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Experimental Design: Ethics, Integrity and the Scientific Method

In Ron Iphofen (ed.), Handbook of Research Ethics and Scientific Integrity. Cham, Switzerland: pp. 459-474 (2020)

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  1. Paying People to Participate in Research: Why not?Paul McNeill - 1997 - Bioethics 11 (5):390-396.
    This paper argues against paying people to participate in research. Volunteering to participate as a subject in a research program is not like taking a job. The main difference is to do with the risks inherent in research. Experimentation on human beings is, by definition, trying out something with an unknown consequence and exposes people to risks of harm which cannot be known in advance. This is the main reason for independent review by committee of research programs. It is based (...)
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  • Values in Science.Ernan McMullin - 1982 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1982 (4):3-28.
    This paper argues that the appraisal of theory is in important respects closer in structure to value-judgement than it is to the rule-governed inference that the classical tradition in philosophy of science took for granted.
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  • Values in science.Ernan McMullin - 2012 - Zygon 47 (4):686-709.
    In this essay, which was his presidential address to the Philosophy of Science Association, Ernan McMullin argued that the watershed between “classic” philosophy of science and the “new” philosophy of science can best be understood by analyzing the change in our perception of the role played by values in science. He begins with some general remarks about the nature of value, goes on to explore some of the historical sources for the claim that judgement in science is value‐laden, and concludes (...)
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  • Integrity.Lynne McFall - 1987 - Ethics 98 (1):5-20.
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  • What's wrong with exploitation?Robert Mayer - 2007 - Journal of Applied Philosophy 24 (2):137–150.
    This paper offers a new answer to an old question. Others have argued that exploitation is wrong because it is coercive, or degrading, or fails to protect the vulnerable. But these answers only work for certain cases; counterexamples are easily found. In this paper I identify a different answer to the question by placing exploitation within the larger family of wrongs to which it belongs. Exploitation is one species of wrongful gain, and exploiters always gain at the expense of others (...)
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  • Sustaining public trust: Falling short in the protection of human research participants.Anna C. Mastroianni - 2008 - Hastings Center Report 38 (3):pp. 8-9.
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  • National Security Neuroscience and the Reverse Dual-Use Dilemma.Gary Marchant & Lyn Gulley - 2010 - American Journal of Bioethics Neuroscience 1 (2):20-22.
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  • International Harmonization of Regulation of Nanomedicine.Gary E. Marchant, Douglas J. Sylvester, Kenneth W. Abbott & Tara Lynn Danforth - 2009 - Studies in Ethics, Law, and Technology 3 (3).
    Nanomedicine holds enormous promise for the improved prevention, detection and treatment of disease. Yet, at the same time, countervailing concerns about the potential safety risks of nano-technologies generally, and nanomedical products specifically, threaten to derail or at least delay the introduction and commercial viability of many nanomedicine applications. All around the globe, national governments are struggling with balancing these competing benefits and risks of nanotechnology in the medical and other sectors. It is becoming increasingly clear that reasonable, effective and predictable (...)
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  • The Cambridge Handbook of Endangered Languages.Peter K. Austin & Julia Sallabank (eds.) - 2011 - Cambridge University Press.
    It is generally agreed that about 7,000 languages are spoken across the world today and at least half may no longer be spoken by the end of this century. This state-of-the-art Handbook examines the reasons behind this dramatic loss of linguistic diversity, why it matters, and what can be done to document and support endangered languages. The volume is relevant not only to researchers in language endangerment, language shift and language death, but to anyone interested in the languages and cultures (...)
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  • A Neuroskeptic's Guide to Neuroethics and National Security.Jonathan H. Marks - 2010 - American Journal of Bioethics Neuroscience 1 (2):4-12.
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  • The ethics of biobanking: Assessing the right to control problem for broad consent.Neil C. Manson - 2019 - Bioethics 33 (5):540-549.
    The biobank consent debate is one with deeply held convictions on both the ‘broad’ and ‘specific’ side with little sign of resolution. Recently, Thomas Ploug and Soren Holm have developed an alternative to both specific and broad consent: a meta‐consent framework. The aim here is to consider whether meta‐consent provides a ‘solution’ to the biobank consent debate. We clarify what ‘meta‐consent’ actually is (arguing that the label is a misnomer and ‘consent à la carte’ is more accurate). We identify problems (...)
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  • Against Reflexivity as an Academic Virtue and Source of Privileged Knowledge.Michael Lynch - 2000 - Theory, Culture and Society 17 (3):26-54.
    Reflexivity is a well-established theoretical and methodological concept in the human sciences, and yet it is used in a confusing variety of ways. The meaning of `reflexivity' and the virtues ascribed to the concept are relative to particular theoretical and methodological commitments. This article examines several versions of the concept, and critically focuses on treatments of reflexivity as a mark of distinction or source of methodological advantage. Although reflexivity often is associated with radical epistemologies, social scientists with more conventional leanings (...)
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  • Walden Two. [REVIEW]H. A. L. & B. F. Skinner - 1949 - Journal of Philosophy 46 (20):654.
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  • How do data come to matter? Living and becoming with personal data.Deborah Lupton - 2018 - Big Data and Society 5 (2).
    Humans have become increasingly datafied with the use of digital technologies that generate information with and about their bodies and everyday lives. The onto-epistemological dimensions of human–data assemblages and their relationship to bodies and selves have yet to be thoroughly theorised. In this essay, I draw on key perspectives espoused in feminist materialism, vital materialism and the anthropology of material culture to examine the ways in which these assemblages operate as part of knowing, perceiving and sensing human bodies. I draw (...)
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  • Elucidating the concept of vulnerability: Layers not labels.Florencia Luna - 2009 - International Journal of Feminist Approaches to Bioethics 2 (1):121-139.
    In this article I examine several criticisms of the concept of vulnerability. Rather than rejecting the concept, however, I argue that a sufficiently rich understanding of vulnerability is essential to bioethics. The challenges of international research in developing countries require an understanding of how new vulnerabilities arise from conditions of economic, social and political exclusion. A serious shortcoming of current conceptions of vulnerability in research ethics is the tendency to treat vulnerability as a label fixed on a particular subpopulation. My (...)
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  • Codes of Ethics and the Moral Education of Engineers.Heinz C. Luegenbiehl - 1983 - Business and Professional Ethics Journal 2 (4):41-61.
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  • Ontological Choices and the Value-Free Ideal.David Ludwig - 2016 - Erkenntnis 81 (6):1253-1272.
    The aim of this article is to argue that ontological choices in scientific practice undermine common formulations of the value-free ideal in science. First, I argue that the truth values of scientific statements depend on ontological choices. For example, statements about entities such as species, race, memory, intelligence, depression, or obesity are true or false relative to the choice of a biological, psychological, or medical ontology. Second, I show that ontological choices often depend on non-epistemic values. On the basis of (...)
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  • The Methodology of Experimental Economics.Francesco Guala - 2005 - Cambridge University Press.
    The experimental approach in economics is a driving force behind some of the most exciting developments in the field. The 'experimental revolution' was based on a series of bold philosophical premises which have remained until now mostly unexplored. This book provides the first comprehensive analysis and critical discussion of the methodology of experimental economics, written by a philosopher of science with expertise in the field. It outlines the fundamental principles of experimental inference in order to investigate their power, scope and (...)
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  • The Fate of Knowledge.Helen E. Longino - 2001 - Princeton University Press.
    "--Richard Grandy, Rice University "This is the first compelling diagnosis of what has gone awry in the raging 'science wars.
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  • Negotiating Privacy Through Phatic Communication. A Case Study of the Blogging Self.Stine Lomborg - 2012 - Philosophy and Technology 25 (3):415-434.
    The article provides an instructive in-depth analysis of communicative practices in the personal blog. Its aim is to document the discursive dynamics and interactional ethics of blogging, with a specific focus on negotiations of the blogging self in-between public and private. Based on key findings from an empirical case study of personal blogs, the article addresses the negotiation of the blogging self from three interdependent perspectives: the network structures, patterns of interaction, and thematic orientations of the blog. Instead of approaching (...)
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  • Model robustness as a confirmatory virtue: The case of climate science.Elisabeth A. Lloyd - 2015 - Studies in History and Philosophy of Science Part A 49:58-68.
    I propose a distinct type of robustness, which I suggest can support a confirmatory role in scientific reasoning, contrary to the usual philosophical claims. In model robustness, repeated production of the empirically successful model prediction or retrodiction against a background of independentlysupported and varying model constructions, within a group of models containing a shared causal factor, may suggest how confident we can be in the causal factor and predictions/retrodictions, especially once supported by a variety of evidence framework. I present climate (...)
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  • Unconscious cerebral initiative and the role of conscious will in voluntary action.Benjamin Libet - 1985 - Behavioral and Brain Sciences 8 (4):529-66.
    Voluntary acts are preceded by electrophysiological (RPs). With spontaneous acts involving no preplanning, the main negative RP shift begins at about200 ms. Control experiments, in which a skin stimulus was timed (S), helped evaluate each subject's error in reporting the clock times for awareness of any perceived event.
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  • Clarifying the Concepts of Research Ethics.Robert J. Levine - 1979 - Hastings Center Report 9 (3):21-26.
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  • Feminist Data Studies: Using Digital Methods for Ethical, Reflexive and Situated Socio-Cultural Research.Koen Leurs - 2017 - Feminist Review 115 (1):130-154.
    What could a social-justice oriented, feminist data studies look like? The current datalogical turn foregrounds the digital datafication of everyday life, increasing algorithmic processing and data as an emergent regime of power/knowledge. Scholars celebrate the politics of big data knowledge production for its omnipotent objectivity or dismiss it outright as data fundamentalism that may lead to methodological genocide. In this feminist and postcolonial intervention into gender-, race- and geography-blind ‘big data’ ideologies, I call for ethical, anti-oppressive digital data-driven research in (...)
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  • What difference does quantity make? On the epistemology of Big Data in biology.Sabina Leonelli - 2014 - Big Data and Society 1 (1):2053951714534395.
    Is Big Data science a whole new way of doing research? And what difference does data quantity make to knowledge production strategies and their outputs? I argue that the novelty of Big Data science does not lie in the sheer quantity of data involved, but rather in the prominence and status acquired by data as commodity and recognised output, both within and outside of the scientific community and the methods, infrastructures, technologies, skills and knowledge developed to handle data. These developments (...)
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  • Knowledge from Scientific Expert Testimony without Epistemic Trust.Jon Leefmann & Steffen Lesle - 2018 - Synthese:1-31.
    In this paper we address the question of how it can be possible for a non-expert to acquire justified true belief from expert testimony. We discuss reductionism and epistemic trust as theoretical approaches to answer this question and present a novel solution that avoids major problems of both theoretical options: Performative Expert Testimony (PET). PET draws on a functional account of expertise insofar as it takes the expert’s visibility as a good informant capable to satisfy informational needs as equally important (...)
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  • Knowledge from scientific expert testimony without epistemic trust.Jon Leefmann & Steffen Lesle - 2020 - Synthese 197 (8):3611-3641.
    In this paper we address the question of how it can be possible for a non-expert to acquire justified true belief from expert testimony. We discuss reductionism and epistemic trust as theoretical approaches to answer this question and present a novel solution that avoids major problems of both theoretical options: Performative Expert Testimony. PET draws on a functional account of expertise insofar as it takes the expert’s visibility as a good informant capable to satisfy informational needs as equally important as (...)
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  • The UNESCO Universal Declaration on Bioethics and Human Rights: Perspectives from Kenya and South Africa. [REVIEW]Adèle Langlois - 2008 - Health Care Analysis 16 (1):39-51.
    In October 2005, UNESCO (the United Nations Educational, Scientific and Cultural Organization) adopted the Universal Declaration on Bioethics and Human Rights. This was the culmination of nearly 2 years of deliberations and negotiations. As a non-binding instrument, the declaration must be incorporated by UNESCO’s member states into their national laws, regulations or policies in order to take effect. Based on documentary evidence and data from interviews, this paper compares the declaration’s universal principles with national bioethics guidelines and practice in Kenya (...)
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  • A precautionary principle for dual use research in the life sciences.Frida Kuhlau, Anna T. Höglund, Kathinka Evers & Stefan Eriksson - 2010 - Bioethics 25 (1):1-8.
    Most life science research entails dual-use complexity and may be misused for harmful purposes, e.g. biological weapons. The Precautionary Principle applies to special problems characterized by complexity in the relationship between human activities and their consequences. This article examines whether the principle, so far mainly used in environmental and public health issues, is applicable and suitable to the field of dual-use life science research. Four central elements of the principle are examined: threat, uncertainty, prescription and action. Although charges against the (...)
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  • Autonomy and informed consent: A mistaken association? [REVIEW]Sigurdur Kristinsson - 2007 - Medicine, Health Care and Philosophy 10 (3):253-264.
    For decades, the greater part of efforts to improve regulatory frameworks for research ethics has focused on informed consent procedures; their design, codification and regulation. Why is informed consent thought to be so important? Since the publication of the Belmont Report in 1979, the standard response has been that obtaining informed consent is a way of treating individuals as autonomous agents. Despite its political success, the philosophical validity of this Belmont view cannot be taken for granted. If the Belmont view (...)
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  • Business ethics: Restrictive or empowering? [REVIEW]Bjørn Kjonstad & Hugh Willmott - 1995 - Journal of Business Ethics 14 (6):445 - 464.
    There is a tendency in the business ethics literature to think of ethics in restrictive terms: what one should not do, and how to control this. Drawing on Lawrence Kohlberg''s theory of moral development, the paper focuses on, and draws attention to, another more positive aspect of ethics: the capacity of ethics to inspire and empower individuals, as well as groups. To understand and facilitate such empowerment, it is argued that it is necessary to move beyond Kohlberg''s justice reasoning so (...)
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  • Science, truth, and democracy.Philip Kitcher - 2001 - New York: Oxford University Press.
    Striving to boldly redirect the philosophy of science, this book by renowned philosopher Philip Kitcher examines the heated debate surrounding the role of science in shaping our lives. Kitcher explores the sharp divide between those who believe that the pursuit of scientific knowledge is always valuable and necessary--the purists--and those who believe that it invariably serves the interests of people in positions of power. In a daring turn, he rejects both perspectives, working out a more realistic image of the sciences--one (...)
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  • Trust me, I’m a researcher!: The role of trust in biomedical research.Angeliki Kerasidou - 2017 - Medicine, Health Care and Philosophy 20 (1):43-50.
    In biomedical research lack of trust is seen as a great threat that can severely jeopardise the whole biomedical research enterprise. Practices, such as informed consent, and also the administrative and regulatory oversight of research in the form of research ethics committees and Institutional Review Boards, are established to ensure the protection of future research subjects and, at the same time, restore public trust in biomedical research. Empirical research also testifies to the role of trust as one of the decisive (...)
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  • The importance of values in evidence-based medicine.Michael P. Kelly, Iona Heath, Jeremy Howick & Trisha Greenhalgh - 2015 - BMC Medical Ethics 16 (1):69.
    Evidence-based medicine has always required integration of patient values with ‘best’ clinical evidence. It is widely recognized that scientific practices and discoveries, including those of EBM, are value-laden. But to date, the science of EBM has focused primarily on methods for reducing bias in the evidence, while the role of values in the different aspects of the EBM process has been almost completely ignored.
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  • The effectiveness of business codes: A critical examination of existing studies and the development of an integrated research model. [REVIEW]Muel Kaptein & Mark S. Schwartz - 2008 - Journal of Business Ethics 77 (2):111 - 127.
    Business codes are a widely used management instrument. Research into the effectiveness of business codes has, however, produced conflicting results. The main reasons for the divergent findings are: varying definitions of key terms; deficiencies in the empirical data and methodologies used; and a lack of theory. In this paper, we propose an integrated research model and suggest directions for future research.
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  • The Effectiveness of Business Codes: A Critical Examination of Existing Studies and the Development of an Integrated Research Model.Muel Kaptein & Mark S. Schwartz - 2008 - Journal of Business Ethics 77 (2):111-127.
    Business codes are a widely used management instrument. Research into the effectiveness of business codes has, however, produced conflicting results. The main reasons for the divergent findings are: varying definitions of key terms; deficiencies in the empirical data and methodologies used; and a lack of theory. In this paper, we propose an integrated research model and suggest directions for future research.
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  • Conceptual Clarification and the Task of Improving Research on Academic Ethics.Sara R. Jordan - 2013 - Journal of Academic Ethics 11 (3):243-256.
    What does the term academic ethics mean? How does this term relate to others in the academic integrity literature, such as research misconduct? Does conceptual confusion in the study of academic ethics complicate development of valid analyses of ethical behavior in an academic setting? The intended goal of many empirical projects on academic ethics is to draw causal conclusions about the factors that lead to faculty or students possessing or disregarding academic integrity. Yet, it is not clear that scholars using (...)
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  • Philosophical essays: from ancient creed to technological man.Hans Jonas - 1974 - Chicago: University of Chicago Press.
    Technology and responsibility: reflections on the new tasks of ethics.--Jewish and Christian elements in philosophy: their share in the emergence of the modern mind.--Seventeenth century and after: the meaning of the scientific and technological revolution.--Socio-economic knowledge and ignorance of goals.--Philosophical reflections on experimenting with human subjects.--Against the stream: comments on the definition and redefinition of death.--Biological engineering--a preview--Contemporary problems in ethics from a Jewish perspective.--Biological foundations of individuality.--Spinoza and the theory of organism.--Sight and thought: a review of "visual thinking."--Change and (...)
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  • Why Most Published Research Findings Are False.John P. A. Ioannidis - 2005 - PLoS Med 2 (8):e124.
    Published research findings are sometimes refuted by subsequent evidence, says Ioannidis, with ensuing confusion and disappointment.
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  • Distinguishing between legitimate and illegitimate values in climate modeling.Kristen Intemann - 2015 - European Journal for Philosophy of Science 5 (2):217-232.
    While it is widely acknowledged that science is not “free” of non-epistemic values, there is disagreement about the roles that values can appropriately play. Several have argued that non-epistemic values can play important roles in modeling decisions, particularly in addressing uncertainties ; Risbey 2007; Biddle and Winsberg 2010; Winsberg : 111-137, 2012); van der Sluijs 359-389, 2012). On the other hand, such values can lead to bias ; Bray ; Oreskes and Conway 2010). Thus, it is important to identify when (...)
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  • Normative Moral Neuroscience: The Third Tradition of Neuroethics.Geoffrey S. Holtzman - 2018 - Journal of the American Philosophical Association 4 (3):411-431.
    Neuroethics is typically conceived of as consisting of two traditions: the ethics of neuroscience and the neuroscience of moral judgment. However, recent work has sought to draw philosophical and ethical implications from the neuroscience of moral judgment. Such work, which concernsnormative moral neuroscience(NMN), is sufficiently distinct and complex to deserve recognition as a third tradition of neuroethics. Recognizing it as such can reduce confusion among researchers, eliminating conflations among both critics and proponents of NMN.This article identifies and unpacks some of (...)
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  • “Ethics wars”: Reflections on the Antagonism between Bioethicists and Social Science Observers of Biomedicine1.Klaus Hoeyer - 2006 - Human Studies 29 (2):203-227.
    Social scientists often lament the fact that philosophically trained ethicists pay limited attention to the insights they generate. This paper presents an overview of tendencies in sociological and anthropological studies of morality, ethics and bioethics, and suggests that a lack in philosophical interest might be related to a tendency among social scientists to employ either a deficit model (social science perspectives accommodate the sense of context that philosophical ethics lacks), a replacement model (social scientists have finally found the “right way” (...)
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  • A new direction for science and values.Daniel J. Hicks - 2014 - Synthese 191 (14):3271-95.
    The controversy over the old ideal of “value-free science” has cooled significantly over the past decade. Many philosophers of science now agree that even ethical and political values may play a substantial role in all aspects of scientific inquiry. Consequently, in the last few years, work in science and values has become more specific: Which values may influence science, and in which ways? Or, how do we distinguish illegitimate from illegitimate kinds of influence? In this paper, I argue that this (...)
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  • Suffering as an anchor of critique. The place of critique in critical discourse studies.Benno Herzog - 2018 - Critical Discourse Studies 15 (2):111-122.
    ABSTRACTIf we engage in reflection on standards of critique, we are entering the terrain of metaethics, or the question of which ethical standards we should accept. The question is not only, in the sense of self-awareness, what we as individual researchers or as a critical discourse analysis community think or feel about a specific social phenomenon. The metaethical question is about what we should think or feel.The aim of this article is to argue for a specific perspective on critique, namely, (...)
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  • Ethics, deception, and 'those Milgram experiments'.C. D. Herrera - 2001 - Journal of Applied Philosophy 18 (3):245–256.
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  • A historical interpretation of deceptive experiments in American psychology.C. D. Herrera - 1997 - History of the Human Sciences 10 (1):23-36.
    In debate over the ethics of deceptive experiments in American psy chology, commentators often provide an inaccurate history of these experiments. This happens especially where writers portray experi mental deception as a necessary accompaniment to human experiments, rather than a conscious choice based on values attached to persons and scientific inquiry. Compounding the error, commentators typically give a misleading portrayal of psychologists' attitudes and procedures. Commentators frequently cite Stanley Milgram's work in the 1960s as a harbinger of changed attitudes towards (...)
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  • Does Informed Consent Have an Expiry Date? A Critical Reappraisal of Informed Consent as a Process.Gert Helgesson & Stefan Eriksson - 2011 - Cambridge Quarterly of Healthcare Ethics 20 (1):85-92.
    Informed consent is central to modern research ethics. Informed consent procedures have mainly been justified in terms of respect for autonomy, the core idea being that it should be every competent individual’s right to decide for herself whether or not to participate in scientific studies. A number of conditions are normally raised with regard to morally valid informed consent. These include that potential research subjects get adequate information, understand those aspects that are relevant to them, and, based on that information, (...)
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  • The problems of presumed isomorphism and the ethics review of social science: A response to Schrag.Adam Hedgecoe - 2012 - Research Ethics 8 (2):79-86.
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  • Trustworthiness.Russell Hardin - 1996 - Ethics 107 (1):26-42.
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  • Extending human lifespan and the precautionary paradox.John Harris & Søren Holm - 2002 - Journal of Medicine and Philosophy 27 (3):355 – 368.
    This paper argues that a precautionary approach to scientific progress of the sort advocated by Walter Glannon with respect to life-extending therapies involves both incoherence and irresolvable paradox. This paper demonstrates the incoherence of the precautionary approach in many circumstances and argues that with respect to life-extending therapies we have at present no persuasive reasons for a moratorium on such research.
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