The problem of collecting, analyzing and evaluating evidence on adverse drug reactions (ADRs) is an example of the more general class of epistemological problems related to scientific inference and prediction, as well as a central problem of the health-care practice. Philosophical discussions have critically analysed the methodological pitfalls and epistemological implications of evidence assessment in medicine, however they have mainly focused on evidence of treatment efficacy. Most of this work is devoted to statistical methods of causal inference with a special (...) attention to the privileged role assigned to randomized controlled trials in Evidence Based Medicine. Regardless of whether the RCT’s privilege holds for efficacy assessment, it is nevertheless important to make a distinction between causal inference of intended and unintended effects, in that the unknowns at stake are heterogonous in the two contexts. This point has been emphasized by epidemiologists in the last decade. Their main focus is methodological, and regards the fact that bias and confounding do not affect studies on intended and unintended effects in the same way. However, deeper concerns ground the intuition for such a distinction; these are related to the constraints which we impose on evidence and their epistemological justification. My thesis is that such constraints ought to be understood to be different in the case of evidence for risk vs. benefit assessment. I present the recent debate on the causal association between acetaminophen and asthma in order to illustrate the point at issue. (shrink)

The Linda paradox is a key topic in current debates on the rationality of human reasoning and its limitations. We present a novel analysis of this paradox, based on the notion of verisimilitude as studied in the philosophy of science. The comparison with an alternative analysis based on probabilistic confirmation suggests how to overcome some problems of our account by introducing an adequately defined notion of verisimilitudinarian confirmation.

I argue that so-called 'background knowledge' in confirmation theory has little, if anything, to do with 'knowledge' in the sense of mainstream epistemology. I argue that it is better construed as 'background information', which need not be believed in, justified, or true.

This paper constitutes one extended argument, which touches on various topics of Critical Rationalism as it was initiated by Karl Popper and further developed in his aftermath. The result of the argument will be that critical rationalism either offers no solution to the problem of induction at all, or that it amounts, in the last resort, to a kind of Critical Rationalist Inductivism as it were, a version of what I call Good Old Induction. One may think of David Miller (...) as a contemporary representative of what I consider as the ‘no solution’ version of critical rationalism, while Alan Musgrave stands for the version of ‘critical rationalist induction’. Popper’s own writings admit of either interpretation. (shrink)

This paper analyzes concepts of independence and assumptions of convexity in the theory of sets of probability distributions. The starting point is Kyburg and Pittarelli’s discussion of “convex Bayesianism” (in particular their proposals concerning E-admissibility, independence, and convexity). The paper offers an organized review of the literature on independence for sets of probability distributions; new results on graphoid properties and on the justification of “strong independence” (using exchangeability) are presented. Finally, the connection between Kyburg and Pittarelli’s results and recent developments (...) on the axiomatization of non-binary preferences, and its impact on “complete” independence, are described. (shrink)

The focus of this study is cognitive choice: the selection of one cognitive option (a hypothesis, a theory, or an axiom, for instance) rather than another. The study proposes that cognitive choice should be based on the plausibilities of states posited by rival cognitive options and the utilities of these options' information outcomes. The proposal introduces a form of decision theory that is novel because comparative; it permits many choices among cognitive options to be based on merely comparative plausibilities and (...) utilities. This form of decision theory intersects with recommendations by advocates of decision theory for cognitive choice, on the one hand, and defenders of comparative evaluation of scientific hypotheses and theories, on the other. But it differs from prior decision-theoretic proposals because it requires no more than minimal precision in specifying plausibilities and utilities. And it differs from comparative proposals because none has shown how comparative evaluations can be carried out within a decision-theoretic framework. (shrink)

In normative decision theory, the weight of an uncertain event in a decision is governed solely by the probability of the event. A large body of empirical research suggests that a single notion of probability does not accurately capture peoples' reactions to uncertainty. As early as the 1920s, Knight made the distinction between cases where probabilities are known and where probabilities are unknown. We distinguish another case –- the unknowable uncertainty –- where the missing information is unavailable to all. We (...) propose that missing information influences the attractiveness of a bet contingent upon an uncertain event, especially when the information is available to someone else. We demonstrate that the unknowable uncertainty –- falls in preference somewhere in between the known and the known uncertainty. (shrink)

This paper contributes to a theory of rational choice for decision-makers with incomplete preferences due to partial ignorance, whose beliefs are representable as sets of acceptable priors. We focus on the limiting case of `Complete Ignorance' which can be viewed as reduced form of the general case of partial ignorance. Rationality is conceptualized in terms of a `Principle of Preference-Basedness', according to which rational choice should be isomorphic to asserted preference. The main result characterizes axiomatically a new choice-rule called `Simultaneous (...) Expected Utility Maximization'. It can be interpreted as agreement in a bargaining game (Kalai-Smorodinsky solution) whose players correspond to the (extremal) `acceptable priors' among which the decision maker has suspended judgment. An essential but non-standard feature of Simultaneous Expected Utility choices is their dependence on the entire choice set. This is justified by the conception of optimality as compromise rather than as superiority in pairwise comparisons. (shrink)

According to the Dutch Book Argument (DBA), if an agent's subjective probabilities fail to satisfy the axioms of the probability calculus and so make the agent vulnerable to a Dutch Book, the agent's subjective probabilities are incoherent and the agent is therefore irrational. Critics of DBA have argued, however, that probabilistic incoherence is compatible with various kinds of rationality – logico-semantic, epistemic, instrumental and prudential. In this paper, I provide an interpretation of DBA on which it is true that probabilistic (...) incoherence entails agent irrationality. Articulating this interpretation requires the specification of some of the connections among the varieties of rationality. Once this is done, it becomes possible to vindicate a modest version of DBA. (shrink)

People are less willing to accept bets about an event when they do not know the true probability of that event. Such uncertainty aversion has been used to explain certain economic phenomena. This paper considers how far standard private information explanations (with strategic decisions to accept bets) can go in explaining phenomena attributed to uncertainty aversion. This paper shows that if two individuals have different prior beliefs about some event, and two sided private information, then each individual’s willingness to bet (...) will exhibit a bid ask spread property. Each individual is prepared to bet for the event, at sufficiently favorable odds, and against, at sufficiently favorable odds, but there is an intermediate range of odds where each individual is not prepared to bet either way. This is only true if signals are distributed continuously and sufficiently smoothly. It is not true, for example, in a finite signal model. (shrink)

Charles Morgan has argued that nonmonotonic logic is ``impossible''. We show here that those arguments are mistaken, and that Morgan's preferred alternative, the representation of nonmonotonic reasoning by ``presuppositions'' fails to provide a framework in which nonmonotonic reasoning can be constructively criticised. We argue that an inductive logic, based on probabilistic acceptance, offers more than Morgan's approach through presuppositions.

The presentation of analogical arguments in the critical thinking literature fails to reflect cognitive research on analogy. Part of the problem is that these treatments of analogy do not address counterarguments, an important aspect of the analysis of analogical argumentation. In this paper, I present a taxonomy of four counterarguments, false analogy, misanalogy, disanalogy, and counteranalogy, analyzed along two dimensions, orientation and effect. The counterarguments are treated in the framework of the multiconstraint theory of analogy (Holyoak and Thagard, 1995). This (...) framework is also extended to account for the evidence brought to light by the consideration of counterarguments. The result is a psychologically motivated treatment of analogical arguments that will be useful both for critical and pedagogical purposes. (shrink)

The Pyrrhonian sceptic Favorinus of Arelata personified indeterminacy, cultivating his (or her) borderline status to undermine dogmatism. Inspired by the techniques of Favorinus, I show, by example, that ‘vague’ has borderline cases. These concrete steps lead to a more abstract argument that ‘vague’ has borderline borderline cases and borderline borderline borderline cases. My specimens are intended supplement earlier non-constructive proofs of the vagueness of ‘vague’.

Entropy is ubiquitous in physics, and it plays important roles in numerous other disciplines ranging from logic and statistics to biology and economics. However, a closer look reveals a complicated picture: entropy is defined differently in different contexts, and even within the same domain different notions of entropy are at work. Some of these are defined in terms of probabilities, others are not. The aim of this chapter is to arrive at an understanding of some of the most important notions (...) of entropy and to clarify the relations between them, After setting the stage by introducing the thermodynamic entropy, we discuss notions of entropy in information theory, statistical mechanics, dynamical systems theory and fractal geometry. (shrink)

The Institute Vienna Circle held a conference in Vienna in 2003, Cambridge and Vienna a?

Sections 1 through 3 present all of the main ideas behind the probabilistic logic of evidential support. For most readers these three sections will suffice to provide an adequate understanding of the subject. Those readers who want to know more about how the logic applies when the implications of hypotheses about evidence claims (called likelihoods) are vague or imprecise may, after reading sections 1-3, skip to section 6. Sections 4 and 5 are for the more advanced reader who wants a (...) detailed understanding of some telling results about how this logic may bring about convergence to the truth. (shrink)

The Principle of Indifference is a central element of the ‘classical’ conception of probability, but, for all its strong intuitive appeal, it is widely believed that it faces a devastating objection: the so-called (by Poincare´) ‘Bertrand paradoxes’ (in essence, cases in which the same probability question receives different answers). The puzzle has fascinated many since its discovery, and a series of clever solutions (followed promptly by equally clever rebuttals) have been proposed. However, despite the long-standing interest in this problem, an (...) important assumption, necessary for its generation, has been overlooked. My aim in this paper is to identify this assumption. Since what it claims turns out to be prima facie problematic, I will urge that the burden of proof now shifts to the objectors to PI; they have to provide reasons why this assumption holds. (shrink)

So far no known measure of confirmation of a hypothesis by evidence has satisfied a minimal requirement concerning thresholds of acceptance. In contrast, Shogenji’s new measure of justification (Shogenji, Synthese, this number 2009) does the trick. As we show, it is ordinally equivalent to the most general measure which satisfies this requirement. We further demonstrate that this general measure resolves the problem of the irrelevant conjunction. Finally, we spell out some implications of the general measure for the Conjunction Effect; in (...) particular we give an example in which the effect occurs in a larger domain, according to Shogenji justification, than Carnap’s measure of confirmation would have led one to expect. (shrink)

In Thinking and Acting John Pollock offers some criticisms of Bayesian epistemology, and he defends an alternative understanding of the role of probability in epistemology. Here, I defend the Bayesian against some of Pollock's criticisms, and I discuss a potential problem for Pollock's alternative account.

Schwitzgebel (2001) — henceforth 'S' — offers three examples in order to convince us that there are situations in which individuals are neither accurately describable as believing that p or failing to so believe, but are rather in 'in-between states of belief'. He then argues that there are no 'Bayesian' or representational strategies for explicating these, and proposes a dispositional account. I do not have any fundamental objection to the idea that there might be 'in-between states of belief'. What I (...) shall argue, rather, is that: (I) S does not provide a convincing argument that there really are such states; (II) S does not show, as he claims, that 'in-between states of belief' could not be accounted for in terms of degrees of belief; (III) S’s dispositional account of 'in-between states of belief' is more problematic than the 'degree of belief' alternative. (shrink)

A central problem facing a probabilistic approach to the problem of induction is the difficulty of sufficiently constraining prior probabilities so as to yield the conclusion that induction is cogent. The Principle of Indifference, according to which alternatives are equiprobable when one has no grounds for preferring one over another, represents one way of addressing this problem; however, the Principle faces the well-known problem that multiple interpretations of it are possible, leading to incompatible conclusions. I propose a partial solution to (...) the latter problem, drawing on the notion of explanatory priority. The resulting synthesis of Bayesian and inference-to-best-explanation approaches affords a principled defense of prior probability distributions that support induction. (shrink)

Intelligent design advocate William Dembski has introduced a measure of information called "complex specified information", or CSI. He claims that CSI is a reliable marker of design by intelligent agents. He puts forth a "Law of Conservation of Information" which states that chance and natural laws are incapable of generating CSI. In particular, CSI cannot be generated by evolutionary computation. Dembski asserts that CSI is present in intelligent causes and in the flagellum of Escherichia coli, and concludes that neither have (...) natural explanations. In this paper, we examine Dembski's claims, point out significant errors in his reasoning, and conclude that there is no reason to accept his assertions. (shrink)

Can some evidence confirm a conjunction of two hypotheses more than it confirms either of the hypotheses separately? We show that it can, moreover under conditions that are the same for ten different measures of confirmation. Further we demonstrate that it is even possible for the conjunction of two disconfirmed hypotheses to be confirmed by the same evidence.

This paper presents a new 'discontinuous' view of Popper's theory of corroboration, where theories cease to have corroboration values when new severe tests are devised which have not yet been performed, on the basis of a passage from The Logic of Scientific Discovery. Through subsequent analysis and discussion, a novel problem for Popper's account of corroboration, which holds also for the standard view, emerges. This is the problem of the Big Test : that the severest test of any hypothesis is (...) actually to perform all possible tests. But this means that Popper's demand for 'the severest tests' amounts simply to a demand for 'all possible tests'. The paper closes by considering how this bears on accommodation vs. prediction, with respect to corroboration. (shrink)

The subject matter of this thesis is analytic ontology. Chapters II and III deal with two versions of trope theory, or moderate nominalism; these are defined as ontologies which recognise properties and relations but no (real) universals. The key notion of both theories, trope, is characterised as an abstract particular. What the abstractness amounts to differs between the two. Yet another difference is that simplicity is an essential trait of a trope according to one theory, but not according to the (...) other. Though exact similarity is said to play an important role in both theories, as it turns out, this does not seem to be the case. The ontology dealt with in chapter IV is a mixture of moderate nominalism concerning qualities and realism concerning relations. In it, quality instances (moments) and universal relations are the ultimate constituents of the universe. While relations and moments are considered to be constituents of states of affairs, which are characterised as objects of higher orders, complexes that are objects of the first order are made up of moments on their own. Among these complexes one finds the ordinary objects. Paradoxically, although relations are necessary for the existence of complex first order objects, relations are not thought to be among the contents of these objects. The main subject of chapter V is a particular version of moderate realism; it is an ontology which is realistic in its recognition of universals and moderate in its recognition of instances of these universals. Instances combine to form complex networks. A theoretically motivated claim is that although each instance has a predicational aspect as well as a universal one, it is simple in the sense of lacking internal predicative structure; though, this claim can be called into question. Keywords: analytic ontology, moderate nominalism, moderate realism, particular, universal, abstract, concrete, abstract particular, abstract universal, concrete particular, concrete universal, trope, moment, complex unity, collection, instance, unit attribute, intensional aspect, predicational aspect, continuous composite, articulated composite. (shrink)

The anti-causal prophecies of last century have been disproved. Causality is neither a ‘relic of a bygone’ nor ‘another fetish of modern science’; it still occupies a large part of the current debate in philosophy and the sciences. This investigation into causal modelling presents the rationale of causality, i.e. the notion that guides causal reasoning in causal modelling. It is argued that causal models are regimented by a rationale of variation, nor of regularity neither invariance, thus breaking down the dominant (...) Human paradigm. The notion of variation is shown to be embedded in the scheme of reasoning behind various causal models: e.g. Rubin’s model, contingency tables, and multilevel analysis. It is also shown to be latent – yet fundamental – in many philosophical accounts. Moreover, it has significant consequences for methodological issues: the warranty of the causal interpretation of causal models, the levels of causation, the characterisation of mechanisms, and the interpretation of probability. This book offers a novel philosophical and methodological approach to causal reasoning in causal modelling and provides the reader with the tools to be up to date about various issues causality rises in social science. (shrink)

How to regard the weight we give to a proposition on the grounds of its being endorsed by an authority? I examine this question as it is raised within the epistemology of science, and I argue that “authority-based weight” should receive special handling, for the following reason. Our assessments of other scientists’ competence or authority are nearly always provisional, in the sense that to save time and money, they are not made nearly as carefully as they could be---indeed, they are (...) typically made on the basis of only a small portion of the available evidence. Consequently, we need to represent the authority-based elements of our epistemic attitudes in such a way as to allow the later revision of those elements, in case we decide in the light of new priorities that a more conscientious assessment is warranted. I look to the literature in confirmation theory, statistics, and economics for a semiformal model of this revision process, and make a particular proposal of my own. The discussion also casts some light on the question of why certain aspects of science’s epistemic state are not made public. (shrink)

Bayesian confirmation theory—abbreviated to in these notes—is the predominant approach to confirmation in late twentieth century philosophy of science. It has many critics, but no rival theory can claim anything like the same following. The popularity of the Bayesian approach is due to its flexibility, its apparently effortless handling of various technical problems, the existence of various a priori arguments for its validity, and its injection of subjective and contextual elements into the process of confirmation in just the places where (...) critics of earlier approaches had come to think that subjectivity and sensitivity to context were necessary. (shrink)

How should probabilities be interpreted in causal models in the social and health sciences? In this paper we take a step towards answering this question by investigating the case of cancer in epidemiology and arguing that the objective Bayesian interpretation is most appropriate in this domain.

Arguably no concept is more fundamental to science than that of causality, for investigations into cases of existence, persistence, and change in the natural world are largely investigations into the causes of these phenomena. Yet the metaphysics and epistemology of causality remain unclear. For example, the ontological categories of the causal relata have been taken to be objects (Hume 1739), events (Davidson 1967), properties (Armstrong 1978), processes (Salmon 1984), variables (Hitchcock 1993), and facts (Mellor 1995). (For convenience, causes and effects (...) will usually be understood as events in what follows.) Complicating matters, causal relations may be singular (Socrates’s drinking hemlock caused Socrates’s death) or general (Drinking hemlock causes death); hence the relata might be tokens (e.g., instances of properties) or types (e.g., types of events) of the category in question. Other questions up for grabs are: Are singular causes metaphysically and/or epistemologically prior to general causes or vice versa (or neither)? What grounds the intuitive asymmetry of the causal relation? Are macro-causal relations reducible to micro-causal relations? And perhaps most importantly: Are causal facts (e.g., the holding of causal relations) reducible to non-causal facts (e.g., the holding of certain spatiotemporal relations)? (shrink)

The weather report says that the chance of a hurricane arriving later today is 90%. Forewarned is forearmed: expecting a hurricane, before leaving home you pack your hurricane lantern.

Bayes' Theorem is a simple mathematical formula used for calculating conditional probabilities. It figures prominently in subjectivist or Bayesian approaches to epistemology, statistics, and inductive logic. Subjectivists, who maintain that rational belief is governed by the laws of probability, lean heavily on conditional probabilities in their theories of evidence and their models of empirical learning. Bayes' Theorem is central to these enterprises both because it simplifies the calculation of conditional probabilities and because it clarifies significant features of subjectivist position. Indeed, (...) the Theorem's central insight — that a hypothesis is confirmed by any body of data that its truth renders probable — is the cornerstone of all subjectivist methodology. (shrink)

Roughly speaking, classical statistical physics is the branch of theoretical physics that aims to account for the thermal behaviour of macroscopic bodies in terms of a classical mechanical model of their microscopic constituents, with the help of probabilistic assumptions. In the last century and a half, a fair number of approaches have been developed to meet this aim. This study of their foundations assesses their coherence and analyzes the motivations for their basic assumptions, and the interpretations of their central concepts. (...) The most outstanding foundational problems are the explanation of time-asymmetry in thermal behaviour, the relative autonomy of thermal phenomena from their microscopic underpinning, and the meaning of probability. A more or less historic survey is given of the work of Maxwell, Boltzmann and Gibbs in statistical physics, and the problems and objections to which their work gave rise. Next, we review some modern approaches to (i) equilibrium statistical mechanics, such as ergodic theory and the theory of the thermodynamic limit; and to (ii) non-equilibrium statistical mechanics as provided by Lanford's work on the Boltzmann equation, the so-called Bogolyubov-Born-Green-Kirkwood-Yvon approach, and stochastic approaches such as `coarse-graining' and the `open systems' approach. In all cases, we focus on the subtle interplay between probabilistic assumptions, dynamical assumptions, initial conditions and other ingredients used in these approaches. (shrink)

Crupi et al. (2008) offer a confirmation-theoretic, Bayesian account of the conjunction fallacy—an error in reasoning that occurs when subjects judge that Pr( h 1 & h 2 | e ) > Pr( h 1 | e ). They introduce three formal conditions that are satisfied by classical conjunction fallacy cases, and they show that these same conditions imply that h 1 & h 2 is confirmed by e to a greater extent than is h 1 alone. Consequently, they suggest (...) that people are tracking this confirmation relation when they commit conjunction fallacies. I offer three experiments testing the merits of Crupi et al.’s account specifically and confirmation-theoretic accounts of the conjunction fallacy more generally. The results of Experiment 1 show that, although Crupi et al.’s conditions do seem to be causally linked to the conjunction fallacy, they are not necessary for it; there exist cases that do not meet their three conditions in which subjects still tend to commit the fallacy. The results of Experiments 2 and 3 show that Crupi et al.’s conditions, and those offered by other confirmation-theoretic accounts of the fallacy, are not sufficient for the fallacy either; there exist cases that meet all three of CFT’s conditions in which subjects do not tend to commit the fallacy. Additionally, these latter experiments show that such confirmation-theoretic conditions are at best only weakly causally relevant to the presence of the conjunction fallacy. Given these findings, CFT’s account specifically, and any general confirmation-theoretic account more broadly, falls short of offering a satisfying explanation of the presence of the conjunction fallacy. (shrink)

Despite having put the concept of HPS on the institutional map, N.R. Hanson’s distinctive account of the interdependence between history of science and philosophy of science has been mostly forgotten, and misinterpreted where it is remembered. It is argued that Hanson’s account is worthy of renewed attention and extension since, through its special emphasis on a variety of different normative criteria, it provides the framework for a fruitful and transformative interaction between the two disciplines. This essay also examines two separate (...) threads of Hanson’s account of philosophy of science: his analysis of the conceptual dynamics of science and of the interrelation of the history and philosophy of science. While the two strands appear incongruent, and were perhaps inconsistent, a new interpretation of them is offered which is both consistent with Hanson’s fundamental intuitions and defensible in its own right. It is demonstrated that Hanson’s account compares favorably with those of Kuhn and Lakatos, and that it may provide a constructive means of scaling the barriers erected by fears of the genetic fallacy and ‘whiggish’ history. (shrink)

Can some evidence confirm a conjunction of two hypotheses more than it confirms either of the hypotheses separately? We show that it can, moreover under conditions that are the same for nine different measures of confirmation. Further we demonstrate that it is even possible for the conjunction of two disconfirmed hypotheses to be confirmed by the same evidence.

While there are several arguments on either side, it is far from clear as to whether or not countable additivity is an acceptable axiom of subjective probability. I focus here on de Finetti's central argument against countable additivity and provide a new Dutch book proof of the principle, To argue that if we accept the Dutch book foundations of subjective probability, countable additivity is an unavoidable constraint.

In 1959 Carnap published a probability model that was meant to allow forreasoning by analogy involving two independent properties. Maher (2000)derived a generalized version of this model axiomatically and defended themodel''s adequacy. It is thus natural to now consider how the model mightbe extended to the case of more than two properties. A simple extension waspublished by Hess (1964); this paper argues that it is inadequate. Amore sophisticated one was developed jointly by Carnap and Kemeny in theearly 1950s but never (...) published; this paper gives the first published descriptionof Carnap and Kemeny''s model and argues that it too is inadequate. Since noother way of extending the two-property model is currently known, the conclusionof this paper is that a satisfactory extension to multiple properties requires somenew approach. (shrink)

Several forms of symmetry in degrees of evidential support areconsidered. Some of these symmetries are shown not to hold in general. This has implications for the adequacy of many measures of degree ofevidential support that have been proposed and defended in the philosophical literature.

This paper is concerned with formal solutions to the lottery paradox on which high probability defeasibly warrants acceptance. It considers some recently proposed solutions of this type and presents an argument showing that these solutions are trivial in that they boil down to the claim that perfect probability is sufficient for rational acceptability. The argument is then generalized, showing that a broad class of similar solutions faces the same problem. An argument against some formal solutions to the lottery paradox The (...) argument generalized Some variations Adding modalities Anticipated objections. (shrink)

The epistemic state of complete ignorance is not a probability distribution. In it, we assign the same, unique, ignorance degree of belief to any contingent outcome and each of its contingent, disjunctive parts. That this is the appropriate way to represent complete ignorance is established by two instruments, each individually strong enough to identify this state. They are the principle of indifference (PI) and the notion that ignorance is invariant under certain redescriptions of the outcome space, here developed into the (...) ‘principle of invariance of ignorance' (PII). Both instruments are so innocuous as almost to be platitudes. Yet the literature in probabilistic epistemology has misdiagnosed them as paradoxical or defective since they generate inconsistencies when conjoined with the assumption that an epistemic state must be a probability distribution. To underscore the need to drop this assumption, I express PII in its most defensible form as relating symmetric descriptions and show that paradoxes still arise if we assume the ignorance state to be a probability distribution. *Received February 2007; revised July 2007. †To contact the author, please write to: Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PA 15260; e-mail: [email protected]. (shrink)

Reasoning that compares two objects or situations to draw conclusions about previously unknown properties of one of them has traditionally been taken to be ampliative and probabilistic. I propose that it is apodeictic reasoning from a premise about isomorphic structures that is often uncertain, but which we may have good reasons to believe. I characterize the structures and their isomorphism, describe patterns of reasoning appropriate to them, and discuss some complications not immediately obvious.

This paper justifies the inference of probabilities from symmetries. I supply some examples of important and correct inferences of this variety. Two explanations of such inferences -- an explanation based on the Principle of Indifference and a proposal due to Poincaré and Reichenbach -- are considered and rejected. I conclude with my own account, in which the inferences in question are shown to be warranted a posteriori, provided that they are based on symmetries in the mechanisms of chance setups.