Nano fullerenes with the ability to store electrostatic energy that can be used as nano supercapacitors with very high capacity. Also, with these nanotubes, the nervous network can be repaired. Carbon nano fullerenes are allotropes of carbon such as diamond and graphite. These compounds are made of carbon and take on spherical and elliptical shapes. Those that are spherical are called buckyballs.Fullerenes do not have much chemical activity. The width of the graphite plate is (...) about a few nanometers. The length of the nanotubes ranges from a few micrometers to less than a meter. Their unique molecular structure creates unusual macroscopic properties. Nano supercapacitor can store 100 times more energy than previous devices of its kind. Finally, such devices can store waves of energy from renewable sources such as wind and deliver that energy to the power grid when needed. In general, nanoelectric supercapacitors can store large amounts of energy, but they tend to charge slowly and wear out quickly. Meanwhile, capacitors have a longer life and can be discharged quickly, but store much less total energy. In order to make nano supercapacitors, nanostructured arrays of electrostatic capacitors can be created.Electrostatic nanocapacitors are the simplest type of electronic energy storage device. They store electrical charge on the surface of two metal electrodes separated by an insulating material. The electrical storage capacity of the nano supercapacitor is directly proportional to the surface area of these sandwich-like electrodes. (shrink)

The nature and structure of time and time-intervals in physical, chemical and biological systems will be elucidated. The relation and dependence among time, energy and taking place of natural processes will be critically analyzed. The bio-processes taking place in nano-time intervals will be identified. Their relevance to nano-bio-science and nano-bio-technology will be developed and nano-time interval-aspect of nano-sciences and nano-technology will be advanced. -/- .

A short position paper on how we can preemptively anticipate and design nanotechnology-safe futures.

The development of machine learning and deep learning (DL) in the field of AI (artificial intelligence) is the direct result of the advancement of nano-electronics. Machine learning is a function that provides the system with the capacity to learn from data without being programmed explicitly. It is basically a mathematical and probabilistic model. DL is part of machine learning methods based on artificial neural networks, simply called neural networks (NNs), as they are inspired by the biological NNs that constitute (...) organic brains. Despite its similarity to biological organs such as human brains, major problems arise in trying to attribute moral responsibility to autonomic systems based on hardware including nano-electronic devices, which are sought to replace humans (moral agents) in the context of AI. It is suggested that the required emotional environment which enables actions according to reasons in humans is not witnessed at AI devices. Though AI technology raises an enticing resemblance to human actions, this resemblance is to be considered with a skeptical eye. It is because actions are associated with reasons while causes are connected to operations. Human agents are capable of acting upon their reasons, while AI devices are limited only to operations as they are conditioned by their programming, which is considered as an embodiment of some causes. As moral responsibility goes hand in hand with the capacity to act (according to reasons), attributing moral responsibility to AI devices is revealed to be but a misleading metaphor. (shrink)

Safe-by-Design (SBD) frameworks for the development of emerging technologies have become an ever more popular means by which scholars argue that transformative emerging technologies can safely incorporate human values. One such popular SBD methodology is called Value Sensitive Design (VSD). A central tenet of this design methodology is to investigate stakeholder values and design those values into technologies during early stage research and development (R&D). To accomplish this, the VSD framework mandates that designers consult the philosophical and ethical literature to (...) best determine how to weigh moral trade-offs. However, the VSD framework also concedes the universalism of moral values, particularly the values of freedom, autonomy, equality trust and privacy justice. This paper argues that the VSD methodology, particularly applied to nano-bio-info-cogno (NBIC) technologies, has an insufficient grounding for the determination of moral values. As such, an exploration of the value-investigations of VSD are deconstructed to illustrate both its strengths and weaknesses. This paper also provides possible modalities for the strengthening of the VSD methodology, particularly through the application of moral imagination and how moral imagination exceed the boundaries of moral intuitions in the development of novel technologies. (shrink)

Nanotechnology, as with many technologies before it, places a strain on existing legislation and poses a challenge to all administrative agencies tasked with regulating technology-based products. It is easy to see how statutory schemes become outdated, as our ability to understand and affect the world progresses. In this article, we address the regulatory problems that nanotechnology posses for the Food and Drug Administration’s (FDA) classification structure for ‘‘drugs’’ and ‘‘devices.’’ The last major modification to these terms was in 1976, with (...) the enactment of the Medical Device Amendments. There are serious practical differences for a classification as a drug or device in terms of time to market and research. Drugs are classified, primarily, as acting by ‘‘chemical action.’’ We lay out some legal, philosophic, and scientific tools that serve to provide a useful, as well as legally and scientifically faithful, distinction between drugs and devices for the purpose of regulatory classification. These issues we raise are worth the consideration of anyone who is interested in the regulation of nano-products or other novel technologies. (shrink)

El presente articuLo pretende encuadrar y definir las implicaciones éticas reLativas a La aplicación biomédica de las nanotecnologías, a través de La vaLoración deL estado del arte.Las nanotecnologías, expresiÓn de La habilidad humana de manipuLar la materia a escala atómico/molecular se presentan como un instrumento capaz de modificar la investigaciÓn científica y la medicina de manera radicaL.Debates a todo nivel han subrayado las dificultades de darles una definición clara y unívoca, a causa de la convergencia de diversos ámbitos del saber (...) comprendidos en ellas.No obstante que Las nanotecnoLogías estén ya presentes en las ciencias computacionaLes y en La eLectrÓnica, es en eL ámbito médico-sanitario que se proyectan Las aplicaciones más entusiastas: instrumentos de diagnóstico y suministración de fármacos menos invasivos y más eficaces. Estas tecnoLogías se presentan al mismo tiempo como terapias pero también como instrumentos de prevención únicos, Las mismas características que hacen peculiar eL empLeo de las nano tecnologías en medicina, sugieren también precauciones: por una parte la dimensión mínima de las nanopartículasfacilita su ingreso en el organismo humano, traspasando las defensas naturales del organismo, agilizando una distribuciÓn de los fármacos altamente precisa. Por otra parte, estas mismas características pueden revelarse dañinas para el organismo humano .Dado que se trata de tecnología en rápida progresiÓn cuyos adelantos no son fáciles de predecir. los riesgos, aunque sÓlo aquellos potenciales, deben ser cuidadosamente valorados ya sea para las aplicaciones presentes como para aquellas futuras.Por tanto, encuadrar las implicaciones bioéticas de las nanotecnologías significa comprender y valorar su impacto sobre la salud humana. (shrink)

In the present paper, on the basis of the theory of production principles and production revolutions, we reveal the interrelation between K-waves and major technological breakthroughs in history and make some predictions about features of the sixth Kondratieff wave in the light of the Cybernetic Revolution which, we think, started in the 1950s. We assume that the sixth K-wave in the 2030s and 2040s will merge with the final phase of the Cybernetic Revolution (which we call the phase of self-regulating (...) systems). This period will be characterized by breakthroughs in medical technologies which will manage to combine many other technologies into a single complex of MBNRIC-technologies (med-bio-nano-robo-info-cognitive technologies). The article offers some predictions concerning the development of these technologies. (shrink)

This study has proven that the economic system is determined by various components, in particular, it includes the real sector of the economy, which is formed on mega-, macro, meso-, micro-and nano-levels. In addition, it was proved that the nano-level is determined by the activities of individuals whose economic activity begins with the birth and attitude of parents, attending various educational and upbringing institutions, and studying at university. A separate segment of the nano-level of the economic system (...) is the baby industry responsible for the production of goods and services for children and future parents. All these aspects are indicators of the development of the baby economy. Such an economic category as the baby economy was separated and defined. The study uses the following methods: analysis, synthesis, structural analysis, systemic approach, observation, comparison, multifactor regression. These methods made it possible to achieve the results, which involve isolation of the baby economy as a component of nanoeconomy and definition of such components of the baby economic segment of nanoeconomy as a family or household economy, the baby industry, the economy of the educational process and upbringing. For this purpose, the value-institutional approach was applied. In addition, multifactorial analysis of the impact of indicators of the baby economy development on the population of a country with a transitive economy with incomes below the subsistence minimum was performed. This analysis identified a direct but minor relationship between these phenomena, which demonstrates the need to intensify and create a policy for the baby economy in similar states. The theoretical significance of the obtained results is determined by the introduction of a new economic category of "the baby economy" for the formation of a nano economic component within socio-economic systems. (shrink)

In the present paper, on the basis of the theory of production principles and production revolutions, we reveal the interrelation between K-waves and major technological breakthroughs in history and make forecasts about features of the sixth Kondratieff wave in the light of the Cybernetic Revolution that, from our point of view, started in the 1950s. We assume that the sixth K-wave in the 2030s and 2040s will merge with the final phase of the Cybernetic Revolution (which we call a phase (...) of self-regulating systems). This period will be characterized by the breakthrough in medical technologies which will be capable to combine many other technologies into a single complex of MANBRIC-technologies (med-bio-nano-robo-info-cognitive technologies). The article offers some forecasts concerning the development of these technologies. (shrink)

Since 2004, it has been mandated by law that all Danish undergraduate university programmes have to include a compulsory course on the philosophy of science for that particular program. At the Faculty of Science and Technology, Aarhus University, the responsibility for designing and running such courses were given to the Centre for Science Studies, where a series of courses were developed aiming at the various bachelor educations of the Faculty. Since 2005, the Centre has been running a dozen different courses (...) ranging from mathematics, computer science, physics, chemistry over medical chemistry, biology, molecular biology to sports science, geology, molecular medicine, nano science, and engineering. -/- We have adopted a teaching philosophy of using historical and contemporary case studies to anchor broader philosophical discussions in the particular subject discipline under consideration. Thus, the courses are tailored to the interests of the students of the particular programme whilst aiming for broader and important philosophical themes as well as addressing the specific mandated requirements to integrate philosophy, some introductory ethics, and some institutional history. These are multiple and diverse purposes which cannot be met except by compromise. -/- In this short presentation, we discuss our ambitions for using case studies to discuss philosophical issues and the relation between the specific philosophical discussions in the disciplines and the broader themes of philosophy of science. We give examples of the cases chosen to discuss various issues of scientific knowledge, the role of experiments, the relations between mathematics and science, and the issues of responsibility and trust in scientific results. Finally, we address the issue of how and why science students can be interested in and benefit from mandatory courses in the philosophy of their subject. (shrink)

Safe-by-Design (SBD) frameworks for the development of emerging technologies have become an ever more popular means by which scholars argue that transformative emerging technologies can safely incorporate human values. One such popular SBD methodology is called Value Sensitive Design (VSD). A central tenet of this design methodology is to investigate stakeholder values and design those values into technologies during early stage research and development (R&D). To accomplish this, the VSD framework mandates that designers consult the philosophical and ethical literature to (...) best determine how to weigh moral trade-offs. However, the VSD framework also concedes the universalism of moral values, particularly the values of freedom, autonomy, equality trust and privacy justice. This paper argues that the VSD methodology, particularly applied to nano-bio-info-cogno (NBIC) technologies, has an insufficient grounding for the determination of moral values. As such, an exploration of the value-investigations of VSD are deconstructed to illustrate both its strengths and weaknesses. This paper also provides possible modalities for the strengthening of the VSD methodology, particularly through the application of moral imagination and how moral imagination exceed the boundaries of moral intuitions in the development of novel technologies. (shrink)

The essential biological processes that sustain life are catalyzed by protein nano-engines, which maintain living systems in far-from-equilibrium ordered states. To investigate energetic processes in proteins, we have analyzed the system of generalized Davydov equations that govern the quantum dynamics of multiple amide I exciton quanta propagating along the hydrogen-bonded peptide groups in α-helices. Computational simulations have confirmed the generation of moving Davydov solitons by applied pulses of amide I energy for protein α-helices of varying length. The stability and (...) mobility of these solitons depended on the uniformity of dipole-dipole coupling between amide I oscillators, and the isotropy of the exciton-phonon interaction. Davydov solitons were also able to quantum tunnel through massive barriers, or to quantum interfere at collision sites. The results presented here support a nontrivial role of quantum effects in biological systems that lies beyond the mechanistic support of covalent bonds as binding agents of macromolecular structures. Quantum tunneling and interference of Davydov solitons provide catalytically active macromolecular protein complexes with a physical mechanism allowing highly efficient transport, delivery, and utilization of free energy, besides the evolutionary mandate of biological order that supports the existence of such genuine quantum phenomena, and may indeed demarcate the quantum boundaries of life. (shrink)

This chapter examines how advances in nanotechnology might impact criminal sentencing. While many scholars have considered the ethical implications of emerging technologies, such as nanotechnology, few have considered their potential impact on crucial institutions such as our criminal justice system. Specifically, I will discuss the implications of two types of technological advances for criminal sentencing: advanced tracking devices enabled by nanotechnology, and nano-neuroscience, including neural implants. The key justifications for criminal punishment- including incapacitation, deterrence, rehabilitation, and retribution – apply (...) very differently to criminal sentences using these emerging technologies than they do to imprisonment. Further, use of these technologies would represent a shift away from retribution as the primary justification for criminal punishment. In addition, the possibility of nano-neural implants entails a new model of rehabilitation: namely, involuntary rehabilitation aimed at changing an offender’s character, rather than his environment. (shrink)

The monograph presents the ideas about the main changes that occurred in the development of technologies from the emergence of Homo sapiens till present time and outlines the prospects of their development in the next 30–60 years and in some respect until the end of the twenty-first century. What determines the transition of a society from one level of development to another? One of the most fundamental causes is the global technological transformations. Among all major technological breakthroughs in history the (...) most important are three production revolutions: 1) the Agrarian Revolution; 2) the Industrial Revolution; and 3) the Cybernetic one. The book introduces the theory of production revolutions which is a new valuable explanatory paradigm that analyzes causes and trends of dramatic shifts in historical process. The authors describe the course of technological transformations in history and demonstrate a possible application of the theory to explain the present and forthcoming technological changes. They analyze the technological shifts which took place in the second half of the twentieth and early twenty-first centuries and forecast the main shifts in the next half a century. On this basis the authors present a detailed analysis of the latest production revolution which is denoted as ‘Сybernetic’. They make some predictions about its development in the nearest five decades and up to the end of the twenty-first century and show that the development of various self-regulating systems will be the main trend of this revolution. The authors argue that the transition to the starting final phase of the Cybernetic Revolution (in the 2030–2040s) will first occur in the field of medicine (in some its innovative branches). In future we will deal with the started convergence of innovative technologies which will form the system of MANBRIC-technologies (i.e. the technological paradigm based on medicine, additive, nano- and bio- technologies, robotics, IT and cognitive technologies). The monograph gives an outline of the future breakthroughs in medicine and some other technologies (between the 2010s and 2070s). (shrink)

In this article, a classification of the global catastrophic risks connected with the possible existence (or non-existence) of extraterrestrial intelligence is presented. If there are no extra-terrestrial intelligences (ETIs) in our light cone, it either means that the Great Filter is behind us, and thus some kind of periodic sterilizing natural catastrophe, like a gamma-ray burst, should be given a higher probability estimate, or that the Great Filter is ahead of us, and thus a future global catastrophe is high probability. (...) If ETIs exist in our light cone, it is most likely they exist in the form of ET artificial general intelligence (ETAI). ETAI may be traveling at near-light speed as an explosive wave of intelligence in the form of some nano-mechanisms which could reach us at any moment; may send us potentially dangerous messages with AI-virus payloads; or be near or on Earth in some dormant form. This dormant form could be nanobots, which could act as berserkers, and be triggered when humans unwittingly cross some threshold. If ETIs are nearby and less advanced, they could find our messaging extra-terrestrial intelligence (METI) messages and send their “fleet” to or direct weapons toward Earth. Even extinct ETIs could have left dangerous remnants in the form of AI systems that our civilization may encounter. If our existence is a simulation, this could be run by ETIs. Even a false belief in the existence of ETIs could potentially fuel millennial sects. If humanity is the first intelligence to emerge, it may kill or prevent the existence of all future potential ETI, a different type of catastrophe. Several options to prevent catastrophic risks are connected with ETI: sending requests for help, using random strategies to escape the Fermi paradox, Great Filter prediction, or the hope that ETIs will find the remains of our extinct civilization and resurrect it. (shrink)

David Bohm, in his "causal theory", made the correct Hegelian synthesis of Einstein's thesis that there is a "there" there, and Bohr's antithesis of "thinglessness" (Nick Herbert’s term). Einstein was a materialist and Bohr was an idealist. Bohm showed that quantum reality has both. This is “physical dualism” (my term). Physical dualism may be a low energy approximation to a deeper monism of cosmic consciousness called "the super-implicate order" (Bohm and Hiley’s term), “pregeometry” (Wheeler’s term), “substratum” (Dirac’s term), “funda-MENTAL space” (...) (Hameroff’s term), “Chi” (Chinese medicine & Falun Gong) etc., but for our immediate pragmatic purpose of constructing naturally conscious nano-computers and of virtually reverse engineering alleged reports of propellantless UFO propulsion (French Intelligence Report, 1999 [email protected] Vol. 5, No. 11, Part 1 -- August 1, 1999 & NIDS report "Best UFO Cases - Europe", I. Von Ludwiger) to the stars and beyond, physical dualism will work. (shrink)

Various understandings and definitions of time will be reviewed. The nature and structure of time will be reviewed and the concepts of time and passage of time will be refreshed. The fundamental role played by energy and four natural forces in the actions, reactions and interactions concerning matter, anti-matter, energy in space and time will be critically analyzed. The reality how time is constructed during the construction of materials will be presented and discussed. The classical and quantum ideas in this (...) regard will be comprehensively studied. How these ideas will give us a fresh insight about the nature, structure and role of time in the construction of materials through natural scientific and manmade processes will be highlighted. The relations among matter, anti-matter, energy and time will be freshly stated. The milli-, micro-, nano, pico-, femto-, atto-times will be qualitatively analyzed considering physical, inorganic, organic and bio-materials and their construction and structure. The physics of timelessness also will be put forward. -/- . (shrink)

In the present article we analyze the relationships between K-waves and major technological breakthroughs in history and offer forecasts about features of the sixth Kondratieff wave. We use for our analysis the basic ideas of long cycles' theory and related theories (theories of the leading sector, technological styles etc.) as well as the ideas of our own theory of production principles and production revolutions. The latest of production revolution is the Cybernetic Revolution that, from our point of view, started in (...) the 1950s. We assume that in the 2030s and 2040s the sixth K-wave will merge with the final phase of the Cybernetic Revolution (which we call a phase of self-regulating systems). This period will be characterized by the breakthrough inmedical technologies which will be capable to combine many other technologies into a single system of MANBRIC-technologies (medico-additive-nano-bio-roboto-info-cognitive technologies). The article also presents a forecast of the process of global ageing and argueswhy the technological breakthrough will occur in health care sector and connected spheres. (shrink)

In this chapter, we analyze the relationship between Kondratieff waves and major technological revolutions on the basis of the theory of production principles and production revolutions, and offer some forecasts about the features of the Sixth Kondratieff Wave/the Fourth Industrial Revolution. We show that the technological breakthrough of the Sixth Kondratieff Wave may be interpreted as both the Fourth Industrial Revolution and as the final phase of the Cybernetic Revolution. We assume that the sixth K-wave in the 2030s and 2040s (...) will merge with the final phase of the Cybernetic Revolution (which we call a phase of selfregulating systems). This period will be characterized by the breakthrough in medical technologies which will be capable of combining a number of other technologies into a single system of new and innovative technologies (we denote this system as a system of MANBRIC-technologies—i.e. medical, additive, nano-, bio-, robo-, info-, and cogno-technologies). (shrink)

Defining Ecosophy (ecological wisdom) like a contemporary philosophy of survival, security and a sustainable Human Development, terrestrial nature and society, the author of this article approaches the correlation between it and the digital version of security in the context of new technologies. Human survival is in connection with the protection, optimal functioning of the natural environment and the development of human society. Human evolution, physical and psychological (the issues of Anthropoecology, a medical-biological science, deals with them), depends on the natural (...) and social environment, on the development of new techniques and technologies. New technologies (nano-, bio-, info-, socio-technologies) can ensure the security and the increasing development of the human being, but they can threaten it too. The author does not deny behaviours, the possibility that human intellect could be non-biological. Moreover, the author believes if it comes to it, that we will not be able to speak about the human species. New technologies like the traditional and less new, are intended to help in solving various problems related to health, society interactions with nature, human society and diverse cultures, societies and states. The philosophy of security and the digital one, like the components of Ecosophy, along with philosophical aspects of Anthropoecology, General Ecology and Social Ecology, needs like any other science or philosophy to elaborate systems of concepts, principles and laws. (shrink)

Nanowires ( SiNWs) have high mobility and surface-to-volume ratio, which makes them easy to control using a weak electric field. These one-dimensional nanostructures are created from nanowires with a diameter in the range of nanometers and a length of more than a micrometer. It has been done in the manufacture of nanowires through regular one-dimensional arrays with the help of different physical and chemical methods. Methods such as the use of electron beam or lithography method, heavy ion irradiation, laser, chemical (...) and electrochemical methods such as water heat and spontaneous assembly methods used to make the membranes of molds can also be used . In making one-dimensional nanostructures such as Oligophenylene vanillin nanowires The electro-accumulation method consists of three general steps: firstly, the creation of a porous template as a suitable substrate and framework for the accumulation of nanowires, secondly, the growth of nanowires along the cavities of the template, and thirdly, removing the template and separating the nanowires from it. The nanowires are directly dependent on the characteristics of the mold surface such as the size distribution of the holes, the density of the holes and the superiority of the surface of the nano-holes. In order to control the properties of Oligophenylene vanillin nanowires, parameters that are effective in the formation and optimization of the diameter of the holes and the thickness of the mold should be considered. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE OS BEZERROS NATIMORTOS EM VACAS Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 15. NATIMORTOS Por natimortos, entende-se todos aqueles produtos (bezerros/bezerras) que nascem vivos após um tempo de gestação fisiológica normal, mas que morrem nas primeiras 24 horas de vida, ou às vezes nascem mortos, sem evidência clara de que a morte tenha ocorrido 48 horas (ou menos) antes do parto (FRAZER, 2005; GORDON, 1996). (...) Essa evidência, provém das mudanças autolíticas que o produto expelido apresenta. A causa que origina os natimortos é difícil de diagnosticar pela complexa e abundante presença de situações que poderiam levar à apresentação deste quadro. Entre essa complexa explicação etiológica, de origem nutricional podemos enumerar: 15.1 Nitratos e nitritos Um excesso de nitrogênio, seja não proteico ou originado da metabolização proteica excessiva, pode gerar natimortos, uma vez que os nitratos do alimento convertem-se no rúmen em nitritos e depois em amônio, que é excretado ou degradado de diferentes formas. Sob certas condições ambientais, como geadas, secas, granizo, etc. o metabolismo de algumas plantas como a cevada, aveia, milho, pastos e forragens de rápido crescimento não funciona normalmente, e os nitratos acumulam-se nas folhas e no caule; quando estes nitratos são consumidos pelo animal, alteram-se os processos metabólicos e ao haver excesso de nitritos e nitratos, há uma acumulação dos mesmos na corrente sanguínea, algo prejudicial. Os nitritos ligam-se à hemoglobina e geram a metahemoglobina, o que reduz a capacidade condutora do oxigênio no sangue, dificultando a chegada do mesmo ao feto, levando à óbito o produto em formação (DUPCHAK, 2005). Os sinais na vaca gestante geralmente são ofegantes, respiração rápida, tremores musculares, pulso fraco e acelerado, fraqueza, que termina com a queda do animal e convulsões terminais. Também se sabe que os nitratos têm um efeito vasodilatador, o que origina uma diminuição da pressão sanguínea, em todo caso a morte possui origem na acumulação de metahemoglobina. As vacas afetadas por esse excesso de nitratos desenvolvem incoordenação e dificuldades na capacidade respiratória que vão seguidas por colapso e morte. O sinal mais claro é que o sangue fica escuro. Sob condições de hipoxia o feto pode morrer ao ser iniciado o trabalho de parto, evento fisiológico de alto consumo de oxigênio pela contração muscular marcada necessária para conseguir a expulsão do produto. O estudo desses compostos podem não parecer importantes na vida corriqueira e laboral do campo, porém quando se aparecem problemas de difícil diagnóstico e tratamento, faz-se necessário um aprofundamento de toda a cadeia alimentar ou de ingestão dos animais, alimentos, bebidas, locais de descanso e dormida etc. Pois bem, o presente comentário norteia o assunto sobre os nitratos e nitritos que nada mais são do que compostos não proteicos e que em sua composição possuem nitrogênio e oxigênio, nitrato NO3- e nitrito NO2-. Diante da fermentação ruminal, o alimento rico em NO3- é reduzido pelo rúmen e se transforma em NO2- um composto altamente tóxico que, após absorvido na corrente sanguínea, causa anóxia por morte celular, sendo prejudicial tanto para o bovino adulto, quanto jovem e ainda mais para o feto em desenvolvimento. A ingestão excessiva desses compostos por meio da água ou das forragens podem ocasionar intoxicações. As forragens podem acumular nitrogênio através da fertilização do solo ou da planta com compostos ricos em N, são exemplos de plantas que acumulam bastante nitrato a Braquiária radicans e todas as plantas do gênero Amaranthus spp., para que se diminua o teor de nitratos presentes na forragem o mais indicado é o processo de ensilagem. Ainda relacionada a alimentação, vale ressaltar para o produtor rural que altos teores de nitrato ou nitrito no corpo animal ocasiona a deficiência da vitamina A que é essencial para o mecanismo fisiológico e metabólico do animal. As tabelas 1 e 2 trazem as concentrações ou os níveis ideais e máximos de nitrato presente nas forragens e na água, e se os teores expressos são recomendáveis ou não para a administração aos animais. Vale notar que os nitratos são compostos que se apresentam juntamente com o potássio K, o sódio Na e o próprio nitrogênio N na forma de nitrato e nitrito presente na água ou na matéria seca dos alimentos. Tabela 1: Concentrações de nitrato e recomendações quando apresentados na forma de nitrato de potássio KNO, nitrato de sódio NaNO, e N em forma de nitrato e nitrito na MS dos alimentos Forma de nitrato reportado Recomendações NO3-N NO3- KNO3- NaNO3- —————— 0 – 0,15% 0 – 0,65% 0 – 1% 0 – 0,9% Seguro para os ruminantes, pode utilizar 0,15 – 0,45% 0,65 – 2% 1 – 3% 0,9 – 2,7% Misturar com outros alimentos, compondo no máximo 50% da mistura > 0,45% > 2% > 3% > 2,7% Aumenta o nível de intoxicação, o mais indicado é não usar Fonte: BERCHIELLI et al., 2006. Tabela 2: Concentrações de NO3- e recomendações sobre os níveis de nitrato presente na água para bovinos Conteúdo de NO3- ppm Conteúdo de NO3-N ppm Recomendação 0 - 44 10 Pode utilizar 45 - 132 10 - 20 É seguro se o alimento tiver pouco nitrato e uma dieta balanceada 133 - 220 20 - 46 Prejudicial se for usada por muito tempo 220 – 660 40 – 100 Pode haver perdas e é um risco para vacas leiteiras 660 – 800 100 – 200 Aumenta a possibilidade de perdas, não é indicado usar > 800 > 200 Não utilizar Fonte: TEIXEIRA, 1997. Todas essas informações podem não parecer importantes para a prática no campo, porém em situações de problemas relacionados a altos índices de fetos que nascem mortos tais tabelas podem ser de extrema importância e salvar vidas. No caso de intoxicações, o indicado é o tratamento por azul de metileno a 1% sob dosagem de 4 – 14 mg/kg de peso vivo do animal. Todos esses manejos podem salvar o feto, o que faz com que o mesmo nasça vivo e torne-se um animal produtivo para a propriedade. 15.2 Minerais A deficiência de cobre, também tem sido apontada como uma das possíveis causas de origem de natimortos, uma vez que o cobre está ligado à albumina no sangue e no fígado está ligado à aminoácidos. Sua deficiência gera anemia já que o mesmo está envolvido no metabolismo do ferro, necessário para a formação da hemoglobina. Na deficiência, muda-se a cor da pelagem e da pele devido a necessidade do cobre no mecanismo de síntese da polifenil oxidase, que transforma a tironina em melanina; a escassez altera também a enzima lisil oxidase, necessária na formação das cadeias polipeptídicas de colágeno, por onde surgem os problemas ósseos e articulares (DE ROSA & MATIOLLI, 2002). Altera-se também a atividade do citocromo oxidase que está envolvido na síntese dos fosfolipídios, que formam a camada de mielina necessária para a transmissão nervosa e a resposta motora, causando ataxia e problemas de necrose graves que ocasionam a morte do feto. Além disso, as concentrações de dopamina e noradrenalina são alteradas, afetando o endotélio vascular, resultando adicionalmente em problemas cardiovasculares com graves crises hemolíticas que também causam a morte do produto. Geralmente, diz-se que a soma de todos estes problemas conformam os fatores desencadeadores de morte súbita do feto. Quando há uma deficiência nutricional de cobre, o animal começa a usar seus depósitos hepáticos, se os depósitos se esgotam, evidencia-se uma diminuição nos níveis sanguíneos e aparece a hipocupremia e hipocuprose; depois dos sinais acima mencionados, ocorre a degeneração progressiva do miocárdio, o que também contribui para a morte súbita do feto. O excesso de molibdênio gera uma deficiência de cobre e este também está inter-relacionado com o zinco. Para que não haja dominância de um e deficiência de outro sempre deve-se frisar as quantidades exigidas dos minerais pelos bovinos. O Cu é um elemento essencial e sua disponibilidade deve ser de 10 – 18 mg/kg de MS. O Mo deve ser fornecido em quantidades que não ultrapassem os 15 – 20 mg/kg de MS, a relação entre o Cu e o Mo não deve ser superior que 20, um excesso de Mo causa deficiência de Cu induzida. Por fim, o Zn deve ser fornecido em quantidades que não ultrapassem os 21 – 73 mg/kg de MS. 15.3 Vitaminas A vitamina A é necessária para manter a integridade dos epitélios digestivo, respiratório, genito-urinário e ocular, além disso é fundamental para o desenvolvimento ósseo já que controla a atividade dos osteoclastos e osteoblastos, também assegura a manutenção da permeabilidade das membranas celulares e da pressão do líquido cefalorraquidiano, portanto a sua deficiência provoca queratinização dos tecidos epiteliais, problemas gastrointestinais, o que acaba complicando-se com a invasão de germes e doenças infecciosas. Sua escassez ou falta também ocasionam malformações ósseas e problemas nervosos como ataxia e falhas na contratilidade do miométrio, o que, por fim, resulta na morte do vitelo. Na avitaminose A, as células epiteliais são achatadas e apresentam menor resistência à infecção, pode-se dar que todos os canais glandulares se bloqueiem causando atrofia glandular e morte do bezerro por não poder realizar suas funções fisiológicas. Os betacarotenos das forragens são as fontes mais importantes de vitamina A. A vitamina A deve estar intrinsecamente presente na dieta dos animais em quantidades de 50.000 – 125.000 UI/dia. 15.4 fito-toxicidade O excesso de fitoestrogênios produzidos por leguminosas como o trevo vermelho, trevo subterrâneo, feijão de soja, etc., que possuem estrogênios vegetais semelhantes aos 17β-estradiol que interagem com os receptores nucleares desta hormona e influenciam sobre os seus processos endócrinos. Ocorre estrogenismo que gera infertilidade, já que se limita a liberação de LH e no animal gestante aumenta a contractilidade uterina gerando abortos ou natimortos. Entre os fitoestrógenos estão as isoflavonas, que sofrem algum tipo de transformação no rúmen, onde o Isoflavonoide formononetina se converte em equol enquanto as demais se degradam a produtos inativos. A progesterona é a hormona responsável por manter as condições ideais para a gestação, aumentando-se os níveis de estrogênios ocorrerá a inibição da progesterona e apresentam-se condições adversas para o desenvolvimento e/ou vida do feto. Para se livrar desse problema o mais indicado é a utilização de forragens que além de suprir as necessidades nutricionais dos animais sejam de boa qualidade e utilizadas o mais fresco possível. REFERÊNCIAS BIBLIOGRÁFICAS BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. ROSA, Diana E.; MATTIOLI, Guillermo Alberto. Metabolismo y deficiencia de cobre en los bovinos. Analecta Veterinaria, v. 22, 2002. DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. DUPCHAK, K. Nitratos en Forrajes para Vacas Lecheras. Engormix 2005. Disponível em. Acesso em: Abril de 2020. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. SARTORI, Roberto; GUARDIEIRO, Monique Mendes. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. (shrink)

Abstract: Samples of LaxSr1-xMnO3 (x = 0.5, 0.55, 0.6, 0.66, and 0.7) were prepared by the citrate-nitrate autocombustion method. The prepared nano-particles were investigated and characterized using X-Ray diffraction (XRD) and Transmission Electron Microscopy (TEM) to confirm the formation of the samples in single phase without any impurities and to calculate the particle size. The magnetic susceptibility χM was measured as a function of temperature and magnetic field intensity. From χM(T) and M(H) the saturation magnetization (Ms), remanent magnetization (Mr) (...) and coercivity (Hc) of the samples were estimated. The correlation among physical properties and the ratio of divalent cation substitution was discussed and reported to shed more light on technological applications of the investigated samples. (shrink)

The concepts developed using Upanishadic insight regarding human consciousness, mind and mental processes and their applications in information acquisition and transmission by, through and in human body will be used to model human cognitive processes. A sequential reversible process by the stepwise transformation of (i) infrasonic form of energy and transformation of information already stored in (ii) biochemical form within as memory, and retrieved as inner mental world into (iii) electrochemical and then into (iv) mechanical form while communicating and the (...) reverse of it as the (i) input stimuli from outside world as light, sound, chemical, mechanical and heat forms, into (ii) electrochemical, (iii) biochemical and finally into (iv) infra sonic form while acquiring and understanding processes is put forward and discussed. Comparisons will be made between energy transformations in electronics communication processes and these psychic energy transformations that give rise to cognitive processes. This comparison gives an insight and theory of origin, structure, function and cessation of human mental functions. A comparative diagram that describes application of infrasonic energy transformations associated with bionics as biochemical, electrochemical and mechanical forms will be given. (shrink)