Animal models have long been used to investigate human mental disorders, including depression, anxiety, and schizophrenia. This practice is usually justified in terms of the benefits (to humans) outweighing the costs (to the animals). I argue on utility maximization grounds that we should phase out animal models in neuropsychiatric research. Our leading theories of how human minds and behavior evolved invoke sociocultural factors whose relation to nonhuman minds, societies, and behavior has not been homologized. Thus it (...) is not at all clear that we are gaining the epistemic or clinical benefits we want from this animal-based research. (shrink)

This paper provides a historical analysis of a shift in the way animal models of mental disorders were conceptualized: the shift from the mid-twentieth-century view, adopted by some, that animal models model syndromes classified in manuals such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), to the later widespread view that animal models model component parts of psychiatric syndromes. I argue that in the middle of the twentieth century the attempt to maximize (...) the face validity of animal models sometimes led to the pursuit of the ideal of an animal model that represented a behaviorally defined psychiatric syndrome as described in manuals such as the DSM. I show how developments within psychiatric genetics and related criticism of the DSM in the 1990s and 2000s led to the rejection of this ideal and how researchers in the first decade of the twenty-first century came to believe that animal models of mental disorders should model component parts of mental disorders, adopting a so-called endophenotype approach. (shrink)

The initiation of bipedal gait is a willed action that causes a body at rest to move. Newton's first principle of motion is applied to experimental footprint data. leading to the premise that the big toe is the source of the body action force that initiates and controls bipedal gait.

The chapter discusses the principle of conservatism and traces how the general principle is related to the specific one. This tracing suggests that the principle of conservatism needs to be refined. Connecting the principle in cognitive science to more general questions about scientific inference also allows us to revisit the question of realism versus instrumentalism. The framework deployed in model selection theory is very general; it is not specific to the subject matter of science. The chapter outlines some non-Bayesian ideas (...) that have been developed in model selection theory. The principle of conservatism, like C. Lloyd Morgan's canon, describes a preference concerning kinds of parameters. It says that a model that postulates only lower-level intentionality is preferable to one that postulates higher-level intentionality if both fit the data equally well. The model selection approach to parsimony helps explain why unification is a theoretical virtue. (shrink)

[penultimate draft; prepared for publication in Aristotle’s Parts of Animals: A Critical Guide, ed. Sophia Connell – please cite final version] -/- Parts of Animals II.10 makes a new beginning in Aristotle’s study of animals. In it, Aristotle proposes to “now speak as if we are once more at an origin, beginning first with those things that are primary” (655b28-9). This is the start of his account of the non-uniform parts of blooded animals: parts such as eyes, noses, mouths, etc., (...) as opposed to uniform parts like blood and flesh. PA II.10 proposes a new strategy for studying these parts: “one ought to speak about the human kind first” (656a10). Beginning “first” with the “primary” things thus amounts to beginning with humans (655b28-9). -/- Why does Aristotle think this strategy is appropriate for his project? One answer is that it reflects a fundamental anthropocentrism. Lloyd, for instance, has raised the possibility that the basic assumptions that guide Aristotle’s biology may to some extent reflect the anthropocentrism of his culture, where the relation of humans to animals was “a preoccupation of popular beliefs”. In this paper, I develop an interpretation that both builds on and challenges this suggestion. I do so by investigating how Aristotle thinks this strategy works in theory and in practice: his justifications for adopting it and its interaction with his scientific commitments. I argue that Aristotle adopts it in part because he thinks that humans are such that his scientific concepts apply to them in a particularly clear way. (This too is a form of anthropocentrism: one that might be resisted by arguing that humans are not the best illustrations of these concepts—that Aristotle ought to look elsewhere for models with the features he desires.) -/- More specifically, Aristotle holds that starting with humans helps establish the causal explanations of the parts of other animals, particularly when they are recalcitrant. What makes humans suitable for this role is a special teleological relation between their parts and the ends they serve: in humans, he supposes, this connection is particularly tight (in a way I explain below). Consequently, Aristotle thinks he can use humans to illuminate which sorts of features tend to be for the sake of which ends, and then extend the results of this inquiry to the parts of the other animals. (shrink)

One might be inclined to assume, given the mouse donning its cover, that the behavior of interest in Nicole Nelson's book Model Behavior (2018) is that of organisms like mice that are widely used as “stand-ins” for investigating the causes of human behavior. Instead, Nelson's ethnographic study focuses on the strategies adopted by a community of rodent behavioral researchers to identify and respond to epistemic challenges they face in using mice as models to understand the causes of disordered human (...) behaviors associated with mental illness. Although Nelson never explicitly describes the knowledge production activities in which her behavioral geneticist research subjects engage as “exemplary”, the question of whether or not these activities constitute “model behavior(s)”—generalizable norms for engaging in scientific research—is one of the many thought-provoking questions raised by her book. As a philosopher of science interested in this question, I take it up here. (shrink)

Should models of consciousness be detailed _mechanistic_ models of particular types of systems, or should they be _minimal_ models that abstract away from the underlying mechanistic details and provide generalisations? Detailed mechanistic models may afford a complete and precise account of consciousness in human beings and other, physiologically similar mammals. But they do not provide a good model of consciousness in other animals, such as non-vertebrates, let alone artificial systems. Minimal models can be applicable to (...) a wide range of different conscious systems. But do they provide genuine explanations that are autonomous from explanations by detailed mechanistic models? This paper provides a taxonomy of minimal models and measures of consciousness, clarifies their relation to detailed mechanistic models, and highlights benefits of different minimalist approaches to consciousness. (shrink)

Over 1.5 million living animal species have been described—of which around 1 million are insects—but it has been estimated there are over 7 million animal species in total. Animals range in length from 8.5 micrometres to 33.6 metres. In this paper an Artificial Neural Network (ANN) model, was developed and tested to predict animal species. There are a number of features that influence the classification of animal species. Such as the existence of hair/ feather, if the (...) animal gives birth or spawns, it is airborne, aquatic, predator, toothed, backboned, venomous, has –fins, has-tail, cat-sized, and domestic. A model based on the Multilayer Perceptron Topology was proposed and trained, using data set what was collected from UCI Machine Learning Repository. Evaluation of the proposed model shows that the ANN model is able to correctly predict the animal category with 100% accuracy. (shrink)

This paper critically examines the philosophical underpinnings of current experimental investigation into animal affect-related decision-making. Animals’ affective states are standardly operationalised by linking positively valenced states with “approach” behaviours and negatively valenced states with “avoidance” behaviours. While this operationalisation has provided a helpful starting point to investigate the ecological role of animals’ internal states, there is extensive evidence that valenced and motivational states do not always neatly align, namely, instances where “wanting” does not entail “liking” (and vice versa). To (...) address this limitation, this paper proposes the (re-)integration of dominance as a dimension of affect. In particular, I argue that dominance, construed as a measure of organisms’ self-assessed behavioural control, can provide the necessary nuance to understand animal affect-related decision-making. Thus, after addressing the theoretical and methodological challenges related to incorporating dominance into a definition of “core affect”, this paper introduces the “Valence-Arousal-Dominance” model of animal affect. This model is explored for its potential applications in two domains. Firstly, in the study of animal affect-related decision-making under predation risk, and secondly, in the study of animal wellbeing. Through these applications, this model aims to bring experimental paradigms of animal affect-related behaviour closer to ecologically relevant scenarios. (shrink)

Growing awareness of the ethical implications of neuroscience in the early years of the 21st century led to the emergence of the new academic field of “neuroethics,” which studies the ethical implications of developments in the neurosciences. However, despite the acceleration and evolution of neuroscience research on nonhuman animals, the unique ethical issues connected with neuroscience research involving nonhuman animals remain underdiscussed. This is a significant oversight given the central place of animal models in neuroscience. To respond to (...) these concerns, the Center for Neuroscience and Society and the Center for the Interaction of Animals and Society at the University of Pennsylvania hosted a workshop on the “Neuroethics of Animal Research” in Philadelphia, Pennsylvania. At the workshop, expert speakers and attendees discussed ethical issues arising from neuroscience research involving nonhuman animals, including the use of animal models in the study of pain and psychiatric conditions, animal brain-machine interfaces, animal–animal chimeras, cerebral organoids, and the relevance of neuroscience to debates about personhood. This paper highlights important emerging ethical issues based on the discussions at the workshop. This paper includes recommendations for research in the United States from the authors based on the discussions at the workshop, loosely following the format of the 2 Gray Matters reports on neuroethics published by the Presidential Commission for the Study of Bioethical Issues. (shrink)

There has recently been an explosion of formal models of signalling, which have been developed to learn about different aspects of meaning. This paper discusses whether that success can also be used to provide an original naturalistic theory of meaning in terms of information or some related notion. In particular, it argues that, although these models can teach us a lot about different aspects of content, at the moment they fail to support the idea that meaning just is (...) some kind of information. As an alternative, I suggest a more modest approach to the relationship between informational notions used in models and semantic properties in the natural world. (shrink)

This article addresses three questions concerning Kant’s views on non-rational animals: do they intuit spatio-temporal particulars, do they perceive objects, and do they have intentional states? My aim is to explore the relationship between these questions and to clarify certain pervasive ambiguities in how they have been understood. I first disambiguate various nonequivalent notions of objecthood and intentionality: I then look closely at several models of objectivity present in Kant’s work, and at recent discussions of representational and relational theories (...) of intentionality. I argue ultimately that, given the relevant disambiguations, the answers to all three questions will likely be positive. These results both support what has become known as the nonconceptualist reading of Kant, and make clearer the price the conceptualist must pay to sustain her position. (shrink)

Where do human numerical abilities come from? This article is a commentary on Leibovich et al.’s “From 'sense of number' to 'sense of magnitude' —The role of continuous magnitudes in numerical cognition”. Leibovich et al. argue against nativist views of numerical development by noting limitations in newborns’ vision and limitations regarding newborns’ ability to individuate objects. I argue that these considerations do not undermine competing nativist views and that Leibovich et al.'s model itself presupposes that infant learners have numerical representations.

Model of intelligence and new methods to assess IQ. MA thesis in 1998 (Comenius University). Art exhibitions "From Animation" London 2013, "Fading Memory" Weißenohe 2015, TAIF Tokyo 2017. Conferences in Santorini, Daejon 2016, Geneva 2017.

Products made from animal fur and skin have been a major part of human civilization. However, in modern society, the unsustainable consumption of these products – often considered luxury goods – has many negative environmental impacts. This study explores how people’s perceptions of biodiversity affect their attitudes and behaviors toward consumption. To investigate the information process deeper, we add the moderation of beliefs about biodiversity loss. Following the Bayesian Mindsponge Framework (BMF) analytics, we use mindsponge-based reasoning for constructing conceptual (...) models and employ Bayesian analysis aided by Markov Chain Monte Carlo (MCMC) algorithms on a dataset of 535 Vietnamese urban residents. The results show that people’s preference for using products made from animal skin/fur is negatively associated with perceived consequences of biodiversity loss when they believe biodiversity loss is real and a major problem. In contrast, if urban residents believe biodiversity loss is unreal or not a significant issue, the association between perceived consequences of biodiversity loss and personal preference happens in the opposite direction. The same effects of biodiversity loss perception on people’s possession of skin/fur products was not found, indicating a more complex information process on behaviors compared to attitudes. Nevertheless, in the scenario that people believe biodiversity loss is not a significant issue, the higher the perceived consequences of biodiversity loss are, the greater number of animal-based products they likely own. Our results suggest that policymakers should not neglect the factor of personal belief besides knowledge and awareness in environmental campaigns. (shrink)

Although the cognition is significant in strategic reasoning, its role has been weakly analyzed, because only the average intelligence is usually considered. For example, prisoner's dilemma in game theory, would have different outcomes for persons with different intelligence. I show how various levels of intelligence influence the quality of reasoning, decision, or the probability of psychosis. I explain my original methodology developed for my MA thesis in clinical psychology in 1998, and grant research in 1999, demonstrating the bias of the (...) classic IQ method, and how the intelligence limits thinking. Based on that I defined Personality Model, providing insight into understanding of psychosis (schizophrenia, bi-polar), which has not been explained yet by psychology or psychiatry. In addition, it enables to analyze and assess non-linear problems, utilizable in computer programming, visualization (animation) or other fields including Baduk game. I've already applied some principles in complex information system www.each.co.uk, and video-animations exhibited in London, Germany, Tokyo. I need to mention my experience in chess composition between 1994 and 2000, winning a few international prizes and inventing a special class of fairy rules redefining the mate. The chess composition principles or patterns show the way to organize logical series to higher advanced mechanisms (like calculus), applicable to other fields. One of such principles is a logical aesthetic innovation: new strategy, defined by Italian composers. Finally I show how the simple redefinition of the classic utility concept links economics and psychology to explain irrational / destructive behavior. All presented results (from the research) can be repeated. (shrink)

Products made from animal fur and skin have been a major part of human civilization. However, in modern society, the unsustainable consumption of these products – often considered luxury goods – has many negative environmental impacts. This study explores how people’s perceptions of biodiversity affect their attitudes and behaviors toward consumption. To investigate the information process deeper, we add the moderation of beliefs about biodiversity loss. Following the Bayesian Mindsponge Framework (BMF) analytics, we use mindsponge-based reasoning for constructing conceptual (...) models and employ Bayesian analysis aided by Markov Chain Monte Carlo (MCMC) algorithms on a dataset of 535 Vietnamese urban residents. The results show that people’s preference for using products made from animal skin/fur is negatively associated with perceived consequences of biodiversity loss when they believe biodiversity loss is real and a major problem. In contrast, if urban residents believe biodiversity loss is unreal or not a significant issue, the association between perceived consequences of biodiversity loss and personal preference happens in the opposite direction. The same effects of biodiversity loss perception on people’s possession of skin/fur products was not found, indicating a more complex information process on behaviors compared to attitudes. Nevertheless, in the scenario that people believe biodiversity loss is not a significant issue, the higher the perceived consequences of biodiversity loss are, the greater number of animal-based products they likely own. Our results suggest that policymakers should not neglect the factor of personal belief besides knowledge and awareness in environmental campaigns. (shrink)

In 1995, as a student of psychology inspired by natural science, I defined a logical model of personality explaining psychosis. I created (for my MA thesis, 1998 and grant research, 1999) new kind of tests assessing intelligence, creativity, prejudices, expectations to show more exact methods in psychology. During my Phd study in economics, I developed 'Maximization of Uniqueness (Originality)' model enhancing the classic utility to explain irrational motivations linking economics and psychology. Later I became computer programmer developing functional programming. According (...) to Personality model (and my experience in chess composition), I've built server and client logic of information system www.each.co.uk, and produced visual art. I presented the excerpts of 'Personality Model' in a few articles, and later as part of my art exhibitions: From Animation (Oct 2013, Holland Park, London), Parallax 12 (Feb 2015, Chelsea Town Hall, London), Fading Memory (Sep 2015, Weißenohe / Nuremberg, Germany). Another work: The Science is a subset of the Art extends Personality Model to art, society. At the end I add example and explanation of a special problem, when the higher intelligence leads to a wrong solution. It was published in Japanese Journal Problem Paradise in 1999. All presented results can be repeated. Computer testing would enable to acquire more data and more exact analysis. (shrink)

Computer simulations constitute a significant scientific tool for promoting scientific understanding of natural phenomena and dynamic processes. Substantial leaps in computational force and software engineering methodologies now allow the design and development of large-scale biological models, which – when combined with advanced graphics tools – may produce realistic biological scenarios, that reveal new scientific explanations and knowledge about real life phenomena. A state-of-the-art simulation system termed Reactive Animation (RA) will serve as a study case to examine the contemporary philosophical (...) debate on the scientific value of simulations, as we demonstrate its ability to form a scientific explanation of natural phenomena and to generate new emergent behaviors, making possible a prediction or hypothesis about the equivalent real-life phenomena. (shrink)

The field of special pedagogy has received increased global attention in recent years. This resulted in the development of a variety of schooling (or non-schooling) and of teaching methods that are tailored to the needs of non-neurotypical individuals. Regardless of whether or not they wish to be “healed”, their needs require special consideration. This study aims to determine if incorporating anime into teaching methods would benefit individuals with ADHD. In this article, we will consider the desires of people with ADHD, (...) the functioning of their brains, the effect of prescribed medications, as well as the impact of video and the need for it in relation to contemporary educational models and methods. In support of this, three short surveys conducted at the onset of the pandemic will be presented, along with anime recommendations for each education field. Do teachers and professors have the freedom to teach as they wish, the right to use what methods they want. or the responsibility to find and choose the best educational methods for their students? Do the neurodiverse individuals have the freedom to discontinue their education or the right to receive a proper education? Which prevails? (shrink)

Does the capacity to think require the capacity to sense? A lively debate on this topic runs throughout the history of philosophy and now animates discussions of artificial intelligence. Many have argued that AI systems such as large language models cannot think and understand if they lack sensory grounding. I argue that thought does not require sensory grounding: there can be pure thinkers who can think without any sensory capacities. As a result, the absence of sensory grounding does not (...) entail that large language models cannot think or understand. I also consider to what extent quasi-sensory grounding can at least boost the performance of a language model. (shrink)

Objective: Kindling is an animal model of epilepsy induced by electrical stimulation of the brain. The present study aimed to present a different perspective with a bibliometric approach by using the literature data on the “Kindling model” related keywords in the Web of Science (WoS) online database between 1980 and 2023. -/- Methods: The bibliometric data were obtained from the online database WoS and analyzed and visualized with the VoS Viewer Program. The bibliometric datasets were analyzed and visualized regarding (...) article productivity numbers according to years, article productivity numbers according to countries, the most used keywords according to authors, and cross-country cooperation. -/- Result: Considering the results of the analysis of the published datasets, 2022 was determined as the year with the highest article productivity, and an acceleration was observed in the publication increase rate on the subject in general. When the order of the countries in the top three in the number of article productivity was examined, the USA, Germany, and Japan are the main countries, respectively. The most used keywords by the authors were determined as “Epilepsy”, “Kindling”, and “Hippocampus”. In the cooperation among countries, it was found that the USA, Germany, and Japan had more cooperation with other countries, respectively. -/- Conclusıon: This study will contribute to the literature by providing a detailed understanding of the research basis, relevant research results, current research boundaries and main research focus in the Kindling Model. (shrink)

Explanation of logic of psychoses: schizophrenia and bi-polar, with empirical confirmation - e.g. IQ decreases the likelihood of psychosis, and bi-polar is more likely than schizophrenia... MA thesis in 1998 (Comenius University), Presented at Art exhibition "From Animation", London, Holland Park (W8 6LU), Conferences in Santorini, Daejon, Adelaide 2016.

Presented at the European Conference for Cognitive Science in Bochum, Sept. 2019. I synthesize some ideas I take to be promising with regard to a criterion for mental representations in animals. I sketch constitutive conditions for having a depicting perspective on the environment instead of merely reacting successfully to it. Perception, so my argument, is the key to understand the essence of mind in its basic form and beyond.(© Adrian Wieczorek).

A considerable body of recent work in developmental psychology and animal behavior has addressed the cognitive processes required to recognize oneself in a mirror. Most models of such "mirrored self-recognition" (MSR) treat it as the result of inferential processes drawing on the subject’s possession of some sort of mature "self-awareness". The present chapter argues that such an approach to MSR is not obligatory, and suggests some empirical grounds for rejecting it. We also sketch the outlines of an alternative, (...) "embodied" theory of MSR, and propose a way to evaluate it using the tools of adaptive robotics. (shrink)

This is a model of consciousness. The hard problem of consciousness, what it feels like, is answered. The work builds on medical research analyzing the source and mechanisms associated with our feelings. It goes further by describing a generic model with wide applicability. The model is fully consistent with medical pathways in humans, but easily extends to animals and AI. The essence of the model is the interplay between associative memory and physiology. The model is a clear and concrete counterexample (...) to the famous philosophical objections to a scientific explanation. (shrink)

[This paper is written in Czech language.] The aim of the article is to re-evaluate the still-surviving anthropological trope which, in reaction to an inquiry into the essence of man, compares humans with animals and points to culture as the means by which humans complete their “deficient” nature. This motif contrasting humans with animals has been extended by A. Gehlen who characterises humans as “beings of deficiencies”. In his view, the morphological-instinctive insufficiency of the human being must be stabilised by (...) cultural institutions, i.e. complexes of habitual actions. Merleau-Ponty, however, demonstrates that bodily beings always relate to their environment in an indirect way, on the basis of certain “standards” and “norms” of interaction, which exist by way of institution. The anthropological trope confronting humans and animals thus cannot produce, as in Gehlen, a contrast between an allegedly “direct” relationship to the world in animals, and a supposedly “indirect” relationship to the world in humans. It can be meaningfully retained only if it is interpreted in a Merleau-Pontyan way, that is, as an invitation to understand the transformation of the norms of indirect interaction with the world found in animals into those found in people, that is, if viewed as a comparison of their respective institutions. (shrink)

The present comment concerns a recent AI & Ethics article which purports to report evidence of speciesist bias in various popular computer vision (CV) and natural language processing (NLP) machine learning models described in the literature. I examine the authors' analysis and show it, ironically, to be prejudicial, often being founded on poorly conceived assumptions and suffering from fallacious and insufficiently rigorous reasoning, its superficial appeal in large part relying on the sequacity of the article's target readership.

What is the class of possible semiotic systems? What kinds of systems could count as such systems? The human mind is naturally considered the prototypical semiotic system. During years of research in semiotics the class has been broadened to include i.e. living systems like animals, or even plants. It is suggested in the literature on artificial intelligence that artificial agents are typical examples of symbol-processing entities. It also seems that semiotic processes are in fact cognitive processes. In consequence, it is (...) natural to ask the question about the relation between semiotic studies and research on artificial cognitive systems within cognitive science. Consequently, my main question concerns the problem of inclusion or exclusion from the semiotic spectrum at least some artificial systems. I would like to consider some arguments against the possibility of artificial semiotic systems and I will try to repeal them. Then I will present an existing natural-language using agent of the SNePS system and interpret it in terms of Peircean theory of signs. I would like also to show that some properties of semiotic systems in Peircean sense could be also found in a discussed artificial system. Finally, I will have some remarks on the status of semiotics in general. (shrink)

This article provides the foundation for a new predictive theory of animal learning that is based upon a simple logical model. The knowledge of experimental subjects at a given time is described using logical equations. These logical equations are then used to predict a subject’s response when presented with a known or a previously unknown situation. This new theory suc- cessfully anticipates phenomena that existing theories predict, as well as phenomena that they cannot. It provides a theoretical account for (...) phenomena that are beyond the domain of existing models, such as extinction and the detection of novelty, from which “external inhibition” can be explained. Examples of the methods applied to make predictions are given using previously published results. The present theory proposes a new way to envision the minimal functions of the nervous system, and provides possible new insights into the way that brains ultimately create and use knowledge about the world. (shrink)

Meanings are present everywhere in our environment and within ourselves. But these meanings do not exist by themselves. They are associated to information and have to be created, to be generated by agents. The Meaning Generator System (MGS) has been developed on a system approach to model meaning generation in agents following an evolutionary perspective. The agents can be natural or artificial. The MGS generates meaningful information (a meaning) when it receives information that has a connection with an internal constraint (...) to which the agent is submitted. The generated meaning is to be used by the agent to implement actions aimed at satisfying the constraint. We propose here to highlight some characteristics of the MGS that could be related to items of philosophy of information. (shrink)

Helianthus annuus seeds contain various chemical components and evaluate different biological activities. The present study was carried out to investigate the central nervous system (CNS) activity of methanolic extract of Helianthus annuus seeds in mice model. General behaviour, antidepressant activity and anxiolytic activity was observed. The results revealed that the methanol extract of Helianthus annuus seeds at 100 and 200 mg/kg caused a significant increase in the spontaneous activity (general behavioural profile), moderate increase in anxiolytic activity (light-dark box and elevated (...) plus maze test) and remarkable increase in antidepressant activity (tail suspension test). The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models. (shrink)

This work is an examination of Peter Singer’s notion of speciesism: case for animal rights in Ejagham culture. It primarily deals with an evaluation of the phenomenon of animal rights from the standpoint of Peter Singer’s notion of speciesism. Singer’s notion of speciesism deals with the moral obligation humans owe to animals as against the bias or prejudice that humanity has greater moral worth than non-human animals. Most opponents of speciesism contend that, animals are not members of the (...) moral community as such humans have no moral obligation to them. Contrary to this view, proponents of speciesism argue that animals are capable of suffering and should be considered morally. Thus, the emphasis here is that just like many societies of the world, the Ejagham people are guilty of speciesism. Among the several ways by which speciesism is practiced, this work identifies hunting, deforestation, bush burning and fishing as ways by which the Ejagham people are guilty. Using the tool of critical analysis, evaluation and prescription, this work submits that animals have interest, as such, should be granted rights. (shrink)

A common view of how-possibly explanations in biology treats them as explanatorily incomplete. In addition to this interpretation of how-possibly explanation, I argue that there is another interpretation, one which features what I term “explanatory strategies.” This strategy-centered interpretation of how-possibly explanation centers on there being a different explanatory context within which how-possibly explanations are offered. I contend that, in conditions where this strategy context is recognized, how-possibly explanations can be understood as complete explanations. I defend this alternative interpretation by (...) analyzing the explanatory value of simple physical models the nineteenth century developmental biologist Wilhelm His constructed for animal development. (shrink)

A growing body of work within the animal ethical discourse is taking a ‘Political Turn’. It is primarily characterised by efforts to propose transformation of our legal and political institutions to account for a just human-animal-relationship in society. In this article, I examine the underrated potential of a virtue ethical approach, as this perspective is currently lacking in the turn’s literature. For instance, we get a clearer idea of who ought to represent animals according to many of the (...) turn’s institutional reform proposals in terms of relevant political character traits. Likewise, what virtuous role modelling for politicians entails in creating ‘animal friendly’ moral norms, and how citizens can navigate their own correct political decision-making. Furthermore, we can better discuss the role of individuals in societal justice issues if we reframe our personal virtues as public political virtues. I conclude that including virtue ethical accounts would result in a more comprehensive political turn, not in spite of lacking a ‘language of rights’, but precisely because of its rich and diverse ‘language of virtues’. (shrink)

The difficulty of primary students in solving simple fractions is because students fail to understand the concept of simple fractions. Meanwhile, the results of previous studies allow the integration of PowToon animation multimedia into a constructivist approach to facilitate the conception of the simple fraction. This research aims to develop constructivist-based PowToon animation multimedia (CoPAM) as a valid, practical, and effective learning media for simple fraction material. PowToon was developed using a research and development (R&D) method with a define, design, (...) and development (3-D) model that involved 12 fourth-grade primary students. The data analysis used was descriptive analysis with data collection methods using observation, tests (pre-test and post-test), validation questionnaires (validation of media and material experts, teacher responses, and student responses), and documentation. The results showed that CoPAM has very feasible product criteria for validity, practicality, and effectiveness to facilitate primary students in understanding simple fractions. The recommendations for the next study are needed to further develop and test CoPAM products or the like (which could go through the dissemination stage) by involving a larger and wider number of participants by testing inferential statistics. (shrink)

The Intelligible Living Thing, posited as the model of our visible and tangible universe in Plato’s Timaeus, is often taken for a richly structured whole, which is not a simple sum of its four major parts. This assumption seems unwarranted – most specifically, the dialogue contains no hint at any complex intelligible blue print of the world as a teleologically arranged whole, whose goodness is irreducible to the well-being and individual perfection of its parts. To construe the rich structure of (...) the world is necessary insofar as the Demiurge creates material likenesses of the austere immaterial species. While the life forms included in our universe conform to their intelligible paradigms, this is not, strictly speaking, true about the considerations guiding the Demiurgic activity which gives rise to the universe itself, whose goodness is also to be measured by comparing it to the disordered pre-cosmic matter. The paper discusses several implications of this austere interpretation of the model and its role in creation. It suggests that the Forms that compose the model should be understood as abstract particulars rather than universals, and critically discusses the relation of Timaeus’ account to the so-called Principle of Plenitude. (shrink)

The data analyzed in this paper are part of the results described in Bueno et al. (2000). Three cytogenetics endpoints were analyzed in three populations of a species of wild rodent – Akodon montensis – living in an industrial, an agricultural, and a preservation area at the Itajaí Valley, State of Santa Catarina, Brazil. The polychromatic/normochromatic ratio, the mitotic index, and the frequency of micronucleated polychromatic erythrocites were used in an attempt to establish a genotoxic profile of each area. It (...) was assumed that the three populations were in the same conditions with respect to the influence of confounding factors such as animal age, health, nutrition status, presence of pathogens, and intra- and inter-populational genetic variability. Therefore, any differences found in the endpoints analyzed could be attributed to the external agents present in each area. The statistical models used in this paper are mixtures of negative-binomials and Poisson variables. The Poisson variables are used as approximations of binomials for rare events. The mixing distributions are beta densities. The statistical analyzes are under the bayesian perspective, as opposed to the frequentist ones often considered in the literature, as for instance in Bueno et al. (2000). (shrink)

Psychiatric research is in crisis because of repeated failures to discover new drugs for mental disorders. Lack of measurement validity could partly account for these failures. If researchers do not actually measure the effects of drugs on the disorders they aim to investigate, one should expect suboptimal treatment outcomes. I argue that this is the case, focusing on depression, and fear & anxiety disorders. In doing so, I show how psychiatric research illustrates a more general phenomenon that I call “validity (...) drift.” A validity drift occurs when, in the course of developing new measurement procedures, researchers end up studying something different from what they originally aimed to study. I analyze the different ways in which scientists attempt to validate procedures for measuring mental disorders for the purpose of testing drugs in animal models. I show how those validation efforts might fail, thereby leading to validity drifts. Overall, this analysis highlights the complex interplay between the development of new measurement procedures, their calibration, and scientific theories of the target phenomena. (shrink)

Many neurodegenerative and neuropsychiatric diseases and other brain disorders are accompanied by impairments in high-level cognitive functions including memory, attention, motivation, and decision-making. Despite several decades of extensive research, neuroscience is little closer to discovering new treatments. Key impediments include the absence of validated and robust cognitive assessment tools for facilitating translation from animal models to humans. In this review, we describe a state-of-the-art platform poised to overcome these impediments and improve the success of translational research, the Mouse (...) Translational Research Accelerator Platform (MouseTRAP), which is centered on the touchscreen cognitive testing system for rodents. It integrates touchscreen-based tests of high-level cognitive assessment with state-of-the art neurotechnology to record and manipulate molecular and circuit level activity in vivo in animal models during human-relevant cognitive performance. The platform also is integrated with two Open Science platforms designed to facilitate knowledge and data-sharing practices within the rodent touchscreen community, touchscreencognition and mousebytes. Touchscreencognition includes the Wall, showcasing touchscreen news and publications, the Forum, for community discussion, and Training, which includes courses, videos, SOPs, and symposia. To get started, interested researchers simply create user accounts. We describe the origins of the touchscreen testing system, the novel lines of research it has facilitated, and its increasingly widespread use in translational research, which is attributable in part to knowledge-sharing efforts over the past decade. We then identify the unique features of MouseTRAP that stand to potentially revolutionize translational research, and describe new initiatives to partner with similar platforms such as McGill’s M3 platform. (shrink)

Depression is a widespread and debilitating disorder, but developing effective treatments has proven challenging. Despite success in animal models, many treatments fail in human trials. While various factors contribute to this translational failure, standardization practices in animal research are often overlooked. This paper argues that certain standardization choices in behavioral neuroscience research on depression can limit the generalizability of results from rodents to humans. This raises ethical and scientific concerns, including animal waste and a lack of (...) progress in treating human patients. To address these issues, animal ethics committees can establish reasonable expectations for preclinical research and highlight the impact of standardization on generalizability. Such efforts can help improve translation from animal models to human patients and ultimately benefit those suffering from depression. (shrink)

Coherence and correspondence are classical contenders as theories of truth. In this paper we examine them instead as interacting factors in the dynamics of belief across epistemic networks. We construct an agent-based model of network contact in which agents are characterized not in terms of single beliefs but in terms of internal belief suites. Individuals update elements of their belief suites on input from other agents in order both to maximize internal belief coherence and to incorporate ‘trickled in’ elements of (...) truth as correspondence. Results, though often intuitive, prove more complex than in simpler models (Hegselmann & Krause 2002, 2006; Grim, Singer, Reade & Fisher 2015). The optimistic finding is that pressures toward internal coherence can exploit and expand on small elements of truth as correspondence is introduced into epistemic networks. Less optimistic results show that pressures for coherence can also work directly against the incorporation of truth, particularly when coherence is established first and new data is introduced later. (shrink)

In the last decade alone, a growing body of preliminary evidence suggests that classic psychedelics (CPs) can rapidly and durably ameliorate symptoms and cognitive deficits associated with depression. However, the mechanisms by which CPs work in the brain are not well understood. Rodent translational research, in which experimental findings from rodents are translated to humans, is fundamental in achieving this goal. This chapter focuses on a representative subset of human and rodent studies investigating CPs for depression, including the various lines (...) of research that have been initiated to understand how they work. Our aim is to show that in addition to epistemic challenges that scientists face in translating findings from rodents to humans, there is also mismatch between experimental approaches used to investigate CPs in humans and rodents. We thus show current experimental practices are not conducive to mechanistic discovery. We end with a set of positive proposals to expedite the drive to translate CPs into effective treatments for depression. -/- Keywords: classic psychedelics, psychiatry, clinical trials, collaboration, extrapolation, major depressive disorder, open science, philosophy of science, rodent models, scientific practice, translation, validity . (shrink)

There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not (...) yet possible with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity. (shrink)

In this chapter I investigate the kinds of changes that psychiatric kinds undergo when they become explanatory targets of areas of sciences that are not “mature” and are in the early stages of discovering mechanisms. The two areas of science that are the targets of my analysis are cognitive neuroscience and cognitive neurobiology.

Let us call the deliberate modification of an individual’s genome to improve it or its progeny intentional genetic enhancement. Governments are almost certain to require that any proposed intentional genetic enhancement of a human (IGEH) be tested first on (what researchers call) animal “models.” Intentional genetic enhancement of animals (IGEA), then, is an ambiguous concept because it could mean one of two very different things: an enhancement made for the sake of the animal’s own welfare, or an (...) enhancement made for the sake of satisfying a human desire. In either case, experimental procedures are likely to entail substantial risks to the experimental animals. What rules should govern IGEA? I criticize the abolitionist conclusions of animal rightists—that no IGEA should be permitted—and I criticize the permissive conclusions of speciesists—that all IGEA should be permitted. Both views are unsatisfying. I suggest instead that current animal welfare law provides a defensible platform on which to begin building ethically justifiable policy in this area. (shrink)

There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not (...) yet possible with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity. (shrink)

Optogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities (...) and dangers such therapies may offer. In this review, we focus on the memory-modifying potential of optogenetics, investigating what it is capable of and how it differs from other memory modification technologies. We then outline the safety challenges that need to be addressed before optogenetics can be used in humans. Finally, we re-examine crucial neuroethical concerns expressed in regard to other MMTs in the light of optogenetics and address those that appear to be unique to the memory-modifying potential of optogenetic technology. (shrink)

In the quest to discover the neural bases of cognition, rigorous behavioral tools are equally as important as sophisticated tools for neural intervention. This paper evaluates several episodes in the development of a novel behavioral tool for rodent cognitive testing, the rodent touchscreen operant chamber. Using conceptual tools on offer in the philosophical literature on exploratory experimentation and control, I illuminate how optimization of this behavioral tool and an understanding of the causal knowledge it may be used to generate historically (...) has involved dynamic interplay between community-driven exploratory practices operating in parallel with causal hypothesis-driven research. (shrink)

A study of the significance of Plato's resumption of the simile of model and likeness in the Timaeus, with attention to the place of the Timaeus in the "longer way" that Plato has Socrates announce in the Republic. The reader embarked on the "longer way," I argue, will find in the accounts of the elements and of the kinds of animals unannounced but detailed exhibitions of the "god-given" method of dialectic that Plato has Socrates announce in the Philebus.