor capta o sinal (hormônio) no exterior da célula, o que resulta na produção de um novo sinal (mudança nas concentrações de AMPc) no interior da célula. Embora o sistema AMPc seja utilizado por muitos hormônios, não é um sistema universal; existem outros sistemas mensageiros intracelulares que também são utilizados para responder os hormô-nios que não entram nas células, por exemplo o sistema cálcio-calmodulina, ou os siste-mas baseados em receptores com atividade de cineses de tirosina. Nos casos que os hor-mônios possa atravessar livremente a membrana celular, como acontece com os hormôni-os esteroides, o hormônio se une a receptores presentes no citoplasma, que depois ingres-sam ao núcleo celular para intervir na regulação da transcrição do genoma. -/- De maneira independente ao mecanismo de ação de um determinado hormônio, sua presença finalmente desencadeará mudanças em um ou mais sistemas efetores da célula, o que permitirá que a mesma responda a mensagem que o emissor transmitiu originalmente. É evidente que para compreender a ação de qualquer hormônio é indispensável conhecer seu mecanismo de ação, o papel dos mensageiros intracelulares e as característi-cas dos sistemas efetores. Deve-se conhecer também quais são os fatores que afetam a transdução da mensagem já que uma célula pode regular seus sistemas efetores e dessa forma ter uma resposta maior, menor ou alterada ante a mesma mensagem. -/- -/- Resposta -/- Como mencionado, qualquer mensagem provoca uma resposta (embora somente seja potencial) sobre o efetor que a recebe. No sistema endócrino, as mensagens hormonais viajam constantemente pelo organismo e são captadas por todas as células que possuem receptores ativos para um determinado hormônio. Uma única célula pode ter receptores para diferentes hormônios, pelo qual pode estar recebendo diversas mensagens simultaneamente, e cada uma dessas mensagens pode afetar a resposta de outras mensagens. Por exemplo, a presença de progesterona pode alterar a resposta das células endometriais ao estradiol. Ademais, as células podem estar recebendo ao mesmo tempo uma informação não hormonal, como as concentrações de diversos metabólitos na circulação, ou a recebida pelo sistema nervoso. A célula analisa toda essa informação e com base nela decide se deve responder a mensagem hormonal que está recebendo como deve responder, com que intensidade e durante quanto tempo. A resposta final pode ser uma resposta física imediata (contração, secreção de um hormônio armazenado previa-mente), uma modificação bioquímica a curto prazo (síntese de um determinado hormônio ou outra substância), ou o início de uma série de mudanças que levam a uma mudança a longo prazo (divisão celular, diferenciação celular, crescimento, morte celular). -/- -/- Feedback ou retroalimentação -/- Quando em um sistema de comunicação se produz uma resposta, em muitos casos essa resposta engloba a geração de informação que vai retornar ao emissor, e que agora constituirá um ou mais dos elementos que o emissor tomará em conta antes de transmitir uma nova mensagem. Assim, se um jornal transmite uma mensagem “menina pobre necessita de doação de roupas”, a resposta de alguns efetores (telespectadores) que virão a doar roupas será conhecida pelo emissor, que assim saberá que já não será mais neces-sário voltar a transmitir a mensagem, o que o fará tomar a decisão de transmitir uma mensagem diferente como “menina pobre já não necessita de roupas, porém requer de ali-mentos para sua família”. Essa modificação da mensagem provocada pela resposta do efetor é conhecida como retroalimentação. -/- De forma análoga, no sistema endócrino a resposta da célula efetora geralmente é reconhecida pelo emissor, que em consequência modifica sua mensagem. Na maioria dos casos se produz uma retroalimentação negativa, que consiste em que a resposta do efetor provoca uma redução na intensidade da mensagem transmitida pelo emissor. Quando os gonadotropos de uma vaca secretam hormônio folículo estimulante (FSH), as células da granulosa de seus folículos ovarianos respondem realizando diversas funções, uma das quais é a secreção de inibina. A elevação nas concentrações circulantes de inibina é capta-da pelos gonadotropos, que logo sabem que o FSH já transmitiu sua mensagem, pelo que reduzem a secreção deste hormônio. A retroalimentação negativa é muito importante em qualquer sistema endócrino já que permite manter as concentrações hormonais dentro de limites aceitáveis. -/- A retroalimentação negativa pode ser de onda ultracurta, curta ou longa. A onda ultracurta é quando o hormônio produzido por uma célula pode inibir sua própria secre-ção. A retroalimentação negativa de onda curta é quando o hormônio produzido por uma célula pode inibir a de um órgão imediatamente superior na hierarquia (por exemplo, quando a progesterona produzida pelo corpo lúteo do ovário inibe a secreção de LH pelos gonadotropos da hipófise). O feedback negativo de onda longa sucede quando o hormônio produzido por uma célula inibe a uma célula de um órgão que está dois ou mais níveis por cima na escala hierárquica, por exemplo, quando a testosterona produzida pelas células de Leydig do testículo inibe diretamente os neurônios produtores de GnRH, saltando as células produtoras de LH e adenohipófise. -/- Existe também a retroalimentação positiva, da qual o primeiro hormônio estimula a secreção de um segundo hormônio, o que por sua vez estimula o primeiro, com o que se estabelece um círculo progressivo de estimulação. Um exemplo de retroalimentação positiva é a que se produz pouco antes da ovulação entre o LH hipofisário e o estradiol de origem folicular. Os dois hormônios se estimulam mutuamente até que alcancem níveis elevados de LH que provoca a ovulação. O círculo de feedback positivo termina quando o pico pré-ovulatório de LH mudanças sobre o folículo que incluem a perda da capacidade de produção de estrógenos. Todo o sistema de retroalimentação positiva deve ter um final abrupto sobre o qual se rompe o ciclo de estimulação mútua, já que não mais deverá ser produzida quantidades elevadas dos hormônios, até que todos os recursos do organismo sejam utilizados para esse fim. -/- -/- CLASSIFICAÇÃO QUÍMICA DOS HORMÔNIOS -/- Do ponto de vista químico e sobre o estudo da Fisiologia da Reprodução Animal, existem quatro grupos principais de hormônios: polipeptídios, esteroides, aminas e prostaglandinas; dentro de cada grupo, por sua vez, existem mais grupos de inúmeros outros hormônios dispostos em subdivisões. -/- -/- Hormônios polipeptídios -/- Os polipeptídios são cadeias de aminoácidos. Quando uma dessas cadeias está constituída por poucos aminoácidos é denominada simplesmente de polipeptídios, mas quando uma cadeia de aminoácidos é longa e adquire uma configuração espacial de três dimensões o polipeptídio é denominado proteína (figura 2). Muitos neurohormônios hipo-talâmicos são polipeptídios, como o liberador de gonadotropinas (GnRH), constituído por 10 aminoácidos, o hormônio liberador de tirotropina (TRH), formado por 3 aminoácidos, o somatostatina, constituído por 14 aminoácidos, a ocitocina que é formada por 8 aminoá-cidos etc. O sistema nervoso central e a hipófise produzem peptídeos opioides. -/- Entre os hormônios polipeptídios que por seu tamanho são considerados proteínas encontramos a prolactina, o hormônio do crescimento, os lactogênios placentários, a relaxina, a insulina e fatores de crescimento parecidos com a insulina (IGFs). Existe outro grupo de hormônios polipeptídios classificados como glicoproteínas. Trata-se de proteí-nas que possuem carboidratos unidos a alguns de seus aminoácidos. -/- -/- Figura 2: classificação dos hormônios polipeptídios. Fonte: ZARCO, 2018. -/- -/- Há um grupo de hormônios glicoproteicos que constituem uma família de molécu-las similares entre si, dentro das quais estão o hormônio luteinizante (LH), o hormônio folículo estimulante (FSH), o hormônio estimulante da tireoide (TSH), a gonadotropina coriônica humana (hCG) e a gonadotropina coriônica equina (eCG); todos estão formados pela subunidade alfa que é idêntica para os hormônios de uma determinada espécie animal, e por uma subunidade beta específica para cada hormônio. As duas subunidades mantém-se unidas através de ligações dissulfeto. Deve-se mencionar que os carboidratos associados as glicoproteínas podem ser distintos em diferentes idades, épocas do ano ou estados fisiológicos; esse processo é conhecido como microheterogenicidade, e recente-mente têm-se dado grande importância a seu estudo, já que é reconhecido fatores tais como a vida média de um hormônio ou sua atividade biológica podem ser modificados de acordo com o tipo de carboidratos presentes na molécula. -/- Existe outra família de hormônios glicoproteicos, que incluem a inibina A, a B, e a activina A, AB e B. Todos os hormônios polipeptídios possuem algumas características comuns. Em primeiro lugar, trata-se de moléculas hidrossolúveis que não conseguem atravessar as membranas celulares pelo qual se unem a receptores transmembranais que flutuam sobre a parede externa da membrana da célula branca e requerem de um segundo mensageiro intracelular, como o cálcio ou o AMPc, para levar sua mensagem ao interior da célula. -/- Os hormônios desse grupo, não podem ser administrados por via dérmica, oral, retal ou intravaginal, já que não podem atravessar a pela ou as mucosas intestinais, retais ou vaginais. Os polipeptídios são digeridos no estômago, o que também impede sua admi-nistração oral. Outra característica que deve-se tomar em conta é que as proteínas (embora não os polipeptídios pequenos) podem se desnaturalizar por fatores como o calor (são termolábeis), a congelação, ou mudanças de pH m a desnaturalização consiste em uma mudança na forma natural da proteína, o que leva a perda de sua função. Por essa razão, ao trabalhar com hormônios proteicos devem-se tomar cuidados especiais durante seu manejo para evitar a exposição a fatores desnaturalizantes. -/- -/- Hormônios esteroides -/- São moléculas derivadas do colesterol; a célula esteroidogênica pode sintetizar o colesterol, obtê-lo de reservas intracelulares ou da circulação. Na célula esteroidogênica existem diversas enzimas que atuam sequencialmente sobre a molécula de colesterol, provocando mudanças sucessivas até obter o hormônio final que será secretado, ao qual dependerá das enzimas que estão presentes e ativas na célula. -/- Existem cinco grupos principais de hormônios esteroides; os progestágenos, os estrógenos, os glicocorticoides e os mineralocorticoides (figura 3). -/- Os progestágenos são hormônios que favorecem o desenvolvimento da gestação; seus efeitos incluem, entre outros, a estimulação da secreção endometrial de substâncias nutritivas para o embrião, a estimulação do desenvolvimento embrionário e placentário, a inibição das contrações uterinas, bem como fazer com que a cérvix fique fechada. O principal hormônio natural desse grupo é a progesterona, mas existem uma grande quantidade de progestágenos sintéticos utilizados na medicina veterinária, tais como o acetato fluorogestona (FGA), o acetato de melengestrol (MGA), o altrenogest e o norgestomet. -/- Os estrógenos são os hormônios femininos responsáveis, entre outras funções, dos sinais do estro ou receptividade sexual nas fêmeas. A maior parte de seus efeitos estão no alcance da fertilização do ovócito. Os estrógenos, além de estimular a conduta sexual feminina, favorecem, entre outras coisas, a abertura da cérvix para permitir a passagem do espermatozoide, e as contrações uterinas para impulsionar o sêmen em direção aos ovidutos. O principal estrógeno natural é o estradiol 17β, outros membros naturais do grupo são a estrona, a equilina e a equilenina, esses dois últimos presentes exclusivamente em éguas gestantes. Também existem numerosos estrógenos sintéticos, tais como o valerato de estradiol, o benzoato de estradiol e o cipionato de estradiol. -/- Os andrógenos são hormônios masculinos. Possuem uma grande quantidade de efeitos encaminhados a alcançar o êxito reprodutivo do macho, como estimular a conduta sexual, estimular a produção de espermatozoides e estimular as secreções das glândulas sexuais acessórias. O andrógeno principal é a testosterona, outros andrógenos naturais incluem a androstenediona e a di-hidrotestosterona. Existe também inúmeros andrógenos sintéticos. -/- Os glicocorticoides ou corticosteroides possuem funções principalmente metabó-licas e de adaptação ao estresse. O principal corticosteroide na maioria das espécies é o cortisol, enquanto que nos ratos e outros roedores é a corticosterona. Na reprodução, os corticosteroides desempenham um papel relevante, em particular durante o parto e a lac-tação. -/- Os mineralocorticoides, como a aldotestosterona, se encarregam da regulação do balanço de líquidos e eletrólitos no organismo. -/- -/- Figura 3: subgrupos dos hormônios esteroides. Fonte: ZARCO, 2018. -/- -/- Os hormônios esteroides como grupos são hidrossolúveis, pelo qual podem atra-vessar livremente as membranas celulares, por essa razão utilizam receptores intracelula-res que se encontram no citoplasma da célula branca; também pode-se administrar por via oral, pela pele, e através das mucosas retal ou vaginal. São moléculas termoestáveis e não são digeridas no estômago, embora algumas possas sofrer modificações na pH ácido, alterando sua função. -/- -/- Aminas -/- São moléculas derivadas de um aminoácido que se modifica pela ação de enzimas específicas. Existem dois tipos de hormônios aminas: as catecolaminas e as indolaminas (figura 4). As catecolaminas derivam do aminoácido tirosina, e incluem a dopamina, a a-drenalina e a noradrenalina. As indolaminas derivam-se do triptofano, e incluem a seroto-nina e a melatonina. -/- As aminas são moléculas hidrossolúveis que não podem atravessar as membranas celulares e portanto atuam através de receptores membranais e segundos mensageiros intracelulares. -/- -/- Figura 4: classificação dos hormônios peptídicos. Fonte: ZARCO, 2018. -/- -/- Prostaglandinas -/- São substâncias derivadas do ácido araquidônico. A principal fonte desse ácido graxo são os fosfolipídios da membrana celular, a partir dos quais se podem liberar o ácido araquidônico mediante a ação da enzima fosfolipase A2. O ácido araquidônico se transforma em prostaglandina H mediante a ação da enzima ciclo-oxigenase (ou sintetase de prostaglandinas), que mais adiante se transforma em diferentes prostaglandinas especí-ficas pela ação de diversas enzimas. O tipo de prostaglandina produzido por cada célula dependerá do complemento de enzimas presentes. -/- A prostaglandina mais importante na reprodução é a PGF2α, a qual é responsável pela destruição do corpo lúteo na maioria das espécies; também provoca contrações uteri-nas, pelo qual é importante para o parto, e o transporte dos espermatozoides e a involução uterina depois do parto. Na prática veterinária a PGF2α natural (dinoprosr) ou seus seme-lhantes sintéticos (cloprostenol, luprostiol etc.) são utilizados para a sincronização do ciclo estral, para a indução do parto e para tratar diversas patologias. Outra prostaglandina com algumas ações relacionadas com a reprodução é a prostaglandina E2 (PGE2). -/- As prostaglandinas são substâncias anfipáticas (com propriedades hidrossolúveis e lipossolúveis), pelo qual podem atravessar as membranas celulares. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- AUSTIN, Colin Russell; SHORT, R. Reproduction in mammals. Cambridge, 1972. -/- BEARDEN, Henry Joe et al. Reproducción animal aplicada. México: Manual Moderno, 1982. -/- BECKER, Jill B. et al. (Ed.). Behavioral endocrinology. Mit Press, 2002. -/- BITTAR, Edward (Ed.). Reproductive endocrinology and biology. Elsevier, 1998. -/- BURNSTEIN, Kerry L. (Ed.). Steroid hormones and cell cycle regulation. Kluwer Academic Pub., 2002. -/- CUNNINGHAM, James. Tratado de fisiologia veterinária. Elsevier Health Sciences, 2011. -/- CUPPS, Perry T. (Ed.). Reproduction in domestic animals. Elsevier, 1991. -/- DUKES, Henry Hugh; SWENSON, Melvin J.; REECE, William O. Dukes fisiologia dos animais domésticos. Editora Guanabara Koogan, 1996. -/- FELDMAN, Edward C. et al. Canine and feline endocrinology-e-book. Elsevier health sciences, 2014. -/- FUSCO, Giuseppe; MINELLI, Alessandro. The Biology of Reproduction. Cambridge University Press, 2019. -/- GILBERT, Scott F. Biologia del desarrollo. Ed. Médica Panamericana, 2005. -/- GORE, Andrea C. GnRH: the master molecule of reproduction. Springer Science & Business Media, 2002. -/- HAFEZ, Elsayed Saad Eldin; HAFEZ, Bahaa. Reprodução animal. São Paulo: Manole, 2004. -/- HERNÁNDEZ PARDO, Blanca. Endocrinología: Lo esencial de un vistazo. México: Panamericana, 2016. -/- HYTTEL, Poul; SINOWATZ, Fred; VEJLSTED, Morten. Embriologia veterinária. São Paulo: Elsevier Brasil, 2012. -/- ILLERA MARTIN, Mariano. Endocrinología veterinaria y fisiología de la reproducción. Madrid: COLIBAC, 1984. -/- JOHNSON, Martin H. Essential reproduction. Nova Jersey: John Wiley & Sons, 2018. -/- MANDOKI, Juan José et al. Hormone multifunctionalities: a theory of endocrine signaling, command and control. Progress in biophysics and molecular biology, v. 86, n. 3, p. 353-377, 2004. -/- MANDOKI, Juan José et al. Reflections on the mode of functioning of endocrine systems. Archives of medical research, v. 41, n. 8, p. 653-657, 2010. -/- MCKINNON, Angus O. et al. (Ed.). Equine reproduction. Nova Jersey: John Wiley & Sons, 2011. -/- MELMED, Shlomo (Ed.). The pituitary. Londres: Academic press, 2010. -/- NORRIS, David O.; LOPEZ, Kristin H. (Ed.). Hormones and reproduction of vertebrates. Academic Press, 2010. -/- PARHAR, Ishwar S. (Ed.). Gonadotropin-releasing hormone: molecules and receptors. Elsevier, 2002. -/- PIMENTEL, C. A. Fisiologia e endocrinologia da reprodução da fêmea bovina. I Simpósio de Reprodução de Bovinos, Porto Alegre, RS, 2002. -/- PINEDA, Mauricio H. et al. McDonald's veterinary endocrinology and reproduction. Iowa state press, 2003. -/- RAMOS DUEÑAS, J. I. Endocrinología de la reproducción animal. 2018. -/- SALISBURY, Glenn Wade et al. Physiology of reproduction and artificial insemination of cattle. WH Freeman and Company., 1978. -/- SANDERS, Stephan. Endocrine and reproductive systems. Elsevier Health Sciences, 2003. -/- SORENSEN, Anton Marinus. Reproducción animal: principios y prácticas. México, 1982. -/- SQUIRES, E. James. Applied animal endocrinology. Cambridge: Cabi, 2010. -/- YEN, Samuel SC; JAFFE, Robert B.; BARBIERI, Robert L. Endocrinología de la Reproducción. Fisiología, fisiopatología y manejo clínico. Madrid: Ed. Médica Panamericana, 2001. -/- ZARCO, L. Endocrinología. In. PORTA, L. R.; MEDRANO, J. H. H. Fisiología reproductiva de los animales domésticos. Cidade do México: FMVZ-UNAM, 2018. (shrink)

Climate negotiations under the United Nations Framework Convention on Climate Change have so far failed to achieve a robust international agreement to reduce greenhouse gas emissions. Game theory has been used to investigate possible climate negotiation solutions and strategies for accomplishing them. Negotiations have been primarily modelled as public goods games such as the Prisoner’s Dilemma, though coordination games or games of conflict have also been used. Many of these models have solutions, in the form of equilibria, corresponding to possible (...) positive outcomes—that is, agreements with the requisite emissions reduction commitments. Other work on large-scale social dilemmas suggests that it should be possible to resolve the climate problem. It therefore seems that equilibrium selection may be a barrier to successful negotiations. Here we use an N-player bargaining game in an agent-based model with learning dynamics to examine the past failures of and future prospects for a robust international climate agreement. The model suggests reasons why the desirable solutions identified in previous game-theoretic models have not yet been accomplished in practice and what mechanisms might be used to achieve these solutions. (shrink)

What role, if any, do ‘seemings’ play in philosophy? Clarifying the relevant type of philosophical inquiry will enable us to pinpoint what epistemic contributions ‘seemings’ could make thereto. It will also reveal what turns on the question—nothing less, I propose, than the very possibility of philosophy. However, the answer I develop appeals not to seemings, but rather to intuitions conceived as a particular type of presentation—a “consciousness of seizing upon” how the world is, as Husserl put it. After distinguishing presentations (...) from seemings, I prise apart two kinds of presentational phenomenology, eventually arguing that the ‘contentful’ sort is poised to do the needed epistemic work. (shrink)

We consider the varieties and directions of influence that the source and target domains involved in a conceptual metaphor can have on each other during the course of understanding metaphorical utterances based on the metaphor. Previous studies have been restricted both as to direction of influence and as to type of influence. They have been largely confined to the “forward” (source to target) direction of influence, and they have concentrated on the transfer of features or propositions and (to some extent) (...) the highlighting of aspects of a domain. By contrast, this article stresses the importance both of other varieties of influence (e.g., transfer of queries and uncertainty effects) and of “reverse” influence (target to source). We seek to curb the natural tendency to think that, because metaphor involves an overall move from source to target, therefore all inter-domain influences in the course of understanding go in that direction. The bulk of the article explores the theoretical issues involved. These issues have arisen out of a reasoning-based approach to metaphor, seeking to make best use of information from metaphorical utterance, context, source and target domains, and known metaphorical mappings, by applying a complex overall reasoning process. The article briefly explains the thorough implementation of reverse influence in a computer program for metaphorical reasoning called ATT-Meta, although the theoretical considerations are relevant to all disciplines concerned with metaphor. We make some suggestions for further computational and psychological research on metaphor. (shrink)