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  1. Investigating Subsumption in SNOMED CT: An Exploration Into Large Description Logic-Based Biomedical Terminologies.Olivier Bodenreider, Barry Smith, Anand Kumar & Anita Burgun - 2007 - Artificial Intelligence in Medicine 39 (3):183-195.
    Formalisms based on one or other flavor of Description Logic (DL) are sometimes put forward as helping to ensure that terminologies and controlled vocabularies comply with sound ontological principles. The objective of this paper is to study the degree to which one DL-based biomedical terminology (SNOMED CT) does indeed comply with such principles. We defined seven ontological principles (for example: each class must have at least one parent, each class must differ from its parent) and examined the properties of SNOMED (...)
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  • A Terminological and Ontological Analysis of the NCI Thesaurus.Werner Ceusters, Barry Smith & Louis Goldberg - 2005 - Methods of Information in Medicine 44 (4):498-507.
    We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers from the same broad range (...)
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  • Ontologie-basierte Qualitätssicherung medizinischer Terminologien.Barry Smith - 2004 - Kooperative Versorgung, Vernetzte Forschung, Ubiquitäre Information, Proceedings of Gmds 2004:193-195.
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  • Would SNOMED CT Benefit From Realism-Based Ontology Evolution?Werner Ceusters, Kent Spackman & Barry Smith - 2007 - AMIA Annual Symposium Proceedings 2007:105-109.
    If SNOMED CT is to serve as a biomedical reference terminology, then steps must be taken to ensure comparability of information formulated using successive versions. New releases are therefore shipped with a history mechanism. We assessed the adequacy of this mechanism for its treatment of the distinction between changes occurring on the side of entities in reality and changes in our understanding thereof. We found that these two types are only partially distinguished and that a more detailed study is required (...)
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  • The Significance of SNODENT.Louis Goldberg, Werner Ceusters, John Eisner & Barry Smith - 2005 - Medical Informatics Europe 2005: 737-742.
    SNODENT is a dental diagnostic vocabulary incompletely integrated in SNOMED-CT. Nevertheless, SNODENT could become the de facto standard for dental diagnostic coding. SNODENT's manageable size, the fact that it is administratively self-contained, and relates to a well-understood domain provides valuable opportunities to formulate and test, in controlled experiments, a series of hypothesis concerning diagnostic systems. Of particular interest are questions related to establishing appropriate quality assurance methods for its optimal level of detail in content, its ontological structure, its construction and (...)
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  • Formalizing UMLS Relations Using Semantic Partitions in the Context of a Task-Based Clinical Guidelines Model.Anand Kumar, Matteo Piazza, Barry Smith, Silvana Quaglini & Mario Stefanelli - 2004 - In IFOMIS Reports. Saarbrücken: IFOMIS.
    An important part of the Unified Medical Language System (UMLS) is its Semantic Network, consisting of 134 Semantic Types connected to each other by edges formed by one or more of 54 distinct Relation Types. This Network is however for many purposes overcomplex, and various groups have thus made attempts at simplification. Here we take this work further by simplifying the relations which involve the three Semantic Types – Diagnostic Procedure, Laboratory Procedure and Therapeutic or Preventive Procedure. We define operators (...)
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  • Ontologies and Terminologies: Continuum or Dichotomy?Natalia Grabar, Thierry Hamon & Olivier Bodenreider - 2012 - Applied Ontology 7 (4):375-386.
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  • Establishing and Harmonizing Ontologies in an Interdisciplinary Health Care and Clinical Research Environment.Barry Smith & Mathias Brochhausen - 2008 - Studies in Health, Technology and Informatics 134:219-234.
    Ontologies are being ever more commonly used in biomedical informatics and we provide a survey of some of these uses, and of the relations between ontologies and other terminology resources. In order for ontologies to become truly useful, two objectives must be met. First, ways must be found for the transparent evaluation of ontologies. Second, existing ontologies need to be harmonised. We argue that one key foundation for both ontology evaluation and harmonisation is the adoption of a realist paradigm in (...)
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  • Strategies for Referent Tracking in Electronic Health Records.Werner Ceusters & Barry Smith - 2006 - Journal of Biomedical Informatics 39 (3):362-378.
    The goal of referent tracking is to create an ever-growing pool of data relating to the entities existing in concrete spatiotemporal reality. In the context of Electronic Healthcare Records (EHRs) the relevant concrete entities are not only particular patients but also their parts, diseases, therapies, lesions, and so forth, insofar as these are salient to diagnosis and treatment. Within a referent tracking system, all such entities are referred to directly and explicitly, something which cannot be achieved when familiar concept-based systems (...)
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  • Effects of Guideline-Based Training on the Quality of Formal Ontologies: A Randomized Controlled Trial.M. Boeker, L. Jansen, J. Röhl, N. Grewe, D. Seddig-Raufie & S. Schulz - 2013 - PLoS ONE 1.
    BACKGROUND -/- The importance of ontologies in the biomedical domain is generally recognized. However, their quality is often too poor for large-scale use in critical applications, at least partially due to insufficient training of ontology developers. -/- OBJECTIVE -/- To show the efficacy of guideline-based ontology development training on the performance of ontology developers. The hypothesis was that students who received training on top-level ontologies and design patterns perform better than those who only received training in the basic principles of (...)
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