A political discourse of peace marked the distribution and use of radioisotopes in biomedical research and in medical diagnosis and therapy in the post-World War II period. This occurred during the era of expansion and strengthening of the United States' influence on the promotion of sciences and technologies in Europe as a collaborative effort, initially encouraged by the policies and budgetary distribution of the Marshall Plan. This article follows the importation of radioisotopes by two Spanish research groups, one in experimental (...) endocrinology and one in molecular biology. For both groups foreign funds were instrumental in the early establishment of their laboratories. The combination of funding and access to previously scarce radioisotopes helped position these groups at the forefront of research in Spain. (shrink)

This paper develops a theory of perception that reconciles representationalism and relationalism by relying on pragmatist ideas. I call it the pragmatic view of perception. I argue that fully reconciling representationalism and relationalism requires, first, providing a theory in which how we perceive the world involves representations; second, preserving the idea that perception is constitutively shaped by its objects; and third, offering a direct realist account of perception. This constitutes what I call the Hybrid Triad. I discuss how Charles Peirce’s (...) theory of perception can provide a framework for such a view and I devote the rest of the paper to developing my own pragmatic and Peircean theory of perception. In particular, I argue that considering perception as a continuous temporal process, which essentially involves interaction with the environment, allows us to do justice to the Hybrid Triad. I motivate this view by discussing how a pragmatic theory of perception would deal with issues such as the distinction between veridical and non-veridical experiences and the nature of perceptual objects. (shrink)

A political discourse of peace marked the distribution and use of radioisotopes in biomedical research and in medical diagnosis and therapy in the post-World War II period. This occurred during the era of expansion and strengthening of the United States' influence on the promotion of sciences and technologies in Europe as a collaborative effort, initially encouraged by the policies and budgetary distribution of the Marshall Plan. This article follows the importation of radioisotopes by two Spanish research groups, one in experimental (...) endocrinology and one in molecular biology. For both groups foreign funds were instrumental in the early establishment of their laboratories. The combination of funding and access to previously scarce radioisotopes helped position these groups at the forefront of research in Spain. (shrink)

Me propongo mostrar que tanto la naturalización, ahora también en versión neurológica, como la tecnologización contemporáneas son fruto de interpretaciones que pretenden ofrecer una nueva imagen del hombre, por ejemplo, a través de fórmulas como la de «homo poieticus». Pero la cuestión decisiva es ver si a partir de estas nuevas imágenes se puede reconstruir la realidad personal, manteniendo las pretensiones expresadas mediante el valor de dignidad de la persona humana o quedan realmente sustituidas por otras que rebasan el sentido (...) humanizador, por el que desde diversas tradiciones nos comprendemos e intentamos mejorar la vida humana. A tal efecto, quisiera aprovechar no sólo el siempre fecundo pensamiento aristotélico, sino también el kantiano y nietzscheano, en versión hermenéutica, y su enlace con la tradición de la filosofía española de Ortega, Zubiri y Laín, porque creo que ofrecen una base adecuada para incorporar y articular los nuevos conocimientos neurocientíficos y las propuestas de intervención tecnocientíficas. (shrink)

Current Perspectives in Philosophy of Biology.

Naturalised realism’ is presented as a version of realism which is more compatible with the history of science than convergent or explanationist forms of realism. The account is unpacked according to four theses: 1) Whether realism is warranted with regards to a particular theory depends on the kind and quality of evidence available for that theory; 2) Reference is about causal interaction with the world; 3) Most of science happens somewhere in between instrumentalism and scientific realism on a continuum of (...) stances towards the status of theories; 4) The degree to which realism is warranted has something to do with the degree to which theories successfully refer, rather than with the truth of theories. (shrink)

In this article, against the background of a notion of ‘assembled’ truth, the evolutionary progressiveness of a theory is suggested as novel and promising explanation for the success of science. A new version of realism in science, referred to as ‘naturalised realism’ is outlined. Naturalised realism is ‘fallibilist’ in the unique sense that it captures and mimics the self-corrective core of scientific knowledge and its progress. It is argued that naturalised realism disarms Kyle Stanford’s anti-realist ‘new induction’ threats by showing (...) that ‘explanationism’ and his ‘epistemic instrumentalism’ are just two positions among many on a constantly evolving continuum of options between instrumentalism and full-blown realism. In particular it is demonstrated that not only can naturalised realism redefine the terms of realist debate in such a way that no talk of miracles need enter the debate, but it also promises interesting defenses against inductive- and under-determination-based anti-realist arguments. (shrink)

Immanuel Kant has built up a dualistic epistemology that seems to fit to the peculiarities of chemistry quite well. Friedrich Paneth used Kant’s concept and characterised simple and basic substances which refer to the empirical and to the transcendental world, respectively. This paper takes account of the Kantian influences in Paneth’s philosophy of chemistry, and discusses pertinent topics, like observables, atomism and realism.

I investigate a new understanding of realism in science, referred to as ‘interactive realism’, and I suggest the ‘evolutionary progressiveness’ of a theory as novel criterion for this kind of realism. My basic claim is that we cannot be realists about anything except the progress affected by myriad science-reality interactions that are constantly moving on a continuum of increased ‘fitness’ determined according to empirical constraints. Moreover to reflect this movement accurately, there is a corresponding continuum of verdicts about the status (...) of the knowledge conveyed by theories – ranging from stark instrumentalism to full-blown realism. This view may sound like a pessimistic inductivist's dream, but actually this is so only if one evaluates it from within a traditional context where the ‘truth’ of a single theory is the exclusive criterion for realism. I, on the other hand, want to redefine the terms of realist debate in such a way that the units of assessment of realism are sequences of theories evaluated according to their ‘evolutionary progressiveness’. I unpack ‘interactive realism’ by defining my notion of ‘evolutionary progressiveness’, the notion of ‘truth-as-historied reference’ underpinning it, and the continuum of interaction between theories and aspects of reality it affects. I conclude that, although interactive realism is a radically non-standard kind of realism, it is at least more realistic about science as a fractured complex multi-faceted enterprise than most other kinds of realism on the block, because it shows coherence amidst fragmentation. (shrink)

Recently, philosophers have come forth with approaches to chemistry based on its actual practice, imparting to it a proper aim and character of its own. These approaches add to the currently growing movement of pluralist philosophies of science. We draw on recent pluralist accounts from chemistry and analyse three notions from modern chemical practice and theory in terms of these accounts, in order to complement the so far more general pluralist approaches with specific evidence. Our survey reveals that the concept (...) of element indicates conceptual pluralisms in chemistry. that electronegativity illustrates methodological pluralism in determining one and the same concept, and that acidity is an instance of plurality hidden behind ‘one notion’. (shrink)

In this short essay I address the central topic of the Centenary Workshop on Acidity, that is the relations of the classical protonist acid–base theory by Brønsted and the electronist approach by Lewis. Emphasis is laid on the empirical background of both approaches and the over-theoretization of chemical phenomena (essentialism) is criticized.

forthcoming in Philosophy and Phenomenological Research.

This paper engages critically with anti-representationalist arguments pressed by prominent enactivists and their allies. The arguments in question are meant to show that the “as-such” and “job-description” problems constitute insurmountable challenges to causal-informational theories of mental content. In response to these challenges, a positive account of what makes a physical or computational structure a mental representation is proposed; the positive account is inspired partly by Dretske’s views about content and partly by the role of mental representations in contemporary cognitive scientific (...) modeling. (shrink)

H. B. D. Kettlewell's (1955, 1956) classic field experiments on industrial melanism in polluted and unpolluted settings using the peppered moth, Biston betularia, are routinely cited as establishing that the melanic (dark) form of the moth rose in frequency downwind of industrial centers because of the cryptic advantage dark coloration provides against visual predators in soot-darkened environments. This paper critiques three common myths surrounding these investigations: (1) that Kettlewell used a model that identified crypsis as the only selective force responsible (...) for the spread of the melanic gene, (2) that Kettlewell's field experiments alone established that selection for crypsis was the most important factor in the spread of melanic forms, and (3) that Kettlewell's investigations in an unpolluted wood near Dorset constituted a control for his earlier Birmingham studies (contra Hagen 1993, 1996). This analysis further identifies two features that distinguish manipulative experiments in evolutionary biology from experiments in other contexts. First, experiments in evolutionary biology rest on a wealth of information provided by strictly observational ecological studies; in the absence of such information experiments in evolutionary biology make no sense. Second, there is a trade-off between how much control investigators have over the conditions being studied and how informative the results of the experiment will be with regard to natural populations. (shrink)

: Bayesians and error statisticians have relied heavily upon examples from physics in developing their accounts of scientific inference. The present essay demonstrates it is possible to analyze H.B.D. Kettlewell's classic study of natural selection from Deborah Mayo's error statistical point of view (Mayo 1996). A comparison with a previous analysis of this episode from a Bayesian perspective (Rudge 1998) reveals that the error statistical account makes better sense of investigations such as Kettlewell's because it clarifies how core elements in (...) the design of experiments are used to minimize erroneous inferences rather than dwelling on whether the strategies used are reasonable. (shrink)

: Most work done in philosophy of experiment has focused on experiments taken from the domain of physics. The present essay tests whether Allan Franklin's (1984, 1986, 1989, 1990) philosophy of experiment developed in the context of high energy physics can be extended to include examples from evolutionary biology, such as H. B. D. Kettlewell's (1955, 1956, 1958) famous studies of industrial melanism in the peppered moth, Biston betularia. The analysis demonstrates that many of the techniques used by evolutionary biologists (...) exemplify the strategies Franklin lists, and identifies an additional strategy that can likewise be justified by appeal to Bayes's Theorem. (shrink)

This paper develops a new version of instrumentalism, in light of progress in the realism debate in recent decades, and thereby defends the view that instrumentalism remains a viable philosophical position on science. The key idea is that talk of unobservable objects should be taken literally only when those objects are assigned properties (or described in terms of analogies involving things) with which we are experientially (or otherwise) acquainted. This is derivative from the instrumentalist tradition in so far as the (...) distinction between unobservable and observable is taken to have significance with respect to meaning. (shrink)

Naturalism in the philosophy of science has proceeded differently than the familiar forms of meta-philosophical naturalism in other sub-fields, taking its cues from “science as we know it” (Cartwright in The Dappled World, Oxford University Press, Oxford, 1999, p. 1) rather than from a philosophical conception of “the Scientific Image.” Its primary focus is scientific practice, and its philosophical analyses are complementary and accountable to empirical studies of scientific work. I argue that naturalistic philosophy of science is nevertheless criterial for (...) other versions of meta-philosophical naturalism; relying on a conflicting conception of scientific understanding would constitute a “first philosophy” imposed on the sciences. Moreover, naturalistic philosophy of science provides the basis for a “radically” naturalistic alternative to the familiar forms of orthodox or liberal naturalism. Goodman, Sellars and Hempel had previously challenged empiricist scruples against causal connections or nomological necessity by arguing that scientific concepts already had modal import. The radical naturalism I defend similarly challenges meta-philosophical naturalists’ conception of the Scientific Image as anormative, and instead shows how the normativity of scientific understanding in practice is a scientifically intelligible natural phenomenon. This account then provides a basis for naturalistic reflection on how other practices and normative concerns fit together with the best scientific understanding of human ways of life. (shrink)

The interpretive plasticity of Kuhn’s philosophical work has been reinforced by readings informed by other philosophical, historiographic or sociological projects. This paper highlights several aspects of Kuhn’s work that have been neglected by such readings. First, Kuhn’s early contribution to several subsequent philosophical developments has been unduly neglected. Kuhn’s postscript discussion of “exemplars” should be recognized as one of the earliest versions of a conception of theories as “mediating models.” Kuhn’s account of experimental practice has also been obscured by readings (...) that assimilate his views to Quinean holism. Second, three distinctive Kuhnian themes have been insufficiently recognized. Kuhn’s challenge to received philosophical views has been domesticated by reading him as offering an alternative conception of scientific knowledge. Kuhn is better understood as rejecting knowledge-centric accounts altogether, in favor of understanding the practice of research. Kuhn’s conception of that activity, as conceptual “articulation,” has accordingly also not been given its due. Finally, Kuhn’s career-long insistence on the mutual accountability of philosophy of science and the philosophy of mind and language calls attention to the extent to which these fields have now drifted apart. (shrink)

This survey of major developments in North American philosophy of science begins with the mid-1960s consolidation of the disciplinary synthesis of internalist history and philosophy of science (HPS) as a response to criticisms of logical empiricism. These developments are grouped for discussion under the following headings: historical metamethodologies, scientific realisms, philosophies of the special sciences, revivals of empiricism, cognitivist naturalisms, social epistemologies, feminist theories of science, studies of experiment and the disunity of science, and studies of science as practice and (...) culture. A unifying theme of the survey is the relation between historical metamethodologists and scientific realists, which dominated philosophical work in the late 1970s. I argue that many of the alternative cognitive naturalisms, social epistemologies, and feminist theories that have been proposed can be understood as analogues to the differences between metamethodological theories of scientific rationality and realist accounts of successful reference to real causal processes. Recent work on experiment, scientific practice, and the culture of science may, however, challenge the underlying conception of the field according to which realism and historical rationalism (or their descendants) are the important alternatives available, and thus may take philosophy of science in new directions. (shrink)

Roth (1987) effectively distinguishes Quinean indeterminacy of translation from the more general underdetermination of theories by showing how indeterminacy follows directly from holism and the role of a shared environment in language learning. However, Roth is mistaken in three further consequences he draws from his interpretation of indeterminacy. Contra Roth, natural science and social science are not differentiated as offering theories about the shared environment and theories about meanings respectively; the role of the environment in language learning does not justify (...) an empiricist sense of objective evidence; and his advocacy of methodological pluralism does not appropriately sustain the project of social scientific methodology in response to holism and indeterminacy. (shrink)

Attention to scientific practice offers a novel response to philosophical queries about how conceptual understanding is empirically accountable. The locus of the issue is thereby shifted, from perceptual experience to experimental and fieldwork interactions. More important, conceptual articulation is shown to be not merely ?spontaneous? and intralinguistic, but instead involves a establishing a systematic domain of experimental operations. The importance of experimental practice for conceptual understanding is especially clearly illustrated by cases in which entire domains of scientific investigation were first (...) made accessible to articulated conceptual understanding. We thereby see more clearly how experimental systems themselves, and not merely the theories and models they make possible, have an intentional directedness and ?representational? import. (shrink)

Riddles of induction – old or new, Hume’s or Goodman’s – pose unanswered challenges to assumptions that experiences logically legitimate expectations or classifications. The challenges apply both to folk beliefs and to scientific ones. In particular, Goodman’s ‘new riddle’ famously confounds efforts to specify how additional experiences confirm the rightness of currently preferred ways of organizing objects, i.e. our favored theories of what kinds there are.1 His riddle serves to emphasize that neither logic nor experience certifies accepted groupings of objects (...) into kinds.2 Hacking strongly endorses Goodman’s riddle and its chief consequences – nature does not dictate any organizing scheme to us, and different schemes need have no connection to one another. (shrink)

The swiftly growing field of neurobiological research utilizes highly advanced technologies (e.g., magnetic resonance imaging, electron microscopy) to mediate between investigators and the brains they investigate. Here, the author analyzes a device called the “slam freezer” that quick-freezes neurons to be studied under the microscope. Employing insights from Don Ihde’s philosophy of technology, work that carefully amalgamates continental philosophy with philosophy of science, the author draws out the practices of interpretation in slam-freezing research. This interdisciplinary approach to understanding scientific methodology (...) sets the stage for further philosophical investigation of research in neuroscience. (shrink)

Thinkers from a variety of fields analyze the roles of imaging technologies in science and consider their implications for many issues, from our conception of selfhood to the authority of science. In what follows, I encourage scholars to develop an applied philosophy of imaging, that is, to collect these analyses of scientific imaging and to reflect on how they can be made useful for ongoing scientific work. As an example of this effort, I review concepts developed in Don Ihde’s phenomenology (...) of technology and refigure them for use in the analysis of scientific practice. These concepts are useful for drawing out the details of the interpretive frameworks scientists bring to laboratory images. Next, I apply these ideas to a contemporary debate in neurobiology over the interpretation of images of neurons which have been frozen at the moment of transmitter release. This reveals directions for further thought for the study of neurotransmission. (shrink)

We consider the use of interventions for resolving a problem of unidentified statistical models. The leading examples are from latent variable modelling, an influential statistical tool in the social sciences. We first explain the problem of statistical identifiability and contrast it with the identifiability of causal models. We then draw a parallel between the latent variable models and Bayesian networks with hidden nodes. This allows us to clarify the use of interventions for dealing with unidentified statistical models. We end by (...) discussing the philosophical and methodological import of our result. (shrink)

In this paper, I argue that if one is already an advocate of scientific realism, then one would be also a realist about laws of nature. To show this, I argue that only scientific realists would accept that non-accidental regularities require explanation and that their genuine explanation is given by laws of nature. Then, from this conclusion, it seems that scientific realists have reason to believe that there are laws of nature in an objective sense. If this is correct, the (...) conclusion is that there are no reasons for advocates of scientific realism to be skeptics about laws of nature. (shrink)

In Extragalactic Reality: The Case of Gravitational Lensing Hacking resumes the discussion of scientific realism from the last chapter of Representing and Intervening. Since the criterion of manipulability cannot be applied to astronomical objects, experimental entity realism seems to be restricted to terrestrial entities. In fact, Hacking explicitly argues against astronomical realism. The case at issue is the existence of gravitational lenses. In this paper, I question Hacking 's chief witness for astronomical antirealism: the gravitational lens system “0957+ 561”. It (...) will be shown that Hacking 's argumentation is misleading. Discussing astronomical realism as theory realism, Hacking focuses on the question of how to infer the existence of gravitational lenses from the truth of gravitational lens theory. But neither the reconstruction of gravitational lensing in terms of inference to the best explanation nor the argument of underdetermination are tenable under closer inspection. My thesis is that a realist account of gravitational lensing can be given by relying on observation, causal capacities and home truths. (shrink)

Critical realists would have us believe that representations have a connection to the world, that of truth or reference for example, which is independent of their usefulness to us. They would have us believe further that knowledge about this connection serves to put religion and science in their proper places with respect to one another. This essay raises pragmatic objections to these belief's.

In this article I assess the problems and prospects of a microstructural approach to chemical substances. Saul Kripke and Hilary Putnam famously claimed that to be gold is to have atomic number 79 and to be water is to be H2O. I relate the first claim to the concept of element in the history of chemistry, arguing that the reference of element names is determined by atomic number. Compounds are more difficult: water is so complex and heterogeneous at the molecular (...) level that `water is H2O' seems false under some interpretations. I sketch a response to this problem. (shrink)

Structural realism is an attempt to balance the competing demands of the No Miracles Argument and the Pessimistic Meta-Induction. In this paper I trace the development of the structuralist idea through the work of one of its leading advocates, John Worrall. I suggest that properly thought through what the structuralist is offering or should be offering is not an account of how to divide up a theory into two parts—structure and ontology—but (perhaps surprisingly) a certain kind of theory of meaning—semantic (...) holism. I explain how a version of structural realism can be developed using Davidson’s theory of meaning and some advantages this has over the Ramsey-sentence version of structuralism. (shrink)

The patent system appears to make three ontological assumptions often associated with scientific realism: there is a natural world that is independent of human knowledge and technology; invented products can be unobservable things; and invented products have causal powers. Although a straightforward reading of patent laws implies these ontological commitments, it is not at all clear that what the patent system has to say about the world has any bearing on issues of scientific realism. While realists might embrace the patent (...) system’s apparent ontology as providing additional support for their view, anti-realists could propose an alternative interpretation of patent law that does not involve realist ontological commitments. Thus, questions about the patent system’s ontology depend on whether one takes patent laws at face value or defends an interpretation of patent law motivated by philosophical theory. Philosophers of science should pay attention to the practice of patenting, even if they ultimately reject the patent system’s apparent ontology and offer an alternative interpretation. (shrink)

Traditional debates about scientific realism tend to focus on issues concerning scientific representation and de-emphasize issues concerning scientific intervention. Questions about the relation between theories and the world, the nature of scientific inference, and the structure of scientific explanations have occupied a central place in the realism debate, while questions about experimentation and technology have not. Ian Hacking's experimental realism attempts to reverse this trend by shifting the defense of realism away from representation to intervention. Experimental realism, according to Hacking, (...) does not require us to believe that our theories are true, nor does its defense depend on inference to the best explanation. For Hacking, the strongest proof for realism is that we can manipulate objects: 'So far as I'm concerned, if you can spray them, then they are real'. (shrink)

This paper aims (a) to provide characterizations of realism and instrumentalism that are philosophically interesting and applicable to economics; and (b) to defend instrumentalism against realism as a methodological stance in economics. Starting point is the observation that ‘all models are false’, which, or so I argue, is difficult to square with the realist's aim of truth, even if the latter is understood as ‘partial’ or ‘approximate’. The three cheers in favour of instrumentalism are: (1) Once we have usefulness, truth (...) is redundant. (2) There is something disturbing about causal structure. (3) It's better to do what one can than to chase rainbows. (shrink)

A recent movement in the social sciences and philosophy of the social sciences focuses on mechanisms as a central analytical unit. Starting from a pluralist perspective on the aims of the social sciences, I argue that there are a number of important aims to which knowledge about mechanisms—whatever their virtues relative to other aims—contributes very little at best and that investigating mechanisms is therefore a methodological strategy with fairly limited applicability. Key Words: social science • mechanisms • explanation • critical (...) realism • methodology. (shrink)

In the context of calls for "postpositivist" sociology, realism has emerged as a powerful and compelling epistemology for social science. In transferring and transforming scientific realism --a philosophy of natural science--into a justificatory discourse for social science, realism splits into two parts: a strict, highly naturalistic realism and a reflexive, more mediated, and critical realism. Both forms of realism, however, suffer from conceptual ambiguities, omissions, and elisions that make them an inappropriate epistemology for social science. Examination of these problems in (...) detail reveals how a different perspective--centered on the interpretation of meaning--could provide a better justification for social inquiry, and in particular a better understanding of sociological theory and the construction of sociological explanations. (shrink)

Molecular biologists exploit information conveyed by mechanistic models for experimental purposes. In this article, I make sense of this aspect of biological practice by developing Keller’s idea of the distinction between ‘models of’ and ‘models for’. ‘Models of (phenomena)’ should be understood as models representing phenomena and are valuable if they explain phenomena. ‘Models for (manipulating phenomena)’ are new types of material manipulations and are important not because of their explanatory force, but because of the interventionist strategies they afford. This (...) is a distinction between aspects of the same model. In molecular biology, models may be treated either as ‘models of’ or as ‘models for’. By analysing the discovery and characterization of restriction–modification systems and their exploitation for DNA cloning and mapping, I identify the differences between treating a model as a ‘model of’ or as a ‘model for’. These lie in the cognitive disposition of the modeller towards the model: a modeller will look at a model as a ‘model of’ if interested in its explanatory force, or as a ‘model for’ if interested in the material manipulations it can possibly afford. (shrink)

In a 1993 paper, I argued that empirical treatments of the epistemologyused by scientists in experimental work are too abstract in practice tocounter relativist efforts to explain the outcome of scientificcontroversies by reference to sociological forces. This was because, atthe rarefied level at which the methodology of scientists is treated byphilosophers, multiple mutually inconsistent instantiations of theprinciples described by philosophers are employed by contestingscientists. These multiple construals change within a scientificcommunity over short time frames, and these different versions ofscientific methodology (...) can determine the outcome of a controversy. Iillustrated with a comparatively detailed analysis of the methodologyused by biologists debating the existence of an entity called thebacterial mesosome between the mid-1950s and the mid-1970s. This 1993piece has drawn several critiques in the philosophical literature. Inthis present piece I respond to these critiques and argue that they failto address the core argument of the original paper, and I reflectfurther on the methodologies of philosophers of science pursuingempirical or `naturalistic' epistemology. (shrink)

This paper argues that, contrary to the views of Nancy Cartwright and Brian Ellis, explanations are factive: if a statement is taken to be an explanation, it also has to be accepted as true. Taking explanations to be true, in turn, seems to imply that all the entities posited in explanations are real. But this is precisely what some philosophers, such as Cartwright and Ellis, want to deny. What these philosophers do not want to deny, however, is that such statements (...) do explain. As a result, they see themselves forced to reject the facticity of explanation, a strategy that is unacceptable in my view. In order to avoid the further conclusion that all of the entities explanations posit exist, I propose to separate truth from ontology: explanations can be true, but the truth of these explanations alone does not commit us to the entities that these explanations posit. To determine where the ontological commitments of our statements lie, we must instead start with a criterion (a necessary and sufficient condition) for what exists. For instance, if all and only entities with causal powers are real, then this tells us that the only entities our true statements are committed to are entities with causal powers. (shrink)

Several philosophers of science have claimed that the correspondence principle can be generalized from quantum physics to all of (particularly physical) science and that in fact it constitutes one of the major heuristical rules for the construction of new theories. In order to evaluate these claims, first the use of the correspondence principle in (the genesis of) quantum mechanics will be examined in detail. It is concluded from this and from other examples in the history of science that the principle (...) should be qualified with respect to its nature and relativized with respect to its scope of application. At the same time this conclusion implies a qualification and a relativization of the heuristic power of the principle. Generally speaking, intertheoretical correspondence is primarily of a formal-mathematical and empirical but not of a conceptual nature. Moreover, it only applies to certain parts of the theories involved. Finally, a number of philosophical justifications of the principle are discussed and some conclusions are drawn concerning the debates on theory reduction and on the discovery-justification distinction. (shrink)

In this article, I put forward a basic philosophical claim: empirical scientific knowledge, that is, knowledge generated in experimental and observational practices, presupposes real causation. My discussion exploits two core notions from the philosophical analysis of scientific experimentation and observation: the aim of realizing object-apparatus correlations and the required control of the relevant interactions between environment and experimental or observational system. The conclusion is that, without the notion of real causation, acquiring epistemically sound empirical knowledge is impossible. Several empiricist objections (...) to this conclusion are discussed and refuted. As a consequence, empiricism faces an unsolvable dilemma: either it cannot account for empirical knowledge or it should accept the existence of unobservable but real causal interactions. (shrink)