Theory of illness causation is an important issue in all biomedical sciences, and solid etiological explanations are needed in order to develop therapeutic approaches in medicine and preventive interventions in public health. Until now, the literature about the theoretical underpinnings of illness causation research has been scarce and fragmented, and lacking a convenient summary. This interdisciplinary book provides a convenient and accessible distillation of the current status of research into this developing field, and adds a personal flavor to the discussion (...) by proposing the etiological stance as a comprehensive approach to identify modifiable causes of illness. (shrink)

In this paper, we argue that the popular claim that laws of nature explain their instances creates a philosophical puzzle when it is combined with the widely held requirement that explanations need to be underpinned by ‘wordly’ relations. We argue that a “direct solution” to the puzzle that accounts for both explanatory laws and explanatory realism requires endorsing at least a radical metaphysics. Then, we examine the ramifications of a “skeptical solution”, i.e., dissolving it by giving up at least one (...) of these two claims, and argue that adopting it is more favorable to Humean reductionists than to anti-reductionists about laws of nature. (shrink)

This volume argues for a new image of science that understands both natural and social phenomena to be the product of mechanisms, casting the work of science as an effort to understand those mechanisms. Glennan offers an account of the nature of mechanisms and of the models used to represent them in physical, life, and social sciences.

Among the current philosophical attempts to understand causation two seem to be the most prominent. The first is James Woodward’s counterfactual approach; the second is the mechanistic approach advocated by Peter Machamer, Lindley Darden, Carl Craver, Jim Bogen and Stuart Glennan. The counterfactual approach takes it that causes make a difference to their effects, where this difference-making is cashed out in terms of actual and counterfactual interventions. The mechanistic approach takes it that two events are causally related if and only (...) if there is a mechanism that connects them. On the face of it, the two approaches need not be in conflict. The mechanisms might satisfy (or depend on) certain interventionist counterfactuals and, conversely, the interventionist counterfactuals might be made true by the presence of certain mechanisms. But, overall, both approaches tend to be imperialistic. Advocates of each argue that their own approach fairs much better than their opponents’. The question then is this: are we forced to choose between the mechanistic approach and the counterfactual one? In this paper, I argue that, as they stand, both approaches face some important problems that need to be fixed. I shall also argue that there is a sense in which the counterfactual approach is more basic than the mechanistic, though the former will benefit from a better understanding of the mechanisms that are at work in causal connections. So both approaches can work together to offer a better understanding of causation. If they work in tandem, they can offer us a glimpse of what Hume famously called “the secret connexion”. But in so far as the ‘secret connexion’ is an intrinsic relation between the causal relata, neither of the above approaches tells us what this relation is. (shrink)

In Zhong (Philos Phenomenol Res 83:129–147, 2011; Analysis 72:75–85, 2012), I argued that, contrary to what many people might expect, the counterfactual theory of causation will generate (rather than solve) the exclusion problem. Recently some philosophers raise an incisive objection to this argument. They contend that my argument fails as it equivocates between different notions of a physical realizer (see Christensen and Kallestrup in Analysis 72:513–517, 2012). However, I find that their criticism doesn’t threaten the central idea of my view. (...) In this paper, I make two separate responses that appeal to two unequivocal notions of physical realizers, respectively. I aim to show that a modified argument that uses either notion would work. (shrink)

It is widely accepted that supervenience is a minimal commitment of physicalism. In this article, however, I aim to argue that physicalism should be exempted from the supervenience requirement. My arguments rely on a parallel between ontological dependence and causal dependence. Since causal dependence does not require causal determination, ontological dependence should not require ontological determination either. Moreover, my approach has a significant theoretical advantage: if physicalism is not committed to supervenience, then the metaphysical possibility of zombies—which is still wide (...) open after all these years—would pose no challenge to physicalism. (shrink)

Recently some philosophers suggested an exclusion problem for moral non-naturalism, which is similar to the exclusion problem in philosophy of mind. In this article, the author aims to advance the discussion of exclusion in morality by investigating two influential solutions to the exclusion problem: the autonomy solution and the overdetermination solution. The author attempts to show that the moral non-naturalist can solve the exclusion problem in a way that is different from the approach to solving mental-physical exclusion. First, the author (...) argues that while the autonomy solution to mental exclusion may work, a similar autonomy approach to moral exclusion is implausible. Second, the author argues that whereas the overdetermination solution to mental exclusion fails, a similar overdetermination solution to moral exclusion is promising. (shrink)

Universal Bundle Theory holds that objects are fundamentally identical with bundles of universals. Universals are multiply instantiable properties. One popular objection to UBT concerns the possibility of distinct indiscernibles. There are mainly two replies in the literature, corresponding to two representative UBTs, which I shall call the Identity-View and the Instance-View. Each view faces serious problems. This paper proposes a new version of UBT and argues that it is better than these other two versions.

It is widely supposed that methodological naturalism, understood as a thesis about the methodology of science, is metaphysically neutral, and that this in turn guarantees the value-neutrality of science. In this paper we argue that methodological naturalism is underpinned by certain ontological and epistemological assumptions including evidentialism and the causal closure of the physical, adoption of which necessitates commitment to metaphysical naturalism.

It is widely supposed that methodological naturalism, understood as a thesis about the methodology of science, is metaphysically neutral, and that this in turn guarantees the value-neutrality of science. In this paper we argue that methodological naturalism is underpinned by certain ontological and epistemological assumptions including evidentialism and the causal closure of the physical, adoption of which necessitates commitment to metaphysical naturalism.

This article compares causal and constitutive explanation. While scientific inquiry usually addresses both causal and constitutive questions, making the distinction is crucial for a detailed understanding of scientific questions and their interrelations. These explanations have different kinds of explananda and they track different sorts of dependencies. Constitutive explanations do not address events or behaviors, but causal capacities. While there are some interesting relations between building and causal manipulation, causation and constitution are not to be confused. Constitution is a synchronous and (...) asymmetric relation between relata that cannot be conceived as independent existences. However, despite their metaphysical differences, the same key ideas about explanation largely apply to both. Causal and constitutive explanations face similar challenges (such as the problems of relevance and explanatory regress) and both are in the business of mapping networks of counterfactual dependence—i.e. mechanisms—although the relevant counterfactuals are of a different sort. In the final section the issue of developmental explanation is discussed. It is argued that developmental explanations deserve their own place in taxonomy of explanations, although ultimately developmental dependencies can be analyzed as combinations of causal and constitutive dependencies. Hence, causal and constitutive explanation are distinct, but not always completely separate forms of explanation. (shrink)

Given the diversity of explanatory practices that is typical of the sciences a healthy pluralism would seem to be desirable where theories of explanation are concerned. Nevertheless, I argue that explanations are only unifying in Kitcher's unificationist sense if they are backed by the kind of understanding of underlying mechanisms, dispositions, constitutions, and dependencies that is central to a causalist account of explanation. This case can be made through analysis of Kitcher's account of the conditions under which apparent improvements in (...) unifying power may be judged spurious. But to clarify what is at issue I consider an archaeological case in which debate about the merits of an ambitious explanatory account reproduces exactly the intuitions that divide Salmon and Kitcher. The case in question is the “demic-diffusion” account of contemporary linguistic diversity advanced by Renfrew in the late 1980s: the thesis that the diffusion of agricultural populations, itself attributed to demographic pressure, was responsible for the spread of the ancestral root languages (e.g., proto-Indo-Eurpoean) that account for the existence and distribution of linguistic macrofamilies. The credibility of this powerfully unifying argument pattern depends entirely on the plausibility of its claims about the conditions and mechanisms actually responsible for the explanandum, the spread of agriculture, and not on an elaboration of its unificationist virtues. (shrink)

What features will something have if it counts as an explanation? And will something count as an explanation if it has those features? In the second half of the 20th century, philosophers of science set for themselves the task of answering such questions, just as a priori conceptual analysis was generally falling out of favor. And as it did, most philosophers of science just moved on to more manageable questions about the varieties of explanation and discipline-specific scientific explanation. Often, such (...) shifts are sound strategies for problem-solving. But leaving fallow certain basic conceptual issues can also result in foundational debates. (shrink)

This paper reviews the debate on the notion of biological function and on functional explanation as this takes place in philosophy. It describes the different perspectives, issues, intuitions, theories and arguments that have emerged. The author shows that the debate has been too heavily influenced by the concerns of a naturalistic philosophy of mind and argues that in order to improve our understanding of biology the attention should be shifted from the study of intuitions to the study of the actual (...) practice of biological inquiry. (shrink)

This paper is concerned with reasonings that purport to explain why certain organisms have certain traits by showing that their actual design is better than contrasting designs. Biologists call such reasonings 'functional explanations'. To avoid confusion with other uses of that phrase, I call them 'design explanations'. This paper discusses the structure of design explanations and how they contribute to scientific understanding. Design explanations are contrastive and often compare real organisms to hypothetical organisms that cannot possibly exist. They are not (...) causal but appeal to functional dependencies between an organism's different traits. These explanations point out that because an organism has certain traits, it cannot be alive if the trait to be explained were replaced by a specified alternative. They can be understood from a mechanistic point of view as revealing the constraints on what mechanisms can be alive. (shrink)

This essay addresses issues concerningexplanation by exploring how explanatorystructures function within contemporarychemistry. Three examples are discussed:explanations of the behavior of gases using theideal gas law, explanations of trends inchemical properties using the periodic table,and explanations of molecular geometry usingdiagrammatic orbital schemes. In each case,the general explanatory structure, rather thanparticular explanations, occupies center stagein the analysis. It is argued that thisquasi-empirical investigation may be morefruitful than previous analyses that attempt toisolate the essential features of individualexplanations. There are two reasons for thisconclusion, (...) each discussed in some detail. First, the traditional analyses rely on highlyprecarious reasoning. Second, empiricallygrounded investigations provide a more naturalconnection to the core aim of analyses ofexplanation, namely to provide a rationale forthe widely expressed preference for explanatorytheories in science. (shrink)

This paper explores some issues about the choice of variables for causal representation and explanation. Depending on which variables a researcher employs, many causal inference procedures and many treatments of causation will reach different conclusions about which causal relationships are present in some system of interest. The assumption of this paper is that some choices of variables are superior to other choices for the purpose of causal analysis. A number of possible criteria for variable choice are described and defended within (...) a broadly interventionist approach to causation. (shrink)

This paper defends an interventionist treatment of mechanisms and contrasts this with Waskan (forthcoming). Interventionism embodies a difference-making conception of causation. I contrast such conceptions with geometrical/mechanical or “actualist” conceptions, associating Waskan’s proposals with the latter. It is argued that geometrical/mechanical conceptions of causation cannot replace difference-making conceptions in characterizing the behavior of mechanisms, but that some of the intuitions behind the geometrical/mechanical approach can be captured by thinking in terms of spatio-temporally organized difference-making information.

This essay explores the connection between representation and explanation in the sciences. I suggest that scientific representation schemes be viewed as pragmatic tools for acquiring the sort of articulated awareness that is the hallmark of nontrivial knowledge. Crystal field theory in chemistry illustrates this perspective. Certain representations achieve the status of being paradigmatically explanatory, thereby shaping models of intelligibility. In turn, these explanatory preferences serve largely to define and differentiate disciplinary communities by implicitly endorsing particular epistemic aims and values. In (...) this way, the pragmatic nature of explanatory discourse effectively grants its intellectual utility. (shrink)

This paper describes an alternative to the common view that explanation in the special sciences involves subsumption under laws. According to this alternative, whether or not a generalization can be used to explain has to do with whether it is invariant rather than with whether it is lawful. A generalization is invariant if it is stable or robust in the sense that it would continue to hold under a relevant if it is stable or robust in the sense that it (...) would continue to hold under a relevant class of changes. Unlike lawfulness, invariance comes in degrees and has other features that are well suited to capture the characteristics of explanatory generalizations in the special sciences. For example, a generalization can be invariant even if it has exceptions or holds only over a limited spatio-temporal interval. The notion of invariance can be used to resolve a number of dilemmas that arise in standard treatments of explanatory generalizations in the special sciences. (shrink)

Claims pertaining to understanding are made in a variety of contexts and ways. As a result, few in the philosophical literature have made an attempt to precisely characterize the state that is y understanding x. This paper builds an account that does just that. The account is motivated by two main observations. First, understanding x is somehow related to being able to manipulate x. Second, understanding is a mental phenomenon, and so what manipulations are required to be an understander must (...) only be mental manipulations. Combining these two insights, the paper builds an account (URM) of understanding as a certain representational capacity—specifically, understanding x involves possessing a representation of x that could be manipulated in useful ways. By tying understanding to representation, the account correctly identifies that understanding is a fundamentally cognitive achievement. However, by also demanding that which representations count as understanding-conferring be determined by their practical effects, URM captures the insight that understanding is vitally connected to practice. URM is fully general, and can apply equally well to understanding states of affairs, understanding events, and even understanding people and works of art. The ultimate test of URM is its applicability in actual scientific and philosophical discourse. To that end the paper discusses the importance of understanding in the philosophy of science, psychology, and computer science. (shrink)

What happens to the causal structure of a world when time is reversed? At first glance it seems there are two possible answers: the causal relations are reversed, or they are not. I argue that neither of these answers is correct: we should either deny that time-reversed worlds have causal relations at all, or deny that causal concepts developed in the actual world are reliable guides to the causal structure of time-reversed worlds. The first option is motivated by the instability (...) of time-reversed dynamical evolutions under interventions. The second option is motivated by a recognition of how contingent structural features of the actual world shape our causal concepts and reasoning strategies. (shrink)

Part I of this paper introduces a range of mechanistic theories of causality, including process theories and the complex-systems theories, and some of the problems they face. Part II argues that while there is a decisive case against a purely mechanistic analysis, a viable theory of causality must incorporate mechanisms as an ingredient, and describes one way of providing an analysis of causality which reaps the rewards of the mechanistic approach without succumbing to its pitfalls.

This paper focuses on two questions: Is understanding intimately bound up with accurately representing the world? Is understanding intimately bound up with downstream abilities? We will argue that the answer to both these questions is “yes”, and for the same reason-both accuracy and ability are important elements of orthogonal evaluative criteria along which understanding can be assessed. More precisely, we will argue that representational-accuracy and intelligibility are good-making features of a state of understanding. Interestingly, both evaluative claims have been defended (...) by philosophers in the literature on understanding as the criterion of evaluation. We argue that proponents of both approaches have important insights and that, drawing on both their own observations and a few novel arguments, we can construct a more complete picture of understanding evaluation. We thus posit the theory of there being Multiple Understanding Dimensions. The main thing to note about our dualism regarding the evaluative criteria of understanding is that it accounts for the intuitions about cases underlying both previously held positions. (shrink)

Systems medicine is a promising new paradigm for discovering associations, causal relationships and mechanisms in medicine. But it faces some tough challenges that arise from the use of big data: in particular, the problem of how to integrate evidence and the problem of how to structure the development of models. I argue that objective Bayesian models offer one way of tackling the evidence integration problem. I also offer a general methodology for structuring the development of models, within which the objective (...) Bayesian approach fits rather naturally. (shrink)

Husserl’s early picture of explanation in the sciences has never been completely provided. This lack represents an oversight, which we here redress. In contrast to currently accepted interpretations, we demonstrate that Husserl does not adhere to the much maligned deductive-nomological (DN) model of scientific explanation. Instead, via a close reading of early Husserlian texts, we reveal that he presents a unificationist account of scientific explanation. By doing so, we disclose that Husserl’s philosophy of scientific explanation is no mere anachronism. It (...) is, instead, tenable and relevant. We discuss how Husserl and other contemporary thinkers draw theoretical inspiration from the same source—namely, Bernard Bolzano. Husserl’s theory of scientific explanation shares a common language and discusses the same themes as, for example, Phillip Kitcher and Kit Fine. To advance our novel reading, we discuss Husserl’s investigations of grounding, inter-lawful explanation, intra-mathematical explanation, and scientific unification. (shrink)

The mechanistic and causal accounts of explanation are often conflated to yield a ‘causal-mechanical’ account. This paper prizes them apart and asks: if the mechanistic account is correct, how can causal explanations be explanatory? The answer to this question varies according to how causality itself is understood. It is argued that difference-making, mechanistic, dualist and inferentialist accounts of causality all struggle to yield explanatory causal explanations, but that an epistemic account of causality is more promising in this regard.

This paper addresses questions about how the levels of causality (generic and single-case causality) are related. One question is epistemological: can relationships at one level be evidence for relationships at the other level? We present three kinds of answer to this question, categorised according to whether inference is top-down, bottom-up, or the levels are independent. A second question is metaphysical: can relationships at one level be reduced to relationships at the other level? We present three kinds of answer to this (...) second question, categorised according to whether single-case relations are reduced to generic, generic relations are reduced to single-case, or the levels are independent. We then explore causal inference in autopsy. This is an interesting case study, we argue, because it refutes all three epistemologies and all three metaphysics. We close by sketching an account of causality that survives autopsy—the epistemic theory. (shrink)

According to Michael Friedman’s theory of explanation, a law X explains laws Y1, Y2, …, Yn precisely when X unifies the Y’s, where unification is understood in terms of reducing the number of independently acceptable laws. Philip Kitcher criticized Friedman’s theory but did not analyze the concept of independent acceptability. Here we show that Kitcher’s objection can be met by modifying an element in Friedman’s account. In addition, we argue that there are serious objections to the use that Friedman makes (...) of the concept of independent acceptability. (shrink)

Our goal in this paper is to experimentally investigate whether folk conceptions of explanation are psychologistic. In particular, are people more likely to classify speech acts as explanations when they cause understanding in their recipient? The empirical evidence that we present suggests this is so. Using the side-effect effect as a marker of mental state ascriptions, we argue that lay judgments of explanatory status are mediated by judgments of a speaker’s and/or audience’s mental states. First, we show that attributions of (...) both understanding and explanation exhibit a side-effect effect. Next, we show that when the speaker’s and audience’s level of understanding is stipulated, the explanation side-effect effect goes away entirely. These results not only extend the side-effect effect to attributions of understanding, they also suggest that attributions of explanation exhibit a side-effect effect because they depend upon attributions of understanding, supporting the idea that folk conceptions of explanation are psychologistic. (shrink)

While the concept event has been an important tool in our thinking about causation and action, the concept process has not been appealed to so readily. However, recently, several philosophers have...

Objects appear to causally interact with one another in virtual worlds, such as video games, virtual reality, and training simulations. Is this causation real or is it illusory? In this paper I argue that virtual causation is as real as physical causation. I achieve this in two steps: firstly, I show how virtual causation has all the important hallmarks of relations that are causal, as opposed to merely accidental, and secondly, I show how virtual causation is genuine according to one (...) influential metaphysical theory of causation: the mechanistic approach. (shrink)

Hume’s famous argument against the credibility of testimony about miracles invokes two premises: 1) The reliability of the witness (the extent to which he is informed and truthful) must be compared with the intrinsic probability of the miracle. 2) The initial probability of a miracle is always small enough to outweigh the improbability that the testimony is false (even when the witness is assumed to be reliable). I defend the first premise of the argument, showing that Hume’s argument can be (...) applied to purported observations of miracles, as well. I then show that Hume failed to provide an adequate support for his second premise. A more cogent defence can be provided for a weaker premise. The resultant argument has, consequently, a less sweeping conclusion than Hume’s. (shrink)

In this paper I adduce a new argument in support of the claim that IBE is an autonomous form of inference, based on a familiar, yet surprisingly, under-discussed, problem for Hume’s theory of induction. I then use some insights thereby gleaned to argue for the claim that induction is really IBE, and draw some normative conclusions.

We suggest a rigorous theory of how objective single-case transition probabilities fit into our world. The theory combines indeterminism and relativity in the “branching space–times” pattern, and relies on the existing theory of causae causantes (originating causes). Its fundamental suggestion is that (at least in simple cases) the probabilities of all transitions can be computed from the basic probabilities attributed individually to their originating causes. The theory explains when and how one can reasonably infer from the probabilities of one “chance (...) set-up” to the probabilities of another such set-up that is located far away. (shrink)

In the current literature on scientific explanation unification became unfashionable in favour of causal approaches. We want to bring unification back into the picture. In this paper we demonstrate that resemblance questions do occur in scientific practice and that they cannot be properly answered without unification. Our examples show that resemblance questions about particular facts demand what we call causal network unification, while resemblance questions about regularities require what we call mechanism unification. We clarify how these types of unification relate (...) to Philip Kitcher’s account, but also to causal and mechanistic accounts of explanation. (shrink)

This article has three aims. The first is to give a partial explication of the concept of unification. My explication will be partial because I confine myself to unification of particular events, because I do not consider events of a quantitative nature, and discuss only deductive cases. The second aim is to analyze how unification can be reached. My third aim is to show that unification is an intellectual benefit. Instead of being an intellectual benefit unification could be an intellectual (...) harm, i.e., a state of mind we should try to avoid by all means. By calling unification an intellectual benefit, we claim that this form of understanding has an intrinsic value for us. I argue that unification really has this alleged intrinsic value. (shrink)

In this paper we discuss three interrelated questions. First: is explanation in mathematics a topic that philosophers of mathematics can legitimately investigate? Second: are the specific aims that philosophers of mathematical explanation set themselves legitimate? Finally: are the models of explanation developed by philosophers of science useful tools for philosophers of mathematical explanation? We argue that the answer to all these questions is positive. Our views are completely opposite to the views that Mark Zelcer has put forward recently. Throughout this (...) paper, we show why Zelcer’s arguments fail. (shrink)

In a recent article in this journal, Federica Russo and Jon Williamson argue that an analysis of causality in terms of probabilistic relationships does not do justice to the use of mechanistic evidence to support causal claims. I will present Ronald Giere's theory of probabilistic causation, and show that it can account for the use of mechanistic evidence (both in the health sciences—on which Russo and Williamson focus—and elsewhere). I also review some other probabilistic theories of causation (of Suppes, Eells, (...) and Humphreys) and show that they cannot account for the use of mechanistic evidence. I argue that these theories are also inferior to Giere's theory in other respects. (shrink)