Cancer is a paradigmatic case of a complex causal process; causes of cancer operate at a variety of temporal and spatial scales, and the respects in which these causes act and interact are diverse. There are, for instance, temporal order effects, organizational effects, structural effects, and dynamic relationships between causes operating at different temporal and spatial scales. Because of this complexity, models of cancer initiation and progression often involve deliberate choices to focus on one time scale, one causal pathway, or (...) one aspect of cancer’s dynamics. As in most of biology, modeling cancer involves simplification and idealization. At the same time, theoretical perspectives inform the construction of these models. Such perspectives might involve viewing cancer ‘as’ a genetic disease, metabolic disease, stem cell disease, an infectious disease, or a disease of tissue disorganization. This paper will argue that purportedly competing theoretical views of cancer are not at odds, but can be viewed as mutually informative. Models are most often developed in the service of asking very specific questions, and this requires limiting our view of the phenomena to a specific temporal or spatial scale, a particular cause, or a particular outcome, dynamic, or pattern. Thus, while some models may seem at odds, often they are simply concerned with different questions, or, they are complementary and mutually informative. I hope to bring this case to bear on debates among philosophers of science over perspectivism and realism, as well pluralism about the aims and scope of scientific theory. (shrink)

This book examines the philosophical conception of abductive reasoning as developed by Charles S. Peirce, the founder of American pragmatism. It explores the historical and systematic connections of Peirce's original ideas and debates about their interpretations. Abduction is understood in a broad sense which covers the discovery and pursuit of hypotheses and inference to the best explanation. The analysis presents fresh insights into this notion of reasoning, which derives from effects to causes or from surprising observations to explanatory theories. The (...) author outlines some logical and AI approaches to abduction as well as studies various kinds of inverse problems in astronomy, physics, medicine, biology, and human sciences to provide examples of retroductions and abductions. The discussion covers also everyday examples with the implication of this notion in detective stories, one of Peirce’s own favorite themes. The author uses Bayesian probabilities to argue that explanatory abduction is a method of confirmation. He uses his own account of truth approximation to reformulate abduction as inference which leads to the truthlikeness of its conclusion. This allows a powerful abductive defense of scientific realism. This up-to-date survey and defense of the Peircean view of abduction may very well help researchers, students, and philosophers better understand the logic of truth-seeking. (shrink)

This encyclopedia entry urges what it takes to be correctives to common (mis)understandings concerning the phenomenon of incommensurability and incomparability and briefly outlines some of their philosophical upshots.

In the methodology of scientific research programs (MSRP) there are important features on the problem of prediction, especially regarding novel facts. In his approach, Imre Lakatos proposed three different levels on prediction: aim, process, and assessment. Chapter 5 pays attention to the characterization of prediction in the methodology of research programs. Thus, it takes into account several features: (1) its pragmatic characterization, (2) the logical perspective as a proposition, (3) the epistemological component, (4) its role in the appraisal of research (...) programs, and (5) its place as a value for scientific research. -/- The notion of “novel facts” is highly relevant in his conception, where several aspects are involved: the directions of novel facts, the different kinds of novelty, and the transition from six possible options of “novel facts” to four choices. Thereafter, the prediction of novel facts as the criterion of appraisal is considered. On the one hand, this requires analyzing the theoretical, empirical, and heuristic possibilities of appraisal; and, on the other, whether there is an overemphasis on the role of prediction in methodology of scientific research programs. As a consequence, there is an analysis of Lakatos’ criterion of appraisal in MSRP and economics. (shrink)

Das Thema dieses Bandes ist die Frage, ob die Wissenschaftstheorie eine normative Disziplin ist. Zunächst überrascht die Frage, denn für viele Wissenschaftstheoretiker ist die Antwort ein klares „Ja“; sie halten es für einen Allgemeinplatz, dass die Wissenschaftstheorie ein normatives Unternehmen ist. Bei genauerem Hinsehen stellt sich jedoch heraus, dass die Frage unterschiedliche Interpretationen zulässt, die einzeln diskutiert werden müssen. Dies geschieht im ersten Abschnitt. Im zweiten Abschnitt suchen wir nach möglichen Erklärungen dafür, warum die Wissenschaftstheorie bisher bei dem Projekt, eine (...) allseits akzeptable Methodologie wissenschaftlichen Schließens zu formulieren und zu begründen, so wenig Erfolg hatte. Eine mögliche Erklärung für den ausbleibenden Erfolg ist der Partikularismus, wonach Methoden keine allgemeine, sondern nur eine lokale, bereichsabhängige Gültigkeit haben. Im dritten Abschnitt wollen wir an Hand des Bayesianismus zeigen, dass die Methodologie doch nicht so schlecht da steht, wie es zunächst den Anschein hat. Der Bayesianismus ist für viele Wissenschaftstheoretiker der aussichtsreichste Kandidat für eine allgemeine Theorie induktiven Räsonierens. Wir besprechen seine Vorzüge, stellen aber auch dar, welche Konzessionen er an den Partikularismus machen muss. (shrink)

This open access book provides the first explicit case study for an application of the method of reflective equilibrium (RE), using it to develop and defend a precautionary principle. It thereby makes an important and original contribution to questions of philosophical method and methodology. The book shows step-by-step how RE is applied, and develops a methodological framework which will be useful for everyone who wishes to use reflective equilibrium. With respect to precautionary principles, the book demonstrates how a rights-based precautionary (...) principle can be constructed and defended. The case study succeeds in demonstrating that RE can be successfully applied and puts real constraints on the justification process. This is all the more remarkable as the case study was designed as an open-ended process, without presupposing any specific results. This book will be highly relevant both to people interested in philosophical methodology and epistemology, as well as to researchers who are interested in using philosophical methods and tools and applying them to practical problems. (shrink)

Expanding his collected essays on architectural theory and criticism, Chris Abel pursues his explorations across disciplinary and regional boundaries in search of a deeper understanding of architecture in the evolution of human culture and identity formation. From his earliest writings predicting the computer-based revolution in customised architectural production, through his novel studies on 'tacit knowing' in design or hybridisation in regional and colonial architecture, to his radical theory of the 'extended self', Abel has been a consistently fresh and provocative thinker, (...) contesting both conventions and intellectual fashions. This revised third edition includes a new introduction and six additional chapters by the author covering a broad range of related topics, up to recent concerns with genetic design methods and virtual selves. Together with the former essays, the book presents a unique global perspective on the changing cultural issues and technologies shaping human identities and the built environment in diverse parts of the world, both East and West (from the book cover). (shrink)

Qualitative researchers sometimes talk about objectivity in relation to qualitative data sets. In this paper, I defend a reconstructed notion of objective qualitative data sets that may serve as a useful and reachable guiding ideal in qualitative data generation. In the first part of the paper, I develop the ideal. According to it, a qualitative data set is objective to the extent that it, in conjunction with true assumptions, possesses a combination of good-making features in virtue of which the data (...) set is suited to serve as evidence base for a satisfying answer to the research question under study. In the second part of the paper, I examine and reject two possible lines of objection to this ideal: One is that it picks out the wrong good-making features. The other is that the very focus on good-making features is misguided: the objectivity of a qualitative data set should instead be seen as a matter of how it was generated or evaluated. (shrink)

David Hull's (1988c) model of science as a selection process suffers from a two-fold inability: (a) to ascertain when a lineage of theories has been established; i.e., when theories are descendants of older theories or are novelties, and what counts as a distinct lineage; and (b) to specify what the scientific analogue is of genotype and phenotype. This paper seeks to clarify these issues and to propose an abstract model of theories analogous to particulate genetic structure, in order to reconstruct (...) relationships of descent and identity. (shrink)

Thomas S. Kuhn is famous both for his work on the Copernican Revolution and his ‘paradigm’ view of scientific revolutions. But Kuhn later abandoned the notion of paradigm in favour of a more ‘evolutionary’ view of the history of science. Kuhn’s position therefore moved closer to ‘continuity’ models of scientific progress, for instance ‘chain-of-reasoning’ models, originally championed by D. Shapere. The purpose of this paper is to contribute to the debate around Kuhn’s new ‘developmental’ view and to evaluate these competing (...) models with reference to some major innovations in the history of cosmology, from Copernicanism to modern cosmology. This evaluation is made possible through some unexpected overlap between Kuhn’s earlier discontinuity model and various versions of the later continuity models. It is the thesis of this paper that the ‘chain-of-reasoning’ model accounts better for the cosmological evidence than both Kuhn’s early paradigm model and his later developmental view of the history of science. (shrink)

Thought experiments have played a pivotal role in many debates within ethics—and in particular within applied ethics—over the past 30 years. Nonetheless, despite their having become a commonly used philosophical tool, there is something odd about the extensive reliance upon thought experiments in areas of philosophy, such as applied ethics, that are so obviously oriented towards practical life. Herein I provide a moderate defence of their use in applied philosophy against those three objections. I do not defend all possible uses (...) of thought experiments but suggest that we should distinguish between legitimate and illegitimate uses. Their legitimate uses are determined not so much by the modal content of any actual thought experiment itself, but by the extent to which the argument in which it is nested follows basic tenets of informal logic and respects the fundamental contingency of applied ethical problems. In pursuing these ideas, I do not so much provide a set of criteria for their legitimate use, but more modestly present two significant ways in which their use can go awry. (shrink)

This paper warns against destructive effects of subjectivist thinking. Subjectivist accounts, as Alan Sokal exposed, promote a distorted view of scientific practice. For example, Einstein's 1905 special theory of relativity relied on data produced by Fizeau, a physicist trained in classical mechanics. Einstein's use of Fizeau's results shows that the ontological foundation of uncontroversial data transcends conventional speculations. Einstein's employment of Fizeau's results mitigates against ideas such as paradigm shifts and revolutionary science. Instead, the ontology of shared horizons of fact (...) remains largely unadulterated. The descriptions scientists use accommodate received view shifts, but the horizon of fact remains unimpeachably the same. The apt performance of science shows what it means to move further away from error. The only direction away from error is toward truth. To deny the reality of this directionality flies in the face of common sense and prudent science. (shrink)

This paper warns against destructive effects of subjectivist thinking. Subjectivist accounts, as Alan Sokal exposed, promote a distorted view of scientific practice. For example, Einstein's 1905 special theory of relativity relied on data produced by Fizeau, a physicist trained in classical mechanics. Einstein's use of Fizeau's results shows that the ontological foundation of uncontroversial data transcends conventional speculations. Einstein's employment of Fizeau's results mitigates against ideas such as paradigm shifts and revolutionary science. Instead, the ontology of shared horizons of fact (...) remains largely unadulterated. The descriptions scientists use accommodate received view shifts, but the horizon of fact remains unimpeachably the same. The apt performance of science shows what it means to move further away from error. The only direction away from error is toward truth. To deny the reality of this directionality flies in the face of common sense and prudent science. (shrink)

The extended mind thesis maintains that while minds may be centrally located in one?s brain-and-body, they are sometimes partly constituted by tools in our environment. Critics argue that we have no reason to move from the claim that cognition is embedded in the environment to the stronger claim that cognition can be constituted by the environment. I will argue that there are normative reasons, both scientific and ethical, for preferring the extended account of the mind to the rival embedded account. (...) nema. (shrink)

The study of the history of ideas is usually devoted to big problems and to concluded debates. We have attempted to analyze a current theory whose fate and explanatory power is still not determined. The term microparadigm is used to define a currently and widely accepted theory limited in time and in the field of application, compared to the greater problems usually investigated by historians of science. Among the characteristics defining a microparadigm we found: 1) the status of an accepted (...) theory with creative scientific power; 2) the presence of anomalies and unproven inferences; 3) a limited field of application; 4) the peculiarity of interaction with non-scientific ideas. In this context, we discuss the rise of the current microparadigm concerning the pathogenesis and biology of lymphoid neoplasms. We show that the current view of the neoplastic lymphoid cells as populations frozen at a particular differentiative stage has been creative for the last 10 years, thus allowing the generation of a large body of data that would not have been collected within the previous view of the leukemic cell as completely “anarchic”. This paradigm, although containing some anomalies, has survived the impact of molecular biology in hematology and is still creative. We think that microparadigms are widely distributed in everyday science and that an analysis of them is as useful for active scientist as is the study of macroparadigms, which by themselves cannot be representative of everyday science. Finally, the study of microparadigms while they are still operative can be useful to evidence the weakness of the theory and to suggest where new data should be sought. (shrink)

Perspicuous representation, Wittgenstein offers, is not another methodology, but it consists in seeing the connections. The Wittgensteinian perspicuous representation is therapeutic. The method he suggests for philosophy is the same method he suggests for social sciences. In both of these cases, he tries to get us to see the confusions we become entangled in when philosophizing and theorizing. In both of these disciplines he warns us not to advance explanatory, metaphysical theories. In this paper, I connect this concern with Wittgenstein’s (...) critique of Frazer. In criticizing Frazer, Wittgenstein adopts the important part of Spengler’s view. Nonetheless, there are differences between Wittgenstein’s views and those of Spengler; this paper aims to show similarities as well as these differences. The first part of the paper briefly summarizes Frazer’s views. The second part focuses on Wittgenstein’s critique of Frazer concerning science and technology. The third part gives an account of his critique regarding method of social sciences and philosophy. The last part concentrates on Wittgenstein’s critique of Frazer pertaining to the tolerance towards alternative forms of life. Key Words: context-free vacuum • evolutionary explanation • incommensurability • methodology of social sciences • perspicuous representation • science • technology • tolerance • totem and taboo. (shrink)

Thomas Kuhn’s conception of paradigms has proved tremendously popular with the social sciences, in spite of the fact that Kuhn himself stopped using the concept by the time of his death; and the idea has come in for some fairly harsh treatment by philosophers of science. In this article I examine the historiography of the Second World War, paying specific attention to internal and external mechanisms of maintaining consensus – or lack therefore – within the field to see if anything (...) like paradigms can be said to exist in historical writing. (shrink)

This article attempts to show the continuing practical relevance of hermeneutics through the example of legal interpretation. The article begins with the very concrete nature of legal hermeneutics that forms everyday legal practice – the interrelation of meaning and application – and expands at a more theoretical to show how legal hermeneutics, and hermeneutics more generally, offers what Ricoeur calls an interpretive “choice in favor of meaning.” The choice in favour of meaning underscores the restorative character of hermeneutics that legal (...) hermeneutics can epitomize. The article concludes with some of the challenges facing contemporary legal hermeneutics. (shrink)

Traditionally, Thomas S. Kuhn’s The Structure of Scientific Revolutions (1962) is largely identified with his analysis of the structure of scientific revolutions. Here, we contribute to a minority tradition in the Kuhn literature by interpreting the history of evolutionary biology through the prism of the entire historical developmental model of sciences that he elaborates in The Structure. This research not only reveals a certain match between this model and the history of evolutionary biology but, more importantly, also sheds new light (...) on several episodes in that history, and particularly on the publication of Charles Darwin’s On the Origin of Species (1859), the construction of the modern evolutionary synthesis, the chronic discontent with it, and the latest expression of that discontent, called the extended evolutionary synthesis. Lastly, we also explain why this kind of analysis hasn’t been done before. (shrink)

This article develops a model-based account of the standardization of physical measurement, taking the contemporary standardization of time as its central case study. To standardize the measurement of a quantity, I argue, is to legislate the mode of application of a quantity concept to a collection of exemplary artefacts. Legislation involves an iterative exchange between top-down adjustments to theoretical and statistical models regulating the application of a concept, and bottom-up adjustments to material artefacts in light of remaining gaps. The model-based (...) account clarifies the cognitive role of ad hoc corrections, arbitrary rules, and seemingly circular inferences involved in contemporary timekeeping, and explains the stability of networks of standards better than its conventionalist and constructivist counterparts. 1 Introduction2 Making Time Universal2.1 Stability and accuracy2.2 Multiple realizability2.3 The challenges of synchronicity2.4 Divergent standards2.5 The leap second3 The Two Faces of Stability3.1 An explanatory challenge3.2 Conventionalist explanations3.3 Constructivist explanations4 Models and Standardization4.1 A third alternative4.2 Stability reconceived4.3 Legislative freedom4.4 Discovering gaps4.5 Nature and society entangled4.6 Remark on scope5 Conclusions. (shrink)

What is artificial life? Much has been said about this interesting collection of efforts to artificially simulate and synthesize lifelike behavior and processes, yet we are far from having a robust philosophical understanding of just what Alifers are doing and why it ought to interest philosophers of science, and philosophers of biology in particular. In this paper, I first provide three introductory examples from the particular subset of artificial life I focus on, known as ‘soft Alife’ (s-Alife), and follow up (...) with a more in-depth review of the Avida program, which serves as my case study of s-Alife. Next, I review three well-known accounts of thought experiments, and then offer my own synthesized account, to make the argument that s-Alife functions as thought experimentation in biology. I draw a comparison between the methodology of the thought-experimental world that yields real-world results, and the s-Alife research that informs our understanding of natural life. I conclude that the insights provided by s-Alife research have the potential to fundamentally alter our understanding of the nature of organic life and thus deserve the attention of both philosophers and natural scientists. (shrink)

We examine the criticisms and subsequent changes that arise in the course of peer review. Fifty-two scholars who had recently published in Administrative Science Quarterly were surveyed regarding their peer review experience and how their article changed from initial journal submission to eventual publication. Papers that challenged theoretical perspectives faced distinctively high levels of criticism and change, particularly with attention to methodology, while those that offered a new perspective or that extended or combined established perspectives were less criticized and changed. (...) The number of challenge-oriented publications was small as well, suggesting that either few such submissions survive the review process or few are submitted in the first place. Overall, peer review appears open to expansion of the variety of theoretical argument but does little to aid in the winnowing out of established perspectives. (shrink)

L’article propose une analyse comparative des positions de Popper et de Kuhn sur quatre points liés : la comparaison des « cadres théoriques » ou des « paradigmes scientifiques » ; le pouvoir contraignant que sont susceptibles d’avoir les arguments invoqués dans les discussions critiques ; les éléments qui, en fin de compte, pèsent ou doivent peser sur les praticiens lorsqu’il s’agit d’élire un cadre théorique au détriment d’un autre ; et enfin, la conception qu’ont chacun des deux auteurs de (...) ce que Kuhn a nommé la « science normale ». On commence par discuter en détails les comptes-rendus dans lesquels Popper explique pourquoi les choix scientifiques de Galilée et de Kepler sont conformes à la méthodologie falsificationniste. On montre de là, premièrement, qu’à suivre à la lettre ces comptes-rendus, il faut conclure que les données expérimentales non problématiques — les énoncés de base unanimement acceptés — ne suffisent pas à elles seules à imposer en droit la falsification empirique (puisque sur la base des mêmes mesures de Tycho Brahé, Kepler a eu raison d’admettre que l’hypothèse des orbites circulaires était empiriquement réfutée, tandis que Galilée a eu raison d’admettre le contraire). On montre alors, deuxièmement, qu’au-delà des différences importantes entre Popper et Kuhn au niveau des lexiques et de l’idéal de scientificité, la méthodologie poppérienne, bien qu’elle se revendique « logique », ne donne concrètement pas plus que la conception kuhnienne pourtant si souvent stigmatisée comme « sociologique », lorsqu’il s’agit d’indiquer ce qu’un bon scientifique devrait faire, que ce soit en période « révolutionnaire » ou en période de « science normale ». (shrink)

Ian Hacking’s Representing and Intervening is often credited as being one of the first works to focus on the role of experimentation in philosophy of science, catalyzing a movement which is sometimes called the “philosophy of experiment” or “new experimentalism”. In the 1980s, a number of other movements and scholars also began focusing on the role of experimentation and instruments in science. Philosophical study of experimentation has thus seemed to be an invention of the 1980s whose central figure is Hacking. (...) This article aims to assess this historical claim, made by Hacking himself as well as others. It does so first by highlighting how a broader perspective on the history of philosophy reveals this invention narrative to be incorrect, since experimentation was a topic of interest for earlier philosophers. Secondly, the article evaluates a revision of this historical claim also made by some philosophers of experiment: the rediscovery narrative, which frames Hacking and others as having rediscovered the work of these earlier authors. This second narratives faces problems as well. Therefore we develop a third narrative which we call the contextualist narrative. Rather than considering experimentation in an essentialist manner as a fixed research object that is either present or not in the work of specific authors, experimentation should be addressed through a narrative that asks in what way it becomes a philosophical problem for certain authors and for what purpose. Such contextualization enables a repositioning of Hacking’s philosophy of experiment in relation to the specific debates in which he intervened, such as the realism-antirealism debate, the Science Wars and the debate on incommensurability. (shrink)

Although postmodernist thought has become prominent in some educational circles, its influence on science education has until recently been rather minor. This paper examines the proposal of Michalinos Zembylas, published earlier in this journal, that Lyotardian postmodernism should be applied to science educational reform in order to achieve the much sought after positive transformation. As a preliminary to this examination several critical points are raised about Lyotard's philosophy of education and philosophy of science which serve to challenge and undermine Zembylas’ (...) project. Subsequently, the three main theses of Lyotard that Zembylas considers beneficial and wishes to transpose onto science classrooms and pedagogy are scrutinized and found to be more of a hindrance than a help to curriculum reformers. (shrink)

In a widely received paper on theory choice, Kuhn made three central claims. First, as a matter of empirical fact, different theories tend to score differently with regard to what Kuhn considered to be the standard set of theoretical virtues, i.e., empirical accuracy, internal and external consistency, scope, simplicity, and fertility. Whereas some theories will for instance be more empirically accurate than others, other theories will have greater external coherence with our background theories. Second, hardly ever does a theory’s being (...) virtuous in one particular respect legitimize a choice for that theory—not even when that virtue is empirical accuracy. Third, following from the first two .. (shrink)

What are the implications of taking seriously Chaïm Perelman's proposition that “definitions are rhetorical”? Efforts to find Real Definitions are dysfunctional to the extent they direct argumentation toward pseudo “is” claims and away from explicit “ought” claims about how words are to be used. Addressing definitional disputes explicitly as propositions ofought rather thanis could put on the agenda the pragmatic concerns of definitional choice that might otherwise remain tacit.

This article explores the relationship between epistemic relativism and Pyrrhonian scepticism. It is argued that a fundamental argument for contemporary epistemic relativism derives from the Pyrrhonian problem of the criterion. Pyrrhonian scepticism is compared and contrasted with Cartesian scepticism about the external world and Humean scepticism about induction. Epistemic relativism is characterized as relativism due to the variation of epistemic norms, and is contrasted with other forms of cognitive relativism, such as truth relativism, conceptual relativism and ontological relativism. An argument (...) from the Pyrrhonian problem of the criterion to epistemic relativism is presented, and is contrasted with three other arguments for epistemic relativism. It is argued that the argument from the criterion is the most fundamental argument for epistemic relativism. Finally, it is noted how the argument of the present paper fits with the author’s previous suggestion that a particularist response to the Pyrrhonian sceptic may be combined with a naturalistic view of epistemic warrant to meet the challenge of epistemic relativism. (shrink)

The contemporary debate between scientific realism and anti-realism is conditioned by a polarity between two opposing arguments: the realist’s success argument and the anti-realist’s pessimistic induction. This polarity has skewed the debate away from the problem that lies at the source of the debate. From a realist point of view, the historical approach to the philosophy of science which came to the fore in the 1960s gave rise to an unsatisfactory conception of scientific progress. One of the main motivations for (...) the scientific realist appeal to the success of science was the need to provide a substantive account of the progress of science as an increase of knowledge about the same entities as those referred to by earlier theories in the history of science. But the idea that a substantive conception of progress requires continuity of reference has faded from the contemporary debate. In this paper, I revisit the historical movement in the philosophy of science in an attempt to resuscitate the original agenda of the debate about scientific realism. I also briefly outline the way in which the realist should employ the theory of reference as the basis for a robust account of scientific progress which will satisfy realist requirements. (shrink)

This paper revisits one of the key ideas developed in The Structure of Scientific Revolutions. In particular, it explores the methodological form of incommensurability which may be found in the original edition of Structure. It is argued that such methodological incommensurability leads to a form of epistemic relativism. In later work, Kuhn moved away from the original idea of methodological incommensurability with his idea of a set of epistemic values that provides a basis for rational theory choice, but do not (...) constitute an algorithm for such choice. The paper also explores the sceptical basis for the epistemic relativism of the original view that Kuhn proposes in Structure. It suggests that the main sceptical rationale for such relativism may be avoided by a particularist and naturalist conception of epistemic normativity. When this approach is combined with the appeal to external methodological standards endorsed by the later Kuhn and his critics, the epistemic relativism of Structure may be completely repudiated. (shrink)

This essay analyses the positions which are related to the quantitative and qualitative research models in the social disciplines; it examines the universality and invariance of scientific laws; and it presents the inadequacy of the conceptions of logical positivism and of classical epistemology, as..

: A central claim of Longino's contextual empiricism is that scientific inquiry, even when "properly conducted", lacks the capacity to screen out the influence of contextual values on its results. I'll show first that Longino's attack against the epistemic integrity of science suffers from fatal empirical weaknesses. Second I'll explain why Longino's practical proposition for suppressing biases in science, drawn from her contextual empiricism, is too demanding and, therefore, unable to serve its purpose. Finally, drawing on Bourdieu's sociological analysis of (...) scientific communities, I'll sketch an alternative view of scientific practice reconciling a thoroughly social view of science (such as Longino's) with a defense of its epistemic integrity. (shrink)

The interpretive plasticity of Kuhn’s philosophical work has been reinforced by readings informed by other philosophical, historiographic or sociological projects. This paper highlights several aspects of Kuhn’s work that have been neglected by such readings. First, Kuhn’s early contribution to several subsequent philosophical developments has been unduly neglected. Kuhn’s postscript discussion of “exemplars” should be recognized as one of the earliest versions of a conception of theories as “mediating models.” Kuhn’s account of experimental practice has also been obscured by readings (...) that assimilate his views to Quinean holism. Second, three distinctive Kuhnian themes have been insufficiently recognized. Kuhn’s challenge to received philosophical views has been domesticated by reading him as offering an alternative conception of scientific knowledge. Kuhn is better understood as rejecting knowledge-centric accounts altogether, in favor of understanding the practice of research. Kuhn’s conception of that activity, as conceptual “articulation,” has accordingly also not been given its due. Finally, Kuhn’s career-long insistence on the mutual accountability of philosophy of science and the philosophy of mind and language calls attention to the extent to which these fields have now drifted apart. (shrink)

This paper describes the historical background and early formation of Wilhelm Johannsen's distinction between genotype and phenotype. It is argued that contrary to a widely accepted interpretation his concepts referred primarily to properties of individual organisms and not to statistical averages. Johannsen's concept of genotype was derived from the idea of species in the tradition of biological systematics from Linnaeus to de Vries: An individual belonged to a group - species, subspecies, elementary species - by representing a certain underlying type. (...) Johannsen sharpened this idea theoretically in the light of recent biological discoveries, not least those of cytology. He tested and confirmed it experimentally combining the methods of biometry, as developed by Francis Galton, with the individual selection method and pedigree analysis, as developed for instance by Louis Vilmorin. The term "genotype" was introduced in W. Johannsen's 1909 treatise, but the idea of a stable underlying biological "type" distinct from observable properties was the core idea of his classical bean selection experiment published 6 years earlier. The individual ontological foundation of population analysis was a self-evident presupposition in Johannsen's studies of heredity in populations from their start in the early 1890s till his death in 1927. The claim that there was a "substantial but cautious modification of Johannsen's phenotype-genotype distinction" from a statistical to an individual ontological perspective derives from a misreading of the 1903 and 1909 texts. The immediate purpose of this paper is to correct this reading of the 1903 monograph by showing how its problems and results grow out of Johannsen's earlier work in heredity and plant breeding. Johannsen presented his famous selection experiment as the culmination of a line of criticism of orthodox Darwinism by William Bateson, Hugo de Vries, and others. They had argued that evolution is based on stepwise rather than continuous change in heredity. Johannsen's paradigmatic experiment showed how stepwise variation in heredity could be operationally distinguished from the observable, continuous morphological variation. To test Galton's law of partial regression, Johannsen deliberately chose pure lines of self-fertilizing plants, a pure line being the descendants in successive generations of one single individual. Such a population could be assumed to be highly homogeneous with respect to hereditary type, and Johannsen found that selection produced no change in this type. Galton, he explained, had experimented with populations composed of a number of stable hereditary types. The partial regression which Galton found was simply an effect of selection between types, increasing the proportion of some types at the expense of others. (shrink)

Louis Pasteur’s defeat of belief in spontaneous generation has been a classical rationalist example of how the experimental approach of modern science can reveal superstition. Farley and Geison told a counter-story of how Pasteur’s success was due to political and ideological support rather than superior experimental science. They claimed that Pasteur violated proper norms of scientific method, and that the French Academy of Science did not see this, or did not want to. Farley and Geison argued that Pouchet’s experiments were (...) as valid as those of Pasteur. In this paper I argue that the core of the scientific debate was not general theories for or against spontaneous generation but the outcome of specific experiments. It was on the conduct of these experiments that the Academy made judgements favorable to Pasteur. Claude Bernard was a colleague of Pasteur, supportive and sometimes critical. I argue that Bernard’s fact-oriented methodology of “experimental medicine” is a better guide to explaining the controversy than the hypothetic-deductive view of scientific method typical of logical empiricism. (shrink)

ABSTRACT: This paper presents a discourse analysis of 40 semi-structured interviews with scientists on their views of Occam's razor and simplicity. It finds that there are many different interpretations and thoughts about the precise meaning of the principle as well as many scientists who reject it outright, or only a very limited version. In light of the variation of scientists' opinions, the paper looks at the discursive uses of simplicity in scientists' thinking and how scientists' interpretations of Occam's razor impact (...) on philosophy's representation of the principle and affects the communication between philosophy and science. (shrink)

: According to Kuhn, theory choice is not governed by algorithms, but by values, which influence yet do not determine theory choice. Cladistic hypotheses, however, seem to be evaluated relative to a parsimony algorithm, which asserts that the best phylogenetic hypothesis is the one that requires the fewest character changes. While this seems to be an unequivocal evaluative rule, it is not. The application of the parsimony principle is ultimately indeterminate because the choice and individuation of characters that figure in (...) parsimony computations are indeterminate. The cladistic approach is Kuhnian because the application of parsimony depends on persuasion, background, training and tradition. (shrink)

: In the last two decades, scientists, government officials, and science policy experts have expressed concerns about the increasing role of financial interests in research. Many believe that these interests are undermining research by causing bias and error, suppression of results, and even outright fraud. This paper seeks to shed some light on this view by (1) explicating the concept research bias, (2) describing some ways that financial interests can cause research biases, and (3) discussing some strategies for mitigating or (...) managing the influence of financial interests. These strategies include (a) using government funds to counter-balance privately funded research, (b) increasing public input into government funding decisions, (c) disclosing and managing conflicts of interest in research, (d) auditing data, (e) expanding access to data. Since it is neither possible nor desirable to eliminate financial interests from research, the wisest policy is to manage and counter-balance these interests for the good of science and society. (shrink)

: This essay provides an analysis of conflicts of interest in science. It gives an overview of some current conflict of interest policies and distinguishes between real, apparent, and potential conflicts of interest. The essay argues that scientists should disclose real, apparent, and potential conflicts of interest and that they should avoid conflicts that threaten scientific objectivity or trustworthiness. The essay also uses several hypothetical scenarios to illustrate some of the key points made in the analysis and suggests some strategies (...) for buffering the impact of conflicts of interest in science. (shrink)